{"id":"https://openalex.org/W2167862973","doi":"https://doi.org/10.1111/j.1538-7836.2005.01419.x","title":"The vitamin K cycle","display_name":"The vitamin K cycle","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W2167862973","doi":"https://doi.org/10.1111/j.1538-7836.2005.01419.x","mag":"2167862973","pmid":"https://pubmed.ncbi.nlm.nih.gov/16102054"},"language":"en","primary_location":{"id":"doi:10.1111/j.1538-7836.2005.01419.x","doi":"https://doi.org/10.1111/j.1538-7836.2005.01419.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1538-7836.2005.01419.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1538-7836.2005.01419.x","source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2167862973"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1538-7836.2005.01419.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072765407","display_name":"Darrel W. Stafford","orcid":"https://orcid.org/0000-0001-6830-3874","observed_orcids":["https://orcid.org/0000-0001-6830-3874"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D.W. STAFFORD","raw_affiliation_strings":["Department of Biology and Pathology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. dws@email.unc.edu","Department of Biology and Pathology, University of North Carolina, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Pathology, University of North Carolina, Chapel Hill, NC 27599-3280, USA. dws@email.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Biology and Pathology, University of North Carolina, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072765407"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.3938,"has_fulltext":true,"cited_by_count":422,"citation_normalized_percentile":{"value":0.91368421,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"3","issue":"8","first_page":"1873","last_page":"1878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-k-cycle","display_name":"vitamin K cycle","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gamma-glutamyl-carboxylase","display_name":"gamma-glutamyl carboxylase","score":0.8059999942779541},{"id":"https://openalex.org/keywords/vitamin-k-dependent-proteins","display_name":"vitamin K-dependent proteins","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gla-domain","display_name":"Gla domain","score":0.734000027179718},{"id":"https://openalex.org/keywords/vitamin-k-epoxide","display_name":"vitamin K epoxide","score":0.8069999814033508},{"id":"https://openalex.org/keywords/vitamin-k-epoxide-reductase","display_name":"vitamin K epoxide reductase","score":0.996999979019165},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C24428623","wikidata":"https://www.wikidata.org/wiki/Q901081","display_name":"Carboxylation","level":3,"score":0.9625691175460815},{"id":"https://openalex.org/C2776765323","wikidata":"https://www.wikidata.org/wiki/Q82305736","display_name":"Vitamin K epoxide reductase","level":5,"score":0.7971993684768677},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6773133277893066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6086117625236511},{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.5500116944313049},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5357078313827515},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.5131462216377258},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4968402683734894},{"id":"https://openalex.org/C7860815","wikidata":"https://www.wikidata.org/wiki/Q258658","display_name":"Protein precursor","level":3,"score":0.46845126152038574},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.417211651802063},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3395792841911316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22823545336723328},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.1471354365348816},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.09001600742340088},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014812","descriptor_name":"Vitamin K","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014812","descriptor_name":"Vitamin K","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064417","descriptor_name":"Vitamin K Epoxide Reductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1538-7836.2005.01419.x","doi":"https://doi.org/10.1111/j.1538-7836.2005.01419.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1538-7836.2005.01419.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1538-7836.2005.01419.x","source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:16102054","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16102054","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thrombosis and haemostasis : JTH","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1538-7836.2005.01419.x","doi":"https://doi.org/10.1111/j.1538-7836.2005.01419.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1538-7836.2005.01419.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1538-7836.2005.01419.x","source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167862973.pdf","grobid_xml":"https://content.openalex.org/works/W2167862973.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W142880273","https://openalex.org/W907662363","https://openalex.org/W1543394411","https://openalex.org/W1608454915","https://openalex.org/W1875660519","https://openalex.org/W1923964414","https://openalex.org/W1928861100","https://openalex.org/W1965363899","https://openalex.org/W1967136383","https://openalex.org/W1969287839","https://openalex.org/W1979862336","https://openalex.org/W1992076740","https://openalex.org/W1995813025","https://openalex.org/W2002893321","https://openalex.org/W2007303097","https://openalex.org/W2014898505","https://openalex.org/W2023706685","https://openalex.org/W2026527319","https://openalex.org/W2029983490","https://openalex.org/W2040974567","https://openalex.org/W2042366680","https://openalex.org/W2057093225","https://openalex.org/W2057755727","https://openalex.org/W2058579856","https://openalex.org/W2063151587","https://openalex.org/W2072714604","https://openalex.org/W2079247052","https://openalex.org/W2086277815","https://openalex.org/W2092548381","https://openalex.org/W2094626555","https://openalex.org/W2103693854","https://openalex.org/W2109583835","https://openalex.org/W2113985697","https://openalex.org/W2125606313","https://openalex.org/W2154246409","https://openalex.org/W2164327527","https://openalex.org/W2414388747","https://openalex.org/W2917240025"],"related_works":["https://openalex.org/W141572041","https://openalex.org/W1500799784","https://openalex.org/W1990696646","https://openalex.org/W2410235617","https://openalex.org/W2156961879","https://openalex.org/W4280528361","https://openalex.org/W1567790730","https://openalex.org/W2884836796","https://openalex.org/W2053785284","https://openalex.org/W4414592391"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":25},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
