{"id":"https://openalex.org/W2167944119","doi":"https://doi.org/10.1002/jor.20863","title":"Mechanical stimulation alters tissue differentiation and molecular expression during bone healing","display_name":"Mechanical stimulation alters tissue differentiation and molecular expression during bone healing","publication_year":2009,"publication_date":"2009-02-25","ids":{"openalex":"https://openalex.org/W2167944119","doi":"https://doi.org/10.1002/jor.20863","mag":"2167944119","pmid":"https://pubmed.ncbi.nlm.nih.gov/19242967","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2726267"},"language":"en","primary_location":{"id":"doi:10.1002/jor.20863","doi":"https://doi.org/10.1002/jor.20863","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jor.20863","pdf_url":null,"source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2726267","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011134299","display_name":"Kristy T. Salisbury Palomares","orcid":"https://orcid.org/0009-0001-7615-081X","observed_orcids":["https://orcid.org/0009-0001-7615-081X"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristy T. Salisbury Palomares","raw_affiliation_strings":["Department of Mechanical Engineering, Boston University, Boston, Massachusetts 02215, USA","Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118","Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Boston University, Boston, Massachusetts 02215, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073053371","display_name":"Ryan E. Gleason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan E. Gleason","raw_affiliation_strings":["Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013488510","display_name":"Zachary D. Mason","orcid":"https://orcid.org/0000-0001-7458-1408","observed_orcids":["https://orcid.org/0000-0001-7458-1408"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary D. Mason","raw_affiliation_strings":["Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118","Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053051638","display_name":"Dennis M. Cullinane","orcid":"https://orcid.org/0009-0005-4561-1037","observed_orcids":["https://orcid.org/0009-0005-4561-1037"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis M. Cullinane","raw_affiliation_strings":["Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081041296","display_name":"Thomas A. Einhorn","orcid":"https://orcid.org/0000-0002-5075-4885","observed_orcids":["https://orcid.org/0000-0002-5075-4885"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Einhorn","raw_affiliation_strings":["Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112844477","display_name":"Louis C. Gerstenfeld","orcid":"https://orcid.org/0000-0002-0477-1211","observed_orcids":["https://orcid.org/0000-0002-0477-1211"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis C. Gerstenfeld","raw_affiliation_strings":["Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014872089","display_name":"Elise Feng\u2010i Morgan","orcid":"https://orcid.org/0000-0002-3994-1890","observed_orcids":["https://orcid.org/0000-0002-3994-1890"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elise F. Morgan","raw_affiliation_strings":["Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118","Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, Massachusetts 02118","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Orthopaedic and Developmental Biomechanics Laboratory, Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014872089"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":5.1482,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.95780746,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"27","issue":"9","first_page":"1123","last_page":"1132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.11020000278949738,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanical-stimulation","display_name":"mechanical stimulation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.9559999704360962},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/femoral-osteotomy","display_name":"femoral osteotomy","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cyclic-bending","display_name":"cyclic bending","score":0.7049999833106995},{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":0.8349999785423279},{"id":"https://openalex.org/keywords/col2a1","display_name":"COL2A1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/col10a1","display_name":"COL10A1","score":1.0},{"id":"https://openalex.org/keywords/bmp3","display_name":"BMP3","score":0.746999979019165},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.7459999918937683},{"id":"https://openalex.org/keywords/bmp6","display_name":"BMP6","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bmp-7","display_name":"BMP-7","score":0.996999979019165},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.5479999780654907},{"id":"https://openalex.org/keywords/external-fixation","display_name":"external fixation","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.7608127593994141},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.717085599899292},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6617286205291748},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6454006433486938},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5105894207954407},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4914952516555786},{"id":"https://openalex.org/C2776389721","wikidata":"https://www.wikidata.org/wiki/Q2167748","display_name":"Osteotomy","level":2,"score":0.469990611076355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4047365188598633},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3874451816082001},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3738287091255188},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34939485788345337},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3236059248447418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2721766233444214},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21756455302238464},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2111492156982422},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005264","descriptor_name":"Femoral Fractures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005264","descriptor_name":"Femoral Fractures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005264","descriptor_name":"Femoral Fractures","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010027","descriptor_name":"Osteotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010812","descriptor_name":"Physical Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016474","descriptor_name":"Weight-Bearing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017102","descriptor_name":"Fracture Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024043","descriptor_name":"Collagen Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024121","descriptor_name":"Collagen Type X","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024121","descriptor_name":"Collagen Type X","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055415","descriptor_name":"Bone Morphogenetic Protein 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055415","descriptor_name":"Bone Morphogenetic Protein 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055418","descriptor_name":"Bone Morphogenetic Protein 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055418","descriptor_name":"Bone Morphogenetic Protein 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055419","descriptor_name":"Bone Morphogenetic Protein 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jor.20863","doi":"https://doi.org/10.1002/jor.20863","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jor.20863","pdf_url":null,"source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:19242967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19242967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2726267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2726267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Orthop Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2726267","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2726267","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Orthop Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2207816155","display_name":null,"funder_award_id":"AR-053353","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8090044747","display_name":"Inducing Skeletal Repair by Mechanical Stimulation","funder_award_id":"R01AR053353","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W80132655","https://openalex.org/W119888207","https://openalex.org/W1480928262","https://openalex.org/W1546962148","https://openalex.org/W1605863475","https://openalex.org/W1916156238","https://openalex.org/W1966260373","https://openalex.org/W1975155665","https://openalex.org/W1981284961","https://openalex.org/W1982941239","https://openalex.org/W1989022336","https://openalex.org/W1989103420","https://openalex.org/W1997473015","https://openalex.org/W2005036145","https://openalex.org/W2006001607","https://openalex.org/W2011114620","https://openalex.org/W2018450058","https://openalex.org/W2018626421","https://openalex.org/W2020075378","https://openalex.org/W2028778208","https://openalex.org/W2029554371","https://openalex.org/W2031948569","https://openalex.org/W2036169965","https://openalex.org/W2041871015","https://openalex.org/W2044811076","https://openalex.org/W2049072682","https://openalex.org/W2055559862","https://openalex.org/W2058066470","https://openalex.org/W2058504739","https://openalex.org/W2060276230","https://openalex.org/W2063158203","https://openalex.org/W2065005994","https://openalex.org/W2074870817","https://openalex.org/W2077077811","https://openalex.org/W2077749978","https://openalex.org/W2085481239","https://openalex.org/W2087472570","https://openalex.org/W2098379653","https://openalex.org/W2107723436","https://openalex.org/W2109293470","https://openalex.org/W2111312751","https://openalex.org/W2119500803","https://openalex.org/W2120761640","https://openalex.org/W2128874621","https://openalex.org/W2138810157","https://openalex.org/W2152297596","https://openalex.org/W2162513940","https://openalex.org/W2272870230","https://openalex.org/W2996228208"],"related_works":["https://openalex.org/W2028354496","https://openalex.org/W2084441825","https://openalex.org/W2018296440","https://openalex.org/W2065005994","https://openalex.org/W6992643309","https://openalex.org/W2908520704","https://openalex.org/W2152723687","https://openalex.org/W2903527563","https://openalex.org/W1973024050","https://openalex.org/W2073742371"],"abstract_inverted_index":{"Further":[0],"understanding":[1],"of":[2,14,26,54,69,82,121,204,212],"how":[3,43],"mechanical":[4,27,44,83,231],"cues":[5,232],"modulate":[6,235],"skeletal":[7,101],"tissue":[8,102],"differentiation":[9],"can":[10,46,233],"identify":[11],"potential":[12,244],"means":[13],"enhancing":[15],"repair":[16,66],"following":[17],"injury":[18],"or":[19,141,251],"disease.":[20],"Prior":[21],"studies":[22],"examined":[23],"the":[24,48,80,110,157],"effects":[25],"loading":[28],"on":[29,132],"osteogenesis,":[30],"chondrogenesis,":[31],"and":[32,67,74,104,136,174,208,210,219,237,241],"fibrogenesis":[33],"in":[34,156,190,239],"an":[35,59,93,188],"effort":[36],"to":[37,85,99],"enhance":[38],"bony":[39,199],"union.":[40],"However,":[41,221],"exploring":[42],"stimuli":[45],"divert":[47],"bone":[49,90,183,213],"healing":[50],"process":[51],"towards":[52],"formation":[53,91],"other":[55],"mesenchymal":[56],"tissues,":[57],"as":[58,72],"endpoint,":[60],"may":[61],"elucidate":[62],"new":[63],"avenues":[64],"for":[65,138,160,163,246,249],"regeneration":[68],"tissues":[70],"such":[71],"cartilage":[73,87,191],"fibrous":[75],"tissue.":[76],"This":[77],"study":[78],"investigated":[79],"use":[81],"stimulation":[84,179],"promote":[86],"rather":[88],"than":[89],"within":[92],"osteotomy.":[94],"Our":[95],"overall":[96],"goal":[97],"was":[98,154,223],"define":[100],"distribution":[103],"molecular":[105,175],"expression":[106],"patterns":[107],"induced":[108,202],"by":[109,128],"stimulation.":[111,226],"Retired":[112],"breeder":[113],"Sprague-Dawley":[114],"rats":[115],"(n":[116],"=":[117],"85)":[118],"underwent":[119],"production":[120],"a":[122,144,243],"mid-diaphyseal,":[123],"transverse":[124],"femoral":[125],"osteotomy":[126],"followed":[127],"external":[129],"fixation.":[130,172],"Beginning":[131],"postoperative":[133],"day":[134],"10":[135],"continuing":[137],"1,":[139],"2,":[140],"4":[142],"weeks,":[143],"cyclic":[145],"bending":[146],"motion":[147],"(+35":[148],"degrees/-25":[149],"degrees":[150],"at":[151],"1":[152],"Hz)":[153],"applied":[155],"sagittal":[158],"plane":[159],"15":[161],"min/day":[162],"5":[164],"consecutive":[165],"days/week.":[166],"Control":[167],"animals":[168],"experienced":[169],"continuous":[170],"rigid":[171],"Histological":[173],"analyses":[176],"indicated":[177],"that":[178,230],"substantially":[180],"altered":[181],"normal":[182],"healing.":[184],"Stimulated":[185],"specimens":[186,197],"exhibited":[187],"increase":[189],"volume":[192],"over":[193],"time,":[194],"while":[195],"control":[196],"demonstrated":[198],"bridging.":[200],"Stimulation":[201],"upregulation":[203],"cartilage-related":[205],"genes":[206],"(COL2A1":[207],"COL10A1)":[209],"downregulation":[211],"morphogenetic":[214],"proteins":[215],"(BMPs)":[216],"-4,":[217],"-6":[218],"-7.":[220],"BMP-3":[222],"upregulated":[224],"with":[225],"These":[227],"findings":[228],"illustrate":[229],"selectively":[234],"osteogenesis":[236],"chondrogenesis":[238],"vivo,":[240],"suggest":[242],"basis":[245],"treatment":[247],"regimens":[248],"injured":[250],"diseased":[252],"cartilaginous":[253],"tissues.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
