{"id":"https://openalex.org/W2168276302","doi":null,"title":"Characterization of extracellular and surface bound adherence proteins of Staphylococcus aureus","display_name":"Characterization of extracellular and surface bound adherence proteins of Staphylococcus aureus","publication_year":2012,"publication_date":"2012-11-02","ids":{"openalex":"https://openalex.org/W2168276302","mag":"2168276302"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26899507","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Characterization_of_extracellular_and_surface_bound_adherence_proteins_of_Staphylococcus_aureus/26899507","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/41210","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072440020","display_name":"Torgny Schennings","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Torgny Schennings","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072440020"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bacterial-adhesion","display_name":"bacterial adhesion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/extracellular-adherence-protein","display_name":"extracellular adherence protein","score":0.8500000238418579},{"id":"https://openalex.org/keywords/eap","display_name":"EAP","score":0.9900000095367432},{"id":"https://openalex.org/keywords/complement-inactivation","display_name":"complement inactivation","score":0.5289999842643738},{"id":"https://openalex.org/keywords/opsonization","display_name":"opsonization","score":0.5860000252723694},{"id":"https://openalex.org/keywords/immunization","display_name":"immunization","score":0.4410000145435333},{"id":"https://openalex.org/keywords/endocarditis","display_name":"endocarditis","score":0.5920000076293945},{"id":"https://openalex.org/keywords/wound-infection","display_name":"wound infection","score":0.7260000109672546},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.7570000290870667},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.6660000085830688},{"id":"https://openalex.org/keywords/host-immune-evasion","display_name":"host immune evasion","score":0.5270000100135803},{"id":"https://openalex.org/keywords/memory-cells","display_name":"memory cells","score":0.35499998927116394},{"id":"https://openalex.org/keywords/experimental-infection-model","display_name":"experimental infection model","score":0.4059999883174896},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.3930000066757202},{"id":"https://openalex.org/keywords/fibronectin-binding","display_name":"fibronectin binding","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.862135648727417},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.6260306239128113},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6052286028862},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5707477331161499},{"id":"https://openalex.org/C3019232848","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Surface protein","level":2,"score":0.4710376560688019},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41497617959976196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30824822187423706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3054601550102234},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.27180802822113037},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.24909138679504395},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2114579975605011},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20424920320510864},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.16430658102035522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12806397676467896}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26899507","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Characterization_of_extracellular_and_surface_bound_adherence_proteins_of_Staphylococcus_aureus/26899507","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/41210","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41210","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2168276302","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/handle/10616/41210","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/41210","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41210","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W75594743","https://openalex.org/W82839181","https://openalex.org/W115774976","https://openalex.org/W202011599","https://openalex.org/W1523347396","https://openalex.org/W1530203607","https://openalex.org/W1610159684","https://openalex.org/W1852799255","https://openalex.org/W1860766709","https://openalex.org/W1893269826","https://openalex.org/W1932642151","https://openalex.org/W1963556530","https://openalex.org/W1963589824","https://openalex.org/W1982886266","https://openalex.org/W1984591680","https://openalex.org/W1986438546","https://openalex.org/W1987841902","https://openalex.org/W1992281042","https://openalex.org/W1992434978","https://openalex.org/W1994895410","https://openalex.org/W1999985155","https://openalex.org/W2001061324","https://openalex.org/W2015400027","https://openalex.org/W2019119522","https://openalex.org/W2023171524","https://openalex.org/W2023638940","https://openalex.org/W2027657428","https://openalex.org/W2035089314","https://openalex.org/W2039939341","https://openalex.org/W2039960414","https://openalex.org/W2043101173","https://openalex.org/W2044025353","https://openalex.org/W2057403631","https://openalex.org/W2058619473","https://openalex.org/W2060534700","https://openalex.org/W2061077498","https://openalex.org/W2064833411","https://openalex.org/W2072645998","https://openalex.org/W2073262651","https://openalex.org/W2074082647","https://openalex.org/W2076628554","https://openalex.org/W2078484832","https://openalex.org/W2079878968","https://openalex.org/W2081072895","https://openalex.org/W2084783722","https://openalex.org/W2086825840","https://openalex.org/W2089493112","https://openalex.org/W2092643722","https://openalex.org/W2096922533","https://openalex.org/W2098159900","https://openalex.org/W2101820543","https://openalex.org/W2108014870","https://openalex.org/W2108702878","https://openalex.org/W2112089883","https://openalex.org/W2112328529","https://openalex.org/W2116959157","https://openalex.org/W2122710851","https://openalex.org/W2123292390","https://openalex.org/W2125363033","https://openalex.org/W2126231551","https://openalex.org/W2126304504","https://openalex.org/W2134254174","https://openalex.org/W2135918794","https://openalex.org/W2136370837","https://openalex.org/W2137156549","https://openalex.org/W2139536543","https://openalex.org/W2142840210","https://openalex.org/W2142962053","https://openalex.org/W2148366823","https://openalex.org/W2152403136","https://openalex.org/W2156502117","https://openalex.org/W2157114924","https://openalex.org/W2159308620","https://openalex.org/W2165337806","https://openalex.org/W2166943205","https://openalex.org/W2170107546","https://openalex.org/W2170466541","https://openalex.org/W2313404538","https://openalex.org/W2319775157","https://openalex.org/W2397550592","https://openalex.org/W2408974792","https://openalex.org/W2415746516"],"related_works":["https://openalex.org/W3034800717","https://openalex.org/W2121136817","https://openalex.org/W7095949826","https://openalex.org/W4210588193","https://openalex.org/W7099250496","https://openalex.org/W2119866231","https://openalex.org/W1986350297","https://openalex.org/W2117337399","https://openalex.org/W2108702878","https://openalex.org/W2968946036"],"abstract_inverted_index":{"Staphylococcus":[0,513,553,628,659],"aureus":[1,65,270,514,629,660],"(S.aureus)":[2],"is":[3,23,42,51,277,354,382,464,630],"a":[4,25,43,124,160,359,404,428,439,600,631,663],"pathogen":[5],"causing":[6],"infections.":[7,319,374],"In":[8,375],"recent":[9],"years":[10],"S.aureus":[11,82,104,158,212,228],"formed":[12],"resistance":[13],"to":[14,28,68,93,143,215,235,260,307,316,349,357,385,446,466,480,588,590,594],"most":[15,237,326],"of":[16,39,63,103,162,169,211,238,289,329,333,379,392,431,493,543,546,597,604,627],"known":[17,240],"antibiotics":[18],"on":[19,59,99,165,280,484],"the":[20,60,100,133,139,148,166,206,233,251,261,287,308,314,338,376,390,422,435,447,460,544,595],"market.":[21],"It":[22,243,353],"today":[24],"global":[26],"interest":[27],"find":[29],"alternative":[30,479],"treatment":[31],"against":[32,127,372,516,658],"multi":[33,489],"drug":[34],"resistant":[35,490],"bacteria.":[36],"The":[37,46,272,320,425,456],"course":[38,391],"an":[40,268,290,478],"infection":[41,128,344,397,451,661],"multifactorial":[44],"process.":[45,424],"first":[47],"step":[48],"after":[49,129,135,267,450],"invasion":[50],"bacterial":[52,108,432],"adhesion.":[53],"Specific":[54],"binding":[55,97,109,181,510,626],"proteins":[56,72,98,145,155,298,321,476],"are":[57,176,213,323],"expressed":[58,156,322],"cell":[61,101,474],"surface":[62,579],"S.":[64,269,330],"with":[66,81,147,194,250,294,364,403,413,453,469,508],"ability":[67,234,315],"bind":[69,190,200,236],"different":[70,419],"matrix":[71,241],"e.g.":[73],"fibronectin,":[74],"fibrinogen,":[75],"collagen,":[76],"laminin":[77],"and":[78,105,137,183,201,222,301,311,438,473,482,504,539,556,572,653],"vitronectin.":[79],"Immunization":[80,293,507],"adhesion":[83,284,578],"proteins,":[84,171,416],"recombinant":[85,415,470],"developed":[86],"in":[87,110,113,116,120,173,205,227,274,341,389,421,434,519,549,599,634,662,668],"E.coli":[88],"(Escherichia":[89],"coli)":[90],"gave":[91],"rise":[92],"specific":[94],"antibodies,":[95],"targeting":[96],"wall":[102],"could":[106,256],"block":[107],"vitro.":[111],"Trials":[112],"vivo,":[114],"performed":[115,412],"experimental":[117,342,395,517,635,665],"endocarditis":[118,518,598],"model":[119,398,667],"rats,":[121],"further":[122,483],"proved":[123],"significant":[125,429],"protection":[126],"immunization.":[130],"To":[131,336],"survive":[132],"environment":[134],"adherence":[136,187,297],"colonization,":[138],"invading":[140,291],"microorganism":[141],"need":[142],"express":[144],"interfering":[146,193],"host":[149,252],"immune":[150,253,309,362],"system.":[151,208,254],"Several":[152],"extra":[153,471],"cellular":[154,179,186,472],"from":[157,512],"have":[159],"plurality":[161],"biological":[163],"effects":[164],"host.":[167],"Examples":[168],"these":[170],"investigated":[172],"this":[174,275],"survey,":[175],"Efb":[177,189,198],"(extra":[178,185],"fibrinogen":[180,191],"protein)":[182],"Eap":[184,231],"protein).":[188],"thus":[192,312,400],"primary":[195],"fibrin":[196],"formation.":[197],"also":[199,244,355,383],"inactivate":[202],"crucial":[203],"factors":[204,305],"complement":[207],"These":[209],"benefits":[210],"believed":[214],"cause":[216],"delayed":[217],"wound":[218,343,396,666],"healing,":[219],"prolonged":[220],"bleeding":[221],"accessed":[223],"scar":[224],"formation":[225],"found":[226,266],"infected":[229,402],"wounds.":[230],"has":[232],"all":[239],"proteins.":[242],"serves":[245],"several":[246,387],"functions":[247],"that":[248,368,462],"interfere":[249],"This":[255],"be":[257],"one":[258],"explanation":[259],"poorly":[262],"functioning":[263],"immunologic":[264],"memory":[265,366],"infection.":[271,393],"hypothesis":[273],"thesis":[276],"mainly":[278],"based":[279],"two":[281],"theories:":[282],"Disturbed":[283],"primarily":[285],"affect":[286],"virulence":[288,304,632],"microorganism.":[292],"recombinantly":[295],"produced":[296],"stimulate":[299],"opsonization":[300],"make":[302],"hidden":[303],"visible":[306],"system":[310],"facilitate":[313],"clear":[317],"out":[318,443],"representative":[324],"for":[325],"common":[327],"species":[328],"aureus,":[331],"irrespective":[332],"antibiotic":[334],"resistance.":[335],"mimic":[337],"clinical":[339],"situation":[340],"models":[345],"it":[346,381,463],"\u0301s":[347],"important":[348,356],"use":[350,467],"small":[351],"inoculate.":[352,407],"obtain":[358],"strong":[360],"adaptive":[361],"response":[363],"circulating":[365],"cells":[367],"consequently":[369],"would":[370],"protect":[371],"recurrent":[373],"modern":[377],"way":[378],"thinking":[380],"essential":[384],"attack":[386],"steps":[388,420],"An":[394],"was":[399,411],"performed,":[401],"minimal":[405],"infectious":[406,423],"Multi":[408],"component":[409],"immunization":[410,657],"four":[414],"targeted":[417],"at":[418],"results":[426],"indicated":[427],"reduction":[430],"load":[433],"immunized":[436],"group":[437,449],"more":[440],"rapid":[441],"clearing":[442],"ratio":[444],"compared":[445],"control":[448],"challenge":[452],"S.aureus.":[454],"Conclusion:":[455],"present":[457],"studies":[458],"support":[459],"theory":[461],"conceivable":[465],"immunizations":[468],"bound":[475],"as":[477],"prevent":[481],"treat":[485],"infections":[486],"caused":[487],"by":[488,552],"microorganisms.":[491],"List":[492],"scientific":[494],"papers":[495],"I.":[496],"T":[497],"Schennings":[498,540,619],"T,":[499,620],"Heimdahl":[500,537],"A,":[501,538],"Coster":[502],"K":[503],"Flock":[505,533],"JI.":[506],"fibronectin":[509],"protein":[511],"protects":[515],"rats.":[520],"Microbial":[521],"Pathogenesis.":[522],"Volume":[523,607],"15,":[524],"Issue":[525,609],"3,":[526],"September":[527],"1993,":[528],"p.":[529,560,613,673],"227-36.":[530],"https://doi.org/10.1006/mpat.1993.1073":[531],"II.":[532],"J-I,":[534],"Heinz":[535],"SA,":[536,618],"T.":[541,566],"Reconsideration":[542],"Role":[545],"Fibronectin":[547],"Binding":[548],"Endocarditis":[550],"Caused":[551],"aureus.":[554],"Infection":[555],"Immunity.":[557],"May":[558],"1996,":[559,612],"1876-1878.":[561],"https://pubmed.ncbi.nlm.nih.gov/8613409":[562],"III.":[563],"M.":[564,568],"Ryd,":[565],"Schennings,":[567,648],"Flock,":[569,623],"A.":[570,622],"Heimdahl,":[571,621],"J-I.":[573,624],"Flock.":[574,655],"Streptococcus":[575],"mutans":[576],"major":[577],"protein,":[580],"P1":[581],"(I":[582],"/":[583],"II),":[584],"does":[585],"not":[586],"contribute":[587],"attachment":[589],"valvular":[591],"vegetation":[592],"or":[593],"development":[596],"rat":[601],"model.":[602],"Archives":[603],"Oral":[605],"Biology.":[606],"41,":[608],"10,":[610],"October":[611],"999-1002.":[614],"https://doi.org/10.1016/S0003-9969(96)00035-0":[615],"IV.":[616],"Hienz":[617],"Collagen":[625],"factor":[633],"endocarditis.":[636],"J":[637],"Infect":[638],"Dis.":[639],"1996":[640],"Jul;":[641],"174":[642],"(1):":[643],"83-8.":[644],"https://doi.org/10.1093/infdis/174.1.83":[645],"V.":[646],"Torgny":[647],"Filip":[649],"Farnebo,":[650],"Laszlo":[651],"Szekely":[652],"Jan-Ingmar":[654],"Protective":[656],"novel":[664],"mice.":[669],"APMIS.":[670],"2012.":[671],"120(10):":[672],"786-93.":[674],"https://doi.org/10.1111/j.1600-0463.2012.02907.x":[675]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}