{"id":"https://openalex.org/W2168301435","doi":"https://doi.org/10.1146/annurev.immunol.22.012703.104603","title":"Multiple Roles of Antimicrobial Defensins, Cathelicidins, and Eosinophil-Derived Neurotoxin in Host Defense","display_name":"Multiple Roles of Antimicrobial Defensins, Cathelicidins, and Eosinophil-Derived Neurotoxin in Host Defense","publication_year":2004,"publication_date":"2004-03-19","ids":{"openalex":"https://openalex.org/W2168301435","doi":"https://doi.org/10.1146/annurev.immunol.22.012703.104603","mag":"2168301435","pmid":"https://pubmed.ncbi.nlm.nih.gov/15032578"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.immunol.22.012703.104603","doi":"https://doi.org/10.1146/annurev.immunol.22.012703.104603","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.immunol.22.012703.104603","pdf_url":null,"source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042752501","display_name":"De Yang","orcid":"https://orcid.org/0000-0001-6705-8504","observed_orcids":["https://orcid.org/0000-0001-6705-8504"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"De Yang","raw_affiliation_strings":["Basic Research Program, National Cancer Institute at Frederick, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Research Program, National Cancer Institute at Frederick, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071427351","display_name":"Arya Biragyn","orcid":"https://orcid.org/0000-0001-5276-6102","observed_orcids":["https://orcid.org/0000-0001-5276-6102"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arya Biragyn","raw_affiliation_strings":["Laboratory of Immunology, Gerontology Research Center, National Institute of Aging, Baltimore, Maryland 20892;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunology, Gerontology Research Center, National Institute of Aging, Baltimore, Maryland 20892;","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048608416","display_name":"David M. Hoover","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Hoover","raw_affiliation_strings":["Macromolecular Crystallography Laboratory, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macromolecular Crystallography Laboratory, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025797603","display_name":"Jacek T. Lubkowski","orcid":"https://orcid.org/0000-0002-8673-6347","observed_orcids":["https://orcid.org/0000-0002-8673-6347"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacek Lubkowski","raw_affiliation_strings":["Macromolecular Crystallography Laboratory, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macromolecular Crystallography Laboratory, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042240287","display_name":"Joost J. Oppenheim","orcid":"https://orcid.org/0000-0003-0271-7921","observed_orcids":["https://orcid.org/0000-0003-0271-7921"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joost J. Oppenheim","raw_affiliation_strings":["Laboratory of Molecular Immunoregulation, Center for Cancer Research; National Cancer Institute at Frederick, Frederick, Maryland 21702"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, Center for Cancer Research; National Cancer Institute at Frederick, Frederick, Maryland 21702","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.3237,"has_fulltext":false,"cited_by_count":573,"citation_normalized_percentile":{"value":0.99130435,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"22","issue":"1","first_page":"181","last_page":"215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.847000002861023},{"id":"https://openalex.org/keywords/defensins","display_name":"defensins","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cathelicidin","display_name":"cathelicidin","score":0.9300000071525574},{"id":"https://openalex.org/keywords/eosinophil-derived-neurotoxin","display_name":"eosinophil-derived neurotoxin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.925000011920929},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/human-beta-defensin-2","display_name":"human beta-defensin 2","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ccr6","display_name":"CCR6","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9800000190734863},{"id":"https://openalex.org/keywords/formyl-peptide-receptor-like-1","display_name":"FPRL1","score":0.949999988079071},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8391426801681519},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8045114278793335},{"id":"https://openalex.org/C129437159","wikidata":"https://www.wikidata.org/wiki/Q4897294","display_name":"Beta defensin","level":4,"score":0.7808012962341309},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.6660945415496826},{"id":"https://openalex.org/C2776498113","wikidata":"https://www.wikidata.org/wiki/Q412820","display_name":"Defensin","level":3,"score":0.5788522958755493},{"id":"https://openalex.org/C2777379352","wikidata":"https://www.wikidata.org/wiki/Q24739493","display_name":"Cathelicidin","level":4,"score":0.5028499960899353},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49304887652397156},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4801742136478424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46640411019325256},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.46023890376091003},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4150884747505188},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3418880105018616}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023082","descriptor_name":"Defensins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D047208","descriptor_name":"Eosinophil-Derived Neurotoxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.immunol.22.012703.104603","doi":"https://doi.org/10.1146/annurev.immunol.22.012703.104603","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.immunol.22.012703.104603","pdf_url":null,"source":{"id":"https://openalex.org/S109088427","display_name":"Annual Review of Immunology","issn_l":"0732-0582","issn":["0732-0582","1545-3278"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Immunology","raw_type":"journal-article"},{"id":"pmid:15032578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15032578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1356092923","display_name":null,"funder_award_id":"N01CO12400","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G174812244","display_name":"DCTD Computer Support","funder_award_id":"n01co12400-79-0-22","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":231,"referenced_works":["https://openalex.org/W97158386","https://openalex.org/W97585627","https://openalex.org/W105738010","https://openalex.org/W176879792","https://openalex.org/W182155550","https://openalex.org/W1500925296","https://openalex.org/W1506297407","https://openalex.org/W1514256649","https://openalex.org/W1519513582","https://openalex.org/W1519996127","https://openalex.org/W1531531679","https://openalex.org/W1538231938","https://openalex.org/W1539711494","https://openalex.org/W1552551253","https://openalex.org/W1571292455","https://openalex.org/W1589692813","https://openalex.org/W1602835962","https://openalex.org/W1608815389","https://openalex.org/W1630083155","https://openalex.org/W1661544713","https://openalex.org/W1664985344","https://openalex.org/W1738567537","https://openalex.org/W1785726601","https://openalex.org/W1828566769","https://openalex.org/W1848455467","https://openalex.org/W1853366991","https://openalex.org/W1863034018","https://openalex.org/W1867119092","https://openalex.org/W1899856807","https://openalex.org/W1902412925","https://openalex.org/W1906070812","https://openalex.org/W1915452953","https://openalex.org/W1916908553","https://openalex.org/W1926920621","https://openalex.org/W1931276869","https://openalex.org/W1932041686","https://openalex.org/W1943160106","https://openalex.org/W1964703096","https://openalex.org/W1964758221","https://openalex.org/W1966050007","https://openalex.org/W1967444908","https://openalex.org/W1968098105","https://openalex.org/W1968134126","https://openalex.org/W1971891360","https://openalex.org/W1974019524","https://openalex.org/W1979844815","https://openalex.org/W1982064271","https://openalex.org/W1982374481","https://openalex.org/W1982664201","https://openalex.org/W1982895681","https://openalex.org/W1985533655","https://openalex.org/W1986224819","https://openalex.org/W1986362742","https://openalex.org/W1987389989","https://openalex.org/W1987901596","https://openalex.org/W1990519548","https://openalex.org/W1991625690","https://openalex.org/W1991845143","https://openalex.org/W1995511384","https://openalex.org/W1997357193","https://openalex.org/W1997683664","https://openalex.org/W1997942004","https://openalex.org/W1997963851","https://openalex.org/W2001740313","https://openalex.org/W2001784844","https://openalex.org/W2002010372","https://openalex.org/W2003242778","https://openalex.org/W2003645154","https://openalex.org/W2004122893","https://openalex.org/W2005335283","https://openalex.org/W2005569459","https://openalex.org/W2007807255","https://openalex.org/W2009074972","https://openalex.org/W2009727907","https://openalex.org/W2011193225","https://openalex.org/W2011623433","https://openalex.org/W2011807378","https://openalex.org/W2013245073","https://openalex.org/W2014941940","https://openalex.org/W2019046938","https://openalex.org/W2021413161","https://openalex.org/W2021556230","https://openalex.org/W2023604719","https://openalex.org/W2024758086","https://openalex.org/W2027074022","https://openalex.org/W2029331076","https://openalex.org/W2029727629","https://openalex.org/W2029815212","https://openalex.org/W2030642888","https://openalex.org/W2032327714","https://openalex.org/W2034280103","https://openalex.org/W2035580952","https://openalex.org/W2035621513","https://openalex.org/W2038307426","https://openalex.org/W2038471033","https://openalex.org/W2040222540","https://openalex.org/W2040597252","https://openalex.org/W2042435973","https://openalex.org/W2046537804","https://openalex.org/W2046954544","https://openalex.org/W2047599457","https://openalex.org/W2048389635","https://openalex.org/W2049192006","https://openalex.org/W2049355859","https://openalex.org/W2050242176","https://openalex.org/W2051142131","https://openalex.org/W2051519058","https://openalex.org/W2053044114","https://openalex.org/W2054458001","https://openalex.org/W2054602599","https://openalex.org/W2055856930","https://openalex.org/W2056001586","https://openalex.org/W2056004187","https://openalex.org/W2056021390","https://openalex.org/W2057421073","https://openalex.org/W2057618822","https://openalex.org/W2058223359","https://openalex.org/W2058367331","https://openalex.org/W2059361679","https://openalex.org/W2059502191","https://openalex.org/W2060300255","https://openalex.org/W2061443292","https://openalex.org/W2063495253","https://openalex.org/W2064440346","https://openalex.org/W2066456239","https://openalex.org/W2072247634","https://openalex.org/W2072432297","https://openalex.org/W2075322040","https://openalex.org/W2075787303","https://openalex.org/W2077231991","https://openalex.org/W2077604052","https://openalex.org/W2077654197","https://openalex.org/W2078781814","https://openalex.org/W2078918986","https://openalex.org/W2079375923","https://openalex.org/W2081166085","https://openalex.org/W2081537251","https://openalex.org/W2082256290","https://openalex.org/W2083772421","https://openalex.org/W2084763821","https://openalex.org/W2084954530","https://openalex.org/W2085793178","https://openalex.org/W2087928412","https://openalex.org/W2087976424","https://openalex.org/W2090042814","https://openalex.org/W2090407536","https://openalex.org/W2090722507","https://openalex.org/W2093412162","https://openalex.org/W2095454990","https://openalex.org/W2097098774","https://openalex.org/W2098083781","https://openalex.org/W2101382753","https://openalex.org/W2103555767","https://openalex.org/W2104159258","https://openalex.org/W2104630130","https://openalex.org/W2104990131","https://openalex.org/W2105884166","https://openalex.org/W2107735101","https://openalex.org/W2110244050","https://openalex.org/W2111075765","https://openalex.org/W2112340256","https://openalex.org/W2116114158","https://openalex.org/W2116558722","https://openalex.org/W2116763454","https://openalex.org/W2124508823","https://openalex.org/W2126466156","https://openalex.org/W2126483186","https://openalex.org/W2126516803","https://openalex.org/W2126994657","https://openalex.org/W2128279713","https://openalex.org/W2130246343","https://openalex.org/W2131036658","https://openalex.org/W2132929600","https://openalex.org/W2132998789","https://openalex.org/W2134209889","https://openalex.org/W2134582553","https://openalex.org/W2134935858","https://openalex.org/W2135284391","https://openalex.org/W2136538608","https://openalex.org/W2137232930","https://openalex.org/W2138207315","https://openalex.org/W2138769023","https://openalex.org/W2139775324","https://openalex.org/W2139959938","https://openalex.org/W2140313585","https://openalex.org/W2140452348","https://openalex.org/W2140472579","https://openalex.org/W2142461098","https://openalex.org/W2143336685","https://openalex.org/W2144082759","https://openalex.org/W2146688138","https://openalex.org/W2148067829","https://openalex.org/W2149794110","https://openalex.org/W2149880504","https://openalex.org/W2150365288","https://openalex.org/W2152154463","https://openalex.org/W2152447881","https://openalex.org/W2153002173","https://openalex.org/W2153328681","https://openalex.org/W2155324715","https://openalex.org/W2156173084","https://openalex.org/W2156911913","https://openalex.org/W2157252835","https://openalex.org/W2157705461","https://openalex.org/W2158304453","https://openalex.org/W2159936883","https://openalex.org/W2161513926","https://openalex.org/W2161524185","https://openalex.org/W2162817739","https://openalex.org/W2162819583","https://openalex.org/W2163208720","https://openalex.org/W2164108103","https://openalex.org/W2164128280","https://openalex.org/W2164206375","https://openalex.org/W2165998893","https://openalex.org/W2167503339","https://openalex.org/W2167925233","https://openalex.org/W2169759699","https://openalex.org/W2179183038","https://openalex.org/W2250074174","https://openalex.org/W2286897117","https://openalex.org/W2316331836","https://openalex.org/W2324516056","https://openalex.org/W2345493110","https://openalex.org/W2385485829","https://openalex.org/W2403527161","https://openalex.org/W2407880738","https://openalex.org/W3140603053","https://openalex.org/W4229662491","https://openalex.org/W4249486154","https://openalex.org/W4313422303"],"related_works":["https://openalex.org/W2288913919","https://openalex.org/W2462725769","https://openalex.org/W1970832390","https://openalex.org/W2138207315","https://openalex.org/W2141632987","https://openalex.org/W2365149762","https://openalex.org/W2155910087","https://openalex.org/W2052430449","https://openalex.org/W2104518375","https://openalex.org/W7132023945"],"abstract_inverted_index":{"Mammals":[0],"generate":[1],"a":[2],"diverse":[3],"array":[4],"of":[5,20],"antimicrobial":[6,21,91,99],"proteins,":[7],"largely":[8],"represented":[9],"by":[10],"defensins":[11,45,49,81],"or":[12],"cathelicidins.":[13,47],"The":[14],"direct":[15],"in":[16,34,70],"vitro":[17],"microbicidal":[18],"activity":[19],"proteins":[22,92],"has":[23,37],"long":[24],"been":[25,41,54],"considered":[26],"an":[27],"important":[28],"innate":[29,96],"immune":[30,62],"defense,":[31],"although":[32],"the":[33],"vivo":[35],"relevance":[36],"only":[38],"very":[39],"recently":[40],"established":[42],"for":[43],"certain":[44],"and":[46,50,97],"Mammalian":[48],"cathelicidins":[51],"have":[52,57,82],"also":[53],"shown":[55],"to":[56,94],"multiple":[58],"receptor-mediated":[59],"effects":[60],"on":[61,76],"cells.":[63,78],"Beta-defensins":[64],"interact":[65],"with":[66],"CCR6;":[67],"murine":[68],"beta-defensin-2":[69],"addition":[71],"activates":[72],"TLR4.":[73],"Cathelicidins":[74],"act":[75],"FPRL1-expressing":[77],"Furthermore,":[79],"several":[80],"considerable":[83],"immunoenhancing":[84],"activity.":[85],"Thus,":[86],"it":[87],"appears":[88],"that":[89],"mammalian":[90],"contribute":[93],"both":[95],"adaptive":[98],"immunity.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":35},{"year":2012,"cited_by_count":33}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
