{"id":"https://openalex.org/W2167925524","doi":"https://doi.org/10.1128/ec.00309-06","title":"Toxoplasma gondii Targets a Protein Phosphatase 2C to the Nuclei of Infected Host Cells","display_name":"Toxoplasma gondii Targets a Protein Phosphatase 2C to the Nuclei of Infected Host Cells","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2167925524","doi":"https://doi.org/10.1128/ec.00309-06","mag":"2167925524","pmid":"https://pubmed.ncbi.nlm.nih.gov/17085638","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1800361"},"language":"en","primary_location":{"id":"doi:10.1128/ec.00309-06","doi":"https://doi.org/10.1128/ec.00309-06","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00309-06","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/ec.00309-06","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035219354","display_name":"Luke A. Gilbert","orcid":"https://orcid.org/0000-0001-5854-0825","observed_orcids":["https://orcid.org/0000-0001-5854-0825"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke A. Gilbert","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, University of California\u2014Los Angeles, Los Angeles, California 90095-1489"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, University of California\u2014Los Angeles, Los Angeles, California 90095-1489","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038035967","display_name":"Sandeep Ravindran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandeep Ravindran","raw_affiliation_strings":["Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011415575","display_name":"Jay M. Turetzky","orcid":"https://orcid.org/0000-0002-3570-787X","observed_orcids":["https://orcid.org/0000-0002-3570-787X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay M. Turetzky","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, University of California\u2014Los Angeles, Los Angeles, California 90095-1489"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, University of California\u2014Los Angeles, Los Angeles, California 90095-1489","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053925806","display_name":"John C. Boothroyd","orcid":"https://orcid.org/0000-0001-9719-745X","observed_orcids":["https://orcid.org/0000-0001-9719-745X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Boothroyd","raw_affiliation_strings":["Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050509930","display_name":"Peter John Bradley","orcid":"https://orcid.org/0000-0002-8481-0638","observed_orcids":["https://orcid.org/0000-0002-8481-0638"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter J. Bradley","raw_affiliation_strings":["Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124","Department of Microbiology, Immunology and Molecular Genetics, University of California\u2014Los Angeles, Los Angeles, California 90095-1489"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, University of California\u2014Los Angeles, Los Angeles, California 90095-1489","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050509930"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":15.3498,"has_fulltext":false,"cited_by_count":169,"citation_normalized_percentile":{"value":0.99781931,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"73","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12691","display_name":"Coccidia and coccidiosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":1.0},{"id":"https://openalex.org/keywords/protein-phosphatase-2c","display_name":"protein phosphatase 2C","score":0.9829999804496765},{"id":"https://openalex.org/keywords/host-cell-invasion","display_name":"host cell invasion","score":0.5770000219345093},{"id":"https://openalex.org/keywords/intracellular-parasites","display_name":"intracellular parasites","score":0.5490000247955322},{"id":"https://openalex.org/keywords/cytochalasin-d","display_name":"cytochalasin D","score":0.890999972820282},{"id":"https://openalex.org/keywords/apicomplexa","display_name":"Apicomplexa","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C40602308","wikidata":"https://www.wikidata.org/wiki/Q7321455","display_name":"Rhoptry","level":5,"score":0.9366399645805359},{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.8903191089630127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8637130856513977},{"id":"https://openalex.org/C2781295650","wikidata":"https://www.wikidata.org/wiki/Q5259304","display_name":"Dense granule","level":4,"score":0.6676445007324219},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6125346422195435},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6003856062889099},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.5342022180557251},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4424774646759033},{"id":"https://openalex.org/C2781023229","wikidata":"https://www.wikidata.org/wiki/Q193030","display_name":"Apicomplexa","level":4,"score":0.3880773186683655},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3619662821292877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1357339322566986},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1163494884967804},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.11538746953010559},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.11486759781837463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071636","descriptor_name":"Protein Phosphatase 2C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000913","descriptor_name":"Antibodies, Protozoan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008670","descriptor_name":"Metals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D014124","descriptor_name":"Toxoplasmosis, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/ec.00309-06","doi":"https://doi.org/10.1128/ec.00309-06","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00309-06","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1800361","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1800361","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryot Cell","raw_type":"Text"},{"id":"pmid:17085638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17085638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/ec.00309-06","doi":"https://doi.org/10.1128/ec.00309-06","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00309-06","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1662478241","display_name":"The Role of Toxoplasma Rhoptries in Host Cell Infection","funder_award_id":"4r01ai064616-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1820289905","display_name":null,"funder_award_id":"R01 #AI064616","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2678402553","display_name":"Toxoplasma rhoptry function","funder_award_id":"R01AI021423","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4676041913","display_name":null,"funder_award_id":"1R01AI064616","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000180943","display_name":null,"funder_award_id":"1R01AI064616","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000864848","display_name":"Multidisciplinary Training in Microbial Pathogenesis","funder_award_id":"T32AI007323","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1444694021","https://openalex.org/W1498141377","https://openalex.org/W1501314544","https://openalex.org/W1577258036","https://openalex.org/W1594700207","https://openalex.org/W1830555632","https://openalex.org/W1833680771","https://openalex.org/W1892570697","https://openalex.org/W1973541716","https://openalex.org/W1987371296","https://openalex.org/W1992557402","https://openalex.org/W1992771067","https://openalex.org/W1993404924","https://openalex.org/W1997313407","https://openalex.org/W2000497765","https://openalex.org/W2007620982","https://openalex.org/W2010230686","https://openalex.org/W2018284639","https://openalex.org/W2027894194","https://openalex.org/W2031521449","https://openalex.org/W2032775667","https://openalex.org/W2033779889","https://openalex.org/W2034911186","https://openalex.org/W2037265145","https://openalex.org/W2041957725","https://openalex.org/W2047308369","https://openalex.org/W2054698731","https://openalex.org/W2060656527","https://openalex.org/W2069184973","https://openalex.org/W2071200698","https://openalex.org/W2071480023","https://openalex.org/W2071990248","https://openalex.org/W2076349701","https://openalex.org/W2079589821","https://openalex.org/W2087585115","https://openalex.org/W2090171435","https://openalex.org/W2092554726","https://openalex.org/W2093119592","https://openalex.org/W2097432311","https://openalex.org/W2114241062","https://openalex.org/W2125948219","https://openalex.org/W2158869723","https://openalex.org/W2164792430","https://openalex.org/W2170139161","https://openalex.org/W2178456244","https://openalex.org/W2343023869","https://openalex.org/W2468657923"],"related_works":["https://openalex.org/W2969267635","https://openalex.org/W1966611413","https://openalex.org/W1972586696","https://openalex.org/W4225415215","https://openalex.org/W7095890226","https://openalex.org/W3012020177","https://openalex.org/W2070763276","https://openalex.org/W3159397585","https://openalex.org/W2079617011","https://openalex.org/W2010230686"],"abstract_inverted_index":{"Intracellular":[0],"pathogens":[1],"have":[2,119],"evolved":[3],"a":[4,42,64,131,155],"wide":[5],"array":[6],"of":[7,28,36,41,90,104,147,166],"mechanisms":[8],"to":[9,62,77,82,111,114,160],"invade":[10],"and":[11,39,74,125],"co-opt":[12],"their":[13],"host":[14,47,72,79,84,116,168],"cells":[15],"for":[16,34,158],"intracellular":[17],"survival.":[18],"Apicomplexan":[19],"parasites":[20,98,129],"such":[21],"as":[22,92],"Toxoplasma":[23,52,159],"gondii":[24,53],"employ":[25],"the":[26,37,46,58,71,78,83,95,101,115,121,142,152,163,173],"action":[27],"unique":[29],"secretory":[30],"organelles":[31],"named":[32],"rhoptries":[33,59,153],"internalization":[35],"parasite":[38,148],"formation":[40],"specialized":[43],"niche":[44],"within":[45],"cell.":[48],"We":[49,118],"demonstrate":[50],"that":[51,97,127,135],"also":[54],"uses":[55],"secretion":[56],"from":[57],"during":[60,170],"invasion":[61,105],"deliver":[63],"parasite-derived":[65],"protein":[66],"phosphatase":[67],"2C":[68],"(PP2C-hn)":[69],"into":[70],"cell":[73,169],"direct":[75],"it":[76],"nucleus.":[80,117],"Delivery":[81],"nucleus":[85],"does":[86],"not":[87],"require":[88],"completion":[89],"invasion,":[91],"evidenced":[93],"by":[94,139,172],"fact":[96],"blocked":[99],"in":[100],"initial":[102],"stages":[103],"with":[106,141],"cytochalasin":[107],"D":[108],"are":[109],"able":[110],"target":[112],"PP2C-hn":[113,124],"disrupted":[120],"gene":[122],"encoding":[123],"shown":[126],"PP2C-hn-knockout":[128],"exhibit":[130],"mild":[132],"growth":[133],"defect":[134],"can":[136],"be":[137],"rescued":[138],"complementation":[140],"wild-type":[143],"gene.":[144],"The":[145],"delivery":[146],"effector":[149],"proteins":[150],"via":[151],"provides":[154],"novel":[156],"mechanism":[157],"directly":[161],"access":[162],"command":[164],"center":[165],"its":[167],"infection":[171],"parasite.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}