{"id":"https://openalex.org/W2168039588","doi":"https://doi.org/10.7555/jbr.27.20120114","title":"A novel recombinant DNA vaccine encoding Mycobacterium tuberculosis ESAT-6 and FL protects against Mycobacterium tuberculosis challenge in mice","display_name":"A novel recombinant DNA vaccine encoding Mycobacterium tuberculosis ESAT-6 and FL protects against Mycobacterium tuberculosis challenge in mice","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2168039588","doi":"https://doi.org/10.7555/jbr.27.20120114","mag":"2168039588","pmid":"https://pubmed.ncbi.nlm.nih.gov/24086174","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3783826"},"language":"en","primary_location":{"id":"doi:10.7555/jbr.27.20120114","doi":"https://doi.org/10.7555/jbr.27.20120114","is_oa":true,"landing_page_url":"https://doi.org/10.7555/jbr.27.20120114","pdf_url":"http://www.jbr-pub.org.cn/en/article/doi/10.7555/JBR.27.20120114","source":{"id":"https://openalex.org/S165426342","display_name":"Journal of Biomedical Research","issn_l":"1674-8301","issn":["1674-8301","2352-4685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biomedical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbr-pub.org.cn/en/article/doi/10.7555/JBR.27.20120114","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048564196","display_name":"Qingtao Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang Qingtao","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Department of Microbiology and Immunology, Nanjing Medical University, 140","Hanzhong Road, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345415","display_name":"Jing Zhang","orcid":"https://orcid.org/0000-0002-6313-5741","observed_orcids":["https://orcid.org/0000-0002-6313-5741","https://orcid.org/0009-0008-4567-5120"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang Jing","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Department of Microbiology and Immunology, Nanjing Medical University, 140","Hanzhong Road, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423086","display_name":"Xia Chen","orcid":"https://orcid.org/0009-0009-8432-6158","observed_orcids":["https://orcid.org/0009-0009-8432-6158"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Xia","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Department of Microbiology and Immunology, Nanjing Medical University, 140","Hanzhong Road, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101047345","display_name":"Mei Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Mei","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Department of Microbiology and Immunology, Nanjing Medical University, 140","Hanzhong Road, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108434354","display_name":"Yanlai Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Yanlai","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Department of Microbiology and Immunology, Nanjing Medical University, 140","Hanzhong Road, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112016748","display_name":"Qiu Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiu Wen","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Department of Microbiology and Immunology, Nanjing Medical University, 140","Hanzhong Road, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016935898","display_name":"Feng Ganzhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Ganzhu","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Department of Microbiology and Immunology, Nanjing Medical University, 140","Hanzhong Road, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102889404","display_name":"Dan Zhao","orcid":"https://orcid.org/0000-0002-0854-9140","observed_orcids":["https://orcid.org/0000-0002-0854-9140"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhao Dan","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Department of Microbiology and Immunology, Nanjing Medical University, 140","Hanzhong Road, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380408","display_name":"Yan Li","orcid":"https://orcid.org/0000-0003-0420-4222","observed_orcids":["https://orcid.org/0000-0003-0420-4222"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yan","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, 140","Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Hanzhong Road, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031610596","display_name":"Fengxia He","orcid":"https://orcid.org/0000-0002-1695-3127","observed_orcids":["https://orcid.org/0000-0002-1695-3127"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"He Fengxia","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Department of Microbiology and Immunology, Nanjing Medical University, 140","Hanzhong Road, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peng Guangyong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peng Guangyong","raw_affiliation_strings":["Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":null,"display_name":"Wang Yingwei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wang Yingwei","raw_affiliation_strings":["Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","Hanzhong Road, Nanjing, Jiangsu 210029, China","Department of Microbiology and Immunology, Nanjing Medical University, 140"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Hanzhong Road, Nanjing, Jiangsu 210029, China","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Nanjing Medical University, 140","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83519826"],"apc_list":null,"apc_paid":null,"fwci":0.6814,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.72664756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":"5","first_page":"406","last_page":"406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/esat-6","display_name":"ESAT-6","score":0.9649999737739563},{"id":"https://openalex.org/keywords/fms-like-tyrosine-kinase-3-ligand","display_name":"FMS-like tyrosine kinase 3 ligand","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dna-vaccine","display_name":"DNA vaccine","score":0.8169999718666077},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.7929999828338623},{"id":"https://openalex.org/keywords/intranasal-immunization","display_name":"intranasal immunization","score":0.6990000009536743},{"id":"https://openalex.org/keywords/intramuscular-vaccination","display_name":"intramuscular vaccination","score":0.7570000290870667},{"id":"https://openalex.org/keywords/th1-cytokines","display_name":"Th1 cytokines","score":0.8629999756813049},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9200000166893005},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.972000002861023},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tuberculosis-protection","display_name":"tuberculosis protection","score":0.43299999833106995},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2781064340","wikidata":"https://www.wikidata.org/wiki/Q22228705","display_name":"ESAT-6","level":4,"score":0.9406999945640564},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.8230321407318115},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6560895442962646},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5789166688919067},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5777817964553833},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5227418541908264},{"id":"https://openalex.org/C2779078216","wikidata":"https://www.wikidata.org/wiki/Q7850848","display_name":"Tuberculosis vaccines","level":4,"score":0.43071386218070984},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.42240971326828003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3259281516075134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2970810532569885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19241350889205933},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09419256448745728},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.043118417263031006}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.7555/jbr.27.20120114","doi":"https://doi.org/10.7555/jbr.27.20120114","is_oa":true,"landing_page_url":"https://doi.org/10.7555/jbr.27.20120114","pdf_url":"http://www.jbr-pub.org.cn/en/article/doi/10.7555/JBR.27.20120114","source":{"id":"https://openalex.org/S165426342","display_name":"Journal of Biomedical Research","issn_l":"1674-8301","issn":["1674-8301","2352-4685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biomedical Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2781218","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3783826","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3783826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3783826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biomed Res","raw_type":"Text"},{"id":"pmid:24086174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24086174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical research","raw_type":"Journal Article"},{"id":"mag:3148916102","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85389A/201305/47436696.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306545035","display_name":"\u5357\u4eac\u533b\u79d1\u5927\u5b66\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":"1007-4376","issn":["1007-4376","1876-4819"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u751f\u7269\u533b\u5b66\u7814\u7a76\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"doi:10.7555/jbr.27.20120114","doi":"https://doi.org/10.7555/jbr.27.20120114","is_oa":true,"landing_page_url":"https://doi.org/10.7555/jbr.27.20120114","pdf_url":"http://www.jbr-pub.org.cn/en/article/doi/10.7555/JBR.27.20120114","source":{"id":"https://openalex.org/S165426342","display_name":"Journal of Biomedical Research","issn_l":"1674-8301","issn":["1674-8301","2352-4685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biomedical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320324856","display_name":"Southeast University","ror":"https://ror.org/04ct4d772"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168039588.pdf","grobid_xml":"https://content.openalex.org/works/W2168039588.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1537788154","https://openalex.org/W1551540190","https://openalex.org/W1578943666","https://openalex.org/W1778019208","https://openalex.org/W1858218633","https://openalex.org/W1973002729","https://openalex.org/W1973012987","https://openalex.org/W1977724887","https://openalex.org/W1989606580","https://openalex.org/W2005959254","https://openalex.org/W2024974612","https://openalex.org/W2026407528","https://openalex.org/W2035340171","https://openalex.org/W2036894627","https://openalex.org/W2050764093","https://openalex.org/W2051570600","https://openalex.org/W2056648197","https://openalex.org/W2062860313","https://openalex.org/W2072274487","https://openalex.org/W2073502830","https://openalex.org/W2087664594","https://openalex.org/W2103887556","https://openalex.org/W2114918609","https://openalex.org/W2118734585","https://openalex.org/W2121449107","https://openalex.org/W2125518600","https://openalex.org/W2134425543","https://openalex.org/W2137972315","https://openalex.org/W2142021677","https://openalex.org/W2156831625","https://openalex.org/W2167447605","https://openalex.org/W2167812452","https://openalex.org/W2325666068","https://openalex.org/W2403361576"],"related_works":["https://openalex.org/W7100391214","https://openalex.org/W2036894627","https://openalex.org/W2364573007","https://openalex.org/W2348020497","https://openalex.org/W2375714503","https://openalex.org/W2368828920","https://openalex.org/W2049449791","https://openalex.org/W2157293574","https://openalex.org/W2053992746","https://openalex.org/W2380922861"],"abstract_inverted_index":{"Mycobacterium":[0,158,179],"tuberculosis":[1,159,180],"6-kDa":[2],"early":[3,18],"secretory":[4],"antigenic":[5],"target":[6,11],"(ESAT-6)":[7],"is":[8,172],"a":[9,46,81,173],"dominant":[10],"antigen":[12],"for":[13,177],"cell-mediated":[14],"immunity":[15],"in":[16,40,71],"the":[17,63,66,76,87,95,107,116,124,129,137,167],"phase":[19],"of":[20,56,65,83,94,106,131,139,145],"tuberculosis.":[21],"The":[22,109],"fms-like":[23],"tyrosine":[24],"kinase":[25],"3":[26],"ligand":[27],"(FL)":[28],"that":[29,112,166],"induces":[30],"potent":[31],"immune":[32,104],"response":[33],"has":[34],"been":[35],"used":[36],"as":[37,149,151],"an":[38],"adjuvant":[39],"vaccine":[41,68,89,120,176],"development.":[42],"In":[43,161],"this":[44],"study,":[45],"new":[47],"recombinant":[48,117,169],"plasmid":[49,77,118,171],"(pIRES-epitope-peptides-FL)":[50],"encoding":[51],"three":[52],"T":[53,141,147],"cell":[54],"epitopes":[55],"ESAT-6":[57],"and":[58,62,91,121,135,143],"FL":[59],"was":[60,69,99],"constructed,":[61],"immunogenicity":[64],"DNA":[67,78,88,119,175],"assessed":[70],"C57BL/6":[72],"mice":[73,113],"immunized":[74],"with":[75,86,115,123],"vaccine.":[79],"Additionally,":[80],"strategy":[82],"intramuscular":[84],"injection":[85],"(prime)":[90],"intranasal":[92],"administration":[93],"epitope":[96],"peptides":[97,125],"(boost)":[98],"employed":[100],"to":[101],"induce":[102],"higher":[103],"reaction":[105],"mice.":[108],"results":[110],"showed":[111],"vaccinated":[114],"boosted":[122],"not":[126],"only":[127],"increased":[128],"levels":[130],"Th1":[132],"cytokines":[133],"(IFN-\u03b3":[134],"IL-12),":[136],"number":[138],"IFN-\u03b3(+)":[140],"cells":[142],"activities":[144],"cytotoxic":[146],"lymphocytes":[148],"well":[150],"IgG,":[152],"but":[153],"also":[154],"enhanced":[155],"protection":[156],"against":[157],"challenge.":[160],"conclusion,":[162],"these":[163],"data":[164],"indicate":[165],"novel":[168],"pIRES-epitope-peptides-FL":[170],"useful":[174],"preventing":[178],"infection.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}