{"id":"https://openalex.org/W2168089366","doi":"https://doi.org/10.1161/hypertensionaha.113.01726","title":"Myocardial Mineralocorticoid Receptor Activation by Stretching and Its Functional Consequences","display_name":"Myocardial Mineralocorticoid Receptor Activation by Stretching and Its Functional Consequences","publication_year":2013,"publication_date":"2013-10-15","ids":{"openalex":"https://openalex.org/W2168089366","doi":"https://doi.org/10.1161/hypertensionaha.113.01726","mag":"2168089366","pmid":"https://pubmed.ncbi.nlm.nih.gov/24126173"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.113.01726","doi":"https://doi.org/10.1161/hypertensionaha.113.01726","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.113.01726","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.113.01726","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.113.01726","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006540108","display_name":"Romina G. D\u00edaz","orcid":"https://orcid.org/0000-0003-0599-510X","observed_orcids":["https://orcid.org/0000-0003-0599-510X"]},"institutions":[{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Romina G. D\u00edaz","raw_affiliation_strings":["From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)","institution_ids":["https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044277060","display_name":"N\u00e9stor Gustavo P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"N\u00e9stor G. P\u00e9rez","raw_affiliation_strings":["From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)","institution_ids":["https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023331167","display_name":"Patricio E. Morgan","orcid":"https://orcid.org/0000-0003-2163-4355","observed_orcids":["https://orcid.org/0000-0003-2163-4355"]},"institutions":[{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Patricio E. Morgan","raw_affiliation_strings":["From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)","institution_ids":["https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006978351","display_name":"Mar\u00eda Celeste Villa\u2010Abrille","orcid":"https://orcid.org/0000-0003-2119-7327","observed_orcids":["https://orcid.org/0000-0003-2119-7327"]},"institutions":[{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda C. Villa-Abrille","raw_affiliation_strings":["From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)","institution_ids":["https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018563506","display_name":"Claudia I. Caldiz","orcid":"https://orcid.org/0000-0002-7579-1367","observed_orcids":["https://orcid.org/0000-0002-7579-1367"]},"institutions":[{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Claudia I. Caldiz","raw_affiliation_strings":["From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)","institution_ids":["https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018198913","display_name":"Mariela B. Nolly","orcid":"https://orcid.org/0000-0001-6552-4209","observed_orcids":["https://orcid.org/0000-0001-6552-4209"]},"institutions":[{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mariela B. Nolly","raw_affiliation_strings":["From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)","institution_ids":["https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088723412","display_name":"Enrique Leo Portiansky","orcid":"https://orcid.org/0000-0002-2572-4668","observed_orcids":["https://orcid.org/0000-0002-2572-4668"]},"institutions":[{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Enrique L. Portiansky","raw_affiliation_strings":["From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)","institution_ids":["https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008441793","display_name":"Irene L. Ennis","orcid":"https://orcid.org/0000-0003-3510-7302","observed_orcids":["https://orcid.org/0000-0003-3510-7302"]},"institutions":[{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Irene L. Ennis","raw_affiliation_strings":["From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)","institution_ids":["https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111817547","display_name":"Horacio Eugenio Cingolani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152408","display_name":"Centro de Investigaciones Cardiovasculares","ror":"https://ror.org/04ebzxq58","country_code":"AR","type":"facility","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4210138160","https://openalex.org/I4210152408","https://openalex.org/I4387155568","https://openalex.org/I874386039"]},{"id":"https://openalex.org/I874386039","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929","country_code":"AR","type":"education","lineage":["https://openalex.org/I874386039"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Horacio E. Cingolani","raw_affiliation_strings":["From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Centro de Investigaciones Cardiovasculares, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de La Plata, La Plata, Argentina (R.G.D., N.G.P., P.E.M., M.C.V.-A., C.I.C., M.B.N., I.L.E., H.E.C.); and Laboratorio de An\u00e1lisis de Im\u00e1genes, Instituto de Patolog\u00eda, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina (E.L.P.)","institution_ids":["https://openalex.org/I4210152408","https://openalex.org/I874386039"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3076,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.8136421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"63","issue":"1","first_page":"112","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.24779999256134033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-stretch","display_name":"myocardial stretch","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9869999885559082},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9570000171661377},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/p90rsk","display_name":"p90RSK","score":0.9049999713897705},{"id":"https://openalex.org/keywords/na-h-exchanger","display_name":"Na+/H+ exchanger","score":0.9470000267028809},{"id":"https://openalex.org/keywords/intracellular-ph","display_name":"intracellular pH","score":0.8349999785423279},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lentiviral-shrna-knockdown","display_name":"lentiviral shRNA knockdown","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7194904685020447},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.6456393599510193},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6420772671699524},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5959702730178833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5759672522544861},{"id":"https://openalex.org/C189135053","wikidata":"https://www.wikidata.org/wiki/Q3454531","display_name":"Mineralocorticoid receptor","level":3,"score":0.5450350642204285},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4783303737640381},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.4752877950668335},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4628123342990875},{"id":"https://openalex.org/C114574056","wikidata":"https://www.wikidata.org/wiki/Q7553395","display_name":"Sodium\u2013hydrogen antiporter","level":3,"score":0.44239628314971924},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4306694269180298},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4116692841053009},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40414637327194214},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35247600078582764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28564298152923584},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2130989134311676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13564804196357727},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000074082","descriptor_name":"Sodium-Hydrogen Exchanger 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018161","descriptor_name":"Receptors, Mineralocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1161/hypertensionaha.113.01726","doi":"https://doi.org/10.1161/hypertensionaha.113.01726","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.113.01726","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.113.01726","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmh:oai:americanae.aecid.es:3918335","doi":null,"is_oa":true,"landing_page_url":"http://sedici.unlp.edu.ar/handle/10915/85165","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:SEDICI (UNLP)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmid:24126173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24126173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"},{"id":"pmh:oai:sedici.unlp.edu.ar:10915/85165","doi":null,"is_oa":true,"landing_page_url":"http://sedici.unlp.edu.ar/handle/10915/85165","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:SEDICI (UNLP)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/96996","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/96996","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1161/hypertensionaha.113.01726","doi":"https://doi.org/10.1161/hypertensionaha.113.01726","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.113.01726","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.113.01726","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168089366.pdf","grobid_xml":"https://content.openalex.org/works/W2168089366.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1595330952","https://openalex.org/W1889002087","https://openalex.org/W1962115317","https://openalex.org/W1984823433","https://openalex.org/W2014040418","https://openalex.org/W2017884988","https://openalex.org/W2028732654","https://openalex.org/W2042027582","https://openalex.org/W2042993494","https://openalex.org/W2043155805","https://openalex.org/W2045297932","https://openalex.org/W2047908219","https://openalex.org/W2049772614","https://openalex.org/W2050312701","https://openalex.org/W2058431890","https://openalex.org/W2059878261","https://openalex.org/W2064685693","https://openalex.org/W2068638594","https://openalex.org/W2080017767","https://openalex.org/W2086041680","https://openalex.org/W2095317086","https://openalex.org/W2096111588","https://openalex.org/W2116052153","https://openalex.org/W2118429250","https://openalex.org/W2123801122","https://openalex.org/W2125560773","https://openalex.org/W2128478402","https://openalex.org/W2129911320","https://openalex.org/W2134207143","https://openalex.org/W2139048802","https://openalex.org/W2139423738","https://openalex.org/W2141490105","https://openalex.org/W2148945565","https://openalex.org/W2151670977","https://openalex.org/W2152094259","https://openalex.org/W2152338271","https://openalex.org/W2154015803","https://openalex.org/W2156250141","https://openalex.org/W2159303384","https://openalex.org/W2164705414","https://openalex.org/W2165017574","https://openalex.org/W2170880252","https://openalex.org/W2234087231","https://openalex.org/W2289116881","https://openalex.org/W2316416522","https://openalex.org/W2323458614","https://openalex.org/W2328926651"],"related_works":["https://openalex.org/W3090234346","https://openalex.org/W2102851659","https://openalex.org/W2234087231","https://openalex.org/W1595330952","https://openalex.org/W1962115317","https://openalex.org/W2159303384","https://openalex.org/W187711175","https://openalex.org/W2531840914","https://openalex.org/W2014040418","https://openalex.org/W2279520969"],"abstract_inverted_index":{"Myocardial":[0,113],"stretch":[1,47,241],"triggers":[2],"an":[3,157],"angiotensin":[4,152,191],"II-dependent":[5],"autocrine/paracrine":[6],"loop":[7],"of":[8,17,44,57,66,86,118,151,160,190,199,209,217,225],"intracellular":[9],"signals,":[10],"leading":[11],"to":[12,40,53,147,247],"reactive":[13,141,193,203],"oxygen":[14,142,194,204],"species-mediated":[15],"activation":[16,117,237,251],"redox-sensitive":[18,119,249],"kinases.":[19],"Based":[20],"on":[21],"pharmacological":[22,58],"strategies,":[23],"we":[24,38],"previously":[25],"proposed":[26],"that":[27,235],"mineralocorticoid":[28],"receptor":[29],"(MR)":[30],"is":[31,243],"necessary":[32],"for":[33],"this":[34],"stretch-triggered":[35,116,210],"mechanism.":[36],"Now,":[37],"aimed":[39],"test":[41],"the":[42,70,82,105,122,134,226],"role":[43],"MR":[45,59,71,114,186,236],"after":[46,239],"by":[48,110],"using":[49],"a":[50,75,94,148,244],"molecular":[51],"approach":[52],"avoid":[54],"secondary":[55],"effects":[56],"blockers.":[60],"Small":[61],"hairpin":[62],"interference":[63],"RNA":[64],"capable":[65],"specifically":[67],"knocking":[68],"down":[69],"was":[72,98,108,166],"incorporated":[73],"into":[74,81],"lentiviral":[76],"vector":[77,91],"(l-shMR)":[78],"and":[79,130,222,242,252],"injected":[80],"left":[83,106],"ventricular":[84],"wall":[85],"Wistar":[87],"rats.":[88],"The":[89],"same":[90],"but":[92,197],"expressing":[93],"nonsilencing":[95],"sequence":[96],"(scramble)":[97],"used":[99],"as":[100],"control.":[101],"Lentivirus":[102],"propagation":[103],"through":[104],"ventricle":[107],"evidenced":[109],"confocal":[111],"microscopy.":[112],"expression,":[115,187],"kinases":[120],"(ERK1/2-p90(RSK)),":[121],"consequent":[123],"Na(+)/H(+)":[124,219],"exchanger-mediated":[125],"changes":[126],"in":[127,145,168,212],"pHi":[128],"(HEPES-buffer),":[129],"its":[131],"mechanical":[132],"counterpart,":[133],"slow":[135,227],"force":[136,228],"response,":[137],"were":[138],"evaluated.":[139],"Furthermore,":[140],"species":[143,195,205],"production":[144,196],"response":[146],"low":[149],"concentration":[150,159],"II":[153],"(1.0":[154],"nmol/L)":[155],"or":[156],"equipotent":[158],"epidermal":[161,200],"growth":[162,201],"factor":[163,246],"(0.1":[164],"\u03bcg/mL)":[165],"compared":[167],"myocardial":[169,240],"tissue":[170],"slices":[171],"from":[172],"both":[173],"groups.":[174],"Compared":[175],"with":[176,180],"scramble,":[177],"animals":[178],"transduced":[179],"l-shMR":[181],"showed":[182],"(1)":[183],"reduced":[184],"cardiac":[185],"(2)":[188],"cancellation":[189,208],"II-induced":[192],"preservation":[198],"factor-induced":[202],"production,":[206],"(3)":[207],"increase":[211],"ERK1/2-p90(RSK)":[213],"phosphorylation,":[214],"(4)":[215],"lack":[216],"stretch-induced":[218],"exchanger":[220],"activation,":[221],"(5)":[223],"abolishment":[224],"response.":[229],"Our":[230],"results":[231],"provide":[232],"strong":[233],"evidence":[234],"occurs":[238],"key":[245],"promote":[248],"kinase":[250],"their":[253],"downstream":[254],"consequences.":[255]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
