{"id":"https://openalex.org/W2167876590","doi":null,"title":"Treatment of children with advanced-stage lymphoblastic lymphoma with pegaspargase.","display_name":"Treatment of children with advanced-stage lymphoblastic lymphoma with pegaspargase.","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W2167876590","mag":"2167876590","pmid":"https://pubmed.ncbi.nlm.nih.gov/25793049","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4359608"},"language":"en","primary_location":{"id":"pmid:25793049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25793049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of pediatrics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4359608/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100766528","display_name":"Yutong Zhang","orcid":"https://orcid.org/0000-0002-6259-7880","observed_orcids":["https://orcid.org/0000-0002-6259-7880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang Yu-Tong","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100520055","display_name":"Li-hua Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Li-Hua","raw_affiliation_strings":["Department of Obstetrics and Gynecology, the First Hospital, Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, the First Hospital, Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhong Xiao-Dan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhong Xiao-Dan","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wang Li-Zhe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang Li-Zhe","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Chang Jian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chang Jian","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"24","issue":"1","first_page":"75","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphoblastic-lymphoma","display_name":"lymphoblastic lymphoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pegaspargase","display_name":"pegaspargase","score":0.8550000190734863},{"id":"https://openalex.org/keywords/l-asparaginase","display_name":"L-asparaginase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pediatric-lymphoma","display_name":"pediatric lymphoma","score":0.5979999899864197},{"id":"https://openalex.org/keywords/advanced-lymphoma","display_name":"advanced-stage lymphoma","score":0.8550000190734863},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/anaphylaxis","display_name":"anaphylaxis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/coagulation-defects","display_name":"coagulation defects","score":0.9409999847412109},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9269999861717224},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.7300000190734863},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.941063404083252},{"id":"https://openalex.org/C2778904437","wikidata":"https://www.wikidata.org/wiki/Q105296036","display_name":"Asparaginase","level":4,"score":0.6905329823493958},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.6165255308151245},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5744255185127258},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4967384934425354},{"id":"https://openalex.org/C2777478502","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic lymphoma","level":4,"score":0.49201104044914246},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.44341564178466797},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.424392431974411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3117918372154236},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.25167322158813477},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.08246412873268127},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.06602388620376587},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"pmid:25793049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25793049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of pediatrics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4359608","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4359608/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Pediatr","raw_type":"Text"},{"id":"pmh:cria:bioline:pe:pe14011","doi":null,"is_oa":true,"landing_page_url":"http://www.bioline.org.br/abstract?id=pe14011","pdf_url":"http://www.bioline.org.br/abstract?id=pe14011","source":{"id":"https://openalex.org/S4306402188","display_name":"Bioline International (Bioline International)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Pediatrics (ISSN: 1018-4406) Vol 24 Num 1","raw_type":"AA"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.779.525","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.779.525","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c2/3a/IJPD-24-75.PMC4359608.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.976.9310","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.976.9310","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.sid.ir/en/VEWSSID/J_pdf/92320140112.pdf","raw_type":"text"},{"id":"mag:2167876590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25793049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4359608","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4359608/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Pediatr","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167876590.pdf","grobid_xml":"https://content.openalex.org/works/W2167876590.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1819755880","https://openalex.org/W1955380536","https://openalex.org/W1965542498","https://openalex.org/W1966763079","https://openalex.org/W1981099712","https://openalex.org/W2008015982","https://openalex.org/W2040689434","https://openalex.org/W2060824604","https://openalex.org/W2075005961","https://openalex.org/W2084089666","https://openalex.org/W2098292727","https://openalex.org/W2107681226","https://openalex.org/W2123822349","https://openalex.org/W2130943712","https://openalex.org/W2163219205","https://openalex.org/W2164407102","https://openalex.org/W2417396511","https://openalex.org/W4241364882"],"related_works":["https://openalex.org/W6997109228","https://openalex.org/W7096078572","https://openalex.org/W2593248403","https://openalex.org/W4405288574","https://openalex.org/W2979127274","https://openalex.org/W4412099903","https://openalex.org/W2572178017","https://openalex.org/W3155294922","https://openalex.org/W3093090760","https://openalex.org/W118139996"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,19,59,83,96,115,124,129,157,169],"feasibility":[4],"of":[5,8,46,55,159],"Pegaspargase":[6,43],"instead":[7],"L-asparaginase":[9,47],"to":[10,142,163],"treat":[11],"children":[12,143],"with":[13,28,76,144,147],"advanced-stage":[14,145],"lymphoblastic":[15],"lymphoma":[16],"(LBL)":[17],"on":[18,58],"Berlin-Frankfurt-Munster":[20],"(BFM)-95":[21],"protocol.":[22,135,165],"METHODS:":[23],"Fifty-four":[24],"newly":[25],"diagnosed":[26],"patients":[27,56,74,107,132],"stage":[29],"III":[30],"or":[31,79],"IV":[32],"LBL":[33,73,146],"and":[34,52,62,151,155,172],"without":[35],"any":[36],"treatment":[37,53],"were":[38,66,90,114],"enrolled":[39],"in":[40,48,100,128,174],"this":[41],"study.":[42],"took":[44],"place":[45],"BFM-95.":[49],"The":[50],"complications":[51],"responses":[54],"treated":[57,75],"BFM-95":[60,64,77,81,110,134,138,164],"protocol":[61,65,78,139],"modified":[63,80,109,175],"then":[67],"evaluated":[68],"respectively.":[69],"Findings":[70],":":[71],"For":[72],"protocol,":[82,111],"complete":[84],"response,":[85],"event-free":[86],"survival,":[87],"overall":[88],"survival":[89],"similar.":[91],"Stage":[92],"4":[93],"myelosuppression":[94],"was":[95,123],"most":[97,116,125],"common":[98,117,126],"complication":[99,127,171],"both":[101],"groups.":[102],"Besides":[103],"that,":[104],"among":[105],"31":[106],"receiving":[108,133],"coagulation":[112],"defects":[113,167],"complication.":[118],"In":[119],"contrast,":[120],"anaphylactic":[121,160],"reaction":[122],"other":[130],"23":[131],"CONCLUSION:":[136],"Modified":[137],"is":[140],"available":[141],"an":[148],"equal":[149],"outcome":[150],"enhances":[152],"its":[153],"compliance":[154],"decreases":[156],"incidence":[158],"reaction,":[161],"compared":[162],"Coagulation":[166],"are":[168],"major":[170],"tolerable":[173],"one.":[176]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
