{"id":"https://openalex.org/W2167792273","doi":"https://doi.org/10.1186/1750-1326-7-33","title":"Progranulin regulates neuronal outgrowth independent of Sortilin","display_name":"Progranulin regulates neuronal outgrowth independent of Sortilin","publication_year":2012,"publication_date":"2012-07-10","ids":{"openalex":"https://openalex.org/W2167792273","doi":"https://doi.org/10.1186/1750-1326-7-33","mag":"2167792273","pmid":"https://pubmed.ncbi.nlm.nih.gov/22781549","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3508877"},"language":"en","primary_location":{"id":"doi:10.1186/1750-1326-7-33","doi":"https://doi.org/10.1186/1750-1326-7-33","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1750-1326-7-33","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-7-33","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-7-33","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055789178","display_name":"Jennifer M. Gass","orcid":"https://orcid.org/0000-0001-8189-4189","observed_orcids":["https://orcid.org/0000-0001-8189-4189"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Gass","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA","Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003957790","display_name":"Chris W. Lee","orcid":"https://orcid.org/0000-0001-9068-5274","observed_orcids":["https://orcid.org/0000-0001-9068-5274"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wing C Lee","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032571276","display_name":"Casey N. Cook","orcid":"https://orcid.org/0000-0002-5963-8442","observed_orcids":["https://orcid.org/0000-0002-5963-8442"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Casey Cook","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079323925","display_name":"NiCole A. Finch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Finch","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008811848","display_name":"Caroline T. Stetler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Stetler","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023325412","display_name":"Karen R. Jansen\u2010West","orcid":"https://orcid.org/0000-0002-1234-7103","observed_orcids":["https://orcid.org/0000-0002-1234-7103"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Jansen-West","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001609822","display_name":"Jada M. Lewis","orcid":"https://orcid.org/0000-0003-0004-6597","observed_orcids":["https://orcid.org/0000-0003-0004-6597"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jada Lewis","raw_affiliation_strings":["Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA","Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050614625","display_name":"Christopher D. Link","orcid":"https://orcid.org/0000-0003-2271-7697","observed_orcids":["https://orcid.org/0000-0003-2271-7697"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D Link","raw_affiliation_strings":["Integrative Physiology Institute for Behavioral Genetics, University of Colorado, UBC447, Boulder, CO, 80309, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Physiology Institute for Behavioral Genetics, University of Colorado, UBC447, Boulder, CO, 80309, USA","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048408999","display_name":"Rosa Rademakers","orcid":"https://orcid.org/0000-0002-4049-0863","observed_orcids":["https://orcid.org/0000-0002-4049-0863"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosa Rademakers","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065151460","display_name":"Anders Nykj\u00e6r","orcid":"https://orcid.org/0000-0001-6422-6736","observed_orcids":["https://orcid.org/0000-0001-6422-6736"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I4210127817","display_name":"Lundbeck Foundation","ror":"https://ror.org/03hz8wd80","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210127817"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anders Nykj\u00e6r","raw_affiliation_strings":["The Lundbeck Foundation Research Center MIND, Department of Medical Biochemistry, Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lundbeck Foundation Research Center MIND, Department of Medical Biochemistry, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I4210127817"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058278504","display_name":"Leonard Petrucelli","orcid":"https://orcid.org/0000-0003-2959-129X","observed_orcids":["https://orcid.org/0000-0003-2959-129X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonard Petrucelli","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058278504"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":6.4566,"has_fulltext":true,"cited_by_count":157,"citation_normalized_percentile":{"value":0.97067709,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.14059999585151672,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.05959999933838844,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progranulin","display_name":"progranulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sortilin","display_name":"sortilin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/sort1","display_name":"SORT1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neuronal-branching","display_name":"neuronal branching","score":0.6809999942779541},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/frontotemporal-lobar-degeneration","display_name":"frontotemporal lobar degeneration","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tdp-43","display_name":"TDP-43","score":0.8980000019073486},{"id":"https://openalex.org/keywords/grn-mutations","display_name":"GRN mutations","score":0.7300000190734863},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.9369999766349792},{"id":"https://openalex.org/keywords/receptor-independent-signaling","display_name":"receptor-independent signaling","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6351090669631958},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.6040789484977722},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.4785619080066681},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4052124321460724},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3924744129180908},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19192492961883545},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12375080585479736},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077153","descriptor_name":"Progranulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077155","descriptor_name":"Granulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099183","descriptor_name":"Sortilin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057174","descriptor_name":"Frontotemporal Lobar Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057174","descriptor_name":"Frontotemporal Lobar Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1750-1326-7-33","doi":"https://doi.org/10.1186/1750-1326-7-33","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1750-1326-7-33","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-7-33","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3508877","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3508877","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Neurodegener","raw_type":"Text"},{"id":"pmid:22781549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22781549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular neurodegeneration","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:312a8fea8e8b42d0acd80a25669f99cb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/312a8fea8e8b42d0acd80a25669f99cb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Neurodegeneration, Vol 7, Iss 1, p 33 (2012)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/a86aca96-c961-4164-adcb-1cebb502bf8f","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/a86aca96-c961-4164-adcb-1cebb502bf8f","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gass, J, Lee, W C, Cook, C, Finch, N, Stetler, C, Jansen-West, K, Lewis, J, Link, C D, Rademakers, R, Nykj\u00e6r, A & Petrucelli, L 2012, 'Progranulin regulates neuronal outgrowth independent of Sortilin', Molecular Neurodegeneration, vol. 7, pp. 33. https://doi.org/10.1186/1750-1326-7-33","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1750-1326-7-33","doi":"https://doi.org/10.1186/1750-1326-7-33","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1750-1326-7-33","pdf_url":"https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-7-33","source":{"id":"https://openalex.org/S40861184","display_name":"Molecular Neurodegeneration","issn_l":"1750-1326","issn":["1750-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Neurodegeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1705633007","display_name":"TDP-43, RNA Metabolism, and ALS/FTD Pathology","funder_award_id":"R01NS063964","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2082520442","display_name":"Misregulation of the TDP-43 RNA target, Sortilin, in neurodegeneration","funder_award_id":"R01NS077402","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3917207315","display_name":null,"funder_award_id":"W81XWH-09-1-0315AL093108","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4700852728","display_name":null,"funder_award_id":"R01 NS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5181078158","display_name":"Progranulin: Mutation and Regulation in Neurodegenerative disease","funder_award_id":"R01NS065782","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7511995389","display_name":"Progranulin, TDP-43 and Cell Death","funder_award_id":"R01AG026251","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G877894594","display_name":null,"funder_award_id":"W81XWH-10-1-0512-1","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167792273.pdf","grobid_xml":"https://content.openalex.org/works/W2167792273.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1578113876","https://openalex.org/W1967056975","https://openalex.org/W1977618591","https://openalex.org/W1979315191","https://openalex.org/W1983688844","https://openalex.org/W1985967806","https://openalex.org/W1998212202","https://openalex.org/W1999981342","https://openalex.org/W2000287765","https://openalex.org/W2001811842","https://openalex.org/W2005731595","https://openalex.org/W2012423618","https://openalex.org/W2017576011","https://openalex.org/W2017790520","https://openalex.org/W2021985297","https://openalex.org/W2027460468","https://openalex.org/W2028471696","https://openalex.org/W2033744604","https://openalex.org/W2034652811","https://openalex.org/W2035228493","https://openalex.org/W2039140356","https://openalex.org/W2039812926","https://openalex.org/W2043610924","https://openalex.org/W2046344792","https://openalex.org/W2046700952","https://openalex.org/W2046839455","https://openalex.org/W2061050597","https://openalex.org/W2068681851","https://openalex.org/W2070063785","https://openalex.org/W2070208966","https://openalex.org/W2073164785","https://openalex.org/W2073935838","https://openalex.org/W2077792283","https://openalex.org/W2084343282","https://openalex.org/W2090477471","https://openalex.org/W2095973840","https://openalex.org/W2115694724","https://openalex.org/W2125044837","https://openalex.org/W2140447941","https://openalex.org/W2150523122","https://openalex.org/W2156512271","https://openalex.org/W2202261228","https://openalex.org/W4234024984"],"related_works":["https://openalex.org/W2008377380","https://openalex.org/W2156512271","https://openalex.org/W2043610924","https://openalex.org/W2036543834","https://openalex.org/W4415790922","https://openalex.org/W4206738848","https://openalex.org/W6980199953","https://openalex.org/W2607714873","https://openalex.org/W2158437869","https://openalex.org/W4406049999"],"abstract_inverted_index":{"BACKGROUND:":[0],"Progranulin":[1],"(PGRN),":[2],"a":[3,23,43,52,59,89],"widely":[4],"secreted":[5],"growth":[6],"factor,":[7],"is":[8,51,152,192,275],"involved":[9,276],"in":[10,95,112,127,150,233,238,277],"multiple":[11],"biological":[12],"functions,":[13],"and":[14,47,122,252,254],"mutations":[15,162,170],"located":[16],"within":[17,207],"the":[18,102,107,148,173,200,213,223,234],"PGRN":[19,40,92,110,141,159,188,204,217,230,247,257,266,278],"gene":[20],"(GRN)":[21],"are":[22,73,124,205],"major":[24],"cause":[25],"of":[26,36,91,109,176,186,203,225,236,246,270],"frontotemporal":[27],"lobar":[28],"degeneration":[29],"with":[30,157],"TDP-43-positive":[31],"inclusions":[32],"(FLTD-TDP).":[33],"In":[34,178],"light":[35],"recent":[37],"reports":[38],"suggesting":[39,198,272],"functions":[41,202],"as":[42,88],"protective":[44],"neurotrophic":[45,71,98,174,201],"factor":[46],"that":[48,140,168,184,199,229,244,255,264],"sortilin":[49],"(SORT1)":[50],"neuronal":[53,116,196,219,280],"receptor":[54],"for":[55,194],"PGRN,":[56],"we":[57,118,137,180,221,262],"used":[58],"Sort1-deficient":[60],"(Sort1-/-)":[61],"murine":[62],"primary":[63,115],"hippocampal":[64],"neuron":[65],"model":[66],"to":[67,79,83,105,131],"investigate":[68],"whether":[69],"PGRN's":[70,97],"effects":[72],"dependent":[74],"on":[75],"SORT1.":[76,226],"We":[77,227,242],"sought":[78],"elucidate":[80],"this":[81,145,259],"relationship":[82],"determine":[84],"what":[85],"role":[86],"SORT1,":[87,271],"regulator":[90],"levels,":[93],"plays":[94],"modulating":[96],"effects.":[99],"RESULTS:":[100],"As":[101],"first":[103],"group":[104],"evaluate":[106],"effect":[108],"loss":[111,245],"Grn":[113],"knockout":[114],"cultures,":[117],"show":[119],"neurite":[120,250],"outgrowth":[121,151,251,268],"branching":[123],"significantly":[125],"decreased":[126],"Grn-/-":[128],"neurons":[129],"compared":[130],"wild-type":[132],"(WT)":[133],"neurons.":[134],"More":[135],"importantly,":[136],"also":[138,181],"demonstrate":[139,228,243],"overexpression":[142],"can":[143],"rescue":[144],"phenotype.":[146],"However,":[147],"recovery":[149],"not":[153],"observed":[154],"following":[155],"treatment":[156],"recombinant":[158],"harboring":[160],"missense":[161],"p.C139R,":[163],"p.P248L":[164],"or":[165],"p.R432C,":[166],"indicating":[167],"these":[169],"adversely":[171],"affect":[172],"properties":[175],"PGRN.":[177],"addition,":[179],"present":[182],"evidence":[183],"cleavage":[185],"full-length":[187],"into":[189],"granulin":[190],"peptides":[191],"required":[193],"increased":[195],"outgrowth,":[197],"contained":[206],"certain":[208],"granulins.":[209],"To":[210],"further":[211],"characterize":[212],"mechanism":[214],"by":[215],"which":[216],"impacts":[218],"morphology,":[220],"assessed":[222],"involvement":[224],"induced-outgrowth":[231],"occurs":[232],"absence":[235],"SORT1":[237],"Sort1-/-":[239],"cultures.":[240],"CONCLUSION:":[241],"impairs":[248],"proper":[249],"branching,":[253],"exogenous":[256,265],"alleviates":[258],"impairment.":[260],"Furthermore,":[261],"determined":[263],"induces":[267],"independent":[269],"another":[273],"receptor(s)":[274],"induced":[279],"outgrowth.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
