{"id":"https://openalex.org/W2167757041","doi":"https://doi.org/10.1093/gerona/glr192","title":"Age-Related Changes in Mouse Taste Bud Morphology, Hormone Expression, and Taste Responsivity","display_name":"Age-Related Changes in Mouse Taste Bud Morphology, Hormone Expression, and Taste Responsivity","publication_year":2011,"publication_date":"2011-11-04","ids":{"openalex":"https://openalex.org/W2167757041","doi":"https://doi.org/10.1093/gerona/glr192","mag":"2167757041","pmid":"https://pubmed.ncbi.nlm.nih.gov/22056740","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3410661"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/glr192","doi":"https://doi.org/10.1093/gerona/glr192","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/glr192","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/67A/4/336/16743480/glr192.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/biomedgerontology/article-pdf/67A/4/336/16743480/glr192.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004263329","display_name":"Yu\u2010Kyong Shin","orcid":"https://orcid.org/0000-0003-3545-2341","observed_orcids":["https://orcid.org/0000-0003-3545-2341"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Kyong Shin","raw_affiliation_strings":["Laboratory of Clinical Investigation, Diabetes Section, National Institute on Aging, Baltimore, MD 21224, USA","Laboratory of Clinical Investigation, Diabetes Section"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, Diabetes Section, National Institute on Aging, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Laboratory of Clinical Investigation, Diabetes Section","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103449123","display_name":"Wei\u2010na Cong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-na Cong","raw_affiliation_strings":["Laboratory of Clinical Investigation, Metabolism Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, Metabolism Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074747520","display_name":"Huan Cai","orcid":"https://orcid.org/0000-0001-7731-8891","observed_orcids":["https://orcid.org/0000-0001-7731-8891"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huan Cai","raw_affiliation_strings":["Laboratory of Clinical Investigation, Metabolism Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, Metabolism Unit","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100662248","display_name":"Wook Kim","orcid":"https://orcid.org/0000-0002-7701-4684","observed_orcids":["https://orcid.org/0000-0002-7701-4684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wook Kim","raw_affiliation_strings":["Laboratory of Clinical Investigation, Diabetes Section"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, Diabetes Section","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033862949","display_name":"Stuart R. Maudsley","orcid":"https://orcid.org/0000-0002-1868-184X","observed_orcids":["https://orcid.org/0000-0002-1868-184X"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart Maudsley","raw_affiliation_strings":["Laboratory of Neurosciences, Receptor Pharmacology Unit, National Institute on Aging, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurosciences, Receptor Pharmacology Unit, National Institute on Aging, Baltimore, Maryland","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000777749","display_name":"Josephine Mary Egan","orcid":"https://orcid.org/0000-0002-8945-0053","observed_orcids":["https://orcid.org/0000-0002-8945-0053"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josephine M. Egan","raw_affiliation_strings":["Laboratory of Clinical Investigation, Diabetes Section"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, Diabetes Section","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061101747","display_name":"Bronwen Martin","orcid":"https://orcid.org/0000-0002-9185-6925","observed_orcids":["https://orcid.org/0000-0002-9185-6925"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bronwen Martin","raw_affiliation_strings":["Laboratory of Clinical Investigation, Metabolism Unit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, Metabolism Unit","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":3.5474,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.91807432,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"67A","issue":"4","first_page":"336","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taste-bud-morphology","display_name":"taste bud morphology","score":0.8579999804496765},{"id":"https://openalex.org/keywords/taste-cells","display_name":"taste cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/sweet-taste","display_name":"sweet taste","score":0.7229999899864197},{"id":"https://openalex.org/keywords/protein-gene-product-9-5","display_name":"protein gene product 9.5","score":0.8610000014305115},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.9909999966621399},{"id":"https://openalex.org/keywords/t1r3","display_name":"T1R3","score":0.8840000033378601},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/taste-receptor-expression","display_name":"taste receptor expression","score":0.49799999594688416},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2777687625","wikidata":"https://www.wikidata.org/wiki/Q862867","display_name":"Taste bud","level":3,"score":0.9494063854217529},{"id":"https://openalex.org/C8868529","wikidata":"https://www.wikidata.org/wiki/Q124794","display_name":"Taste","level":2,"score":0.8945150375366211},{"id":"https://openalex.org/C178006227","wikidata":"https://www.wikidata.org/wiki/Q3454532","display_name":"Taste receptor","level":3,"score":0.5937574505805969},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5751746892929077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5395215749740601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5011837482452393},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.4706261157989502},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28123223781585693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22619053721427917},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.14107823371887207},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.14037811756134033}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013650","descriptor_name":"Taste Buds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/gerona/glr192","doi":"https://doi.org/10.1093/gerona/glr192","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/glr192","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/67A/4/336/16743480/glr192.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2609004","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3410661","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3410661","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3410661","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gerontol A Biol Sci Med Sci","raw_type":"Text"},{"id":"pmid:22056740","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22056740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/gerona/glr192","doi":"https://doi.org/10.1093/gerona/glr192","is_oa":true,"landing_page_url":"https://doi.org/10.1093/gerona/glr192","pdf_url":"https://academic.oup.com/biomedgerontology/article-pdf/67A/4/336/16743480/glr192.pdf","source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology: Series A","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167757041.pdf","grobid_xml":"https://content.openalex.org/works/W2167757041.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W5603278","https://openalex.org/W1603031173","https://openalex.org/W1965193260","https://openalex.org/W1967281537","https://openalex.org/W1968552568","https://openalex.org/W1976214195","https://openalex.org/W1977860649","https://openalex.org/W1988489403","https://openalex.org/W1991945414","https://openalex.org/W1997487079","https://openalex.org/W1999293234","https://openalex.org/W1999634991","https://openalex.org/W2004188327","https://openalex.org/W2004835945","https://openalex.org/W2008002043","https://openalex.org/W2010251404","https://openalex.org/W2012848916","https://openalex.org/W2014669864","https://openalex.org/W2020053294","https://openalex.org/W2022076700","https://openalex.org/W2023939486","https://openalex.org/W2027830931","https://openalex.org/W2028781291","https://openalex.org/W2034780781","https://openalex.org/W2036192441","https://openalex.org/W2038573621","https://openalex.org/W2045452322","https://openalex.org/W2047660785","https://openalex.org/W2051839059","https://openalex.org/W2053252677","https://openalex.org/W2063156429","https://openalex.org/W2063934299","https://openalex.org/W2065749228","https://openalex.org/W2068566319","https://openalex.org/W2072112596","https://openalex.org/W2073213477","https://openalex.org/W2074420111","https://openalex.org/W2080340979","https://openalex.org/W2081037031","https://openalex.org/W2085607060","https://openalex.org/W2086339199","https://openalex.org/W2087276671","https://openalex.org/W2095570535","https://openalex.org/W2101260685","https://openalex.org/W2101769770","https://openalex.org/W2113624371","https://openalex.org/W2115156649","https://openalex.org/W2125119636","https://openalex.org/W2129903551","https://openalex.org/W2129988654","https://openalex.org/W2132316522","https://openalex.org/W2136631382","https://openalex.org/W2145788577","https://openalex.org/W2151677451","https://openalex.org/W2153646267","https://openalex.org/W2167031568","https://openalex.org/W2175803440","https://openalex.org/W2322307334","https://openalex.org/W2332235124","https://openalex.org/W4243095531"],"related_works":["https://openalex.org/W2724290903","https://openalex.org/W2891345577","https://openalex.org/W4391430914","https://openalex.org/W2322307334","https://openalex.org/W4414544225","https://openalex.org/W4387515874","https://openalex.org/W1585953471","https://openalex.org/W2085607060","https://openalex.org/W7203883028","https://openalex.org/W2774111502"],"abstract_inverted_index":{"Normal":[0],"aging":[1,26],"is":[2],"a":[3,51,76],"complex":[4],"process":[5,27],"that":[6],"affects":[7],"every":[8],"organ":[9],"system":[10],"in":[11,36,54,113],"the":[12,15,21,24,67,97,104,114,122,132,136],"body,":[13],"including":[14],"taste":[16,29,34,55,61,94,99,106,119,128,139],"system.":[17],"Thus,":[18],"we":[19],"investigated":[20],"effects":[22],"of":[23,45,60,79,93],"normal":[25],"on":[28],"bud":[30,56,64],"morphology,":[31],"function,":[32],"and":[33,42,58,69,84,103,135,143],"responsivity":[35,129],"male":[37],"mice":[38],"at":[39],"2,":[40],"10,":[41],"18":[43],"months":[44],"age.":[46],"The":[47,72,91],"18-month-old":[48,73,115,123],"animals":[49,74,124,134],"demonstrated":[50,125],"significant":[52,77],"reduction":[53,78],"size":[57],"number":[59,92],"cells":[62,95],"per":[63],"compared":[65,130],"with":[66,118,131],"2-":[68],"10-month-old":[70],"animals.":[71],"exhibited":[75],"protein":[80],"gene":[81],"product":[82],"9.5":[83],"sonic":[85],"hedgehog":[86],"immunoreactivity":[87],"(taste":[88],"cell":[89,120],"markers).":[90],"expressing":[96],"sweet":[98,105,127],"receptor":[100],"subunit,":[101],"T1R3,":[102],"modulating":[107],"hormone,":[108],"glucagon-like":[109],"peptide-1,":[110],"were":[111],"reduced":[112,126],"mice.":[116],"Concordant":[117],"alterations,":[121],"younger":[133],"other":[137],"major":[138],"modalities":[140],"(salty,":[141],"sour,":[142],"bitter)":[144],"remained":[145],"intact.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}