{"id":"https://openalex.org/W2167964993","doi":"https://doi.org/10.1513/pats.200607-145jg","title":"Haplotype Thinking in Lung Disease","display_name":"Haplotype Thinking in Lung Disease","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2167964993","doi":"https://doi.org/10.1513/pats.200607-145jg","mag":"2167964993","pmid":"https://pubmed.ncbi.nlm.nih.gov/17202285","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647613"},"language":"en","primary_location":{"id":"doi:10.1513/pats.200607-145jg","doi":"https://doi.org/10.1513/pats.200607-145jg","is_oa":false,"landing_page_url":"https://doi.org/10.1513/pats.200607-145jg","pdf_url":null,"source":{"id":"https://openalex.org/S128617280","display_name":"Proceedings of the American Thoracic Society","issn_l":"1546-3222","issn":["1546-3222","1943-5665"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the American Thoracic Society","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647613","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035524361","display_name":"Edwin K. Silverman","orcid":"https://orcid.org/0000-0002-3641-3822","observed_orcids":["https://orcid.org/0000-0002-3641-3822"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edwin K. Silverman","raw_affiliation_strings":["Channing Laboratory and Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, Massachusetts","181 Longwood Avenue, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Laboratory and Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"181 Longwood Avenue, Boston, MA 02115","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035524361"],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":null,"apc_paid":null,"fwci":0.2086,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.20740741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"1","first_page":"4","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haplotypes","display_name":"haplotypes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lung-disease","display_name":"lung disease","score":0.7990000247955322},{"id":"https://openalex.org/keywords/genetic-association-studies","display_name":"genetic association studies","score":0.9089999794960022},{"id":"https://openalex.org/keywords/haplotype-association","display_name":"haplotype association","score":0.8679999709129333},{"id":"https://openalex.org/keywords/haplotype-inference","display_name":"haplotype inference","score":0.7590000033378601},{"id":"https://openalex.org/keywords/genetic-etiology","display_name":"genetic etiology","score":0.8349999785423279},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.8994726538658142},{"id":"https://openalex.org/C44432683","wikidata":"https://www.wikidata.org/wiki/Q17145705","display_name":"Haplotype estimation","level":5,"score":0.6166614890098572},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.6057639718055725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5820324420928955},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.530396580696106},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4783344268798828},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.456196129322052},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.4422231614589691},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.41349613666534424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3544706106185913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3459550142288208},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.24445796012878418},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20073142647743225},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07787060737609863}],"mesh":[{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1513/pats.200607-145jg","doi":"https://doi.org/10.1513/pats.200607-145jg","is_oa":false,"landing_page_url":"https://doi.org/10.1513/pats.200607-145jg","pdf_url":null,"source":{"id":"https://openalex.org/S128617280","display_name":"Proceedings of the American Thoracic Society","issn_l":"1546-3222","issn":["1546-3222","1943-5665"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the American Thoracic Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2647613","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647613","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Am Thorac Soc","raw_type":"Text"},{"id":"pmid:17202285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17202285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the American Thoracic Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2647613","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2647613","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Am Thorac Soc","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4755940723","display_name":"Fine Mapping of COPD Susceptibility Genes","funder_award_id":"R01HL075478","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7359959296","display_name":"Genetic Modifiers of Alpha 1-Antitrypsin Deficiency","funder_award_id":"R01HL068926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1891283710","https://openalex.org/W1965278426","https://openalex.org/W1967980922","https://openalex.org/W1981132558","https://openalex.org/W2002255986","https://openalex.org/W2005028693","https://openalex.org/W2005935256","https://openalex.org/W2008047653","https://openalex.org/W2009535611","https://openalex.org/W2015408724","https://openalex.org/W2021753580","https://openalex.org/W2028142113","https://openalex.org/W2029361834","https://openalex.org/W2029784047","https://openalex.org/W2044562395","https://openalex.org/W2049914201","https://openalex.org/W2050633988","https://openalex.org/W2066669827","https://openalex.org/W2071880067","https://openalex.org/W2078078890","https://openalex.org/W2080167581","https://openalex.org/W2090430326","https://openalex.org/W2098611654","https://openalex.org/W2103122550","https://openalex.org/W2107063140","https://openalex.org/W2109347434","https://openalex.org/W2110755408","https://openalex.org/W2111534865","https://openalex.org/W2112871491","https://openalex.org/W2116329478","https://openalex.org/W2116708238","https://openalex.org/W2125391335","https://openalex.org/W2143285785","https://openalex.org/W2149796867","https://openalex.org/W2152664025","https://openalex.org/W2156240295","https://openalex.org/W2162530578","https://openalex.org/W2217809488","https://openalex.org/W2243154754","https://openalex.org/W4211262414"],"related_works":["https://openalex.org/W3107878511","https://openalex.org/W1986858746","https://openalex.org/W1586278659","https://openalex.org/W2023532455","https://openalex.org/W2417328151","https://openalex.org/W7207957789","https://openalex.org/W1994130453","https://openalex.org/W4254719297","https://openalex.org/W2217250768","https://openalex.org/W2168535540"],"abstract_inverted_index":{"To":[0],"identify":[1],"the":[2,61],"genetic":[3,19,23,28,44,72,84],"etiology":[4],"of":[5,8,26,41,63],"a":[6,51],"disease":[7],"interest,":[9],"disease-related":[10],"characteristics":[11],"(phenotypes)":[12],"are":[13],"often":[14],"tested":[15],"for":[16],"association":[17,24,85],"with":[18],"variants":[20,29,45],"(genotypes).":[21],"Although":[22],"studies":[25,40],"single":[27,91],"have":[30],"been":[31,36],"widely":[32],"performed,":[33],"there":[34],"has":[35],"increasing":[37],"interest":[38],"in":[39,71],"multiple":[42],"adjacent":[43],"on":[46],"one":[47],"chromosome,":[48],"known":[49],"as":[50],"haplotype.":[52],"In":[53],"this":[54],"review,":[55],"we":[56,74,88],"will":[57,75,89],"provide":[58],"background":[59],"about":[60],"origin":[62],"haplotypes":[64,80],"and":[65,81,87,93],"why":[66],"they":[67],"can":[68],"be":[69],"useful":[70],"studies;":[73,86],"discuss":[76],"approaches":[77],"to":[78],"determining":[79],"performing":[82],"haplotype-based":[83,94],"compare":[90],"variant":[92],"approaches.":[95]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
