{"id":"https://openalex.org/W2167843940","doi":"https://doi.org/10.1083/jcb.200312008","title":"Cellular stresses induce the nuclear accumulation of importin \u03b1 and cause a conventional nuclear import block","display_name":"Cellular stresses induce the nuclear accumulation of importin \u03b1 and cause a conventional nuclear import block","publication_year":2004,"publication_date":"2004-06-07","ids":{"openalex":"https://openalex.org/W2167843940","doi":"https://doi.org/10.1083/jcb.200312008","mag":"2167843940","pmid":"https://pubmed.ncbi.nlm.nih.gov/15184398","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172376"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.200312008","doi":"https://doi.org/10.1083/jcb.200312008","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200312008","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2172376/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090796003","display_name":"Yoichi Miyamoto","orcid":"https://orcid.org/0000-0003-4016-1119","observed_orcids":["https://orcid.org/0000-0003-4016-1119"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Miyamoto","raw_affiliation_strings":["1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037021574","display_name":"Takuya Saiwaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Saiwaki","raw_affiliation_strings":["1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111780345","display_name":"Jun\u2010ichi Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junichi Yamashita","raw_affiliation_strings":["1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoshinari Yasuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinari Yasuda","raw_affiliation_strings":["1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019416684","display_name":"Ippei Kotera","orcid":"https://orcid.org/0000-0002-2060-7454","observed_orcids":["https://orcid.org/0000-0002-2060-7454"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ippei Kotera","raw_affiliation_strings":["1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009813235","display_name":"Satoshi Shibata","orcid":"https://orcid.org/0000-0002-9300-4494","observed_orcids":["https://orcid.org/0000-0002-9300-4494"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Shibata","raw_affiliation_strings":["1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018076039","display_name":"Masaki Shigeta","orcid":"https://orcid.org/0000-0003-0606-565X","observed_orcids":["https://orcid.org/0000-0003-0606-565X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Shigeta","raw_affiliation_strings":["2Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076833397","display_name":"Yasushi Hiraoka","orcid":"https://orcid.org/0000-0001-9407-8228","observed_orcids":["https://orcid.org/0000-0001-9407-8228"]},"institutions":[{"id":"https://openalex.org/I90023481","display_name":"National Institute of Information and Communications Technology","ror":"https://ror.org/016bgq349","country_code":"JP","type":"facility","lineage":["https://openalex.org/I90023481"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Hiraoka","raw_affiliation_strings":["2Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","3Core Research for Evolutional Science and Technology of Japan Science and Technology, National Institute for Information and Communications Technology, Nishi-ku, Kobe 651-2492, Japan","4Kansai Advanced Research Center, National Institute for Information and Communications Technology, Nishi-ku, Kobe 651-2492, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"3Core Research for Evolutional Science and Technology of Japan Science and Technology, National Institute for Information and Communications Technology, Nishi-ku, Kobe 651-2492, Japan","institution_ids":["https://openalex.org/I90023481"]},{"raw_affiliation_string":"4Kansai Advanced Research Center, National Institute for Information and Communications Technology, Nishi-ku, Kobe 651-2492, Japan","institution_ids":["https://openalex.org/I90023481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065796724","display_name":"Tokuko Haraguchi","orcid":"https://orcid.org/0000-0002-3813-6785","observed_orcids":["https://orcid.org/0000-0002-3813-6785"]},"institutions":[{"id":"https://openalex.org/I90023481","display_name":"National Institute of Information and Communications Technology","ror":"https://ror.org/016bgq349","country_code":"JP","type":"facility","lineage":["https://openalex.org/I90023481"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tokuko Haraguchi","raw_affiliation_strings":["2Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","3Core Research for Evolutional Science and Technology of Japan Science and Technology, National Institute for Information and Communications Technology, Nishi-ku, Kobe 651-2492, Japan","4Kansai Advanced Research Center, National Institute for Information and Communications Technology, Nishi-ku, Kobe 651-2492, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"3Core Research for Evolutional Science and Technology of Japan Science and Technology, National Institute for Information and Communications Technology, Nishi-ku, Kobe 651-2492, Japan","institution_ids":["https://openalex.org/I90023481"]},{"raw_affiliation_string":"4Kansai Advanced Research Center, National Institute for Information and Communications Technology, Nishi-ku, Kobe 651-2492, Japan","institution_ids":["https://openalex.org/I90023481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112152638","display_name":"Yoshihiro Yoneda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Yoneda","raw_affiliation_strings":["1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6351,"has_fulltext":true,"cited_by_count":180,"citation_normalized_percentile":{"value":0.90872187,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"165","issue":"5","first_page":"617","last_page":"623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/importin-alpha","display_name":"importin alpha","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nuclear-accumulation","display_name":"nuclear accumulation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cellular-stress","display_name":"cellular stress","score":0.7429999709129333},{"id":"https://openalex.org/keywords/nuclear-export","display_name":"nuclear export","score":0.8730000257492065},{"id":"https://openalex.org/keywords/importin-beta","display_name":"importin beta","score":0.8830000162124634},{"id":"https://openalex.org/keywords/uv-irradiation","display_name":"UV irradiation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/heat-shock","display_name":"heat shock","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hsc70","display_name":"Hsc70","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nuclear-retention","display_name":"nuclear retention","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C133882971","wikidata":"https://www.wikidata.org/wiki/Q24205524","display_name":"Importin","level":5,"score":0.9640376567840576},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.7978029251098633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6198466420173645},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5998868942260742},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.5573825836181641},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5455176830291748},{"id":"https://openalex.org/C160704184","wikidata":"https://www.wikidata.org/wiki/Q18031028","display_name":"Ran","level":2,"score":0.505650520324707},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.4759613871574402},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3556855022907257}],"mesh":[{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018869","descriptor_name":"Heat-Shock Response","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020931","descriptor_name":"ran GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D028901","descriptor_name":"alpha Karyopherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D028901","descriptor_name":"alpha Karyopherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.200312008","doi":"https://doi.org/10.1083/jcb.200312008","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200312008","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2172376","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2172376/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2172376/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:15184398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15184398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.273.9808","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.9808","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7f/4b/J_Cell_Biol_2004_Jun_7_165(5)_617-623.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.315.7779","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.315.7779","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jcb.rupress.org/content/165/5/617.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2172376","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2172376/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2172376/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317302","display_name":"Boehringer Ingelheim Japan","ror":"https://ror.org/02r1d7x68"},{"id":"https://openalex.org/F4320320907","display_name":"Japan Science and Technology Corporation","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167843940.pdf","grobid_xml":"https://content.openalex.org/works/W2167843940.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1563617960","https://openalex.org/W1984579358","https://openalex.org/W1991018390","https://openalex.org/W1998265781","https://openalex.org/W2013824432","https://openalex.org/W2023574559","https://openalex.org/W2029952484","https://openalex.org/W2034401615","https://openalex.org/W2037449269","https://openalex.org/W2042704408","https://openalex.org/W2067099248","https://openalex.org/W2087302056","https://openalex.org/W2136744885","https://openalex.org/W2137601093","https://openalex.org/W2144236354","https://openalex.org/W2171927045","https://openalex.org/W4211020343"],"related_works":["https://openalex.org/W2012364476","https://openalex.org/W4247025686","https://openalex.org/W2076493643","https://openalex.org/W7099977772","https://openalex.org/W2059131544","https://openalex.org/W2100128613","https://openalex.org/W2068192167","https://openalex.org/W2025959736","https://openalex.org/W2121422799","https://openalex.org/W2343944480"],"abstract_inverted_index":{"We":[0],"report":[1],"here":[2],"that":[3,74,133],"importin":[4,28,50,58,62,86,115,139],"alpha":[5,29,63,87,116,140],"accumulates":[6],"reversibly":[7],"in":[8,11,37,42,91,121,144],"the":[9,38,43,46,57,75,83,89,97,112,122,126,134],"nucleus":[10,123],"response":[12,92,148],"to":[13,31,93,108,119,149],"cellular":[14],"stresses":[15],"including":[16],"UV":[17],"irradiation,":[18],"oxidative":[19],"stress,":[20],"and":[21,56],"heat":[22,101,109],"shock.":[23],"The":[24,70],"nuclear":[25,47,54,68,77,98,136],"accumulation":[26,99,137],"of":[27,45,49,61,85,100,138],"appears":[30],"be":[32,142],"triggered":[33],"by":[34],"a":[35,145],"collapse":[36],"Ran":[39],"gradient,":[40],"resulting":[41],"suppression":[44],"export":[48],"alpha.":[51],"In":[52],"addition,":[53],"retention":[55],"beta/Ran-independent":[59],"import":[60,78],"also":[64],"facilitate":[65],"its":[66],"rapid":[67],"accumulation.":[69],"findings":[71,131],"herein":[72],"show":[73],"classical":[76],"pathway":[79],"is":[80,105,117],"down-regulated":[81],"via":[82],"removal":[84],"from":[88],"cytoplasm":[90],"stress.":[94],"Moreover,":[95],"whereas":[96],"shock":[102,110],"cognate":[103],"70":[104],"more":[106],"sensitive":[107],"than":[111],"other":[113],"stresses,":[114],"able":[118],"accumulate":[120],"at":[124],"all":[125],"stress":[127,151],"conditions":[128],"tested.":[129],"These":[130],"suggest":[132],"stress-induced":[135],"can":[141],"involved":[143],"common":[146],"physiological":[147],"various":[150],"conditions.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
