{"id":"https://openalex.org/W2167876561","doi":"https://doi.org/10.1038/nrd3248","title":"Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis","display_name":"Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis","publication_year":2010,"publication_date":"2010-10-29","ids":{"openalex":"https://openalex.org/W2167876561","doi":"https://doi.org/10.1038/nrd3248","mag":"2167876561","pmid":"https://pubmed.ncbi.nlm.nih.gov/21031003"},"language":"en","primary_location":{"id":"doi:10.1038/nrd3248","doi":"https://doi.org/10.1038/nrd3248","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrd3248","pdf_url":null,"source":{"id":"https://openalex.org/S186543748","display_name":"Nature Reviews Drug Discovery","issn_l":"1474-1776","issn":["1474-1776","1474-1784"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Drug Discovery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080557819","display_name":"Volker Brinkmann","orcid":"https://orcid.org/0000-0003-4735-3682","observed_orcids":["https://orcid.org/0000-0003-4735-3682"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Volker Brinkmann","raw_affiliation_strings":["Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ-386, CH-4056 Basel, Switzerland. volker.brinkmann@novartis.com","Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ-386, CH-4056, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ-386, CH-4056 Basel, Switzerland. volker.brinkmann@novartis.com","institution_ids":["https://openalex.org/I4400600974"]},{"raw_affiliation_string":"Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ-386, CH-4056, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038950669","display_name":"Andreas Billich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andreas Billich","raw_affiliation_strings":["Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ-386, CH-4056, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ-386, CH-4056, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048426910","display_name":"Thomas Baumruker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Baumruker","raw_affiliation_strings":["Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ-386, CH-4056, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus Forum 1, WSJ-386, CH-4056, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056604143","display_name":"Peter Heining","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter Heining","raw_affiliation_strings":["Department of Translational Sciences, Novartis Institutes for BioMedical Research, WKL-135, CH-4057, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Sciences, Novartis Institutes for BioMedical Research, WKL-135, CH-4057, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080807595","display_name":"Robert Schmouder","orcid":"https://orcid.org/0000-0001-9896-7305","observed_orcids":["https://orcid.org/0000-0001-9896-7305"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Schmouder","raw_affiliation_strings":["Department of Translational Sciences, Novartis Institutes for BioMedical Research, 602-330J, 220 Massachusetts Avenue, Cambridge, 02139, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Sciences, Novartis Institutes for BioMedical Research, 602-330J, 220 Massachusetts Avenue, Cambridge, 02139, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111635299","display_name":"Gordon Francis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon Francis","raw_affiliation_strings":["Global Development Neuroscience and Ophthalmics, Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, 07936-1080, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Development Neuroscience and Ophthalmics, Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, 07936-1080, New Jersey, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025554086","display_name":"Shreeram Aradhye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891806","display_name":"Sandoz Group AG (Switzerland)","ror":"https://ror.org/02rse7p59","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4388891806"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Shreeram Aradhye","raw_affiliation_strings":["Department of Biopharma, Sandoz International GmbH, Industriestrasse 25, D-83607, Holzkirchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biopharma, Sandoz International GmbH, Industriestrasse 25, D-83607, Holzkirchen, Germany","institution_ids":["https://openalex.org/I4388891806"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073722339","display_name":"Pascale Burtin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pascale Burtin","raw_affiliation_strings":["Global Development Neuroscience and Ophthalmics, Novartis Pharma AG, Kirschgarten Site, Kirschgartenstrasse 14, WSJ-790, CH-4051, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Development Neuroscience and Ophthalmics, Novartis Pharma AG, Kirschgarten Site, Kirschgartenstrasse 14, WSJ-790, CH-4051, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080557819"],"corresponding_institution_ids":["https://openalex.org/I4400600974"],"apc_list":null,"apc_paid":null,"fwci":11.9417,"has_fulltext":false,"cited_by_count":1290,"citation_normalized_percentile":{"value":0.99842932,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"9","issue":"11","first_page":"883","last_page":"897"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.31299999356269836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.9959999918937683},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate-receptor","display_name":"sphingosine-1-phosphate receptor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7839999794960022},{"id":"https://openalex.org/keywords/lymphocyte-trafficking","display_name":"lymphocyte migration","score":0.8730000257492065},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9070000052452087},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.7979999780654907},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.7630000114440918},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2776036978","wikidata":"https://www.wikidata.org/wiki/Q425137","display_name":"Fingolimod","level":3,"score":0.9968942403793335},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8623329997062683},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6808744668960571},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5882889032363892},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5808044075965881},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.5075315237045288},{"id":"https://openalex.org/C2776549689","wikidata":"https://www.wikidata.org/wiki/Q24782485","display_name":"Sphingosine-1-phosphate receptor","level":5,"score":0.5055320262908936},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.49838876724243164},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49318426847457886},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.47413989901542664},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4722525477409363},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.42109447717666626},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3721301257610321},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29947900772094727},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2772040367126465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1921941339969635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1802576780319214}],"mesh":[{"descriptor_ui":"D000068876","descriptor_name":"Fingolimod Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011409","descriptor_name":"Propylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrd3248","doi":"https://doi.org/10.1038/nrd3248","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrd3248","pdf_url":null,"source":{"id":"https://openalex.org/S186543748","display_name":"Nature Reviews Drug Discovery","issn_l":"1474-1776","issn":["1474-1776","1474-1784"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Drug Discovery","raw_type":"journal-article"},{"id":"pmid:21031003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21031003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Drug discovery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W77603329","https://openalex.org/W156162643","https://openalex.org/W840694428","https://openalex.org/W1545382406","https://openalex.org/W1562769137","https://openalex.org/W1574493485","https://openalex.org/W1610017743","https://openalex.org/W1654241956","https://openalex.org/W1658245879","https://openalex.org/W1949682302","https://openalex.org/W1965529735","https://openalex.org/W1966196831","https://openalex.org/W1966809042","https://openalex.org/W1968323379","https://openalex.org/W1974000699","https://openalex.org/W1974046380","https://openalex.org/W1975104912","https://openalex.org/W1975739381","https://openalex.org/W1976709850","https://openalex.org/W1979620916","https://openalex.org/W1981480494","https://openalex.org/W1981684494","https://openalex.org/W1981802180","https://openalex.org/W1981819567","https://openalex.org/W1983092575","https://openalex.org/W1983910106","https://openalex.org/W1984029930","https://openalex.org/W1984179269","https://openalex.org/W1987289843","https://openalex.org/W1989638281","https://openalex.org/W1991115604","https://openalex.org/W1992031993","https://openalex.org/W1992656196","https://openalex.org/W1993746949","https://openalex.org/W1994995252","https://openalex.org/W1996193406","https://openalex.org/W1997327044","https://openalex.org/W1998000193","https://openalex.org/W1998294017","https://openalex.org/W2001031230","https://openalex.org/W2002301651","https://openalex.org/W2003940208","https://openalex.org/W2005506388","https://openalex.org/W2006073149","https://openalex.org/W2006985918","https://openalex.org/W2007541166","https://openalex.org/W2008249980","https://openalex.org/W2009311745","https://openalex.org/W2011176676","https://openalex.org/W2011879762","https://openalex.org/W2015581524","https://openalex.org/W2017689420","https://openalex.org/W2018662980","https://openalex.org/W2019209482","https://openalex.org/W2021761616","https://openalex.org/W2023475282","https://openalex.org/W2024662669","https://openalex.org/W2024898420","https://openalex.org/W2026339937","https://openalex.org/W2026778930","https://openalex.org/W2029840140","https://openalex.org/W2029897954","https://openalex.org/W2034432056","https://openalex.org/W2035208392","https://openalex.org/W2036071939","https://openalex.org/W2036087370","https://openalex.org/W2041726006","https://openalex.org/W2046401524","https://openalex.org/W2049363669","https://openalex.org/W2049432379","https://openalex.org/W2053830427","https://openalex.org/W2056226760","https://openalex.org/W2056247033","https://openalex.org/W2059921365","https://openalex.org/W2066498736","https://openalex.org/W2067822704","https://openalex.org/W2071205488","https://openalex.org/W2074637566","https://openalex.org/W2075255958","https://openalex.org/W2075826741","https://openalex.org/W2077884399","https://openalex.org/W2078775078","https://openalex.org/W2078845055","https://openalex.org/W2079042391","https://openalex.org/W2080458330","https://openalex.org/W2080771563","https://openalex.org/W2081097093","https://openalex.org/W2081653420","https://openalex.org/W2081972621","https://openalex.org/W2084070992","https://openalex.org/W2084756176","https://openalex.org/W2086062119","https://openalex.org/W2090977730","https://openalex.org/W2091193879","https://openalex.org/W2093157233","https://openalex.org/W2095463291","https://openalex.org/W2100472051","https://openalex.org/W2103477671","https://openalex.org/W2103758700","https://openalex.org/W2104948944","https://openalex.org/W2105192692","https://openalex.org/W2105548401","https://openalex.org/W2108813293","https://openalex.org/W2109380000","https://openalex.org/W2111246573","https://openalex.org/W2113581955","https://openalex.org/W2113809457","https://openalex.org/W2113847305","https://openalex.org/W2119992148","https://openalex.org/W2121492913","https://openalex.org/W2123311421","https://openalex.org/W2124007806","https://openalex.org/W2125036060","https://openalex.org/W2127330795","https://openalex.org/W2130392812","https://openalex.org/W2132228454","https://openalex.org/W2132579946","https://openalex.org/W2134884423","https://openalex.org/W2135746117","https://openalex.org/W2136358628","https://openalex.org/W2139046470","https://openalex.org/W2139367012","https://openalex.org/W2140499334","https://openalex.org/W2143068056","https://openalex.org/W2145185401","https://openalex.org/W2147760936","https://openalex.org/W2151340435","https://openalex.org/W2151535044","https://openalex.org/W2152934805","https://openalex.org/W2154089780","https://openalex.org/W2155245449","https://openalex.org/W2156445027","https://openalex.org/W2156726966","https://openalex.org/W2157076890","https://openalex.org/W2159421712","https://openalex.org/W2161804483","https://openalex.org/W2164250102","https://openalex.org/W2164556363","https://openalex.org/W2165547142","https://openalex.org/W2165704853","https://openalex.org/W2166756963","https://openalex.org/W2168026099","https://openalex.org/W2168400282","https://openalex.org/W2168976923","https://openalex.org/W2169098250","https://openalex.org/W2171264454","https://openalex.org/W2337830301","https://openalex.org/W2340533542","https://openalex.org/W4210548604","https://openalex.org/W4211224425","https://openalex.org/W4241890711","https://openalex.org/W4250145052","https://openalex.org/W4366064463"],"related_works":["https://openalex.org/W2121971093","https://openalex.org/W1987186465","https://openalex.org/W1553744964","https://openalex.org/W2321406476","https://openalex.org/W2909092545","https://openalex.org/W2054368151","https://openalex.org/W1987479248","https://openalex.org/W3147565333","https://openalex.org/W1906556529","https://openalex.org/W1984262941"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":57},{"year":2025,"cited_by_count":56},{"year":2024,"cited_by_count":62},{"year":2023,"cited_by_count":75},{"year":2022,"cited_by_count":84},{"year":2021,"cited_by_count":71},{"year":2020,"cited_by_count":79},{"year":2019,"cited_by_count":84},{"year":2018,"cited_by_count":78},{"year":2017,"cited_by_count":99},{"year":2016,"cited_by_count":95},{"year":2015,"cited_by_count":100},{"year":2014,"cited_by_count":100},{"year":2013,"cited_by_count":91},{"year":2012,"cited_by_count":75}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}