{"id":"https://openalex.org/W2168093113","doi":null,"title":"The Diffusion-Limited Biochemical Signal-Relay Channel","display_name":"The Diffusion-Limited Biochemical Signal-Relay Channel","publication_year":2003,"publication_date":"2003-12-09","ids":{"openalex":"https://openalex.org/W2168093113","mag":"2168093113"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.884.8307","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.884.8307","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://papers.nips.cc/paper/2522-the-diffusion-limited-biochemical-signal-relay-channel.pdf","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083157573","display_name":"Peter J. Thomas","orcid":"https://orcid.org/0000-0001-7533-6770","observed_orcids":["https://orcid.org/0000-0001-7533-6770"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Thomas","raw_affiliation_strings":["Computational Neurobiology Laboratory, (Terrence J. Sejnowski, Director), Salk Institute for Biological Studies, La Jolla, CA#TAB#"],"raw_orcid":"https://orcid.org/0000-0001-7533-6770","affiliations":[{"raw_affiliation_string":"Computational Neurobiology Laboratory, (Terrence J. Sejnowski, Director), Salk Institute for Biological Studies, La Jolla, CA#TAB#","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Donald Spencer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Spencer","raw_affiliation_strings":["Computational Neurobiology Laboratory, (Terrence J. Sejnowski, Director), Salk Institute for Biological Studies, La Jolla, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Neurobiology Laboratory, (Terrence J. Sejnowski, Director), Salk Institute for Biological Studies, La Jolla, CA#TAB#","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074255528","display_name":"Sierra K. Hampton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sierra K. Hampton","raw_affiliation_strings":["Dept. of Electrical & Computer Engineering, University of California, San Diego, La Jolla, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electrical & Computer Engineering, University of California, San Diego, La Jolla, CA#TAB#","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022028438","display_name":"Peter J. Park","orcid":"https://orcid.org/0000-0001-9378-960X","observed_orcids":["https://orcid.org/0000-0001-9378-960X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Park","raw_affiliation_strings":["Dept. of Electrical & Computer Engineering, University of California, San Diego, La Jolla, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electrical & Computer Engineering, University of California, San Diego, La Jolla, CA#TAB#","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002539103","display_name":"Joseph P. Zurkus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph P. Zurkus","raw_affiliation_strings":["Dept. of Electrical & Computer Engineering, University of California, San Diego, La Jolla, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Electrical & Computer Engineering, University of California, San Diego, La Jolla, CA#TAB#","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.22169698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"1263","last_page":"1270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.09229999780654907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.06129999831318855,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/channel-capacity","display_name":"channel capacity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/ligand-receptor-interactions","display_name":"ligand-receptor interactions","score":0.859000027179718},{"id":"https://openalex.org/keywords/transmembrane-receptors","display_name":"transmembrane receptors","score":0.8009999990463257},{"id":"https://openalex.org/keywords/non-gaussian-noise","display_name":"non-Gaussian noise","score":0.921999990940094},{"id":"https://openalex.org/keywords/water-filling","display_name":"water-filling","score":0.6209999918937683},{"id":"https://openalex.org/keywords/stochastic-diffusion","display_name":"stochastic diffusion","score":0.8109999895095825},{"id":"https://openalex.org/keywords/information-processing-in-cells","display_name":"information processing in cells","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.6700325012207031},{"id":"https://openalex.org/C46257984","wikidata":"https://www.wikidata.org/wiki/Q7310895","display_name":"Relay channel","level":4,"score":0.6697511672973633},{"id":"https://openalex.org/C2778156585","wikidata":"https://www.wikidata.org/wiki/Q174053","display_name":"Relay","level":3,"score":0.6476269364356995},{"id":"https://openalex.org/C97744766","wikidata":"https://www.wikidata.org/wiki/Q870845","display_name":"Channel capacity","level":3,"score":0.565348207950592},{"id":"https://openalex.org/C169334058","wikidata":"https://www.wikidata.org/wiki/Q353292","display_name":"Additive white Gaussian noise","level":3,"score":0.5207579135894775},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.516642153263092},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49207180738449097},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.47155141830444336},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4671207070350647},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.43489930033683777},{"id":"https://openalex.org/C2779767902","wikidata":"https://www.wikidata.org/wiki/Q17037278","display_name":"Molecular communication","level":4,"score":0.4340866506099701},{"id":"https://openalex.org/C160562895","wikidata":"https://www.wikidata.org/wiki/Q7239557","display_name":"Precoding","level":4,"score":0.42568427324295044},{"id":"https://openalex.org/C13944312","wikidata":"https://www.wikidata.org/wiki/Q7512748","display_name":"Signal-to-noise ratio (imaging)","level":2,"score":0.4207976162433624},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.38370421528816223},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2757561206817627},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.272969126701355},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.2192637324333191},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18546247482299805},{"id":"https://openalex.org/C47798520","wikidata":"https://www.wikidata.org/wiki/Q190157","display_name":"Transmitter","level":3,"score":0.16898062825202942},{"id":"https://openalex.org/C207987634","wikidata":"https://www.wikidata.org/wiki/Q176862","display_name":"MIMO","level":3,"score":0.13987404108047485},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10528519749641418},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.884.8307","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.884.8307","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://papers.nips.cc/paper/2522-the-diffusion-limited-biochemical-signal-relay-channel.pdf","raw_type":"text"},{"id":"mag:2168093113","doi":null,"is_oa":false,"landing_page_url":"https://materias.df.uba.ar/example/files/2012/07/10.1.1.9.3496.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4363606243","display_name":"neural information processing systems","issn_l":"1049-5258","issn":["1049-5258"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Neural Information Processing Systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1639951707","https://openalex.org/W2001932342","https://openalex.org/W2020307765","https://openalex.org/W2038364742","https://openalex.org/W2078760718","https://openalex.org/W2099111195","https://openalex.org/W2132856372","https://openalex.org/W2147210834"],"related_works":["https://openalex.org/W7098946230","https://openalex.org/W7096023984","https://openalex.org/W3102953539","https://openalex.org/W1989087468","https://openalex.org/W2400910495","https://openalex.org/W2886830728","https://openalex.org/W4417248693","https://openalex.org/W2797876308","https://openalex.org/W1622908138","https://openalex.org/W1994681034"],"abstract_inverted_index":{"Biochemical":[0],"signal-transduction":[1],"networks":[2],"are":[3],"the":[4,101,105,109,115,124],"biological":[5],"information-processing":[6],"systems":[7],"by":[8,46,52],"which":[9],"individual":[10],"cells,":[11],"from":[12,123],"neurons":[13],"to":[14,19,54,83,91],"amoebae,":[15],"perceive":[16],"and":[17,33,50,79,104],"respond":[18],"their":[20],"chemical":[21],"environments.":[22],"We":[23,74,113],"introduce":[24],"a":[25,29,38,47,55,60,67,119],"simplified":[26],"model":[27,75],"of":[28,86],"single":[30],"biochemical":[31],"relay":[32],"analyse":[34],"its":[35,81,93],"capacity":[36,117],"as":[37],"communications":[39,69],"channel.":[40,128],"A":[41],"diffusible":[42],"ligand":[43],"is":[44],"released":[45],"sending":[48],"cell":[49],"received":[51],"binding":[53],"transmembrane":[56],"receptor":[57],"protein":[58],"on":[59],"receiving":[61],"cell.":[62],"This":[63],"receptor-ligand":[64,106],"interaction":[65,107],"creates":[66],"nonlinear":[68],"channel":[70,77,94,110,116],"with":[71],"non-Gaussian":[72],"noise.":[73],"this":[76],"numerically":[78],"study":[80],"response":[82],"input":[84],"signals":[85],"different":[87],"frequencies":[88],"in":[89,99],"order":[90],"estimate":[92,114],"capacity.":[95],"Stochastic":[96],"effects":[97],"introduced":[98],"both":[100],"diffusion":[102],"process":[103],"give":[108],"low-pass":[111],"characteristics.":[112],"using":[118],"water-filling":[120],"formula":[121],"adapted":[122],"additive":[125],"white-noise":[126],"Gaussian":[127]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
