{"id":"https://openalex.org/W2167861472","doi":"https://doi.org/10.1084/jem.157.4.1354","title":"Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection.","display_name":"Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection.","publication_year":1983,"publication_date":"1983-04-01","ids":{"openalex":"https://openalex.org/W2167861472","doi":"https://doi.org/10.1084/jem.157.4.1354","mag":"2167861472","pmid":"https://pubmed.ncbi.nlm.nih.gov/6339670","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2186986"},"language":"en","primary_location":{"id":"doi:10.1084/jem.157.4.1354","doi":"https://doi.org/10.1084/jem.157.4.1354","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.157.4.1354","pdf_url":"http://jem.rupress.org/content/jem/157/4/1354.full.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://jem.rupress.org/content/jem/157/4/1354.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113888925","display_name":"J. Wayne Streilein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J W Streilein","raw_affiliation_strings":["University of Texas Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055215832","display_name":"Paul R. Bergstresser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P R Bergstresser","raw_affiliation_strings":["From the Departments of CeU Biology , Internal Medicine, and Dermatology , The University of Texas Health Science Center at Dallas , Dallas , Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of CeU Biology , Internal Medicine, and Dermatology , The University of Texas Health Science Center at Dallas , Dallas , Texas 75235","institution_ids":["https://openalex.org/I4210094379"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3214,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.57837414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"157","issue":"4","first_page":"1354","last_page":"1359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.37770000100135803,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.37770000100135803,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.3359000086784363,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.2460000067949295,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haptens","display_name":"haptens","score":0.9860000014305115},{"id":"https://openalex.org/keywords/graft-rejection","display_name":"graft rejection","score":0.8119999766349792},{"id":"https://openalex.org/keywords/h-2-restriction","display_name":"H-2 restriction","score":0.9279999732971191},{"id":"https://openalex.org/keywords/skin-grafts","display_name":"skin grafts","score":0.7260000109672546},{"id":"https://openalex.org/keywords/transplantation-immunology","display_name":"transplantation immunology","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mhc-restriction","display_name":"MHC restriction","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.9560794830322266},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.7039429545402527},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6160963773727417},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5881771445274353},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5615900754928589},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.561457633972168},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4486267864704132},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4156269133090973},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4137764573097229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36778926849365234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3545343279838562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06541815400123596},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003877","descriptor_name":"Dermatitis, Contact","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004139","descriptor_name":"Dinitrofluorobenzene","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006241","descriptor_name":"Haptens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016038","descriptor_name":"Skin Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1084/jem.157.4.1354","doi":"https://doi.org/10.1084/jem.157.4.1354","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.157.4.1354","pdf_url":"http://jem.rupress.org/content/jem/157/4/1354.full.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2186986","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2186986","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:6339670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6339670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1084/jem.157.4.1354","doi":"https://doi.org/10.1084/jem.157.4.1354","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.157.4.1354","pdf_url":"http://jem.rupress.org/content/jem/157/4/1354.full.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6700000166893005,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167861472.pdf","grobid_xml":"https://content.openalex.org/works/W2167861472.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W32485250","https://openalex.org/W1512599796","https://openalex.org/W1533152478","https://openalex.org/W1590561990","https://openalex.org/W1646154561","https://openalex.org/W1963693609","https://openalex.org/W1976463105","https://openalex.org/W1996587366","https://openalex.org/W2007807199","https://openalex.org/W2013203398","https://openalex.org/W2071645491","https://openalex.org/W2093820223","https://openalex.org/W2095973340","https://openalex.org/W2097059118","https://openalex.org/W2112318945","https://openalex.org/W2141495155"],"related_works":["https://openalex.org/W7099711733","https://openalex.org/W2078374566","https://openalex.org/W2615701225","https://openalex.org/W1998304918","https://openalex.org/W2133803901","https://openalex.org/W48528242","https://openalex.org/W2072497849","https://openalex.org/W2030857207","https://openalex.org/W2416900273","https://openalex.org/W2022798082"],"abstract_inverted_index":{"Hapten-immune":[0],"mice":[1],"are":[2,10,44],"capable":[3],"of":[4,49,66],"rejecting":[5],"syngeneic":[6],"skin":[7],"grafts":[8],"that":[9,36],"derivatized":[11],"with":[12],"the":[13,19,24,37,50,64],"relevant":[14],"hapten,":[15],"but":[16],"only":[17],"if":[18],"hapten":[20],"is":[21,26],"applied":[22],"while":[23],"graft":[25],"\"healing":[27],"in.\"":[28],"This":[29],"model":[30],"system":[31],"was":[32],"used":[33,56],"to":[34],"demonstrate":[35],"hapten-specific":[38],"immune":[39],"effectors":[40],"responsible":[41],"for":[42,63],"rejection":[43],"restricted":[45],"by":[46],"H-2":[47],"determinants":[48],"recipient.":[51],"Thus,":[52],"haptens":[53],"can":[54],"be":[55],"in":[57,69],"vivo":[58],"as":[59],"surrogate":[60],"transplantation":[61,70],"antigens":[62],"study":[65],"immunopathogenic":[67],"mechanisms":[68],"immunity.":[71]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}