{"id":"https://openalex.org/W2168288980","doi":"https://doi.org/10.1111/j.1752-7325.2008.00108.x","title":"Considerations on Optimal Fluoride Intake Using Dental Fluorosis and Dental Caries Outcomes \u2013 A Longitudinal Study","display_name":"Considerations on Optimal Fluoride Intake Using Dental Fluorosis and Dental Caries Outcomes \u2013 A Longitudinal Study","publication_year":2008,"publication_date":"2008-11-24","ids":{"openalex":"https://openalex.org/W2168288980","doi":"https://doi.org/10.1111/j.1752-7325.2008.00108.x","mag":"2168288980","pmid":"https://pubmed.ncbi.nlm.nih.gov/19054310","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350236"},"language":"en","primary_location":{"id":"doi:10.1111/j.1752-7325.2008.00108.x","doi":"https://doi.org/10.1111/j.1752-7325.2008.00108.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1752-7325.2008.00108.x","pdf_url":null,"source":{"id":"https://openalex.org/S18039248","display_name":"Journal of Public Health Dentistry","issn_l":"0022-4006","issn":["0022-4006","1752-7325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Public Health Dentistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350236","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047271245","display_name":"John Joseph Warren","orcid":"https://orcid.org/0000-0002-0090-9973","observed_orcids":["https://orcid.org/0000-0002-0090-9973"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John J. Warren","raw_affiliation_strings":["Department of Preventive & Community Dentistry, University of Iowa, Iowa City, IA 52242-1010, USA. john-warren@uiowa.edu","Department of Preventive & Community Dentistry, The University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive & Community Dentistry, University of Iowa, Iowa City, IA 52242-1010, USA. john-warren@uiowa.edu","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Preventive & Community Dentistry, The University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010165489","display_name":"Steven Marc Levy","orcid":"https://orcid.org/0000-0001-9150-4199","observed_orcids":["https://orcid.org/0000-0001-9150-4199"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Levy","raw_affiliation_strings":["Departments of Preventive & Community Dentistry and Epidemiology, University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Preventive & Community Dentistry and Epidemiology, University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034007375","display_name":"Barbara A. Broffitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Broffitt","raw_affiliation_strings":["Department of Preventive & Community Dentistry, The University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive & Community Dentistry, The University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109710853","display_name":"Joseph E. Cavanaugh","orcid":"https://orcid.org/0000-0002-0514-7664","observed_orcids":["https://orcid.org/0000-0002-0514-7664"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Cavanaugh","raw_affiliation_strings":["Department of Biostatistics, University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108676267","display_name":"Michael J. Kanellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Kanellis","raw_affiliation_strings":["Department of Pediatric Dentistry, The University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry, The University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040725570","display_name":"Karin Weber\u2010Gasparoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karin Weber\u2010Gasparoni","raw_affiliation_strings":["Department of Pediatric Dentistry, The University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Dentistry, The University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047271245"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":3.8253,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.92311206,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"69","issue":"2","first_page":"111","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11969","display_name":"Fluoride Effects and Removal","score":0.0997999981045723,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11958","display_name":"Dental Erosion and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dental-fluorosis","display_name":"dental fluorosis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/dental-caries","display_name":"dental caries","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fluoride-intake","display_name":"fluoride intake","score":0.8320000171661377},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7879999876022339},{"id":"https://openalex.org/keywords/primary-dentition","display_name":"primary teeth","score":0.7860000133514404},{"id":"https://openalex.org/keywords/water-fluoridation","display_name":"water fluoridation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/fluoride-supplements","display_name":"fluoride supplements","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C2780828025","wikidata":"https://www.wikidata.org/wiki/Q44793182","display_name":"Fluoride","level":2,"score":0.8778539299964905},{"id":"https://openalex.org/C2777373274","wikidata":"https://www.wikidata.org/wiki/Q1427959","display_name":"Dental fluorosis","level":3,"score":0.7799279093742371},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7329975366592407},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.6953721642494202},{"id":"https://openalex.org/C3019236786","wikidata":"https://www.wikidata.org/wiki/Q1094885","display_name":"Permanent dentition","level":3,"score":0.5127178430557251},{"id":"https://openalex.org/C2779097656","wikidata":"https://www.wikidata.org/wiki/Q1125466","display_name":"Water fluoridation","level":3,"score":0.5107853412628174},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.5049996972084045},{"id":"https://openalex.org/C185017772","wikidata":"https://www.wikidata.org/wiki/Q5259487","display_name":"Dentifrice","level":3,"score":0.4186939001083374},{"id":"https://openalex.org/C188126409","wikidata":"https://www.wikidata.org/wiki/Q641973","display_name":"Dentition","level":2,"score":0.41035839915275574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09890159964561462},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003731","descriptor_name":"Dental Caries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005459","descriptor_name":"Fluorides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009050","descriptor_name":"Fluorosis, Dental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1752-7325.2008.00108.x","doi":"https://doi.org/10.1111/j.1752-7325.2008.00108.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1752-7325.2008.00108.x","pdf_url":null,"source":{"id":"https://openalex.org/S18039248","display_name":"Journal of Public Health Dentistry","issn_l":"0022-4006","issn":["0022-4006","1752-7325"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Public Health Dentistry","raw_type":"journal-article"},{"id":"pmid:19054310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19054310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of public health dentistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3317240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350236","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4350236","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350236","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Public Health Dent","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3317240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350236","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1629912009","display_name":"Longitudinal Study of Fluoride, Diet, Caries & Fluorosis","funder_award_id":"R01DE009551","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G1863522950","display_name":"Fluoride & Other Factors in Childhood and Adolescent Bone Development","funder_award_id":"R01DE012101","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W42632693","https://openalex.org/W1966049240","https://openalex.org/W1967875509","https://openalex.org/W1971494867","https://openalex.org/W1978606593","https://openalex.org/W2008615352","https://openalex.org/W2009055683","https://openalex.org/W2030664660","https://openalex.org/W2035870653","https://openalex.org/W2051574632","https://openalex.org/W2062107277","https://openalex.org/W2072022268","https://openalex.org/W2076304978","https://openalex.org/W2098092745","https://openalex.org/W2115591475","https://openalex.org/W2123461109","https://openalex.org/W2128072770","https://openalex.org/W2139057296","https://openalex.org/W2147476249","https://openalex.org/W2154191705","https://openalex.org/W2157761431","https://openalex.org/W2342346164"],"related_works":["https://openalex.org/W2794319749","https://openalex.org/W2808957475","https://openalex.org/W2003873470","https://openalex.org/W1966049240","https://openalex.org/W2024713713","https://openalex.org/W2015197574","https://openalex.org/W1978606593","https://openalex.org/W2029528057","https://openalex.org/W2115591475","https://openalex.org/W2791614813"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,34,179],"\"optimal\"":[2,262],"intake":[3,44,123,184,251,264],"of":[4,21,36,49,59,73,86,98,120,156,171,217],"fluoride":[5,18,43,75,80,122,183,250,257,263],"has":[6],"been":[7],"widely":[8],"accepted":[9],"for":[10,46,185,207],"decades":[11],"as":[12,70,138,140],"between":[13],"0.05":[14,203],"and":[15,57,66,110,113,136,143,161,192,219,252],"0.07":[16],"mg":[17,204],"per":[19],"kilogram":[20],"body":[22],"weight":[23],"(mg":[24],"F/kg":[25,205],"bw)":[26],"but":[27],"is":[28,39,265],"based":[29],"on":[30,79],"limited":[31],"scientific":[32],"evidence.":[33],"purpose":[35],"this":[37,220],"paper":[38],"to":[40],"present":[41],"longitudinal":[42],"data":[45,151,166],"children":[47,91,157,172,187],"free":[48,58],"dental":[50,60],"fluorosis":[51,165,194,235],"in":[52,62,248,255],"the":[53,64,96,213,243],"early-erupting":[54,67],"permanent":[55,68],"dentition":[56],"caries":[61,190,226],"both":[63],"primary":[65],"teeth":[69],"an":[71,261],"estimate":[72],"optimal":[74],"intake.":[76],"METHODS:":[77],"Data":[78],"ingestion":[81],"were":[82,128,152,167],"obtained":[83,153,168],"from":[84,133,154,169],"parents":[85],"602":[87],"Iowa":[88],"Fluoride":[89],"Study":[90],"through":[92,212],"periodic":[93],"questionnaires":[94],"at":[95,115,124,158,174,195],"ages":[97,159],"6":[99],"weeks;":[100],"3,":[101],"6,":[102],"9,":[103],"12,":[104],"16,":[105],"20,":[106],"24,":[107],"28,":[108],"32,":[109],"36":[111],"months;":[112],"then":[114],"6-month":[116],"intervals":[117],"thereafter.":[118,223],"Estimates":[119],"total":[121],"each":[125],"time":[126,210],"point":[127],"made":[129,145],"by":[130],"summing":[131],"amounts":[132],"water,":[134],"dentifrice,":[135],"supplements,":[137],"well":[139],"other":[141],"foods":[142],"beverages":[144],"with,":[146],"or":[147,201],"containing,":[148],"water.":[149],"Caries":[150],"examinations":[155,170],"5":[160],"9":[162,176,197],"years,":[163],"whereas":[164,232],"only":[173],"age":[175,196],"years.":[177],"RESULTS:":[178],"estimated":[180],"mean":[181,249],"daily":[182],"those":[186,233],"with":[188,225,234],"no":[189,193],"history":[191],"years":[198],"was":[199],"at,":[200],"below,":[202],"bw":[206],"nearly":[208],"all":[209],"points":[211],"first":[214],"48":[215],"months":[216],"life,":[218],"level":[221],"declined":[222],"Children":[224],"had":[227,237],"generally":[228,236],"slightly":[229,238],"less":[230],"intakes,":[231,258],"higher":[239],"intakes.":[240],"CONCLUSIONS:":[241],"Given":[242],"overlap":[244],"among":[245],"caries/fluorosis":[246],"groups":[247],"extreme":[253],"variability":[254],"individual":[256],"firmly":[259],"recommending":[260],"problematic.":[266]},"counts_by_year":[{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}