{"id":"https://openalex.org/W2168187239","doi":"https://doi.org/10.1084/jem.141.1.138","title":"Macrophage-lymphocyte interaction. II. Antigen-mediated physical interactions between immune guinea pig lymph node lymphocytes and syngeneic macrophages.","display_name":"Macrophage-lymphocyte interaction. II. Antigen-mediated physical interactions between immune guinea pig lymph node lymphocytes and syngeneic macrophages.","publication_year":1975,"publication_date":"1975-01-01","ids":{"openalex":"https://openalex.org/W2168187239","doi":"https://doi.org/10.1084/jem.141.1.138","mag":"2168187239","pmid":"https://pubmed.ncbi.nlm.nih.gov/46908","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2190496"},"language":"en","primary_location":{"id":"doi:10.1084/jem.141.1.138","doi":"https://doi.org/10.1084/jem.141.1.138","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.141.1.138","pdf_url":"https://rupress.org/jem/article-pdf/141/1/138/1086677/138.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/141/1/138/1086677/138.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043874873","display_name":"Peter E. Lipsky","orcid":"https://orcid.org/0000-0002-9287-1676","observed_orcids":["https://orcid.org/0000-0002-9287-1676"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P E Lipsky","raw_affiliation_strings":["(From the Section on Biologic Structure , Laboratory of Clinical Investigation , National Institute of Allergy and Infectious Diseases , National Institutes of Health , Bethesda , Maryland 20014)","Section on Biologic Structure, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(From the Section on Biologic Structure , Laboratory of Clinical Investigation , National Institute of Allergy and Infectious Diseases , National Institutes of Health , Bethesda , Maryland 20014)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Section on Biologic Structure, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113768970","display_name":"A. S. Rosenthal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A S Rosenthal","raw_affiliation_strings":["(From the Section on Biologic Structure , Laboratory of Clinical Investigation , National Institute of Allergy and Infectious Diseases , National Institutes of Health , Bethesda , Maryland 20014)","Section on Biologic Structure, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(From the Section on Biologic Structure , Laboratory of Clinical Investigation , National Institute of Allergy and Infectious Diseases , National Institutes of Health , Bethesda , Maryland 20014)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Section on Biologic Structure, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014)","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.6913,"has_fulltext":true,"cited_by_count":195,"citation_normalized_percentile":{"value":0.98239824,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"141","issue":"1","first_page":"138","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.1517000049352646,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-lymphocyte-interaction","display_name":"macrophage-lymphocyte interaction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lymph-node-lymphocytes","display_name":"lymph node lymphocytes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.800000011920929},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/allogeneic-lymphocytes","display_name":"allogeneic lymphocytes","score":0.7099999785423279},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.8390332460403442},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7405768632888794},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5879116654396057},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5736826062202454},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5518032312393188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48707178235054016},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.4765801429748535},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.438758909702301},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.328505277633667},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11419713497161865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0778006911277771}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006649","descriptor_name":"Histocompatibility Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1084/jem.141.1.138","doi":"https://doi.org/10.1084/jem.141.1.138","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.141.1.138","pdf_url":"https://rupress.org/jem/article-pdf/141/1/138/1086677/138.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2190496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2190496","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:46908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/46908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1084/jem.141.1.138","doi":"https://doi.org/10.1084/jem.141.1.138","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.141.1.138","pdf_url":"https://rupress.org/jem/article-pdf/141/1/138/1086677/138.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168187239.pdf","grobid_xml":"https://content.openalex.org/works/W2168187239.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W135731387","https://openalex.org/W1509816485","https://openalex.org/W1561861405","https://openalex.org/W1563351006","https://openalex.org/W1968367408","https://openalex.org/W1976920081","https://openalex.org/W2005480134","https://openalex.org/W2027771189","https://openalex.org/W2033409350","https://openalex.org/W2044623412","https://openalex.org/W2051835481","https://openalex.org/W2068230450","https://openalex.org/W2070170510","https://openalex.org/W2072987192","https://openalex.org/W2082588999","https://openalex.org/W2087692196","https://openalex.org/W2087906157","https://openalex.org/W2098045571","https://openalex.org/W2103320120","https://openalex.org/W2110860053","https://openalex.org/W2132760492","https://openalex.org/W2157626085","https://openalex.org/W2196582141","https://openalex.org/W2408938187","https://openalex.org/W2419864692","https://openalex.org/W4235793354"],"related_works":["https://openalex.org/W7100055062","https://openalex.org/W2409851987","https://openalex.org/W7096095984","https://openalex.org/W130681521","https://openalex.org/W170924701","https://openalex.org/W2189008329","https://openalex.org/W2098045571","https://openalex.org/W7100975892","https://openalex.org/W2103320120","https://openalex.org/W2129567021"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,8,35,52,63,78,102,117,125,157,161,183,195],"specific":[3],"antigen":[4,25,81,106],"on":[5,72],"the":[6,33,40,46,50,57,61,73,76,123,158,169,193],"development":[7],"physical":[9,145,170],"interactions":[10,93,108,120],"between":[11,97,147],"lymph":[12],"node":[13],"lymphocytes":[14,103,113,132,149,184],"(LNL)":[15],"obtained":[16],"from":[17,84,179],"animals":[18,85],"which":[19],"had":[20],"been":[21],"immunized":[22,87],"to":[23,39,88,142,187],"that":[24,32,89,110,144,168],"and":[26,82,99,104,112,150],"macrophages":[27,111,186],"was":[28,70],"examined.":[29],"We":[30],"found":[31],"presence":[34],"antigen,":[36],"either":[37],"limited":[38],"macrophage":[41],"()":[42],"or":[43,54],"free":[44,55],"in":[45,56,75,122,173,192],"medium,":[47,58],"profoundly":[48,59],"increased":[49,60],"degree":[51,62],")":[53],"Mphi-LNL":[64,119],"interaction":[65,69,146,190],"observed.":[66],"This":[67],"enhanced":[68],"dependent":[71],"coincidence":[74],"cultures":[77],"Mphi":[79,152],"bearing":[80],"LNL":[83,126],"specifically":[86,196],"antigen.":[90],"Although":[91],"antigen-independent":[92,180],"developed":[94],"equally":[95],"well":[96],"syngeneic":[98],"allogeneic":[100],"combinations":[101],"macrophages,":[105],"mediated":[107],"required":[109],"be":[114],"syngeneic.":[115],"Prolongation":[116],"antigen-mediated":[118],"resulted":[121],"induction":[124],"DNA":[127],"synthesis,":[128],"initially":[129],"involving":[130],"those":[131],"physically":[133],"associated":[134],"with":[135],"antigen-bearing":[136,151],"Mphi.":[137],"These":[138],"studies":[139],"are":[140],"interpreted":[141],"indicate":[143],"immune":[148,162,197],"represents":[153],"a":[154],"morphological":[155],"correlate":[156],"functional":[159],"activation":[160],"lymphocytes.":[163,198],"Further,":[164],"it":[165],"is":[166],"suggested":[167],"events":[171],"involved":[172],"lymphocyte":[174],"proliferation":[175],"may":[176],"proceed":[177],"sequentially":[178],"reversible":[181],"binding":[182],"by":[185],"prolonged":[188],"antigen-stabilized":[189],"eventuating":[191],"triggering":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
