{"id":"https://openalex.org/W2168064253","doi":"https://doi.org/10.1097/00000542-200508000-00013","title":"Anesthetics Inhibit Membrane Receptor Coupling to the Gq/11Heterotrimeric G Protein in Airway Smooth Muscle","display_name":"Anesthetics Inhibit Membrane Receptor Coupling to the Gq/11Heterotrimeric G Protein in Airway Smooth Muscle","publication_year":2005,"publication_date":"2005-07-27","ids":{"openalex":"https://openalex.org/W2168064253","doi":"https://doi.org/10.1097/00000542-200508000-00013","mag":"2168064253","pmid":"https://pubmed.ncbi.nlm.nih.gov/16052112"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-200508000-00013","doi":"https://doi.org/10.1097/00000542-200508000-00013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-200508000-00013","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102907834","display_name":"Tetsuzo Nakayama","orcid":"https://orcid.org/0000-0002-9301-9151","observed_orcids":["https://orcid.org/0000-0002-9301-9151"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tetsuzo Nakayama","raw_affiliation_strings":["Department of Anesthesiology, Mayo Foundation, Rochester, Minnesota 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Mayo Foundation, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034132414","display_name":"Masao Hayashi","orcid":"https://orcid.org/0000-0002-9321-7406","observed_orcids":["https://orcid.org/0000-0002-9321-7406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masao Hayashi","raw_affiliation_strings":["* Research Fellow, \u2020 Professor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"* Research Fellow, \u2020 Professor","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067856866","display_name":"David O. Warner","orcid":"https://orcid.org/0000-0002-0365-2536","observed_orcids":["https://orcid.org/0000-0002-0365-2536"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David\u00a0O. Warner","raw_affiliation_strings":["* Research Fellow, \u2020 Professor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"* Research Fellow, \u2020 Professor","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108511688","display_name":"Keith A. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith\u00a0A. Jones","raw_affiliation_strings":["* Research Fellow, \u2020 Professor","Mayo Clinic Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"* Research Fellow, \u2020 Professor","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5019,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62123521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"103","issue":"2","first_page":"296","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.06040000170469284,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anesthetic-agents","display_name":"anesthetic agents","score":0.8930000066757202},{"id":"https://openalex.org/keywords/airway-smooth-muscle","display_name":"airway smooth muscle","score":0.8690000176429749},{"id":"https://openalex.org/keywords/calcium-sensitivity","display_name":"calcium sensitivity","score":0.7450000047683716},{"id":"https://openalex.org/keywords/halothane","display_name":"halothane","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hexanol","display_name":"hexanol","score":0.9700000286102295},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.9350000023841858},{"id":"https://openalex.org/keywords/endothelin-1-receptor","display_name":"endothelin-1 receptor","score":0.9509999752044678},{"id":"https://openalex.org/keywords/histamine-receptors","display_name":"histamine receptors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6865254044532776},{"id":"https://openalex.org/C139407321","wikidata":"https://www.wikidata.org/wiki/Q408561","display_name":"Heterotrimeric G protein","level":4,"score":0.6286587715148926},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.4716184437274933},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.4608224630355835},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.44286802411079407},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.4306705892086029},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3693128824234009},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36688607931137085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3521345555782318},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34330499172210693},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33996737003326416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33410215377807617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31505441665649414},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31166985630989075}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000777","descriptor_name":"Anesthetics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043802","descriptor_name":"GTP-Binding Protein alpha Subunits, Gq-G11","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-200508000-00013","doi":"https://doi.org/10.1097/00000542-200508000-00013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-200508000-00013","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:16052112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16052112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1759773198","display_name":"Anesthesia And Airways","funder_award_id":"R01HL045532","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2643217195","display_name":"Nitric Oxide Regulation of Smooth Muscle Tone","funder_award_id":"R01HL054757","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7257268647","display_name":null,"funder_award_id":"HL54757","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7390506544","display_name":null,"funder_award_id":"HL45532","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2061088788","https://openalex.org/W2048670375","https://openalex.org/W2088117776","https://openalex.org/W2118235485","https://openalex.org/W2056316705","https://openalex.org/W2028201340","https://openalex.org/W2239493740","https://openalex.org/W2069156109","https://openalex.org/W78822087","https://openalex.org/W2117379413"],"abstract_inverted_index":{"BACKGROUND:":[0],"Some":[1],"anesthetics":[2,218],"relax":[3],"airway":[4,66,82,112],"smooth":[5,67,83,113],"muscle":[6,84],"in":[7,13,65,75,80,106,141,157,173,195],"part":[8],"by":[9,161,200,216,231],"inhibiting":[10],"acetylcholine-induced":[11],"increases":[12,74],"Ca2+":[14,63,76,142,158,241],"sensitivity,":[15],"an":[16,180],"effect":[17,181],"associated":[18],"with":[19,87],"inhibition":[20,208],"of":[21,29,57,119,209,224,240],"guanosine":[22,101,120,211],"nucleotide":[23,102,128,175,185,197,212],"exchange":[24,103,129,198,213],"at":[25,130,214],"the":[26,30,39,49,58,125,155,193],"alpha":[27],"subunit":[28],"Gq/11":[31],"(Galphaq/11)":[32],"heterotrimeric":[33],"G":[34],"protein.":[35],"This":[36],"study":[37],"tested":[38],"hypothesis":[40],"that":[41,61,207],"these":[42],"anesthetic":[43,178],"effects":[44,71,92],"are":[45,53],"not":[46],"unique":[47],"to":[48],"muscarinic":[50],"receptor":[51,238],"but":[52],"a":[54,138,168,221],"general":[55,222],"property":[56,223],"heptahelical":[59,225],"receptors":[60,226],"increase":[62,140,156,172,194],"sensitivity":[64,77,159],"muscle.":[68,114],"METHODS:":[69],"Anesthetic":[70,91],"on":[72,93,182],"agonist-induced":[73],"were":[78,104],"measured":[79],"porcine":[81,111],"strips":[85],"permeabilized":[86],"S.":[88],"aureus":[89],"alpha-toxin.":[90],"basal":[94,183],"(without":[95],"agonist":[96,165],"stimulation)":[97],"and":[98,135,149,170,189,236],"agonist-promoted":[99,210],"Galphaq/11":[100,174,184,196,215],"determined":[105],"crude":[107],"membranes":[108],"prepared":[109],"from":[110],"The":[115],"nonhydrolyzable,":[116],"radioactive":[117],"form":[118],"5'-triphosphate":[121],"was":[122],"used":[123],"as":[124],"reporter":[126],"for":[127],"Galphaq/11.":[131],"RESULTS:":[132],"Acetylcholine,":[133],"endothelin-1,":[134,235],"histamine":[136,237],"caused":[137,167],"concentration-dependent":[139,171],"sensitivity.":[143,242],"Halothane":[144],"(0.67":[145],"+/-":[146],"0.07":[147],"mM)":[148,152],"hexanol":[150,190],"(10":[151],"significantly":[153,191],"inhibited":[154,192],"induced":[160],"each":[162,201],"agonist.":[163,202],"Each":[164],"also":[166],"time-":[169],"exchange.":[176],"Neither":[177],"had":[179],"exchange,":[186],"whereas":[187],"halothane":[188],"promoted":[199],"CONCLUSION:":[203],"These":[204],"data":[205],"suggest":[206],"some":[217],"may":[219],"be":[220],"involved":[227],"cellular":[228],"processes":[229],"mediated":[230],"Galphaq/11,":[232],"including":[233],"muscarinic,":[234],"activation":[239]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
