{"id":"https://openalex.org/W2168369955","doi":null,"title":"Hepatitis C in Hemophilia","display_name":"Hepatitis C in Hemophilia","publication_year":2006,"publication_date":"2006-06-06","ids":{"openalex":"https://openalex.org/W2168369955","mag":"2168369955"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/9199","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/9199","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/9199","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044232904","display_name":"Dirk Posthouwer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dirk Posthouwer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044232904"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c","display_name":"hepatitis C","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hemophilia","display_name":"hemophilia","score":0.996999979019165},{"id":"https://openalex.org/keywords/hiv-coinfection","display_name":"HIV coinfection","score":0.6489999890327454},{"id":"https://openalex.org/keywords/end-stage-liver-disease","display_name":"end-stage liver disease","score":0.9459999799728394},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/fibroscan","display_name":"FibroScan","score":0.7910000085830688},{"id":"https://openalex.org/keywords/noninvasive-fibrosis-assessment","display_name":"noninvasive fibrosis assessment","score":0.847000002861023},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.8730000257492065},{"id":"https://openalex.org/keywords/pegylated-interferon","display_name":"pegylated interferon","score":0.8659999966621399},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.8460000157356262},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.8420000076293945},{"id":"https://openalex.org/keywords/barriers-to-treatment","display_name":"barriers to treatment","score":0.4560000002384186},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.3490000069141388},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.7099999785423279},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.49300000071525574},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/hcv-genotypes","display_name":"HCV genotypes","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9264676570892334},{"id":"https://openalex.org/C2992139802","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Clotting factor","level":2,"score":0.7493271827697754},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.7081283926963806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5976067185401917},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.5975184440612793},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5910477638244629},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.5884843468666077},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5307063460350037},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.45450717210769653},{"id":"https://openalex.org/C2779936836","wikidata":"https://www.wikidata.org/wiki/Q890200","display_name":"Coagulopathy","level":2,"score":0.45193612575531006},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39454787969589233},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/9199","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/9199","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/9199","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/9199","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2168369955","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/bitstream/1874/9199/1/c1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/9199","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/9199","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":163,"referenced_works":["https://openalex.org/W40038083","https://openalex.org/W122549255","https://openalex.org/W127292899","https://openalex.org/W155781577","https://openalex.org/W178626340","https://openalex.org/W195503229","https://openalex.org/W614531583","https://openalex.org/W1505139021","https://openalex.org/W1556481499","https://openalex.org/W1559207978","https://openalex.org/W1577306603","https://openalex.org/W1620465551","https://openalex.org/W1862952144","https://openalex.org/W1957447204","https://openalex.org/W1963633512","https://openalex.org/W1965612700","https://openalex.org/W1966511412","https://openalex.org/W1967688363","https://openalex.org/W1968553130","https://openalex.org/W1969050678","https://openalex.org/W1969562548","https://openalex.org/W1970160203","https://openalex.org/W1970526583","https://openalex.org/W1970608179","https://openalex.org/W1971784328","https://openalex.org/W1978073437","https://openalex.org/W1978992694","https://openalex.org/W1983047765","https://openalex.org/W1984770517","https://openalex.org/W1985241178","https://openalex.org/W1986300136","https://openalex.org/W1990816300","https://openalex.org/W1991456384","https://openalex.org/W1992239172","https://openalex.org/W1993581467","https://openalex.org/W1993839932","https://openalex.org/W1995085883","https://openalex.org/W1995813950","https://openalex.org/W1996434966","https://openalex.org/W1997724038","https://openalex.org/W1997865776","https://openalex.org/W1998362279","https://openalex.org/W1999004738","https://openalex.org/W2000538721","https://openalex.org/W2001648334","https://openalex.org/W2001973858","https://openalex.org/W2002513752","https://openalex.org/W2003761258","https://openalex.org/W2005431329","https://openalex.org/W2005863439","https://openalex.org/W2006309458","https://openalex.org/W2008759618","https://openalex.org/W2012074872","https://openalex.org/W2012676911","https://openalex.org/W2013851368","https://openalex.org/W2014882815","https://openalex.org/W2015410094","https://openalex.org/W2018446644","https://openalex.org/W2021832575","https://openalex.org/W2024123158","https://openalex.org/W2024822582","https://openalex.org/W2026502021","https://openalex.org/W2027498662","https://openalex.org/W2027545702","https://openalex.org/W2027726359","https://openalex.org/W2031110289","https://openalex.org/W2031173790","https://openalex.org/W2031577492","https://openalex.org/W2037377025","https://openalex.org/W2037555620","https://openalex.org/W2039422277","https://openalex.org/W2039435228","https://openalex.org/W2040510423","https://openalex.org/W2042191290","https://openalex.org/W2042557457","https://openalex.org/W2043976325","https://openalex.org/W2044734932","https://openalex.org/W2044742476","https://openalex.org/W2047084211","https://openalex.org/W2047208492","https://openalex.org/W2047919099","https://openalex.org/W2048603714","https://openalex.org/W2048833814","https://openalex.org/W2049695669","https://openalex.org/W2049836074","https://openalex.org/W2051995780","https://openalex.org/W2052509705","https://openalex.org/W2052790789","https://openalex.org/W2054850951","https://openalex.org/W2055350591","https://openalex.org/W2055364389","https://openalex.org/W2056449076","https://openalex.org/W2058110603","https://openalex.org/W2061796430","https://openalex.org/W2062058597","https://openalex.org/W2063455213","https://openalex.org/W2063686056","https://openalex.org/W2064171829","https://openalex.org/W2065663771","https://openalex.org/W2071277949","https://openalex.org/W2071549357","https://openalex.org/W2072160870","https://openalex.org/W2073931583","https://openalex.org/W2075026875","https://openalex.org/W2075453657","https://openalex.org/W2082687051","https://openalex.org/W2085261733","https://openalex.org/W2085660379","https://openalex.org/W2085691878","https://openalex.org/W2089230634","https://openalex.org/W2091445224","https://openalex.org/W2091574686","https://openalex.org/W2091709525","https://openalex.org/W2093748041","https://openalex.org/W2094174828","https://openalex.org/W2102138081","https://openalex.org/W2102865648","https://openalex.org/W2103602992","https://openalex.org/W2104695445","https://openalex.org/W2106109244","https://openalex.org/W2107610652","https://openalex.org/W2110333348","https://openalex.org/W2110335781","https://openalex.org/W2110529807","https://openalex.org/W2110633145","https://openalex.org/W2116345541","https://openalex.org/W2118961281","https://openalex.org/W2119168386","https://openalex.org/W2120247097","https://openalex.org/W2122764811","https://openalex.org/W2124515032","https://openalex.org/W2127685726","https://openalex.org/W2128643232","https://openalex.org/W2130620143","https://openalex.org/W2131219962","https://openalex.org/W2133580842","https://openalex.org/W2134403457","https://openalex.org/W2135155547","https://openalex.org/W2136336812","https://openalex.org/W2138236649","https://openalex.org/W2142866037","https://openalex.org/W2149318954","https://openalex.org/W2150493975","https://openalex.org/W2151769300","https://openalex.org/W2153923196","https://openalex.org/W2154344968","https://openalex.org/W2157776721","https://openalex.org/W2158710467","https://openalex.org/W2160626977","https://openalex.org/W2165715544","https://openalex.org/W2166045485","https://openalex.org/W2171177822","https://openalex.org/W2237448150","https://openalex.org/W2267597726","https://openalex.org/W2269938046","https://openalex.org/W2283791819","https://openalex.org/W2289095218","https://openalex.org/W2315563079","https://openalex.org/W2317554121","https://openalex.org/W2324539587","https://openalex.org/W2333452860","https://openalex.org/W2341829866","https://openalex.org/W3025122695"],"related_works":["https://openalex.org/W1915016692","https://openalex.org/W2619627647","https://openalex.org/W2416968204","https://openalex.org/W3204523883","https://openalex.org/W2001168398","https://openalex.org/W2028169639","https://openalex.org/W1486680309","https://openalex.org/W2082561559","https://openalex.org/W2073938627","https://openalex.org/W2006927772"],"abstract_inverted_index":{"Hepatitis":[0],"is":[1,55,535,543],"a":[2,17,49,176,442,456],"major":[3],"cause":[4],"of":[5,19,52,61,84,88,95,100,118,123,142,144,149,192,199,227,233,243,292,303,353,359,384,438,445,474,521],"morbidity":[6],"and":[7,42,91,146,163,221,294,348,402],"mortality":[8],"in":[9,104,116,138,159,269,287,306,328,356,362,372,380,420,487],"patients":[10,54,64,106,140,165,193,203,234,245,271,286,317,327,385,405,453,478,490],"with":[11,16,107,194,214,272,318,333,338,389,393,489],"hemophilia.":[12],"In":[13,70,153,441,506],"our":[14,357,381],"study":[15,383,444],"follow-up":[18,534],"35":[20],"years,":[21,312],"we":[22,170,186,449],"found":[23,187,450],"that":[24,208,261,316,370,451,511],"the":[25,71,160,172,180,215,225,228,262,301,307,329,363,373,415,435,475,496,526,546],"risk":[26,57,143,497],"for":[27,39,44,58,130,167,250,399,498],"end-stage":[28,500],"liver":[29,157,206,480,501],"disease":[30,502],"(liver":[31],"failure,":[32],"hepatocellular":[33,483],"carcinoma,":[34],"liver-related":[35],"death)":[36],"was":[37,102,314,377,406,486,503],"12%":[38],"HIV":[40,45,400],"negative,":[41],"35%":[43],"coinfected":[46],"patients.":[47],"Although":[48],"significant":[50,205,273],"proportion":[51,191],"hemophilia":[53,73,105,139,319,334],"at":[56],"long-term":[59,436,519],"complications":[60,520],"hepatitis,":[62],"many":[63,311],"still":[65],"have":[66,211,345,349],"not":[67,78,210],"been":[68,212,256],"treated.":[69],"Dutch":[72],"population,":[74],"approximately":[75,200,231,446,504],"30-40%":[76],"were":[77,171,367,387],"treated":[79,388,477],"mainly":[80],"due":[81,413],"to":[82,155,174,275,284,289,323,369,414,418,426,467,493,537],"fear":[83],"side":[85],"effects,":[86],"lack":[87],"clinical":[89],"symptoms,":[90],"expected":[92],"low":[93],"efficacy":[94,302],"treatment.":[96,471],"However,":[97,355,532],"health-related":[98,121],"quality":[99,122],"life":[101,124],"reduced":[103],"chronic":[108,522],"hepatitis":[109,131,523],"C.":[110,132],"Thus":[111],"providing":[112],"an":[113,188,266],"additional":[114],"argument":[115],"favor":[117],"treatment,":[119],"as":[120],"will":[125],"improve":[126],"after":[127,459,470,530],"successful":[128,512],"treatment":[129,403],"Liver":[133],"biopsies":[134],"are":[135,335,342,429,434],"rarely":[136],"performed":[137],"because":[141],"bleeding,":[145],"high":[147,190,351,409,416],"costs":[148],"clotting":[150],"factor":[151],"replacement.":[152],"order":[154,288],"assess":[156,290,538],"fibrosis":[158,196,274,293],"hemophilic":[161,308,364],"population":[162,365],"identify":[164],"eligible":[166],"antiviral":[168,236,248,427],"therapy,":[169],"first":[173,527],"use":[175],"new,":[177],"non-invasive":[178],"device:":[179],"Fibroscan\u00ae.":[181],"With":[182],"this":[183,279,421,439,540],"new":[184],"technique":[185,280],"unexpected":[189],"severe":[195],"or":[197,482,515],"cirrhosis":[198],"35%.":[201],"Many":[202],"had":[204,246,254],"damage":[207],"would":[209,320],"detected":[213],"conventional":[216],"methods":[217],"like":[218],"laboratory":[219],"tests":[220],"ultrasonography.":[222],"Based":[223],"on":[224],"results":[226,259],"Fibroscan\u00ae":[229,263],"examination,":[230],"25%":[232],"started":[235],"therapy":[237,249,253,305,325,419,428,461,513],"within":[238],"three":[239],"months.":[240],"The":[241,395,423],"majority":[242],"these":[244,508],"postponed":[247],"years":[251,469,529],"despite":[252],"frequently":[255],"offered.":[257],"These":[258],"indicate":[260,510],"may":[264,281,411,516],"play":[265],"important":[267],"role":[268],"persuading":[270],"start":[276],"therapy.":[277,531],"Furthermore,":[278,472],"be":[282,412],"used":[283],"follow":[285],"progression":[291],"determine":[295],"prognosis.":[296],"Conflicting":[297],"data":[298],"exist":[299],"about":[300],"IFN-based":[304,324,360,460],"population.":[309,331,375,422],"For":[310],"it":[313],"thought":[315],"respond":[321],"worse":[322],"than":[326],"general":[330,374],"Patients":[332],"often":[336,350],"infected":[337],"HCV":[339,463],"genotype":[340],"1,":[341],"predominantly":[343],"male,":[344],"long-lasting":[346],"infection,":[347],"levels":[352],"viraemia.":[354],"review":[358],"therapies":[361],"responses":[366,425],"similar":[368],"seen":[371],"This":[376,408,485],"also":[378],"corroborated":[379],"pilot":[382],"who":[386,454,491],"Pegylated":[390],"IFN":[391],"combined":[392],"ribavirin.":[394],"sustained":[396,457,544],"virological":[397],"response":[398,410,458],"negative":[401,465],"na\u00efve":[404],"70%.":[407],"compliance":[417],"direct":[424],"precisely":[430],"defined,":[431],"but":[432],"what":[433],"effects":[437],"therapy?":[440],"cohort":[443],"300":[447],"patients,":[448],"all":[452],"achieved":[455],"remained":[462],"RNA":[464],"up":[466],"15":[468],"none":[473],"successfully":[476],"developed":[479],"failure":[481],"carcinoma.":[484],"contrast":[488],"failed":[492],"eradicate":[494],"HCV:":[495],"developing":[499],"13%.":[505],"conclusion,":[507],"findings":[509],"postpones":[514],"even":[517],"prevent":[518],"C":[524],"during":[525],"10-15":[528],"longer":[533],"required":[536],"whether":[539],"favorable":[541],"effect":[542],"over":[545],"next":[547],"decades.":[548]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}