{"id":"https://openalex.org/W2167792970","doi":"https://doi.org/10.2337/diabetes.50.10.2337","title":"Intramyocellular Lipid Is Associated With Resistance to In Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human Skeletal Muscle","display_name":"Intramyocellular Lipid Is Associated With Resistance to In Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human Skeletal Muscle","publication_year":2001,"publication_date":"2001-10-01","ids":{"openalex":"https://openalex.org/W2167792970","doi":"https://doi.org/10.2337/diabetes.50.10.2337","mag":"2167792970","pmid":"https://pubmed.ncbi.nlm.nih.gov/11574417"},"language":"en","primary_location":{"id":"doi:10.2337/diabetes.50.10.2337","doi":"https://doi.org/10.2337/diabetes.50.10.2337","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.50.10.2337","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/50/10/2337/366159/db1001002337.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/diabetes/article-pdf/50/10/2337/366159/db1001002337.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025435359","display_name":"Antti Virkam\u00e4ki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210101041","display_name":"Minerva Foundation","ror":"https://ror.org/0152xm391","country_code":"FI","type":"nonprofit","lineage":["https://openalex.org/I4210101041"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Antti Virkama\u0308ki","raw_affiliation_strings":["Minerva Foundation Institute for Medical Research, University of Helsinki, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minerva Foundation Institute for Medical Research, University of Helsinki, Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210101041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019553315","display_name":"Elena Korsheninnikova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210101041","display_name":"Minerva Foundation","ror":"https://ror.org/0152xm391","country_code":"FI","type":"nonprofit","lineage":["https://openalex.org/I4210101041"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Elena Korsheninnikova","raw_affiliation_strings":["Minerva Foundation Institute for Medical Research, University of Helsinki, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minerva Foundation Institute for Medical Research, University of Helsinki, Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210101041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085096307","display_name":"Anneli Sepp\u00e4l\u00e4\u2010Lindroos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Anneli Seppa\u0308la\u0308-Lindroos","raw_affiliation_strings":["Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057333824","display_name":"Satu Vehkavaara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Satu Vehkavaara","raw_affiliation_strings":["Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082835610","display_name":"Takashi Goto","orcid":"https://orcid.org/0000-0002-2927-1563","observed_orcids":["https://orcid.org/0000-0002-2927-1563"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210101041","display_name":"Minerva Foundation","ror":"https://ror.org/0152xm391","country_code":"FI","type":"nonprofit","lineage":["https://openalex.org/I4210101041"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Takashi Goto","raw_affiliation_strings":["Minerva Foundation Institute for Medical Research, University of Helsinki, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minerva Foundation Institute for Medical Research, University of Helsinki, Helsinki","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210101041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016748559","display_name":"Juha T. Halavaara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Juha Halavaara","raw_affiliation_strings":["Department of Radiology, University of Helsinki, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of Helsinki, Helsinki","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109283436","display_name":"Anna\u2010Maija H\u00e4kkinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Anna-Maija Ha\u0308kkinen","raw_affiliation_strings":["Department of Oncology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028953583","display_name":"Hannele Yki\u2010J\u00e4rvinen","orcid":"https://orcid.org/0000-0001-6766-1549","observed_orcids":["https://orcid.org/0000-0001-6766-1549"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Hannele Yki-Ja\u0308rvinen","raw_affiliation_strings":["Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7125,"has_fulltext":true,"cited_by_count":265,"citation_normalized_percentile":{"value":0.96445509,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"50","issue":"10","first_page":"2337","last_page":"2343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.15800000727176666,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.10239999741315842,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intramyocellular-lipid","display_name":"intramyocellular lipid","score":0.9879999756813049},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.859000027179718},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7860000133514404},{"id":"https://openalex.org/keywords/insulin-stimulated-glucose-uptake","display_name":"insulin-stimulated glucose uptake","score":0.8069999814033508},{"id":"https://openalex.org/keywords/insulin-receptor-tyrosine-phosphorylation","display_name":"insulin receptor tyrosine phosphorylation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.7260000109672546},{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.46399998664855957},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.5299999713897705},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.39899998903274536},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.7609999775886536},{"id":"https://openalex.org/keywords/vastus-lateralis","display_name":"vastus lateralis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/1h-nmr-spectroscopy","display_name":"1H NMR","score":0.7670000195503235},{"id":"https://openalex.org/keywords/type-2-diabetes-risk","display_name":"type 2 diabetes risk","score":0.7839999794960022},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9208531379699707},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.90975022315979},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7765425443649292},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6914346814155579},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.6893605589866638},{"id":"https://openalex.org/C2776643329","wikidata":"https://www.wikidata.org/wiki/Q975459","display_name":"Vastus lateralis muscle","level":3,"score":0.5834226012229919},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5623407959938049},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.4838658571243286},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.45942261815071106},{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.44629910588264465},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4448589086532593},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42259982228279114},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.382076621055603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3569990396499634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27207839488983154}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008066","descriptor_name":"Lipolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2337/diabetes.50.10.2337","doi":"https://doi.org/10.2337/diabetes.50.10.2337","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.50.10.2337","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/50/10/2337/366159/db1001002337.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:11574417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11574417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.891.8752","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.891.8752","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/50/10/2337.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2337/diabetes.50.10.2337","doi":"https://doi.org/10.2337/diabetes.50.10.2337","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diabetes.50.10.2337","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/50/10/2337/366159/db1001002337.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320328021","display_name":"Diabetestutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/004j3q729"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167792970.pdf","grobid_xml":"https://content.openalex.org/works/W2167792970.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W22415497","https://openalex.org/W170853393","https://openalex.org/W652036338","https://openalex.org/W1507716785","https://openalex.org/W1512696907","https://openalex.org/W1553080809","https://openalex.org/W1615913434","https://openalex.org/W1776131825","https://openalex.org/W1924084714","https://openalex.org/W1970737220","https://openalex.org/W1979488931","https://openalex.org/W1984513597","https://openalex.org/W1986131332","https://openalex.org/W1999351520","https://openalex.org/W2012898950","https://openalex.org/W2013874605","https://openalex.org/W2029752088","https://openalex.org/W2037526260","https://openalex.org/W2040459468","https://openalex.org/W2041432351","https://openalex.org/W2041641505","https://openalex.org/W2043067969","https://openalex.org/W2043106623","https://openalex.org/W2061783070","https://openalex.org/W2064575035","https://openalex.org/W2074780710","https://openalex.org/W2075703747","https://openalex.org/W2077128986","https://openalex.org/W2081548668","https://openalex.org/W2085194341","https://openalex.org/W2090950070","https://openalex.org/W2092441434","https://openalex.org/W2100837269","https://openalex.org/W2105912552","https://openalex.org/W2106407243","https://openalex.org/W2106497166","https://openalex.org/W2106693109","https://openalex.org/W2111445543","https://openalex.org/W2112538182","https://openalex.org/W2115817762","https://openalex.org/W2116215087","https://openalex.org/W2120282127","https://openalex.org/W2120838225","https://openalex.org/W2129686285","https://openalex.org/W2132477505","https://openalex.org/W2133711136","https://openalex.org/W2134604231","https://openalex.org/W2134733133","https://openalex.org/W2148562280","https://openalex.org/W2152174497","https://openalex.org/W2154797259","https://openalex.org/W2161201457","https://openalex.org/W2163769778","https://openalex.org/W2164122881","https://openalex.org/W2166233282","https://openalex.org/W2170377446","https://openalex.org/W2181297551","https://openalex.org/W2216710583","https://openalex.org/W2285921488","https://openalex.org/W4317640760"],"related_works":["https://openalex.org/W7099016434","https://openalex.org/W2100583905","https://openalex.org/W7100549965","https://openalex.org/W2085478347","https://openalex.org/W2100432086","https://openalex.org/W2181455721","https://openalex.org/W2068547017","https://openalex.org/W6980615656","https://openalex.org/W7097369440","https://openalex.org/W2020208238"],"abstract_inverted_index":{"To":[0],"examine":[1],"whether":[2],"and":[3,83,113,162,303,315,327],"how":[4],"intramyocellular":[5,36],"lipid":[6],"(IMCL)":[7],"content":[8],"contributes":[9],"to":[10,92,138],"interindividual":[11],"variation":[12],"in":[13,39,53,183,221,248,280,285,320],"insulin":[14,58,90,94,234,243,276,313,318],"action,":[15],"we":[16],"studied":[17],"20":[18],"healthy":[19],"men":[20],"with":[21,102,136,251,311,316],"no":[22],"family":[23],"history":[24],"of":[25,35,41,44,75,88,233,241,264,324],"type":[26],"2":[27,168],"diabetes.":[28],"IMCL":[29,104,115,129,307],"was":[30,60,181,246,267,277],"measured":[31,61],"as":[32],"the":[33,76,89,124,184,194,222,226,242,265,281,286],"resonance":[34,51],"CH(2)":[37],"protons":[38,43],"lipids/resonance":[40],"CH(3)":[42],"total":[45],"creatine":[46],"(IMCL/Cr(T)),":[47],"using":[48,62],"proton":[49],"magnetic":[50],"spectroscopy":[52],"vastus":[54,77],"lateralis":[55,78],"muscle.":[56],"Whole-body":[57,177],"sensitivity":[59],"a":[63],"120-min":[64],"euglycemic-hyperinsulinemic":[65],"(insulin":[66],"infusion":[67,91],"rate":[68],"40":[69,144],"mU/m(2).":[70],"min)":[71],"clamp.":[72],"Muscle":[73],"biopsies":[74],"muscle":[79,322],"were":[80,98,134,211,218],"taken":[81],"before":[82],"30":[84],"min":[85],"after":[86],"initiation":[87],"assess":[93],"signaling.":[95],"The":[96,132],"subjects":[97],"divided":[99],"into":[100],"groups":[101,133],"high":[103],"(HiIMCL;":[105],"9.5":[106],"+/-":[107,118,141,145,154,158,167,171,188,198,290,294],"0.9":[108],"IMCL/Cr(T),":[109,120],"n":[110,121],"=":[111,122],"10)":[112],"low":[114],"(LoIMCL;":[116],"3.0":[117],"0.5":[119,199],"10),":[123],"cut":[125],"point":[126],"being":[127],"median":[128],"(6.1":[130],"IMCL/Cr(T)).":[131],"comparable":[135,212],"respect":[137],"age":[139],"(43":[140],"3":[142,146,172],"vs.":[143,156,169,254,292],"years,":[147],"NS,":[148],"HiIMCL":[149,185,223,249,282,302],"versus":[150],"LoIMCL),":[151],"BMI":[152],"(26":[153],"1":[155,159],"26":[157],"kg/m(2),":[160],"NS),":[161],"maximal":[163],"oxygen":[164],"consumption":[165],"(33":[166],"36":[170],"ml.":[173],"kg(-1).":[174,191,201],"min(-1),":[175,202],"NS).":[176],"insulin-stimulated":[178],"glucose":[179],"uptake":[180],"lower":[182,279],"group":[186,196,224,228,283,288],"(3.0":[187],"0.4":[189],"mg.":[190,200],"min(-1))":[192],"than":[193,225,284],"LoIMCL":[195,227,252,287],"(5.1":[197],"P":[203,258,298],"<":[204,230,259,299],"0.05).":[205],"Serum":[206],"free":[207],"fatty":[208],"acid":[209],"concentrations":[210],"basally,":[213],"but":[214],"during":[215],"hyperinsulinemia,":[216],"they":[217],"35%":[219],"higher":[220],"(P":[229],"0.01).":[231],"Study":[232],"signaling":[235,319],"indicated":[236],"that":[237],"insulin-induced":[238],"tyrosine":[239],"phosphorylation":[240],"receptor":[244],"(IR)":[245],"blunted":[247],"compared":[250],"(57":[253],"142%":[255],"above":[256,296],"basal,":[257,297],"0.05),":[260],"while":[261],"protein":[262],"expression":[263],"IR":[266,269],"unaltered.":[268],"substrate-1-associated":[270],"phosphatidylinositol":[271],"(PI)":[272],"3-kinase":[273],"activation":[274],"by":[275],"also":[278],"(49":[289],"23":[291],"84":[293],"27%":[295],"0.05":[300],"between":[301],"LoIMCL).":[304],"In":[305],"conclusion,":[306],"accumulation":[308],"is":[309],"associated":[310],"whole-body":[312],"resistance":[314],"defective":[317],"skeletal":[321],"independent":[323],"body":[325],"weight":[326],"physical":[328],"fitness.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
