{"id":"https://openalex.org/W2168324813","doi":"https://doi.org/10.1161/01.cir.0000135591.37759.af","title":"Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy","display_name":"Altered Titin Expression, Myocardial Stiffness, and Left Ventricular Function in Patients With Dilated Cardiomyopathy","publication_year":2004,"publication_date":"2004-07-06","ids":{"openalex":"https://openalex.org/W2168324813","doi":"https://doi.org/10.1161/01.cir.0000135591.37759.af","mag":"2168324813","pmid":"https://pubmed.ncbi.nlm.nih.gov/15238456"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.0000135591.37759.af","doi":"https://doi.org/10.1161/01.cir.0000135591.37759.af","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000135591.37759.af","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001463041","display_name":"Sherif F. Nagueh","orcid":"https://orcid.org/0000-0002-4911-8056","observed_orcids":["https://orcid.org/0000-0002-4911-8056"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Sherif F. Nagueh","raw_affiliation_strings":["From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","Sherif F. Nagueh From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210156450","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Sherif F. Nagueh From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gopi Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Gopi Shah","raw_affiliation_strings":["From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","Gopi Shah From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210156450","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Gopi Shah From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638137","display_name":"Yiming Wu","orcid":"https://orcid.org/0000-0002-2885-9496","observed_orcids":["https://orcid.org/0000-0002-2885-9496"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Yiming Wu","raw_affiliation_strings":["From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","Yiming Wu From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210156450","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Yiming Wu From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067476985","display_name":"Guillermo Torre\u2010Amione","orcid":"https://orcid.org/0000-0001-9950-0416","observed_orcids":["https://orcid.org/0000-0001-9950-0416"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Guillermo Torre-Amione","raw_affiliation_strings":["From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","Guillermo Torre-Amione From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210156450","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Guillermo Torre-Amione From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023351155","display_name":"Nicholas M. P. King","orcid":"https://orcid.org/0000-0003-0063-2617","observed_orcids":["https://orcid.org/0000-0003-0063-2617"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Nicholas M.P. King","raw_affiliation_strings":["From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","Nicholas M.P. King From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210156450","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Nicholas M.P. King From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001135809","display_name":"Sunshine M. Lahmers","orcid":"https://orcid.org/0000-0001-7967-0960","observed_orcids":["https://orcid.org/0000-0001-7967-0960"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Sunshine Lahmers","raw_affiliation_strings":["From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","Sunshine Lahmers From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210156450","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Sunshine Lahmers From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010210013","display_name":"Christian C. Witt","orcid":"https://orcid.org/0000-0002-3068-025X","observed_orcids":["https://orcid.org/0000-0002-3068-025X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Christian C. Witt","raw_affiliation_strings":["From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","Christian C. Witt From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210156450","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Christian C. Witt From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062398548","display_name":"K Becker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Katy Becker","raw_affiliation_strings":["From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","Katy Becker From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210156450","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Katy Becker From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044599389","display_name":"Siegfried Labeit","orcid":"https://orcid.org/0000-0002-9009-210X","observed_orcids":["https://orcid.org/0000-0002-9009-210X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Siegfried Labeit","raw_affiliation_strings":["From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","Siegfried Labeit From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210156450","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Siegfried Labeit From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046297189","display_name":"Henk L. M. Granzier","orcid":"https://orcid.org/0000-0002-9516-407X","observed_orcids":["https://orcid.org/0000-0002-9516-407X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Henk L. Granzier","raw_affiliation_strings":["From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","Henk L. Granzier From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Veterinary and Comparative Anatomy (Y.W., N.M.P.K., S. Lahmers, C.C.W., S. Labeit, H.L.G.), Pharmacology and Physiology, Washington State University, Pullman, Wash; and Institut fu\u0308r Ana\u0308sthesiologie und Operative Intensivmedizin (C.C.W., S. Labeit), Universita\u0308tsklinikum Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210156450","https://openalex.org/I72951846"]},{"raw_affiliation_string":"Henk L. Granzier From the Section of Cardiology (S.F.N., G.S., G.T.-A., K.B.), Department of Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.7015,"has_fulltext":false,"cited_by_count":485,"citation_normalized_percentile":{"value":0.9814039,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"110","issue":"2","first_page":"155","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.1315000057220459,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/titin","display_name":"titin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9380000233650208},{"id":"https://openalex.org/keywords/myocardial-stiffness","display_name":"myocardial stiffness","score":0.871999979019165},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.902999997138977},{"id":"https://openalex.org/keywords/titin-isoforms","display_name":"titin isoforms","score":0.8820000290870667},{"id":"https://openalex.org/keywords/diastolic-filling","display_name":"diastolic filling","score":0.8799999952316284},{"id":"https://openalex.org/keywords/ankyrin-repeat-proteins","display_name":"ankyrin repeat proteins","score":0.7360000014305115},{"id":"https://openalex.org/keywords/myocardial-relaxation","display_name":"myocardial relaxation","score":0.3240000009536743},{"id":"https://openalex.org/keywords/exercise-tolerance","display_name":"exercise tolerance","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C90671521","wikidata":"https://www.wikidata.org/wiki/Q74314","display_name":"Titin","level":4,"score":0.8696140050888062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8088674545288086},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7688663005828857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7473924160003662},{"id":"https://openalex.org/C2776383484","wikidata":"https://www.wikidata.org/wiki/Q283656","display_name":"Dilated cardiomyopathy","level":3,"score":0.6136001944541931},{"id":"https://openalex.org/C37140074","wikidata":"https://www.wikidata.org/wiki/Q18047361","display_name":"Obscurin","level":5,"score":0.5770238637924194},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5436193346977234},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.49069106578826904},{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.3139365315437317},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.25824397802352905},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.14136630296707153}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002311","descriptor_name":"Cardiomyopathy, Dilated","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D064211","descriptor_name":"Connectin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.cir.0000135591.37759.af","doi":"https://doi.org/10.1161/01.cir.0000135591.37759.af","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000135591.37759.af","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:15238456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15238456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.574.2011","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.574.2011","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/110/2/155.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3281460886","display_name":"Role of titin in heart function and disease","funder_award_id":"R01HL061497","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G600728188","display_name":"Function of Giant Sarcomere Matrix Proteins in Muscle","funder_award_id":"R01HL062881","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1967680325","https://openalex.org/W1977536303","https://openalex.org/W2006254974","https://openalex.org/W2009876051","https://openalex.org/W2017850911","https://openalex.org/W2019448053","https://openalex.org/W2023189060","https://openalex.org/W2035857806","https://openalex.org/W2050370911","https://openalex.org/W2052959842","https://openalex.org/W2077487028","https://openalex.org/W2077842562","https://openalex.org/W2084955500","https://openalex.org/W2096547046","https://openalex.org/W2102071784","https://openalex.org/W2104627343","https://openalex.org/W2114879284","https://openalex.org/W2115119554","https://openalex.org/W2122760939","https://openalex.org/W2124766034","https://openalex.org/W2131122319","https://openalex.org/W2131671324","https://openalex.org/W2141336992","https://openalex.org/W2144058905","https://openalex.org/W2155014420","https://openalex.org/W2165432497","https://openalex.org/W2990123797"],"related_works":["https://openalex.org/W2100989502","https://openalex.org/W4391657335","https://openalex.org/W2144058905","https://openalex.org/W2574577483","https://openalex.org/W7100723826","https://openalex.org/W1969125099","https://openalex.org/W2122760939","https://openalex.org/W98944900","https://openalex.org/W2153195779","https://openalex.org/W2109408452"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,86],"role":[2],"of":[3,94,151,176,221,240,267,293,300,311],"the":[4,113,149,168,199,203,237,258,298],"giant":[5],"protein":[6],"titin":[7,19,60,83,170,242,249,268,274,302],"in":[8,21,32,73,91,104,112,138,244,253,269,273,277],"patients":[9,22,77,95,139,280],"with":[10,23,62,96,106,115,140,281],"heart":[11,25,75,278],"failure":[12,26,76,279],"is":[13],"not":[14],"well":[15],"established.":[16],"We":[17],"investigated":[18],"expression":[20,66,144,214,219,276,303],"end-stage":[24,254],"resulting":[27],"from":[28,126],"nonischemic":[29],"dilated":[30,282],"cardiomyopathy,":[31],"particular":[33],"as":[34,196],"it":[35],"relates":[36],"to":[37,236,306],"left":[38],"ventricular":[39],"(LV)":[40],"myocardial":[41,290],"stiffness":[42,134],"and":[43,55,110,161,173,184,207,229,257,309],"LV":[44,99,122,155],"function.":[45],"METHODS":[46],"AND":[47],"RESULTS:":[48],"SDS-agarose":[49],"gels":[50],"revealed":[51,130],"small":[52],"N2B":[53],"(stiff)":[54],"large":[56],"N2BA":[57,213,241,261],"(compliant)":[58],"cardiac":[59],"isoforms":[61],"a":[63,92,141,264],"mean":[64],"N2BA:N2B":[65,143,169,204],"ratio":[67,88,172,188,206],"that":[68,131,234,297],"was":[69,84,89,135,189,215,251],"significantly":[70,136,284],"(P<0.003)":[71],"increased":[72,218],"20":[74],"versus":[78],"6":[79],"controls.":[80],"However,":[81],"total":[82],"unchanged.":[85],"coexpression":[87],"highest":[90],"subsample":[93],"an":[97],"impaired":[98],"relaxation":[100],"pattern":[101],"(n=7),":[102],"intermediate":[103],"those":[105],"pseudonormal":[107],"filling":[108,117,287],"(n=6),":[109],"lowest":[111],"group":[114],"restrictive":[116],"(n=7).":[118],"Mechanical":[119],"measurements":[120],"on":[121],"muscle":[123,133],"strips":[124],"dissected":[125],"these":[127,152,270],"hearts":[128,256],"(n=8)":[129],"passive":[132],"reduced":[137],"high":[142],"ratio.":[145],"Clinical":[146],"correlations":[147],"support":[148],"relevance":[150],"changes":[153,192],"for":[154],"function":[156],"(assessed":[157],"by":[158,198,217,288],"invasive":[159],"hemodynamics":[160],"Doppler":[162],"echocardiography).":[163],"A":[164,180],"positive":[165,200],"correlation":[166,201],"between":[167,202],"isoform":[171,205,262,275],"deceleration":[174],"time":[175],"mitral":[177],"E":[178],"velocity,":[179],"wave":[181],"transit":[182],"time,":[183],"end":[185],"diastolic":[186,286],"volume/pressure":[187],"found.":[190],"These":[191],"affect":[193],"exercise":[194],"tolerance,":[195],"indicated":[197],"peak":[208],"O2":[209],"consumption":[210],"(n=10).":[211],"Upregulated":[212],"accompanied":[216],"levels":[220],"titin-binding":[222,294],"proteins":[223,295],"(cardiac":[224],"ankyrin":[225,231],"repeat":[226,232],"protein,":[227],"ankrd2,":[228],"diabetes":[230],"protein)":[233],"bind":[235],"N2A":[238],"element":[239],"(studied":[243],"13":[245],"patients).":[246],"CONCLUSIONS:":[247],"Total":[248],"content":[250],"unchanged":[252],"failing":[255],"more":[259],"compliant":[260],"comprised":[263],"greater":[265],"percentage":[266],"hearts.":[271],"Changes":[272],"cardiomyopathy":[283],"impact":[285],"lowering":[289],"stiffness.":[291],"Upregulation":[292],"indicates":[296],"importance":[299],"altered":[301],"might":[304],"extend":[305],"cell":[307],"signaling":[308],"regulation":[310],"gene":[312],"expression.":[313]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":24},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":35},{"year":2017,"cited_by_count":32},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
