{"id":"https://openalex.org/W2168048072","doi":"https://doi.org/10.1136/jnnp.62.3.234","title":"Loss of large myelinated nerve fibres of the recurrent laryngeal nerve in patients with multiple system atrophy and vocal cord palsy.","display_name":"Loss of large myelinated nerve fibres of the recurrent laryngeal nerve in patients with multiple system atrophy and vocal cord palsy.","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W2168048072","doi":"https://doi.org/10.1136/jnnp.62.3.234","mag":"2168048072","pmid":"https://pubmed.ncbi.nlm.nih.gov/9069477","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1064151"},"language":"en","primary_location":{"id":"doi:10.1136/jnnp.62.3.234","doi":"https://doi.org/10.1136/jnnp.62.3.234","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp.62.3.234","pdf_url":"https://jnnp.bmj.com/content/jnnp/62/3/234.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnnp.bmj.com/content/jnnp/62/3/234.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102714019","display_name":"Masaya Hayashi","orcid":"https://orcid.org/0000-0001-6148-051X","observed_orcids":["https://orcid.org/0000-0001-6148-051X"]},"institutions":[{"id":"https://openalex.org/I4210123749","display_name":"Tokyo Metropolitan Neurological Hospital","ror":"https://ror.org/02j1xhm46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123749"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Hayashi","raw_affiliation_strings":["Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan","institution_ids":["https://openalex.org/I4210123749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025647387","display_name":"Eiji Isozaki","orcid":"https://orcid.org/0000-0003-0166-2041","observed_orcids":["https://orcid.org/0000-0003-0166-2041"]},"institutions":[{"id":"https://openalex.org/I4210123749","display_name":"Tokyo Metropolitan Neurological Hospital","ror":"https://ror.org/02j1xhm46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123749"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"E Isozaki","raw_affiliation_strings":["Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan","institution_ids":["https://openalex.org/I4210123749"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Oda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123749","display_name":"Tokyo Metropolitan Neurological Hospital","ror":"https://ror.org/02j1xhm46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123749"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Oda","raw_affiliation_strings":["Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan","institution_ids":["https://openalex.org/I4210123749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112137604","display_name":"H Tanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123749","display_name":"Tokyo Metropolitan Neurological Hospital","ror":"https://ror.org/02j1xhm46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123749"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Tanabe","raw_affiliation_strings":["Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan","institution_ids":["https://openalex.org/I4210123749"]}]},{"author_position":"last","author":{"id":null,"display_name":"J Kimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123749","display_name":"Tokyo Metropolitan Neurological Hospital","ror":"https://ror.org/02j1xhm46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123749"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J Kimura","raw_affiliation_strings":["Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan","institution_ids":["https://openalex.org/I4210123749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210123749"],"apc_list":null,"apc_paid":null,"fwci":3.5798,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.90944541,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"62","issue":"3","first_page":"234","last_page":"238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.7333999872207642,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.7333999872207642,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.2093999981880188,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":0.996999979019165},{"id":"https://openalex.org/keywords/vocal-cord-palsy","display_name":"vocal cord palsy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/recurrent-laryngeal-nerve","display_name":"recurrent laryngeal nerve","score":1.0},{"id":"https://openalex.org/keywords/myelinated-nerve-fibers","display_name":"myelinated axons","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fiber-diameter","display_name":"fiber diameter","score":0.4860000014305115},{"id":"https://openalex.org/keywords/neuronopathy","display_name":"neuronopathy","score":0.6690000295639038},{"id":"https://openalex.org/keywords/laryngeal-innervation","display_name":"laryngeal innervation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/intrinsic-laryngeal-muscles","display_name":"intrinsic laryngeal muscles","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2776109941","wikidata":"https://www.wikidata.org/wiki/Q740541","display_name":"Recurrent laryngeal nerve","level":3,"score":0.7367468476295471},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.7329095005989075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6548147201538086},{"id":"https://openalex.org/C2779632786","wikidata":"https://www.wikidata.org/wiki/Q920297","display_name":"Cord","level":2,"score":0.6255911588668823},{"id":"https://openalex.org/C2781079905","wikidata":"https://www.wikidata.org/wiki/Q684045","display_name":"Vocal cord paralysis","level":3,"score":0.5567634701728821},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5133172869682312},{"id":"https://openalex.org/C2779618896","wikidata":"https://www.wikidata.org/wiki/Q107231","display_name":"Paralysis","level":2,"score":0.4896734058856964},{"id":"https://openalex.org/C2778097013","wikidata":"https://www.wikidata.org/wiki/Q68212673","display_name":"Palsy","level":3,"score":0.4478302597999573},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23617783188819885},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1867552101612091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05738714337348938},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003711","descriptor_name":"Demyelinating Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012009","descriptor_name":"Recurrent Laryngeal Nerve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014826","descriptor_name":"Vocal Cord Paralysis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D014826","descriptor_name":"Vocal Cord Paralysis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014827","descriptor_name":"Vocal Cords","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/jnnp.62.3.234","doi":"https://doi.org/10.1136/jnnp.62.3.234","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp.62.3.234","pdf_url":"https://jnnp.bmj.com/content/jnnp/62/3/234.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1064151","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1064151","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1064151/pdf/jnnpsyc00003-0018.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurol Neurosurg Psychiatry","raw_type":"Text"},{"id":"pmid:9069477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9069477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurology, neurosurgery, and psychiatry","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1136/jnnp.62.3.234","doi":"https://doi.org/10.1136/jnnp.62.3.234","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp.62.3.234","pdf_url":"https://jnnp.bmj.com/content/jnnp/62/3/234.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168048072.pdf","grobid_xml":"https://content.openalex.org/works/W2168048072.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1998648979","https://openalex.org/W2003664213","https://openalex.org/W2005944282","https://openalex.org/W2043887764","https://openalex.org/W2058789950","https://openalex.org/W2075149753","https://openalex.org/W2093315892","https://openalex.org/W2099505411","https://openalex.org/W2124367836","https://openalex.org/W2151030257","https://openalex.org/W2168829007","https://openalex.org/W2175829562","https://openalex.org/W2322228282"],"related_works":["https://openalex.org/W2288902072","https://openalex.org/W2017359709","https://openalex.org/W1980505077","https://openalex.org/W76020810","https://openalex.org/W3015020866","https://openalex.org/W2081286914","https://openalex.org/W2412578403","https://openalex.org/W2322228282","https://openalex.org/W1966354246","https://openalex.org/W2417289277"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Vocal":[1],"cord":[2,37,99,141,162,174],"palsy":[3,38,100,175],"seen":[4],"in":[5,87,95,102,116,118,137,145],"some":[6],"patients":[7,26,75],"with":[8,27,32,76,97,139],"multiple":[9,28,77,120,152],"system":[10,29,78,121,153],"atrophy":[11,79,122],"may":[12],"result":[13],"from":[14],"neuronopathy":[15],"of":[16,43,61,65,74,83,180],"the":[17,56,62,66,84,88,91,125,148,155,160,178,181,188,194],"recurrent":[18,67],"laryngeal":[19,63,68,196],"nerve.":[20,69],"METHODS:":[21],"Six":[22],"controls":[23],"and":[24,33,49,58,143],"six":[25],"atrophy,":[30,154],"four":[31],"two":[34],"without":[35,147,166],"vocal":[36,98,140,161,173],"were":[39,47,53,114,134],"studied.":[40],"The":[41,105,170],"number":[42,117],"myelinated":[44,85,107,127,157,183],"nerve":[45,108,128],"fibres":[46,86,109,129,158],"counted":[48],"fibre":[50],"diameter":[51],"histograms":[52],"established":[54],"for":[55],"motor":[57,89,190],"sensory":[59],"divisions":[60],"branch":[64],"RESULTS:":[70],"Although":[71],"both":[72,119],"groups":[73],"showed":[80],"selective":[81],"loss":[82,179],"branch,":[90],"change":[92],"was":[93],"greater":[94],"those":[96,103,138,146],"than":[101],"without.":[104],"small":[106,156],"(diameter":[110,130],"<":[111,131],"7":[112],"microm)":[113,133],"decreased":[115,135],"groups,":[123],"whereas":[124],"large":[126,182],"8":[132],"only":[136,176],"palsy,":[142],"preserved":[144],"symptom.":[149],"CONCLUSION:":[150],"In":[151],"innervating":[159],"are":[163],"affected":[164],"first,":[165],"obvious":[167],"clinical":[168],"signs.":[169],"patient":[171],"develops":[172],"after":[177],"fibres,":[184],"which":[185],"mostly":[186],"comprise":[187],"alpha":[189],"axons":[191],"that":[192],"innervate":[193],"intrinsic":[195],"muscles.":[197]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}