{"id":"https://openalex.org/W2168210697","doi":"https://doi.org/10.2214/ajr.169.5.9353448","title":"Hepatosplenic fungal disease: diagnostic accuracy and spectrum of appearances on MR imaging.","display_name":"Hepatosplenic fungal disease: diagnostic accuracy and spectrum of appearances on MR imaging.","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W2168210697","doi":"https://doi.org/10.2214/ajr.169.5.9353448","mag":"2168210697","pmid":"https://pubmed.ncbi.nlm.nih.gov/9353448"},"language":"en","primary_location":{"id":"doi:10.2214/ajr.169.5.9353448","doi":"https://doi.org/10.2214/ajr.169.5.9353448","is_oa":false,"landing_page_url":"https://doi.org/10.2214/ajr.169.5.9353448","pdf_url":null,"source":{"id":"https://openalex.org/S161085503","display_name":"American Journal of Roentgenology","issn_l":"0002-9580","issn":["0002-9580","0361-803X","1546-3141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315781","host_organization_name":"American Roentgen Ray Society","host_organization_lineage":["https://openalex.org/P4310315781"],"host_organization_lineage_names":["American Roentgen Ray Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Roentgenology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061857655","display_name":"Richard C. Semelka","orcid":"https://orcid.org/0000-0001-5773-8071","observed_orcids":["https://orcid.org/0000-0001-5773-8071"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R C Semelka","raw_affiliation_strings":["Department of Radiology, University of North Carolina, Chapel Hill 27599-7510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of North Carolina, Chapel Hill 27599-7510, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046145965","display_name":"Nikolaos Kelekis","orcid":"https://orcid.org/0000-0002-8958-4668","observed_orcids":["https://orcid.org/0000-0002-8958-4668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N L Kelekis","raw_affiliation_strings":["University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025699897","display_name":"Sabah Sallah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Sallah","raw_affiliation_strings":["East Carolina University; University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"East Carolina University; University of North Carolina","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110117602","display_name":"S Worawattanakul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Worawattanakul","raw_affiliation_strings":["University of North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049369986","display_name":"Susan M. Ascher","orcid":"https://orcid.org/0000-0001-5777-4486","observed_orcids":["https://orcid.org/0000-0001-5777-4486"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S M Ascher","raw_affiliation_strings":["Georgetown University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8328,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.91199822,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"169","issue":"5","first_page":"1311","last_page":"1316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"magnetic resonance imaging","score":0.6740000247955322},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.972000002861023},{"id":"https://openalex.org/keywords/fungal-liver-abscess","display_name":"fungal liver abscess","score":0.5929999947547913},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/prolonged-fever","display_name":"persistent fever","score":0.5609999895095825},{"id":"https://openalex.org/keywords/false-positive-results","display_name":"false positives","score":0.5720000267028809},{"id":"https://openalex.org/keywords/t2-weighted-imaging","display_name":"T2-weighted imaging","score":0.7829999923706055},{"id":"https://openalex.org/keywords/acute-presentation","display_name":"acute presentation","score":0.4950000047683716},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.33899998664855957},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.5640000104904175},{"id":"https://openalex.org/keywords/t1-weighted-mri","display_name":"T1-weighted imaging","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9342361688613892},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5629723072052002},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.5310008525848389},{"id":"https://openalex.org/C2991700627","wikidata":"https://www.wikidata.org/wiki/Q464067","display_name":"Fungal disease","level":2,"score":0.5061332583427429},{"id":"https://openalex.org/C156778621","wikidata":"https://www.wikidata.org/wiki/Q1365748","display_name":"Spectrum (functional analysis)","level":2,"score":0.4496111571788788},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44609951972961426},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4405139088630676},{"id":"https://openalex.org/C3020442560","wikidata":"https://www.wikidata.org/wiki/Q4971815","display_name":"Broad spectrum","level":2,"score":0.4378272593021393},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32599687576293945},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.11737671494483948},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013158","descriptor_name":"Splenic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013158","descriptor_name":"Splenic Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013158","descriptor_name":"Splenic Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2214/ajr.169.5.9353448","doi":"https://doi.org/10.2214/ajr.169.5.9353448","is_oa":false,"landing_page_url":"https://doi.org/10.2214/ajr.169.5.9353448","pdf_url":null,"source":{"id":"https://openalex.org/S161085503","display_name":"American Journal of Roentgenology","issn_l":"0002-9580","issn":["0002-9580","0361-803X","1546-3141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315781","host_organization_name":"American Roentgen Ray Society","host_organization_lineage":["https://openalex.org/P4310315781"],"host_organization_lineage_names":["American Roentgen Ray Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Roentgenology","raw_type":"journal-article"},{"id":"pmid:9353448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9353448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AJR. American journal of roentgenology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1965837199","https://openalex.org/W2010982729","https://openalex.org/W2015607586","https://openalex.org/W2025094247","https://openalex.org/W2050634246","https://openalex.org/W2059446614","https://openalex.org/W2068909968","https://openalex.org/W2086885869","https://openalex.org/W2090630408","https://openalex.org/W2094763711","https://openalex.org/W2115196470","https://openalex.org/W2136021209","https://openalex.org/W2158832195","https://openalex.org/W2164809584","https://openalex.org/W2166440049","https://openalex.org/W2316377453","https://openalex.org/W2424196804"],"related_works":["https://openalex.org/W2033750656","https://openalex.org/W2388660198","https://openalex.org/W2930010109","https://openalex.org/W2166440049","https://openalex.org/W3111903003","https://openalex.org/W2039062122","https://openalex.org/W2078270172","https://openalex.org/W3096382389","https://openalex.org/W2320089915","https://openalex.org/W4408944586"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1],"describe":[2],"our":[3],"6-year":[4],"experience":[5],"in":[6,53,59,164,166,185,198,210,222,237,253,266,341,369,387],"the":[7,19,26,60,85,153,199,229,283,296,326,425],"prospective":[8],"examination":[9,41],"of":[10,22,28,87,96,139,155,161,213,219,225,255,282,358,410,427],"patients":[11,37,102,120,165,186,195,215,231,239,285,328,375],"with":[12,64,91,187,206,232,329,376,389,413,433],"suspected":[13,43],"hepatosplenic":[14,44,140,156,207,220,241,429],"fungal":[15,45,141,157,162,208,247,430],"disease":[16,46,142],"to":[17,50,70,84,292],"show":[18],"diagnostic":[20,422],"accuracy":[21,181,322,423],"MR":[23,31,40,147,201,235,304,418,450],"imaging":[24,202,236,419],"and":[25,80,119,135,180,216,268,295,321,343,365,437],"spectrum":[27],"appearances":[29,160],"on":[30,103,121,276,350,363,400],"images.":[32,278,352],"SUBJECTS":[33],"AND":[34],"METHODS:":[35],"All":[36],"who":[38,130],"underwent":[39],"for":[42,124,152,182,424],"from":[47],"January":[48,51],"1990":[49],"1997":[52],"three":[54],"university":[55],"institutions":[56],"were":[57,74,99,115,143,149,169,190,196,244,251,269,333,344,384,397],"included":[58,197],"study.":[61,200],"Patients":[62,73,90,432],"presented":[63],"persistent":[65],"fever":[66],"or":[67,94,127,129],"no":[68,217,414],"response":[69],"antibacterial":[71],"antibiotics.":[72],"grouped":[75],"as":[76,246,272,347,408],"acute,":[77,434],"subacute":[78,116,330,435],"treated,":[79,82,436],"chronic":[81,144,377,438],"according":[83],"duration":[86],"their":[88,449],"symptoms.":[89],"2":[92,108],"weeks":[93,109],"fewer":[95],"possible":[97],"infection":[98],"acute":[100,188,233,302,428],"presentation,":[101,118,234,303,331],"antifungal":[104,122,133],"therapy":[105,123,134],"longer":[106,128],"than":[107,112,263,338],"but":[110],"shorter":[111],"3":[113,125],"months":[114,126],"treated":[117,145],"had":[131,136,286,298,381],"completed":[132],"a":[137],"history":[138],"presentation.":[146],"studies":[148],"prospectively":[150],"interpreted":[151,245],"presence":[154],"lesions.":[158],"The":[159,171,279,373],"lesions":[163,184,209,221,242,250,260,332,379,382,443],"each":[167],"category":[168],"determined.":[170,192],"sensitivity,":[172],"specificity,":[173],"positive":[174,311],"predictive":[175,178,312,317],"value,":[176,179],"negative":[177,316],"detecting":[183],"presentation":[189],"also":[191],"RESULTS:":[193],"Sixty-nine":[194],"revealed":[203,240],"signs":[204],"consistent":[205],"22":[211],"(32%)":[212],"69":[214,226],"demonstration":[218],"47":[223],"(68%)":[224],"patients.":[227,258,372],"In":[228,325],"60":[230],"13":[238,257,284],"that":[243,335,383,444],"disease.":[248,300,431],"True-positive":[249],"present":[252,334],"11":[254],"these":[256],"These":[259,394],"measured":[261,336],"less":[262,337],"1":[264,339],"cm":[265,340,386],"diameter":[267,342,388],"best":[270,345,398],"shown":[271,291,346,399],"well-defined":[273],"high-signal-intensity":[274],"foci":[275],"T2-weighted":[277],"remaining":[280],"two":[281],"false-positive":[287],"lesions;":[288],"one":[289],"was":[290,306,309,314,319,323,361],"have":[293,442],"tuberculosis,":[294],"other":[297],"graft-versus-host":[299],"For":[301],"sensitivity":[305],"100%,":[307,320],"specificity":[308],"96%,":[310],"value":[313,318],"85%,":[315],"97%.":[324],"five":[327,371],"mildly":[348],"hyperintense":[349],"T1-weighted":[351,367],"A":[353],"perilesional":[354,415],"ring":[355],"nearly":[356],"void":[357],"signal":[359],"intensity":[360],"seen":[362],"unenhanced":[364],"gadolinium-enhanced":[366],"images":[368,401],"all":[370,380],"four":[374],"healed":[378,439],"1-3":[385],"irregular,":[390],"angular":[391],"polygonal":[392],"margins.":[393],"lesions,":[395],"which":[396],"obtained":[402],"immediately":[403],"after":[404],"gadolinium":[405],"administration,":[406],"appeared":[407],"regions":[409],"diminished":[411],"enhancement":[412],"changes.":[416],"CONCLUSION:":[417],"has":[420],"high":[421],"diagnosis":[426],"presentations":[440],"may":[441],"can":[445],"be":[446],"distinguished":[447],"by":[448],"appearances.":[451]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
