{"id":"https://openalex.org/W2168317753","doi":"https://doi.org/10.1016/j.cardfail.2009.06.200","title":"An Analysis of the Response to CK-1827452, a Selective Cardiac Myosin Activator, in Stable Heart Failure Patients Stratified by Baseline Cardiac Function","display_name":"An Analysis of the Response to CK-1827452, a Selective Cardiac Myosin Activator, in Stable Heart Failure Patients Stratified by Baseline Cardiac Function","publication_year":2009,"publication_date":"2009-07-31","ids":{"openalex":"https://openalex.org/W2168317753","doi":"https://doi.org/10.1016/j.cardfail.2009.06.200","mag":"2168317753"},"language":"en","primary_location":{"id":"doi:10.1016/j.cardfail.2009.06.200","doi":"https://doi.org/10.1016/j.cardfail.2009.06.200","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2009.06.200","pdf_url":"http://onlinejcf.com/article/S1071916409004205/pdf","source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://onlinejcf.com/article/S1071916409004205/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066514556","display_name":"Fady I. Malik","orcid":"https://orcid.org/0000-0002-5597-5759","observed_orcids":["https://orcid.org/0000-0002-5597-5759"]},"institutions":[{"id":"https://openalex.org/I4210139583","display_name":"Cytokinetics (United States)","ror":"https://ror.org/03tx9ss94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139583"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fady I. Malik","raw_affiliation_strings":["CY 1121 Investigators, Cytokinetics, Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CY 1121 Investigators, Cytokinetics, Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I4210139583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014853503","display_name":"Khalil G. Saikali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139583","display_name":"Cytokinetics (United States)","ror":"https://ror.org/03tx9ss94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139583"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khalil G. Saikali","raw_affiliation_strings":["CY 1121 Investigators, Cytokinetics, Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CY 1121 Investigators, Cytokinetics, Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I4210139583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019171243","display_name":"Michael M. Chen","orcid":"https://orcid.org/0000-0002-8773-0879","observed_orcids":["https://orcid.org/0000-0002-8773-0879","https://orcid.org/0000-0001-6019-7528"]},"institutions":[{"id":"https://openalex.org/I4210139583","display_name":"Cytokinetics (United States)","ror":"https://ror.org/03tx9ss94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139583"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Chen","raw_affiliation_strings":["CY 1121 Investigators, Cytokinetics, Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CY 1121 Investigators, Cytokinetics, Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I4210139583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050464051","display_name":"Jacqueline H. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139583","display_name":"Cytokinetics (United States)","ror":"https://ror.org/03tx9ss94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139583"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline H. Lee","raw_affiliation_strings":["CY 1121 Investigators, Cytokinetics, Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CY 1121 Investigators, Cytokinetics, Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I4210139583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042935709","display_name":"Jonathan H. Goldman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan H. Goldman","raw_affiliation_strings":["ICON Medical Imaging, Inc., Warrington, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICON Medical Imaging, Inc., Warrington, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052880954","display_name":"Andrew A. Wolff","orcid":"https://orcid.org/0000-0002-9094-0359","observed_orcids":["https://orcid.org/0000-0002-9094-0359"]},"institutions":[{"id":"https://openalex.org/I4210139583","display_name":"Cytokinetics (United States)","ror":"https://ror.org/03tx9ss94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210139583"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew A. Wolff","raw_affiliation_strings":["CY 1121 Investigators, Cytokinetics, Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CY 1121 Investigators, Cytokinetics, Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I4210139583"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017097200","display_name":"John R. Teerlink","orcid":"https://orcid.org/0000-0001-9527-0852","observed_orcids":["https://orcid.org/0000-0001-9527-0852"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Teerlink","raw_affiliation_strings":["UCSF, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":0.1979,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.65581445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"15","issue":"6","first_page":"S65","last_page":"S65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-myosin-activator","display_name":"cardiac myosin activator","score":0.9350000023841858},{"id":"https://openalex.org/keywords/stable-heart-failure","display_name":"stable heart failure","score":0.9229999780654907},{"id":"https://openalex.org/keywords/stroke-volume","display_name":"stroke volume","score":0.7360000014305115},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.8519999980926514},{"id":"https://openalex.org/keywords/placebo-controlled-crossover-trial","display_name":"placebo-controlled crossover trial","score":0.47600001096725464},{"id":"https://openalex.org/keywords/systolic-function","display_name":"systolic function","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9353076815605164},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6698285937309265},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6230695843696594},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.5392327308654785},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5159557461738586},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.47332581877708435},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.44971123337745667}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.cardfail.2009.06.200","doi":"https://doi.org/10.1016/j.cardfail.2009.06.200","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2009.06.200","pdf_url":"http://onlinejcf.com/article/S1071916409004205/pdf","source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.cardfail.2009.06.200","doi":"https://doi.org/10.1016/j.cardfail.2009.06.200","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2009.06.200","pdf_url":"http://onlinejcf.com/article/S1071916409004205/pdf","source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168317753.pdf","grobid_xml":"https://content.openalex.org/works/W2168317753.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4207030337","https://openalex.org/W2891746874","https://openalex.org/W2481234813","https://openalex.org/W1971710084","https://openalex.org/W2072108749","https://openalex.org/W2028196543","https://openalex.org/W3164268473","https://openalex.org/W2920829402","https://openalex.org/W3188428900","https://openalex.org/W2053992978"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2025-10-10T00:00:00"}