{"id":"https://openalex.org/W2167948304","doi":"https://doi.org/10.1186/1743-422x-7-378","title":"Antigenic analysis of classical swine fever virus E2 glycoprotein using pig antibodies identifies residues contributing to antigenic variation of the vaccine C-strain and group 2 strains circulating in China","display_name":"Antigenic analysis of classical swine fever virus E2 glycoprotein using pig antibodies identifies residues contributing to antigenic variation of the vaccine C-strain and group 2 strains circulating in China","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2167948304","doi":"https://doi.org/10.1186/1743-422x-7-378","mag":"2167948304","pmid":"https://pubmed.ncbi.nlm.nih.gov/21194462","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3025870"},"language":"en","primary_location":{"id":"doi:10.1186/1743-422x-7-378","doi":"https://doi.org/10.1186/1743-422x-7-378","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1743-422x-7-378","pdf_url":"https://virologyj.biomedcentral.com/counter/pdf/10.1186/1743-422X-7-378","source":{"id":"https://openalex.org/S115714813","display_name":"Virology Journal","issn_l":"1743-422X","issn":["1743-422X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://virologyj.biomedcentral.com/counter/pdf/10.1186/1743-422X-7-378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079717910","display_name":"Ning Chen","orcid":"https://orcid.org/0000-0001-6900-8228","observed_orcids":["https://orcid.org/0000-0001-6900-8228"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Chen","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou 310029, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou 310029, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109590727","display_name":"Chao Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Tong","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dejiang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dejiang Li","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067402833","display_name":"Wan Jing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wan","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049502730","display_name":"Xuemei Yuan","orcid":"https://orcid.org/0009-0008-2412-6923","observed_orcids":["https://orcid.org/0009-0008-2412-6923"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuemei Yuan","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071445149","display_name":"Xiaoliang Li","orcid":"https://orcid.org/0000-0002-4691-3302","observed_orcids":["https://orcid.org/0000-0002-4691-3302"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoliang Li","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043387503","display_name":"Jinrong Peng","orcid":"https://orcid.org/0000-0002-0793-4848","observed_orcids":["https://orcid.org/0000-0002-0793-4848"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinrong Peng","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021770801","display_name":"Weihuan Fang","orcid":"https://orcid.org/0000-0002-2460-0743","observed_orcids":["https://orcid.org/0000-0002-2460-0743","https://orcid.org/0000-0003-4903-3009"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weihuan Fang","raw_affiliation_strings":["Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University, Hangzhou, 310029, PR China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021770801"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":{"value":3290,"currency":"USD","value_usd":3290},"fwci":3.1769,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.8922837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"7","issue":"1","first_page":"378","last_page":"378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.49709999561309814,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.49709999561309814,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.4611999988555908,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classical-swine-fever-virus","display_name":"classical swine fever virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/e2-glycoprotein","display_name":"E2 glycoprotein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antigenic-variation","display_name":"antigenic variation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.5799999833106995},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.6480000019073486},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.7749999761581421},{"id":"https://openalex.org/keywords/epitopes","display_name":"antigenic determinants","score":0.5559999942779541},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/china","display_name":"China","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7931951284408569},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.7806918621063232},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6527413725852966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6111642122268677},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6070604920387268},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5798900127410889},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5770434141159058},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5764539241790771},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.527032196521759},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1883964240550995},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.099058598279953},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006691","descriptor_name":"Classical Swine Fever","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006692","descriptor_name":"Classical Swine Fever Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006692","descriptor_name":"Classical Swine Fever Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1743-422x-7-378","doi":"https://doi.org/10.1186/1743-422x-7-378","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1743-422x-7-378","pdf_url":"https://virologyj.biomedcentral.com/counter/pdf/10.1186/1743-422X-7-378","source":{"id":"https://openalex.org/S115714813","display_name":"Virology Journal","issn_l":"1743-422X","issn":["1743-422X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology Journal","raw_type":"journal-article"},{"id":"pmid:21194462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21194462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3025870","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3025870/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virol J","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.293.5394","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.293.5394","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/65/02/Virol_J_2010_Dec_31_7_378.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:74f815d217c043ee8ab3366e4df23590","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/74f815d217c043ee8ab3366e4df23590","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Virology Journal, Vol 7, Iss 1, p 378 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1743-422x-7-378","doi":"https://doi.org/10.1186/1743-422x-7-378","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1743-422x-7-378","pdf_url":"https://virologyj.biomedcentral.com/counter/pdf/10.1186/1743-422X-7-378","source":{"id":"https://openalex.org/S115714813","display_name":"Virology Journal","issn_l":"1743-422X","issn":["1743-422X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310017","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167948304.pdf","grobid_xml":"https://content.openalex.org/works/W2167948304.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W239355770","https://openalex.org/W277628705","https://openalex.org/W1593781333","https://openalex.org/W1939748157","https://openalex.org/W1971559842","https://openalex.org/W1975304761","https://openalex.org/W1990014502","https://openalex.org/W1993296569","https://openalex.org/W1996977934","https://openalex.org/W1997183021","https://openalex.org/W2002600977","https://openalex.org/W2017731185","https://openalex.org/W2021801466","https://openalex.org/W2032376750","https://openalex.org/W2039236914","https://openalex.org/W2039277389","https://openalex.org/W2050212881","https://openalex.org/W2051553690","https://openalex.org/W2054667493","https://openalex.org/W2057642934","https://openalex.org/W2057655039","https://openalex.org/W2063658795","https://openalex.org/W2066580881","https://openalex.org/W2071186316","https://openalex.org/W2074030098","https://openalex.org/W2080945470","https://openalex.org/W2081014948","https://openalex.org/W2082176485","https://openalex.org/W2090138807","https://openalex.org/W2091638679","https://openalex.org/W2094416665","https://openalex.org/W2108827586","https://openalex.org/W2121967942","https://openalex.org/W2126192775","https://openalex.org/W2131939771","https://openalex.org/W2137977382","https://openalex.org/W2144025702","https://openalex.org/W2146751104","https://openalex.org/W2147073036","https://openalex.org/W2154981737","https://openalex.org/W2160972243","https://openalex.org/W2162113453","https://openalex.org/W2170488050","https://openalex.org/W2327871095"],"related_works":["https://openalex.org/W7095074872","https://openalex.org/W2090138807","https://openalex.org/W2578914510","https://openalex.org/W2426824256","https://openalex.org/W4224098065","https://openalex.org/W2017731185","https://openalex.org/W2074030098","https://openalex.org/W2362715791","https://openalex.org/W2384988818","https://openalex.org/W2295020188"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glycoprotein":[1],"E2,":[2],"the":[3,36,73,98,112,169,173,184,191,204,218,224,228,231,258,285,295,310],"immunodominant":[4],"protein":[5,195],"of":[6,48,72,78,97,127,141,188,190,230,240,243,257,287,294,312,318,320],"classical":[7,322],"swine":[8,323],"fever":[9,324],"virus":[10],"(CSFV),":[11],"can":[12],"induce":[13],"neutralizing":[14],"antibodies":[15],"and":[16,40,51,89,114,146,175,254,276,316],"confer":[17],"protective":[18],"immunity":[19],"in":[20,43,123,281,284],"pigs.":[21],"Our":[22,304],"previous":[23],"phylogenetic":[24],"analysis":[25,249],"showed":[26,250],"that":[27,162,203,251,272,301],"subgroup":[28,34,53,90,100,117,176],"2.1":[29,54,91,101,118,177],"viruses":[30],"branched":[31],"away":[32],"from":[33],"1.1,":[35],"vaccine":[37,87,225,274],"C-strain":[38,50,88,113,149,174,193,275],"lineage,":[39],"became":[41],"dominant":[42],"China.":[44,124],"The":[45],"E2":[46,80,128,151,289],"glycoproteins":[47],"CSFV":[49,86,273],"recent":[52],"field":[55],"isolates":[56],"are":[57],"genetically":[58],"different.":[59],"However,":[60],"it":[61],"has":[62,298],"not":[63,83],"been":[64],"clearly":[65],"demonstrated":[66],"how":[67],"this":[68,209,234],"diversity":[69],"affects":[70],"antigenicity":[71,286],"protein.":[74],"RESULTS:":[75],"Antigenic":[76,125],"variation":[77,171,242,263],"glycoprotein":[79],"was":[81],"observed":[82],"only":[84],"between":[85,172],"strains,":[92,216,226],"but":[93],"also":[94],"among":[95,223],"strains":[96,279],"same":[99],"as":[102,236],"determined":[103],"by":[104],"ELISA-based":[105],"binding":[106,157,189],"assay":[107],"using":[108],"pig":[109],"antisera":[110],"to":[111,158,196,261],"a":[115,180,237],"representative":[116],"strain":[119],"QZ-07":[120],"currently":[121],"circulating":[122,280],"incompatibility":[126],"proteins":[129,153],"markedly":[130],"reduced":[131],"neutralization":[132],"efficiency":[133],"against":[134],"heterologous":[135,156],"strains.":[136,178],"Single":[137],"amino":[138,255],"acid":[139,206],"substitutions":[140],"D705N,":[142],"L709P,":[143],"G713E,":[144],"N723S,":[145],"S779A":[147],"on":[148],"recombinant":[150],"(rE2)":[152],"significantly":[154],"increased":[155],"anti-QZ-07":[159,197],"serum,":[160],"suggesting":[161],"these":[163],"residues":[164,259,300],"may":[165,306],"be":[166,307],"responsible":[167],"for":[168,309],"antigenic":[170,241,262,296],"Notably,":[179],"G713E":[181],"substitution":[182],"caused":[183],"most":[185],"dramatic":[186],"enhancement":[187],"variant":[192,246],"rE2":[194],"serum.":[198],"Multiple":[199],"sequence":[200],"alignment":[201],"revealed":[202,299],"glutamic":[205],"residue":[207,220,232],"at":[208,233],"position":[210,235],"is":[211,221],"conserved":[212],"within":[213],"group":[214,277],"2":[215,278],"while":[217],"glycine":[219],"invariant":[222],"highlighting":[227],"role":[229],"major":[238],"determinant":[239],"E2.":[244],"A":[245],"Simpson's":[247],"index":[248],"both":[252],"codons":[253],"acids":[256],"contributing":[260],"have":[264],"undergone":[265],"similar":[266],"diversification.":[267],"CONCLUSIONS:":[268],"These":[269],"results":[270],"demonstrate":[271],"China":[282],"differ":[283],"their":[288],"glycoproteins.":[290],"Systematic":[291],"site-directed":[292],"mutagenesis":[293],"units":[297],"limit":[302],"cross-reactivity.":[303],"findings":[305],"useful":[308],"development":[311],"serological":[313],"differential":[314],"assays":[315],"improvement":[317],"immunogenicity":[319],"novel":[321],"vaccines.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
