{"id":"https://openalex.org/W2168278385","doi":"https://doi.org/10.1083/jcb.201404111","title":"Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery","display_name":"Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery","publication_year":2014,"publication_date":"2014-08-11","ids":{"openalex":"https://openalex.org/W2168278385","doi":"https://doi.org/10.1083/jcb.201404111","mag":"2168278385","pmid":"https://pubmed.ncbi.nlm.nih.gov/25113031","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4137056"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.201404111","doi":"https://doi.org/10.1083/jcb.201404111","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201404111","pdf_url":"http://jcb.rupress.org/content/jcb/206/4/493.full.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://jcb.rupress.org/content/jcb/206/4/493.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056090448","display_name":"Anar Murphy","orcid":"https://orcid.org/0000-0001-6500-1758","observed_orcids":["https://orcid.org/0000-0001-6500-1758"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anar K. Murphy","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Fitzgerald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Fitzgerald","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011889344","display_name":"Teresa Ro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa Ro","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jee Hyun Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jee Hyun Kim","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057911151","display_name":"Ariana I. Rabinowitsch","orcid":"https://orcid.org/0000-0003-0896-2119","observed_orcids":["https://orcid.org/0000-0003-0896-2119"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariana I. Rabinowitsch","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004787236","display_name":"Dipanjan Chowdhury","orcid":"https://orcid.org/0000-0001-5645-3752","observed_orcids":["https://orcid.org/0000-0001-5645-3752"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipanjan Chowdhury","raw_affiliation_strings":["Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215 2","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003677739","display_name":"Carl L. Schildkraut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl L. Schildkraut","raw_affiliation_strings":["Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461 3","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045783113","display_name":"James A. Borowiec","orcid":"https://orcid.org/0000-0003-4117-0826","observed_orcids":["https://orcid.org/0000-0003-4117-0826"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James A. Borowiec","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016 1","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045783113"],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":4.0267,"has_fulltext":true,"cited_by_count":112,"citation_normalized_percentile":{"value":0.95492695,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"206","issue":"4","first_page":"493","last_page":"507"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replication-protein-a","display_name":"replication protein A","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rpa-phosphorylation","display_name":"RPA phosphorylation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/palb2","display_name":"PALB2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/replication-fork-stalling","display_name":"replication fork stalling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/replication-fork-recovery","display_name":"replication fork recovery","score":0.8109999895095825},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.8370000123977661},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.6430000066757202},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7446199059486389},{"id":"https://openalex.org/C113271649","wikidata":"https://www.wikidata.org/wiki/Q2565234","display_name":"Replication protein A","level":5,"score":0.6731687784194946},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.570865273475647},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5540595650672913},{"id":"https://openalex.org/C151158763","wikidata":"https://www.wikidata.org/wiki/Q1626856","display_name":"Origin recognition complex","level":5,"score":0.5364291071891785},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.512566328048706},{"id":"https://openalex.org/C188036394","wikidata":"https://www.wikidata.org/wiki/Q14902224","display_name":"Replication factor C","level":5,"score":0.4435112178325653},{"id":"https://openalex.org/C98086919","wikidata":"https://www.wikidata.org/wiki/Q118019","display_name":"Eukaryotic DNA replication","level":4,"score":0.4062729477882385},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3253593444824219},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22655177116394043},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.16921088099479675},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.14620089530944824},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076164","descriptor_name":"Fanconi Anemia Complementation Group N Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004277","descriptor_name":"DNA, Single-Stranded","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019384","descriptor_name":"Nucleic Acid Synthesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051716","descriptor_name":"Replication Protein A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051716","descriptor_name":"Replication Protein A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.201404111","doi":"https://doi.org/10.1083/jcb.201404111","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201404111","pdf_url":"http://jcb.rupress.org/content/jcb/206/4/493.full.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3295617","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4137056","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4137056","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4137056","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:25113031","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25113031","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/14065457","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:14065457","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1083/jcb.201404111","doi":"https://doi.org/10.1083/jcb.201404111","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201404111","pdf_url":"http://jcb.rupress.org/content/jcb/206/4/493.full.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2113365936","display_name":"Regulation of RPA Activity in DNA Repair","funder_award_id":"R01GM083185","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G271278226","display_name":null,"funder_award_id":"R01-GM045751","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4283547580","display_name":null,"funder_award_id":"5R01 GM045751","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5550284596","display_name":"Molecular mechanism and relevance of microRNAs in DSB repair pathway choice","funder_award_id":"R01CA142698","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8228936063","display_name":"DNA Replication Initiation Sites in Mammalian Cells","funder_award_id":"5r01gm045751-32","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000900907","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016087","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168278385.pdf","grobid_xml":"https://content.openalex.org/works/W2168278385.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1539182448","https://openalex.org/W1585519565","https://openalex.org/W1605838085","https://openalex.org/W1969458729","https://openalex.org/W1970578083","https://openalex.org/W1973268287","https://openalex.org/W1979371380","https://openalex.org/W1980246358","https://openalex.org/W1981258136","https://openalex.org/W1990494717","https://openalex.org/W1991063481","https://openalex.org/W1992496728","https://openalex.org/W1993243592","https://openalex.org/W1996819572","https://openalex.org/W2000919464","https://openalex.org/W2002150942","https://openalex.org/W2006461182","https://openalex.org/W2009007206","https://openalex.org/W2023712548","https://openalex.org/W2025899010","https://openalex.org/W2029369774","https://openalex.org/W2029579124","https://openalex.org/W2033420162","https://openalex.org/W2034702779","https://openalex.org/W2035151664","https://openalex.org/W2035892621","https://openalex.org/W2044702943","https://openalex.org/W2047119008","https://openalex.org/W2047741179","https://openalex.org/W2050104597","https://openalex.org/W2055761018","https://openalex.org/W2058093809","https://openalex.org/W2063532739","https://openalex.org/W2070990743","https://openalex.org/W2071782656","https://openalex.org/W2084034209","https://openalex.org/W2084772885","https://openalex.org/W2085043619","https://openalex.org/W2085544302","https://openalex.org/W2087261504","https://openalex.org/W2110017381","https://openalex.org/W2114126312","https://openalex.org/W2122543263","https://openalex.org/W2129899300","https://openalex.org/W2131876608","https://openalex.org/W2133940489","https://openalex.org/W2140872369","https://openalex.org/W2150562487","https://openalex.org/W2155650828","https://openalex.org/W2157888312","https://openalex.org/W2159414441","https://openalex.org/W2160506011","https://openalex.org/W2560367415","https://openalex.org/W3093265161","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W2129069151","https://openalex.org/W2157888312","https://openalex.org/W4406845805","https://openalex.org/W4385700895","https://openalex.org/W2022912130","https://openalex.org/W2050104597","https://openalex.org/W3201293209","https://openalex.org/W4406357448","https://openalex.org/W2087261504","https://openalex.org/W2135216900"],"abstract_inverted_index":{"Phosphorylation":[0],"of":[1,57,74,93,111,123,128],"replication":[2,18,66,104,137,166],"protein":[3],"A":[4],"(RPA)":[5],"by":[6,142],"Cdk2":[7],"and":[8,14,68,95],"the":[9,22,29,84],"checkpoint":[10],"kinase":[11],"ATR":[12],"(ATM":[13],"Rad3":[15],"related)":[16],"during":[17,65,165],"fork":[19,30,79,163],"stalling":[20],"stabilizes":[21],"replisome,":[23],"but":[24],"how":[25],"these":[26],"modifications":[27],"safeguard":[28],"is":[31,81],"not":[32],"understood.":[33],"To":[34],"address":[35],"this":[36],"question,":[37],"we":[38],"used":[39],"single-molecule":[40],"fiber":[41],"analysis":[42],"in":[43,101,118],"cells":[44,102],"expressing":[45],"a":[46,119,139],"phosphorylation-defective":[47],"RPA2":[48,125],"subunit":[49],"or":[50,126],"lacking":[51],"phosphatase":[52],"activity":[53],"toward":[54],"RPA2.":[55],"Deregulation":[56],"RPA":[58,76,89,107,154],"phosphorylation":[59,90],"reduced":[60],"synthesis":[61],"at":[62],"forks":[63],"both":[64],"stress":[67],"recovery":[69,80],"from":[70],"stress.":[71,105,167],"The":[72],"ability":[73],"phosphorylated":[75,153],"to":[77,97,113,132,158],"stimulate":[78],"mediated":[82],"through":[83],"PALB2":[85,94,112,129],"tumor":[86],"suppressor":[87],"protein.":[88],"increased":[91],"localization":[92],"BRCA2":[96],"RPA-bound":[98],"nuclear":[99],"foci":[100],"experiencing":[103],"Phosphorylated":[106],"also":[108],"stimulated":[109],"recruitment":[110],"single-strand":[114],"deoxyribonucleic":[115],"acid":[116],"(DNA)":[117],"cell-free":[120],"system.":[121],"Expression":[122],"mutant":[124],"loss":[127],"expression":[130],"led":[131],"significant":[133],"DNA":[134],"damage":[135],"after":[136],"stress,":[138],"defect":[140],"accentuated":[141],"poly-ADP":[143],"(adenosine":[144],"diphosphate)":[145],"ribose":[146],"polymerase":[147],"inhibitors.":[148],"These":[149],"data":[150],"demonstrate":[151],"that":[152],"recruits":[155],"repair":[156],"factors":[157],"stalled":[159],"forks,":[160],"thereby":[161],"enhancing":[162],"integrity":[164]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}