{"id":"https://openalex.org/W2168219694","doi":null,"title":"Plasma membrane order; the role of cholesterol and links to actin filaments :","display_name":"Plasma membrane order; the role of cholesterol and links to actin filaments :","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2168219694","mag":"2168219694"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:su-62279","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-62279","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-62279","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008493137","display_name":"Jelena Dini\u0107","orcid":"https://orcid.org/0000-0003-3371-2381","observed_orcids":["https://orcid.org/0000-0003-3371-2381"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jelena Dini\u0107","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3371-2381","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008493137"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.6119999885559082},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lipid-packing","display_name":"lipid packing","score":0.7049999833106995},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.8960000276565552},{"id":"https://openalex.org/keywords/actin-polymerization","display_name":"actin polymerization","score":0.9070000052452087},{"id":"https://openalex.org/keywords/membrane-blebs","display_name":"membrane blebs","score":0.8140000104904175},{"id":"https://openalex.org/keywords/methyl-beta-cyclodextrin","display_name":"methyl-\u03b2-cyclodextrin","score":0.8500000238418579},{"id":"https://openalex.org/keywords/laurdan","display_name":"Laurdan","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.7197909951210022},{"id":"https://openalex.org/C2778390148","wikidata":"https://www.wikidata.org/wiki/Q15426238","display_name":"Laurdan","level":4,"score":0.6407581567764282},{"id":"https://openalex.org/C14228908","wikidata":"https://www.wikidata.org/wiki/Q2920483","display_name":"Protein filament","level":2,"score":0.6385583877563477},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5620821118354797},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.49732735753059387},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4899367690086365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4638630747795105},{"id":"https://openalex.org/C182306322","wikidata":"https://www.wikidata.org/wiki/Q1779371","display_name":"Order (exchange)","level":2,"score":0.4145231544971466},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.2442915439605713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24231243133544922},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16457927227020264},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:DiVA.org:su-62279","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-62279","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:DiVA.org:uu-188319","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-188319","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2168219694","doi":null,"is_oa":false,"landing_page_url":"http://su.diva-portal.org/smash/get/diva2:441173/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:su-62279","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-62279","pdf_url":null,"source":{"id":"https://openalex.org/S4306400561","display_name":"DiVA (Stockholm University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161593684","host_organization_name":"Stockholm University","host_organization_lineage":["https://openalex.org/I161593684"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":237,"referenced_works":["https://openalex.org/W35851371","https://openalex.org/W72561416","https://openalex.org/W82875452","https://openalex.org/W95054676","https://openalex.org/W303575947","https://openalex.org/W1500690807","https://openalex.org/W1517168785","https://openalex.org/W1518097944","https://openalex.org/W1552359778","https://openalex.org/W1562084799","https://openalex.org/W1562441478","https://openalex.org/W1564861448","https://openalex.org/W1572351103","https://openalex.org/W1583154040","https://openalex.org/W1621209507","https://openalex.org/W1630241876","https://openalex.org/W1635401440","https://openalex.org/W1795202973","https://openalex.org/W1926854487","https://openalex.org/W1934867783","https://openalex.org/W1963931807","https://openalex.org/W1964117622","https://openalex.org/W1965315184","https://openalex.org/W1966110715","https://openalex.org/W1967363104","https://openalex.org/W1967735305","https://openalex.org/W1968682299","https://openalex.org/W1969461041","https://openalex.org/W1970101963","https://openalex.org/W1970160164","https://openalex.org/W1972000711","https://openalex.org/W1972701314","https://openalex.org/W1972977050","https://openalex.org/W1973728337","https://openalex.org/W1974282614","https://openalex.org/W1974928798","https://openalex.org/W1975255486","https://openalex.org/W1975696535","https://openalex.org/W1976058911","https://openalex.org/W1976094538","https://openalex.org/W1976918733","https://openalex.org/W1977471961","https://openalex.org/W1977669212","https://openalex.org/W1978281474","https://openalex.org/W1978299374","https://openalex.org/W1978683809","https://openalex.org/W1980334501","https://openalex.org/W1980857768","https://openalex.org/W1981647923","https://openalex.org/W1983239505","https://openalex.org/W1983261693","https://openalex.org/W1984653721","https://openalex.org/W1988530230","https://openalex.org/W1990912620","https://openalex.org/W1990931034","https://openalex.org/W1991655565","https://openalex.org/W1992692912","https://openalex.org/W1993050100","https://openalex.org/W1993451783","https://openalex.org/W1994127068","https://openalex.org/W1995673366","https://openalex.org/W1996362083","https://openalex.org/W1996654321","https://openalex.org/W1996968937","https://openalex.org/W1998346656","https://openalex.org/W1998697778","https://openalex.org/W1998958945","https://openalex.org/W2000589601","https://openalex.org/W2000638372","https://openalex.org/W2004296371","https://openalex.org/W2005856423","https://openalex.org/W2007524790","https://openalex.org/W2012886666","https://openalex.org/W2013679718","https://openalex.org/W2014030143","https://openalex.org/W2014503023","https://openalex.org/W2014903703","https://openalex.org/W2016851491","https://openalex.org/W2018088003","https://openalex.org/W2018237478","https://openalex.org/W2019027747","https://openalex.org/W2019410894","https://openalex.org/W2019996679","https://openalex.org/W2021211941","https://openalex.org/W2021867116","https://openalex.org/W2022174121","https://openalex.org/W2022350240","https://openalex.org/W2022447364","https://openalex.org/W2024954984","https://openalex.org/W2025580667","https://openalex.org/W2027685072","https://openalex.org/W2028457751","https://openalex.org/W2028968136","https://openalex.org/W2029022457","https://openalex.org/W2031686611","https://openalex.org/W2032062053","https://openalex.org/W2033830571","https://openalex.org/W2034063805","https://openalex.org/W2034146282","https://openalex.org/W2034332162","https://openalex.org/W2037267120","https://openalex.org/W2037735248","https://openalex.org/W2037760821","https://openalex.org/W2038999037","https://openalex.org/W2039473529","https://openalex.org/W2039696862","https://openalex.org/W2040200576","https://openalex.org/W2045338471","https://openalex.org/W2048019766","https://openalex.org/W2049028485","https://openalex.org/W2049185462","https://openalex.org/W2050179335","https://openalex.org/W2050428252","https://openalex.org/W2052965907","https://openalex.org/W2055154266","https://openalex.org/W2055600777","https://openalex.org/W2055864348","https://openalex.org/W2056736540","https://openalex.org/W2056788990","https://openalex.org/W2059571424","https://openalex.org/W2059694983","https://openalex.org/W2061083788","https://openalex.org/W2065790254","https://openalex.org/W2068418997","https://openalex.org/W2068877244","https://openalex.org/W2068881606","https://openalex.org/W2069488204","https://openalex.org/W2069568296","https://openalex.org/W2070782595","https://openalex.org/W2070883788","https://openalex.org/W2072274588","https://openalex.org/W2072384875","https://openalex.org/W2075170822","https://openalex.org/W2075670599","https://openalex.org/W2076649752","https://openalex.org/W2076723104","https://openalex.org/W2078384542","https://openalex.org/W2079420925","https://openalex.org/W2083920232","https://openalex.org/W2084378394","https://openalex.org/W2084998580","https://openalex.org/W2085957103","https://openalex.org/W2086311919","https://openalex.org/W2086679183","https://openalex.org/W2086949826","https://openalex.org/W2088463353","https://openalex.org/W2089003221","https://openalex.org/W2090876478","https://openalex.org/W2091055574","https://openalex.org/W2091701502","https://openalex.org/W2092258235","https://openalex.org/W2093089526","https://openalex.org/W2093861837","https://openalex.org/W2094255247","https://openalex.org/W2094817022","https://openalex.org/W2095273933","https://openalex.org/W2096234619","https://openalex.org/W2098649843","https://openalex.org/W2099593237","https://openalex.org/W2099931322","https://openalex.org/W2100826597","https://openalex.org/W2101773396","https://openalex.org/W2103493988","https://openalex.org/W2104139776","https://openalex.org/W2104205848","https://openalex.org/W2104670055","https://openalex.org/W2106370142","https://openalex.org/W2106508078","https://openalex.org/W2109219135","https://openalex.org/W2110420813","https://openalex.org/W2111711361","https://openalex.org/W2111760068","https://openalex.org/W2113009216","https://openalex.org/W2113263416","https://openalex.org/W2115037258","https://openalex.org/W2116628043","https://openalex.org/W2116856926","https://openalex.org/W2119075209","https://openalex.org/W2120345534","https://openalex.org/W2121936687","https://openalex.org/W2122925019","https://openalex.org/W2125891533","https://openalex.org/W2127353647","https://openalex.org/W2127792983","https://openalex.org/W2129030094","https://openalex.org/W2129232972","https://openalex.org/W2131242309","https://openalex.org/W2131850070","https://openalex.org/W2132143266","https://openalex.org/W2133388060","https://openalex.org/W2133991651","https://openalex.org/W2134283668","https://openalex.org/W2134723427","https://openalex.org/W2135164336","https://openalex.org/W2135371328","https://openalex.org/W2135749649","https://openalex.org/W2136513361","https://openalex.org/W2136534946","https://openalex.org/W2136558879","https://openalex.org/W2136676426","https://openalex.org/W2136795628","https://openalex.org/W2137387260","https://openalex.org/W2138035663","https://openalex.org/W2138059603","https://openalex.org/W2139846514","https://openalex.org/W2141367941","https://openalex.org/W2144476583","https://openalex.org/W2144676492","https://openalex.org/W2144711633","https://openalex.org/W2144760773","https://openalex.org/W2145055214","https://openalex.org/W2146439388","https://openalex.org/W2146739168","https://openalex.org/W2147055245","https://openalex.org/W2147196312","https://openalex.org/W2149255929","https://openalex.org/W2149956571","https://openalex.org/W2149974445","https://openalex.org/W2151151593","https://openalex.org/W2151519197","https://openalex.org/W2154925541","https://openalex.org/W2155654394","https://openalex.org/W2158574095","https://openalex.org/W2158757486","https://openalex.org/W2160085864","https://openalex.org/W2160165571","https://openalex.org/W2163407551","https://openalex.org/W2163790379","https://openalex.org/W2165148465","https://openalex.org/W2169908718","https://openalex.org/W2187415359","https://openalex.org/W2230370122","https://openalex.org/W2377582402","https://openalex.org/W2407996163","https://openalex.org/W2411485411","https://openalex.org/W2791167845","https://openalex.org/W3143159804"],"related_works":["https://openalex.org/W1967648188","https://openalex.org/W1988493557","https://openalex.org/W2142909247","https://openalex.org/W610612759","https://openalex.org/W2071475340","https://openalex.org/W1949145508","https://openalex.org/W2077406349","https://openalex.org/W4313381533","https://openalex.org/W7218151468","https://openalex.org/W1978299374"],"abstract_inverted_index":{"The":[0,231,299],"connection":[1,110],"between":[2],"T":[3,227,232,268],"cell":[4,164,228,233,273,314],"activation,":[5],"plasma":[6,58,83,116,157,179,203,325],"membrane":[7,23,49,59,117,127,148,158,180,204,221,251,264],"order":[8,24,50,60,205,247],"and":[9,21,160,224,248,307],"actin":[10,67,75,112,137,166,175,194,210,276,285,311,320],"filament":[11,211,321],"dynamics":[12],"was":[13],"the":[14,40,82,101,109,115,121,123,135,172,178,182,214,249,259,279,291,294,302,324,337],"main":[15],"focus":[16],"of":[17,42,91,103,111,125,143,147,155,174,184,209,226,239,245,254,261,296,301,339],"this":[18],"study.":[19],"Laurdan":[20],"di-4-ANEPPDHQ,":[22],"sensing":[25],"probes,":[26],"were":[27,54],"shown":[28],"to":[29,56,114,177,323],"report":[30],"only":[31],"on":[32,81],"lipid":[33],"packing":[34],"rather":[35],"than":[36],"being":[37],"influenced":[38],"by":[39],"presence":[41],"membrane-inserted":[43],"peptides":[44],"justifying":[45],"their":[46],"use":[47],"in":[48,61,94,151,163,202,242,266,293,304,336],"studies.":[51],"These":[52],"dyes":[53],"used":[55],"follow":[57],"live":[62],"cells":[63,198,269,306],"at":[64,278],"37\u00b0C.":[65],"Disrupting":[66],"filaments":[68,76,113,176,312],"had":[69,77],"a":[70,88,140,152,207,333],"disordering":[71],"effect":[72,80],"while":[73],"stabilizing":[74],"an":[78,161,200],"ordering":[79],"membrane,":[84,326],"indicating":[85],"there":[86],"is":[87,118,287,313,328],"basal":[89],"level":[90,124],"ordered":[92,104,126,144,156,185,255,263,297,340],"domains":[93,105,159,240,265],"resting":[95,267,305],"cells.":[96],"Lowering":[97],"PI(4,5)P2":[98],"levels":[99],"decreased":[100],"proportion":[102,154],"strongly":[106,169,288],"suggesting":[107],"that":[108,171,270,284,319],"responsible":[119],"for":[120],"maintaining":[122],"domains.":[128,145,186,256,298,341],"Membrane":[129],"blebs,":[130],"which":[131,327],"are":[132],"detached":[133],"from":[134],"underlying":[136],"filaments,":[138],"contained":[139],"low":[141],"fraction":[142],"Aggregation":[146],"components":[149],"resulted":[150],"higher":[153,246],"increase":[162,201],"peripheral":[165,193],"polymerization.":[167,195],"This":[168,257],"suggests":[170,258],"attachment":[173,322],"induces":[181],"formation":[183,338],"Limited":[187],"cholesterol":[188,217],"depletion":[189,218],"with":[190,290,310],"methyl-beta-cyclodextrin":[191],"triggered":[192],"Cholesterol":[196],"depleted":[197,253],"showed":[199,283],"as":[206],"result":[208],"accumulation":[212],"underneath":[213],"membrane.":[215],"Moderate":[216],"also":[219],"induced":[220],"domain":[222],"aggregation":[223,236,281],"activation":[225],"signaling":[229],"events.":[230],"receptor":[234],"(TCR)":[235],"caused":[237],"redistribution":[238],"resulting":[241],"TCR":[243,280,303],"patches":[244],"bulk":[250],"correspondingly":[252],"preexistence":[260],"small":[262],"aggregate":[271],"upon":[272],"activation.":[274],"Increased":[275],"polymerization":[277,286],"sites":[282],"correlated":[289],"changes":[292],"distribution":[295,300],"its":[308],"colocalization":[309],"cycle":[315],"dependent.":[316],"We":[317],"conclude":[318],"regulated":[329],"via":[330],"PI(4,5)P2,":[331],"plays":[332],"crucial":[334],"role":[335]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}