{"id":"https://openalex.org/W2168335693","doi":"https://doi.org/10.1093/nar/gkq926","title":"Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene","display_name":"Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene","publication_year":2010,"publication_date":"2010-10-18","ids":{"openalex":"https://openalex.org/W2168335693","doi":"https://doi.org/10.1093/nar/gkq926","mag":"2168335693","pmid":"https://pubmed.ncbi.nlm.nih.gov/20959293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3045601"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkq926","doi":"https://doi.org/10.1093/nar/gkq926","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq926","pdf_url":"https://academic.oup.com/nar/article-pdf/39/4/1256/3278912/gkq926.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/39/4/1256/3278912/gkq926.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100611819","display_name":"Sun D","orcid":"https://orcid.org/0000-0002-2692-6384","observed_orcids":["https://orcid.org/0000-0002-2692-6384"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. Sun","raw_affiliation_strings":["College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA. sun@pharmacy.arizona.edu","College of Pharmacy, 2BIO5 Institute, 3Arizona Cancer Center and 4Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA. sun@pharmacy.arizona.edu","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"College of Pharmacy, 2BIO5 Institute, 3Arizona Cancer Center and 4Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4388891792","display_name":"BIO5 Institute","ror":"https://ror.org/023drta67","country_code":"US","type":"facility","lineage":["https://openalex.org/I138006243","https://openalex.org/I4388891792"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Guo","raw_affiliation_strings":["College of Pharmacy, 2 BIO5 Institute, 3 Arizona Cancer Center and 4 Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, 2 BIO5 Institute, 3 Arizona Cancer Center and 4 Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4388891792","https://openalex.org/I4390039223"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051519072","display_name":"Yoon Joo Shin","orcid":"https://orcid.org/0000-0001-7872-5552","observed_orcids":["https://orcid.org/0000-0001-7872-5552"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4388891792","display_name":"BIO5 Institute","ror":"https://ror.org/023drta67","country_code":"US","type":"facility","lineage":["https://openalex.org/I138006243","https://openalex.org/I4388891792"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y.-J. Shin","raw_affiliation_strings":["College of Pharmacy, 2 BIO5 Institute, 3 Arizona Cancer Center and 4 Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, 2 BIO5 Institute, 3 Arizona Cancer Center and 4 Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4388891792","https://openalex.org/I4390039223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100611819"],"corresponding_institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":3.7168,"has_fulltext":true,"cited_by_count":113,"citation_normalized_percentile":{"value":0.94762283,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"39","issue":"4","first_page":"1256","last_page":"1265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-quadruplex","display_name":"G-quadruplex","score":0.9620000123977661},{"id":"https://openalex.org/keywords/vegf-promoter","display_name":"VEGF promoter","score":0.8410000205039978},{"id":"https://openalex.org/keywords/polypurine-tract","display_name":"polypurine tract","score":0.8799999952316284},{"id":"https://openalex.org/keywords/non-b-dna","display_name":"non-B DNA structures","score":0.7609999775886536},{"id":"https://openalex.org/keywords/nucleolin","display_name":"nucleolin","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dimethyl-sulfate-footprinting","display_name":"dimethyl sulfate footprinting","score":0.953000009059906},{"id":"https://openalex.org/keywords/dna-supercoiling","display_name":"DNA supercoiling","score":0.7919999957084656},{"id":"https://openalex.org/keywords/chromatin-immunoprecipitation","display_name":"chromatin immunoprecipitation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/g-rich-dna","display_name":"G-rich DNA","score":0.5339999794960022},{"id":"https://openalex.org/keywords/dna-secondary-structure","display_name":"DNA secondary structure","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2776525860","wikidata":"https://www.wikidata.org/wiki/Q18029887","display_name":"Nucleolin","level":4,"score":0.9182513952255249},{"id":"https://openalex.org/C2778021871","wikidata":"https://www.wikidata.org/wiki/Q648006","display_name":"Footprinting","level":4,"score":0.8914787173271179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8475195169448853},{"id":"https://openalex.org/C22427896","wikidata":"https://www.wikidata.org/wiki/Q4493748","display_name":"DNA footprinting","level":5,"score":0.5703946352005005},{"id":"https://openalex.org/C83762044","wikidata":"https://www.wikidata.org/wiki/Q411641","display_name":"G-quadruplex","level":3,"score":0.5610325336456299},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5486368536949158},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.5412274599075317},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5174070596694946},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.49938297271728516},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.43573081493377686},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3366602659225464},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.32799068093299866},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3266969323158264},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24918502569198608},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17278802394866943},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.07505065202713013},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.0},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.0},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000097796","descriptor_name":"Nucleolin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018983","descriptor_name":"DNA Footprinting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054856","descriptor_name":"G-Quadruplexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkq926","doi":"https://doi.org/10.1093/nar/gkq926","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq926","pdf_url":"https://academic.oup.com/nar/article-pdf/39/4/1256/3278912/gkq926.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3045601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3045601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:20959293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20959293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkq926","doi":"https://doi.org/10.1093/nar/gkq926","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkq926","pdf_url":"https://academic.oup.com/nar/article-pdf/39/4/1256/3278912/gkq926.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2337624583","display_name":"Targeting Tumor Angiogenesis with G-Quadruplex Binders","funder_award_id":"R01CA109069","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332140","display_name":"Arizona Biomedical Research Commission","ror":"https://ror.org/01smpj292"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168335693.pdf","grobid_xml":"https://content.openalex.org/works/W2168335693.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W300264704","https://openalex.org/W1480653299","https://openalex.org/W1925850732","https://openalex.org/W1967987158","https://openalex.org/W1975505830","https://openalex.org/W1990971285","https://openalex.org/W1991590162","https://openalex.org/W1994064477","https://openalex.org/W2007897471","https://openalex.org/W2013288089","https://openalex.org/W2015625843","https://openalex.org/W2020307752","https://openalex.org/W2050062156","https://openalex.org/W2057255746","https://openalex.org/W2058825091","https://openalex.org/W2074139680","https://openalex.org/W2086619383","https://openalex.org/W2092156970","https://openalex.org/W2100569171","https://openalex.org/W2104454005","https://openalex.org/W2126125281","https://openalex.org/W2126688731","https://openalex.org/W2142786915","https://openalex.org/W2155139733","https://openalex.org/W2217246609","https://openalex.org/W2264379186","https://openalex.org/W2409931811","https://openalex.org/W2460830885","https://openalex.org/W2764954042","https://openalex.org/W2777057162","https://openalex.org/W4256076312"],"related_works":["https://openalex.org/W2753076694","https://openalex.org/W1991590162","https://openalex.org/W2104454005","https://openalex.org/W2993354363","https://openalex.org/W1987338920","https://openalex.org/W2045840287","https://openalex.org/W2056581209","https://openalex.org/W4414895406","https://openalex.org/W2124604214","https://openalex.org/W2073877214"],"abstract_inverted_index":{"The":[0],"polypurine/polypyrimidine":[1],"(pPu/pPy)":[2],"tract":[3,45,81],"of":[4,39,75,92,127,141,147],"the":[5,29,37,40,53,72,76,93,124,144,148],"human":[6],"vascular":[7],"endothelial":[8],"growth":[9],"factor":[10],"(VEGF)":[11],"gene":[12,150],"is":[13,111,118],"proposed":[14],"to":[15,20,23,113,115,120,123,143,187],"be":[16,171],"structurally":[17],"dynamic":[18],"and":[19,49,59,100,177],"have":[21],"potential":[22],"adopt":[24],"non-B":[25],"DNA":[26,165,176,178,192],"structures.":[27,68],"In":[28],"present":[30],"study,":[31],"we":[32],"further":[33,138],"provide":[34],"evidence":[35],"for":[36],"existence":[38],"G-quadruplex":[41,67,116],"structure":[42],"within":[43,79],"this":[44,80,128],"both":[46,97],"in":[47,50,96,98,101,130,151,158,173,179,181,190],"vitro":[48,99],"vivo":[51,102,182],"using":[52],"dimethyl":[54],"sulfate":[55],"(DMS)":[56],"footprinting":[57,103],"technique":[58],"nucleolin":[60,142],"as":[61,168],"a":[62],"structural":[63],"probe":[64],"specifically":[65,122],"recognizing":[66],"We":[69,105],"observed":[70],"that":[71,108,163],"overall":[73],"reactivity":[74],"guanine":[77,90],"residues":[78,91],"toward":[82],"DMS":[83],"was":[84],"significantly":[85],"reduced":[86],"compared":[87],"with":[88,160],"other":[89],"flanking":[94],"regions":[95],"experiments.":[104],"also":[106],"demonstrated":[107],"nucleolin,":[109],"which":[110],"known":[112],"bind":[114,121],"structures,":[117,166],"able":[119],"G-rich":[125],"sequence":[126],"region":[129,146],"negatively":[131],"supercoiled":[132,174],"DNA.":[133],"Our":[134],"chromatin":[135,180],"immunoprecipitation":[136],"analysis":[137],"revealed":[139],"binding":[140],"promoter":[145],"VEGF":[149],"vivo.":[152],"Taken":[153],"together,":[154],"our":[155,161],"results":[156],"are":[157],"agreement":[159],"hypothesis":[162],"secondary":[164],"such":[167],"G-quadruplexes,":[169],"can":[170],"formed":[172,189],"duplex":[175],"under":[183],"physiological":[184],"conditions":[185],"similar":[186],"those":[188],"single-stranded":[191],"templates.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
