{"id":"https://openalex.org/W2168338684","doi":null,"title":"Dynamic changes in T cell compartments and new approaches in evaluating DSS induced and Gai2 deficient colitis","display_name":"Dynamic changes in T cell compartments and new approaches in evaluating DSS induced and Gai2 deficient colitis","publication_year":2007,"publication_date":"2007-11-06","ids":{"openalex":"https://openalex.org/W2168338684","mag":"2168338684"},"language":"en","primary_location":{"id":"mag:2168338684","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/7471/1/Ram%20svartvit.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002198934","display_name":"Maria Fritsch Fredin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maria Fritsch Fredin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002198934"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23605302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/t-cell-compartment","display_name":"T cell compartment","score":0.7820000052452087},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.8880000114440918},{"id":"https://openalex.org/keywords/intraepithelial-lymphocytes","display_name":"intraepithelial lymphocytes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/thymic-involution","display_name":"thymic involution","score":0.9120000004768372},{"id":"https://openalex.org/keywords/micro-ct","display_name":"micro-CT","score":0.6679999828338623},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.9181772470474243},{"id":"https://openalex.org/C152605822","wikidata":"https://www.wikidata.org/wiki/Q17100626","display_name":"Intraepithelial lymphocyte","level":3,"score":0.8239842653274536},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.617253303527832},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5659060478210449},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5152350068092346},{"id":"https://openalex.org/C2781077229","wikidata":"https://www.wikidata.org/wiki/Q509615","display_name":"Intestinal epithelium","level":3,"score":0.4403454065322876},{"id":"https://openalex.org/C2776280935","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Large intestine","level":2,"score":0.4129931926727295},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3948467969894409},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3864583671092987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38562092185020447},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.3218435049057007},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29886993765830994},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.210771381855011},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1876097321510315}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2168338684","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/7471/1/Ram%20svartvit.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":279,"referenced_works":["https://openalex.org/W2310165","https://openalex.org/W6527825","https://openalex.org/W117177173","https://openalex.org/W143136217","https://openalex.org/W143644769","https://openalex.org/W1492371883","https://openalex.org/W1493159751","https://openalex.org/W1498420538","https://openalex.org/W1499060701","https://openalex.org/W1530782041","https://openalex.org/W1535586386","https://openalex.org/W1545517148","https://openalex.org/W1558813989","https://openalex.org/W1579193869","https://openalex.org/W1580488216","https://openalex.org/W1583750739","https://openalex.org/W1595024798","https://openalex.org/W1598189172","https://openalex.org/W1602530922","https://openalex.org/W1642457845","https://openalex.org/W1748077267","https://openalex.org/W1761355724","https://openalex.org/W1763925139","https://openalex.org/W1775427038","https://openalex.org/W1813646352","https://openalex.org/W1845629018","https://openalex.org/W1855226200","https://openalex.org/W1887031720","https://openalex.org/W1906564878","https://openalex.org/W1910153683","https://openalex.org/W1913056497","https://openalex.org/W1926726618","https://openalex.org/W1935225932","https://openalex.org/W1940136852","https://openalex.org/W1940525264","https://openalex.org/W1942668068","https://openalex.org/W1950783455","https://openalex.org/W1961087288","https://openalex.org/W1963809310","https://openalex.org/W1963825012","https://openalex.org/W1965557584","https://openalex.org/W1967666787","https://openalex.org/W1968062465","https://openalex.org/W1968101319","https://openalex.org/W1968926025","https://openalex.org/W1969359183","https://openalex.org/W1970519040","https://openalex.org/W1970959631","https://openalex.org/W1973661009","https://openalex.org/W1975745651","https://openalex.org/W1976174932","https://openalex.org/W1976591271","https://openalex.org/W1980668544","https://openalex.org/W1985478099","https://openalex.org/W1987728228","https://openalex.org/W1988332355","https://openalex.org/W1988975884","https://openalex.org/W1989210966","https://openalex.org/W1989506542","https://openalex.org/W1990527536","https://openalex.org/W1991090793","https://openalex.org/W1991454367","https://openalex.org/W1991665328","https://openalex.org/W1993644920","https://openalex.org/W1993678078","https://openalex.org/W1994348473","https://openalex.org/W1994443194","https://openalex.org/W1995097896","https://openalex.org/W1995653973","https://openalex.org/W1996306653","https://openalex.org/W1996615467","https://openalex.org/W1997103341","https://openalex.org/W1997531619","https://openalex.org/W1998140184","https://openalex.org/W1999522813","https://openalex.org/W2000208875","https://openalex.org/W2002061924","https://openalex.org/W2004424160","https://openalex.org/W2005387789","https://openalex.org/W2005985351","https://openalex.org/W2006479087","https://openalex.org/W2006654054","https://openalex.org/W2007665550","https://openalex.org/W2007988618","https://openalex.org/W2008386409","https://openalex.org/W2012528572","https://openalex.org/W2013333236","https://openalex.org/W2014257728","https://openalex.org/W2015788300","https://openalex.org/W2016887744","https://openalex.org/W2017991007","https://openalex.org/W2018648914","https://openalex.org/W2018994645","https://openalex.org/W2021877641","https://openalex.org/W2024207529","https://openalex.org/W2028025555","https://openalex.org/W2028829377","https://openalex.org/W2029133355","https://openalex.org/W2029690122","https://openalex.org/W2029826942","https://openalex.org/W2030761613","https://openalex.org/W2031352461","https://openalex.org/W2031429436","https://openalex.org/W2031680738","https://openalex.org/W2032406291","https://openalex.org/W2032450371","https://openalex.org/W2032494769","https://openalex.org/W2033269170","https://openalex.org/W2034217591","https://openalex.org/W2034589035","https://openalex.org/W2036500213","https://openalex.org/W2037895770","https://openalex.org/W2038269648","https://openalex.org/W2039269022","https://openalex.org/W2039395305","https://openalex.org/W2042108397","https://openalex.org/W2042378494","https://openalex.org/W2042667235","https://openalex.org/W2044968471","https://openalex.org/W2048065046","https://openalex.org/W2048288058","https://openalex.org/W2049124088","https://openalex.org/W2050445005","https://openalex.org/W2051476584","https://openalex.org/W2051887924","https://openalex.org/W2052067720","https://openalex.org/W2052446038","https://openalex.org/W2052908247","https://openalex.org/W2053388673","https://openalex.org/W2053486359","https://openalex.org/W2053900723","https://openalex.org/W2054944041","https://openalex.org/W2056167691","https://openalex.org/W2056204715","https://openalex.org/W2057322910","https://openalex.org/W2057437717","https://openalex.org/W2057663849","https://openalex.org/W2060866254","https://openalex.org/W2061984946","https://openalex.org/W2062626858","https://openalex.org/W2065280032","https://openalex.org/W2066300320","https://openalex.org/W2066868012","https://openalex.org/W2067547573","https://openalex.org/W2068567943","https://openalex.org/W2069545526","https://openalex.org/W2071303030","https://openalex.org/W2071644653","https://openalex.org/W2076819781","https://openalex.org/W2077291496","https://openalex.org/W2077417036","https://openalex.org/W2077463770","https://openalex.org/W2077959661","https://openalex.org/W2078256427","https://openalex.org/W2078514099","https://openalex.org/W2078621117","https://openalex.org/W2080424672","https://openalex.org/W2080808232","https://openalex.org/W2082024883","https://openalex.org/W2084048931","https://openalex.org/W2084422721","https://openalex.org/W2084855813","https://openalex.org/W2085918020","https://openalex.org/W2085992091","https://openalex.org/W2086313080","https://openalex.org/W2086454098","https://openalex.org/W2086710105","https://openalex.org/W2087750943","https://openalex.org/W2087809284","https://openalex.org/W2089463658","https://openalex.org/W2089628044","https://openalex.org/W2090197666","https://openalex.org/W2090235914","https://openalex.org/W2090305209","https://openalex.org/W2091203722","https://openalex.org/W2092424797","https://openalex.org/W2093705034","https://openalex.org/W2094320855","https://openalex.org/W2094464340","https://openalex.org/W2094556867","https://openalex.org/W2095016279","https://openalex.org/W2096683371","https://openalex.org/W2098373464","https://openalex.org/W2098599908","https://openalex.org/W2098973755","https://openalex.org/W2100051740","https://openalex.org/W2100564391","https://openalex.org/W2101759139","https://openalex.org/W2101934251","https://openalex.org/W2102054977","https://openalex.org/W2103097055","https://openalex.org/W2103185055","https://openalex.org/W2103357560","https://openalex.org/W2103390588","https://openalex.org/W2106453726","https://openalex.org/W2108572357","https://openalex.org/W2109466762","https://openalex.org/W2110606108","https://openalex.org/W2112679274","https://openalex.org/W2112888863","https://openalex.org/W2113043806","https://openalex.org/W2114569569","https://openalex.org/W2116303795","https://openalex.org/W2116761160","https://openalex.org/W2117462157","https://openalex.org/W2117749834","https://openalex.org/W2118081432","https://openalex.org/W2119027567","https://openalex.org/W2122879998","https://openalex.org/W2123125864","https://openalex.org/W2123307454","https://openalex.org/W2124017330","https://openalex.org/W2124059925","https://openalex.org/W2124984983","https://openalex.org/W2125170859","https://openalex.org/W2125626931","https://openalex.org/W2125799301","https://openalex.org/W2126874760","https://openalex.org/W2127197214","https://openalex.org/W2127432084","https://openalex.org/W2127906539","https://openalex.org/W2127984837","https://openalex.org/W2128155932","https://openalex.org/W2129785704","https://openalex.org/W2130470396","https://openalex.org/W2131727319","https://openalex.org/W2133226723","https://openalex.org/W2134090681","https://openalex.org/W2134787176","https://openalex.org/W2135376666","https://openalex.org/W2137428636","https://openalex.org/W2137914700","https://openalex.org/W2138223843","https://openalex.org/W2138278340","https://openalex.org/W2140167876","https://openalex.org/W2142252231","https://openalex.org/W2143624443","https://openalex.org/W2144437446","https://openalex.org/W2146518773","https://openalex.org/W2149085554","https://openalex.org/W2149565825","https://openalex.org/W2149773503","https://openalex.org/W2149958822","https://openalex.org/W2150026400","https://openalex.org/W2150267721","https://openalex.org/W2151165347","https://openalex.org/W2155841056","https://openalex.org/W2156218775","https://openalex.org/W2156977465","https://openalex.org/W2157329817","https://openalex.org/W2159897442","https://openalex.org/W2160789639","https://openalex.org/W2161485037","https://openalex.org/W2162493503","https://openalex.org/W2164237757","https://openalex.org/W2164280295","https://openalex.org/W2167152940","https://openalex.org/W2168149038","https://openalex.org/W2168329195","https://openalex.org/W2168524781","https://openalex.org/W2169424849","https://openalex.org/W2170069789","https://openalex.org/W2171537180","https://openalex.org/W2171997755","https://openalex.org/W2172135053","https://openalex.org/W2326396329","https://openalex.org/W2334402680","https://openalex.org/W2337711722","https://openalex.org/W2342066803","https://openalex.org/W2400961488","https://openalex.org/W2406906850","https://openalex.org/W2413800090","https://openalex.org/W2417905097","https://openalex.org/W2743422037","https://openalex.org/W2774846296","https://openalex.org/W3028348824","https://openalex.org/W3182923462","https://openalex.org/W4313333865","https://openalex.org/W4313347728"],"related_works":["https://openalex.org/W2045296660","https://openalex.org/W1496356137","https://openalex.org/W2037895770","https://openalex.org/W7099216976","https://openalex.org/W2144972216","https://openalex.org/W7052597695","https://openalex.org/W2158041688","https://openalex.org/W2042674825","https://openalex.org/W7096490225","https://openalex.org/W2350682653"],"abstract_inverted_index":{"The":[0,19,36,198,242,355],"overall":[1],"aim":[2,21,38],"of":[3,11,14,44,52,101,137,150,235,275,323,341,353,382,395],"this":[4],"thesis":[5],"was":[6,22,39,115,311],"to":[7,23,40,161,239,299,320,344,349,375],"increase":[8,145,221],"the":[9,12,26,29,56,64,82,111,126,147,164,170,183,195,215,220,240,246,255,264,270,276,324,338,350,366,380,393],"understanding":[10],"immunopathology":[13],"Inflammatory":[15],"Bowel":[16],"Disease":[17],"(IBD).":[18],"first":[20],"elucidate":[24],"how":[25],"thymus":[27],"and":[28,46,63,90,97,103,110,159,203,219,248,282,294,297,301,303,347,362,365,388],"gut":[30],"epithelium":[31],"were":[32,54,79,86,107,128,157,287],"affected":[33],"by":[34,117,143],"colitis.":[35,48,75,354],"second":[37],"investigate":[41],"new":[42,390],"ways":[43],"assessing":[45],"monitoring":[47,386],"Two":[49],"mouse":[50,70,102,361],"models":[51,78],"colitis":[53,208,228,252,342,387],"used,":[55],"dextran":[57],"sodium":[58],"sulfate":[59],"(DSS)":[60],"induced":[61,124,281],"model":[62],"G\u03b1i2":[65,175,283],"deficient":[66],"(G\u03b1i2":[67],"-/-":[68,176,284],")":[69],"model,":[71],"which":[72],"spontaneously":[73],"develops":[74],"These":[76,155],"two":[77,256],"compared":[80,319,343],"throughout":[81],"study.":[83],"Colitis-induced":[84],"changes":[85,156,200],"analysed":[87],"in":[88,146,182,194,201,222,231,245,263,269,279,290,295,313,327,360,385],"thymocytes":[89,127,225],"intestinal":[91],"intraepithelial":[92],"lymphocytes":[93],"(IEL).":[94],"To":[95],"monitor":[96],"evaluate":[98],"colitis,":[99,125],"cultures":[100,293,318,364],"human":[104,314,363],"colonic":[105],"tissue":[106],"set":[108],"up":[109],"colon":[112,325,335,369],"wall":[113,326,336,370],"thickness":[114,371],"measured":[116],"micro-Computed":[118],"Tomography":[119],"(micro-CT).":[120],"During":[121],"acute":[122,227,339],"DSS":[123,280,328],"shifted":[129],"towards":[130],"a":[131,332],"more":[132],"mature":[133],"phenotype,":[134],"with":[135],"loss":[136],"double":[138,151],"positive":[139],"(DP)":[140],"thymocytes,":[141],"paralleled":[142],"an":[144,232,260],"absolute":[148],"number":[149],"negative":[152],"(DN1)":[153],"thymocytes.":[154],"transient":[158],"returned":[160],"normal":[162],"as":[163],"mice":[165,286,330],"recovered":[166],"or":[167,267],"progressed":[168],"into":[169],"chronic":[171],"phase.":[172],"In":[173],"colitic":[174,285],"mice,":[177],"CD4":[178,187],"+":[179,188,190],"IELs":[180,192],"increased":[181,193,233],"large":[184,249,265],"intestine,":[185],"while":[186],"CD8\u03b1\u03b1":[189],"DP":[191],"small":[196,247,271],"intestine.":[197,272],"dynamic":[199],"thymocyte":[202],"IEL":[204],"composition":[205],"demonstrates":[206],"that":[207,254,368],"affect":[209],"other":[210],"T":[211,237,302],"cell":[212,305],"compartments":[213],"than":[214],"colon.":[216],"Thymic":[217],"involution":[218],"immature":[223,236],"DN1":[224],"during":[226,251,337],"may":[229],"result":[230],"export":[234],"cells":[238],"gut.":[241],"different":[243],"responses":[244],"intestine":[250,266],"suggest":[253],"microenvironments":[257],"induce":[258],"either":[259],"uncontrolled":[261],"inflammation":[262],"suppression":[268],"Approximately":[273],"75%":[274],"genes":[277],"detected":[278],"similarly":[288],"regulated":[289],"ex":[291,316],"vivo":[292,317],"vivo,":[296],"belonged":[298],"cytokines":[300],"B":[304],"markers.":[306],"A":[307],"similar":[308,356],"gene":[309,357],"profile":[310,359],"obtained":[312],"UC":[315],"mouse.":[321],"Measurements":[322],"treated":[329],"demonstrated":[331],"significantly":[333],"thicker":[334],"phase":[340],"healthy":[345],"controls,":[346],"correlated":[348],"macroscopic":[351],"scoring":[352],"expression":[358],"finding":[367],"can":[372],"be":[373],"used":[374],"identify":[376],"responding":[377],"animals":[378],"support":[379],"relevance":[381],"these":[383],"systems":[384],"evaluating":[389],"substances":[391],"for":[392],"treatment":[394],"IBD.":[396]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
