{"id":"https://openalex.org/W2168324349","doi":null,"title":"Estudo do efeito anti-angiog\u00e9nico de novos alvos terap\u00eauticos no tratamento do carcinoma mam\u00e1rio","display_name":"Estudo do efeito anti-angiog\u00e9nico de novos alvos terap\u00eauticos no tratamento do carcinoma mam\u00e1rio","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2168324349","mag":"2168324349"},"language":"pt","primary_location":{"id":"pmh:oai:run.unl.pt:10362/6285","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/6285","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10362/6285","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061741127","display_name":"Joana de Vale Quaresma Gigante Gon\u00e7alves Carinhas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joana de Vale Quaresma Gigante Gon\u00e7alves Carinhas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061741127"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.9150000214576721},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.824999988079071},{"id":"https://openalex.org/keywords/delta-like-ligand-4","display_name":"DLL4","score":0.8199999928474426},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mmtv-neu-transgenic-mice","display_name":"MMTV-neu transgenic mice","score":0.6830000281333923},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-microvessel-density","display_name":"tumor microvessel density","score":0.703000009059906},{"id":"https://openalex.org/keywords/vascular-maturation","display_name":"vascular maturation","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4174922704696655}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:run.unl.pt:10362/6285","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/6285","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2168324349","doi":null,"is_oa":false,"landing_page_url":"https://run.unl.pt/bitstream/10362/6285/1/Carinhas_2011.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:run.unl.pt:10362/6285","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10362/6285","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":145,"referenced_works":["https://openalex.org/W51779297","https://openalex.org/W86656726","https://openalex.org/W114449204","https://openalex.org/W157586078","https://openalex.org/W232361230","https://openalex.org/W1489873347","https://openalex.org/W1493048246","https://openalex.org/W1498522783","https://openalex.org/W1512987131","https://openalex.org/W1573363574","https://openalex.org/W1582847607","https://openalex.org/W1679229092","https://openalex.org/W1802218256","https://openalex.org/W1838110840","https://openalex.org/W1956254370","https://openalex.org/W1960764034","https://openalex.org/W1965813940","https://openalex.org/W1965963514","https://openalex.org/W1968085750","https://openalex.org/W1971162717","https://openalex.org/W1973333497","https://openalex.org/W1974185766","https://openalex.org/W1976874039","https://openalex.org/W1977253322","https://openalex.org/W1977841344","https://openalex.org/W1977999028","https://openalex.org/W1978139448","https://openalex.org/W1980819464","https://openalex.org/W1982093899","https://openalex.org/W1983322974","https://openalex.org/W1984483611","https://openalex.org/W1985564501","https://openalex.org/W1986155425","https://openalex.org/W1986559037","https://openalex.org/W1987454669","https://openalex.org/W1987662957","https://openalex.org/W1988368236","https://openalex.org/W1989292359","https://openalex.org/W1995632399","https://openalex.org/W1995827857","https://openalex.org/W1996810856","https://openalex.org/W1997813173","https://openalex.org/W1998147125","https://openalex.org/W2000292756","https://openalex.org/W2000345957","https://openalex.org/W2001879388","https://openalex.org/W2002606648","https://openalex.org/W2005157049","https://openalex.org/W2006202974","https://openalex.org/W2008004968","https://openalex.org/W2008241074","https://openalex.org/W2011838341","https://openalex.org/W2018527149","https://openalex.org/W2018868898","https://openalex.org/W2021556801","https://openalex.org/W2023205404","https://openalex.org/W2024831440","https://openalex.org/W2028435743","https://openalex.org/W2028817453","https://openalex.org/W2029245342","https://openalex.org/W2031191981","https://openalex.org/W2034269086","https://openalex.org/W2035139099","https://openalex.org/W2035595755","https://openalex.org/W2035855058","https://openalex.org/W2036321929","https://openalex.org/W2037573507","https://openalex.org/W2038894508","https://openalex.org/W2039260492","https://openalex.org/W2039787319","https://openalex.org/W2040827891","https://openalex.org/W2041175983","https://openalex.org/W2041905383","https://openalex.org/W2042082068","https://openalex.org/W2043508733","https://openalex.org/W2046516822","https://openalex.org/W2050645840","https://openalex.org/W2051319925","https://openalex.org/W2051487747","https://openalex.org/W2054001958","https://openalex.org/W2056244148","https://openalex.org/W2056916102","https://openalex.org/W2062240872","https://openalex.org/W2063679199","https://openalex.org/W2070575980","https://openalex.org/W2071697893","https://openalex.org/W2073465941","https://openalex.org/W2075773133","https://openalex.org/W2078767245","https://openalex.org/W2081087829","https://openalex.org/W2081471404","https://openalex.org/W2082133442","https://openalex.org/W2084740377","https://openalex.org/W2085682228","https://openalex.org/W2086606630","https://openalex.org/W2088152537","https://openalex.org/W2089723533","https://openalex.org/W2091228862","https://openalex.org/W2091664424","https://openalex.org/W2092034939","https://openalex.org/W2093924460","https://openalex.org/W2097146615","https://openalex.org/W2097705657","https://openalex.org/W2098728140","https://openalex.org/W2099770647","https://openalex.org/W2103470975","https://openalex.org/W2105029970","https://openalex.org/W2108212727","https://openalex.org/W2110373505","https://openalex.org/W2110863171","https://openalex.org/W2112251383","https://openalex.org/W2115390024","https://openalex.org/W2122706269","https://openalex.org/W2123478725","https://openalex.org/W2123486053","https://openalex.org/W2124056447","https://openalex.org/W2126810504","https://openalex.org/W2127690773","https://openalex.org/W2128635872","https://openalex.org/W2131589770","https://openalex.org/W2133391255","https://openalex.org/W2134698258","https://openalex.org/W2137840051","https://openalex.org/W2138957442","https://openalex.org/W2140836243","https://openalex.org/W2141046053","https://openalex.org/W2141805102","https://openalex.org/W2144026946","https://openalex.org/W2146660065","https://openalex.org/W2146953551","https://openalex.org/W2153360321","https://openalex.org/W2153726848","https://openalex.org/W2154144191","https://openalex.org/W2154861644","https://openalex.org/W2154905243","https://openalex.org/W2157893542","https://openalex.org/W2159121906","https://openalex.org/W2162699163","https://openalex.org/W2163260588","https://openalex.org/W2167351436","https://openalex.org/W2185351394","https://openalex.org/W2323910566","https://openalex.org/W2399616656","https://openalex.org/W2496662343","https://openalex.org/W2789682581"],"related_works":["https://openalex.org/W2318900398","https://openalex.org/W2562713720","https://openalex.org/W2600713409","https://openalex.org/W4229589453","https://openalex.org/W4241029041","https://openalex.org/W6889876720","https://openalex.org/W7049218864","https://openalex.org/W2400607898","https://openalex.org/W2072617082","https://openalex.org/W1966503518"],"abstract_inverted_index":{"O":[0],"ligando":[1],"Delta-like":[2],"4":[3],"(Dll4),":[4],"atrav\u00e9s":[5],"da":[6,15,61,159,171,184],"via":[7,160],"de":[8,35,49,51,103,105,154],"sinaliza\u00e7\u00e3o":[9],"Notch,":[10],"\u00e9":[11,93],"um":[12,59],"potente":[13],"regulador":[14],"angiog\u00e9nese,":[16],"sendo":[17],"expresso":[18],"na":[19,94],"componente":[20],"arterial":[21],"do":[22,128,135,137,167],"sistema":[23],"vascular.":[24],"Nos":[25],"adultos,":[26],"a":[27,58,87,151,163,182],"sua":[28],"express\u00e3o":[29],"encontra-se":[30],"aumentada":[31],"numa":[32],"grande":[33],"variedade":[34],"condi\u00e7\u00f5es":[36],"patol\u00f3gicas.":[37],"Neste":[38,96],"trabalho":[39,97],"avaliou-se":[40],"o":[41,133,157,175],"desenvolvimento":[42,168],"tumoral":[43,169],"em":[44],"ratinhos":[45,115,144],"com":[46,100,108],"perda":[47,101,152],"parcial":[48,102,153],"fun\u00e7\u00e3o":[50,104],"Dll4":[52,106,155],"(Dll4+/-).":[53],"A":[54,83],"muta\u00e7\u00e3o":[55],"Dll4+/-":[56],"conduz":[57],"aumento":[60],"densidade":[62],"vascular,":[63],"mas":[64],"devido":[65],"\u00e0":[66],"fraca":[67,78],"matura\u00e7\u00e3o":[68],"dos":[69],"vasos":[70],"neoformados":[71],"estes":[72],"n\u00e3o":[73],"s\u00e3o":[74],"totalmente":[75],"funcionais,":[76],"t\u00eam":[77],"perfus\u00e3o":[79],"e":[80,107,122,170],"elevada":[81],"extravasa\u00e7\u00e3o.":[82],"\u00e1rea":[84],"primordial":[85],"onde":[86],"terapia":[88],"anti-Dll4":[89],"se":[90],"revela":[91],"promissora":[92],"oncologia.":[95],"efectuaram-se":[98],"ensaios":[99],"prote\u00edna":[109,185],"sol\u00favel":[110,186],"EphB4":[111],"usando":[112],"como":[113,156],"modelo":[114],"transg\u00e9nicos":[116],"que":[117,149],"desenvolvem":[118],"tumores":[119],"mam\u00e1rios":[120],"autonomamente":[121],"met\u00e1stases":[123],"pulmonares,":[124],"por":[125],"sobreexpress\u00e3o":[126],"transg\u00e9nica":[127],"gene":[129],"neu":[130],"(erbB2/her2)":[131],"sob":[132],"controlo":[134],"promotor":[136],"Mouse":[138],"Mammary":[139],"Tumor":[140],"Virus":[141],"(MMTV)":[142],"\u2013":[143],"MMTV-NeuNDL2-5.":[145],"Os":[146],"resultados":[147],"indicaram":[148],"tanto":[150],"bloqueio":[158],"EfrinaB2/EphB4":[161],"conduzem":[162],"uma":[164],"redu\u00e7\u00e3o":[165],"significativa":[166],"metastiza\u00e7\u00e3o":[172],"pulmonar,":[173],"tendo":[174],"efeito":[176],"mais":[177],"pronunciado":[178],"sido":[179],"obtido":[180],"mediante":[181],"administra\u00e7\u00e3o":[183],"EphB4.":[187]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
