{"id":"https://openalex.org/W2167733347","doi":"https://doi.org/10.1148/radiol.2343031701","title":"Telomerase Activity Predicts Malignancy in Percutaneous Image-guided Needle Biopsy Specimens of the Abdomen and Pelvis","display_name":"Telomerase Activity Predicts Malignancy in Percutaneous Image-guided Needle Biopsy Specimens of the Abdomen and Pelvis","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W2167733347","doi":"https://doi.org/10.1148/radiol.2343031701","mag":"2167733347","pmid":"https://pubmed.ncbi.nlm.nih.gov/15734943"},"language":"en","primary_location":{"id":"doi:10.1148/radiol.2343031701","doi":"https://doi.org/10.1148/radiol.2343031701","is_oa":false,"landing_page_url":"https://doi.org/10.1148/radiol.2343031701","pdf_url":null,"source":{"id":"https://openalex.org/S50280174","display_name":"Radiology","issn_l":"0033-8419","issn":["0033-8419","1527-1315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315931","host_organization_name":"Radiological Society of North America","host_organization_lineage":["https://openalex.org/P4310315931"],"host_organization_lineage_names":["Radiological Society of North America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067033760","display_name":"Vikas Kundra","orcid":"https://orcid.org/0000-0002-3262-4059","observed_orcids":["https://orcid.org/0000-0002-3262-4059"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikas Kundra","raw_affiliation_strings":["Division of Abdominal Imaging and Intervention, Department of Radiology and Division of Cytology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA. vkundra@di.mdacc.tmc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Abdominal Imaging and Intervention, Department of Radiology and Division of Cytology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA. vkundra@di.mdacc.tmc.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073961208","display_name":"Jeffrey F. Krane","orcid":"https://orcid.org/0000-0001-7768-3901","observed_orcids":["https://orcid.org/0000-0001-7768-3901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey F. Krane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057697505","display_name":"Paul Nikolaidis","orcid":"https://orcid.org/0000-0002-4397-9832","observed_orcids":["https://orcid.org/0000-0002-4397-9832"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Nikolaidis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047345613","display_name":"Donnella S. Green","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donnella S. Green","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049632527","display_name":"Kelly H. Zou","orcid":"https://orcid.org/0000-0001-6297-8184","observed_orcids":["https://orcid.org/0000-0001-6297-8184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly H. Zou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030427075","display_name":"Kemal Tuncali","orcid":"https://orcid.org/0000-0003-2466-4787","observed_orcids":["https://orcid.org/0000-0003-2466-4787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kemal Tuncali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082096953","display_name":"Eric vanSonnenberg","orcid":"https://orcid.org/0000-0002-4655-9358","observed_orcids":["https://orcid.org/0000-0002-4655-9358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric vanSonnenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023742645","display_name":"Stuart G. Silverman","orcid":"https://orcid.org/0000-0001-9461-8028","observed_orcids":["https://orcid.org/0000-0001-9461-8028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stuart G. Silverman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3781,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66252373,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"234","issue":"3","first_page":"941","last_page":"947"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":1.0},{"id":"https://openalex.org/keywords/percutaneous-needle-biopsy","display_name":"percutaneous needle biopsy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/abdominal-malignancies","display_name":"abdominal malignancies","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pelvic-malignancies","display_name":"pelvic malignancies","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytological-examination","display_name":"cytological examination","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.8270000219345093},{"id":"https://openalex.org/keywords/indeterminate-cytology","display_name":"indeterminate cytology","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cancer-detection","display_name":"cancer detection","score":0.47600001096725464},{"id":"https://openalex.org/keywords/image-guided-biopsy","display_name":"image-guided biopsy","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9246407747268677},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.7515665888786316},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6366481184959412},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.5858193635940552},{"id":"https://openalex.org/C2779983558","wikidata":"https://www.wikidata.org/wiki/Q9597","display_name":"Abdomen","level":2,"score":0.580070972442627},{"id":"https://openalex.org/C18823058","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cytology","level":2,"score":0.5596204996109009},{"id":"https://openalex.org/C2778357063","wikidata":"https://www.wikidata.org/wiki/Q713102","display_name":"Pelvis","level":2,"score":0.530353844165802},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.507550835609436},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.47317221760749817},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3787911832332611},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000008","descriptor_name":"Abdominal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000008","descriptor_name":"Abdominal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000008","descriptor_name":"Abdominal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010386","descriptor_name":"Pelvic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010386","descriptor_name":"Pelvic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010386","descriptor_name":"Pelvic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015641","descriptor_name":"Radiography, Interventional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1148/radiol.2343031701","doi":"https://doi.org/10.1148/radiol.2343031701","is_oa":false,"landing_page_url":"https://doi.org/10.1148/radiol.2343031701","pdf_url":null,"source":{"id":"https://openalex.org/S50280174","display_name":"Radiology","issn_l":"0033-8419","issn":["0033-8419","1527-1315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315931","host_organization_name":"Radiological Society of North America","host_organization_lineage":["https://openalex.org/P4310315931"],"host_organization_lineage_names":["Radiological Society of North America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"journal-article"},{"id":"pmid:15734943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15734943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W86399190","https://openalex.org/W1497143641","https://openalex.org/W1516272650","https://openalex.org/W1516734969","https://openalex.org/W1600373583","https://openalex.org/W1613006671","https://openalex.org/W1941444679","https://openalex.org/W1942212901","https://openalex.org/W1972279617","https://openalex.org/W1972807664","https://openalex.org/W1987675617","https://openalex.org/W1988835345","https://openalex.org/W1990979933","https://openalex.org/W2000238936","https://openalex.org/W2000971601","https://openalex.org/W2002324043","https://openalex.org/W2015037479","https://openalex.org/W2021489383","https://openalex.org/W2031017895","https://openalex.org/W2055618222","https://openalex.org/W2062086731","https://openalex.org/W2069150815","https://openalex.org/W2072106461","https://openalex.org/W2076849186","https://openalex.org/W2080168038","https://openalex.org/W2082653439","https://openalex.org/W2090657779","https://openalex.org/W2091658514","https://openalex.org/W2092213589","https://openalex.org/W2113300169","https://openalex.org/W2122740168","https://openalex.org/W2126224474","https://openalex.org/W2130388017","https://openalex.org/W2148805136","https://openalex.org/W2264570828","https://openalex.org/W2402265739","https://openalex.org/W2408920967","https://openalex.org/W2409793284","https://openalex.org/W2413363510","https://openalex.org/W2419341456","https://openalex.org/W2423134177"],"related_works":["https://openalex.org/W2129603649","https://openalex.org/W2351330306","https://openalex.org/W98143406","https://openalex.org/W2017978761","https://openalex.org/W2423134177","https://openalex.org/W3031569933","https://openalex.org/W2264570828","https://openalex.org/W2358206508","https://openalex.org/W2065210953","https://openalex.org/W2411740452"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"prospectively":[3],"if":[4],"assessment":[5],"of":[6,21,119,140,231,236,243,250],"telomerase":[7,55,97,123,141,208,254,266],"activity":[8,56,124,142,209,255,267],"in":[9,18,57,125,144,162,260],"percutaneous":[10,240],"needle":[11,86],"biopsy":[12,61,241],"specimens":[13,62,132,242],"improves":[14],"sensitivity":[15,187,214,230,259],"and":[16,23,38,59,90,96,117,138,150,160,168,176,218,233,246,253],"specificity":[17,193,220,235],"the":[19,34,75,135,157,172,244,248],"diagnosis":[20,101],"abdominal":[22,58],"pelvic":[24,60],"malignancy.":[25,127,262],"MATERIALS":[26],"AND":[27],"METHODS:":[28],"The":[29,99],"study":[30,81,131],"was":[31,42,51,78,88,102],"approved":[32],"by":[33],"institutional":[35],"review":[36,106],"board,":[37],"written":[39],"informed":[40],"consent":[41],"obtained":[43],"from":[44,63,83,130],"all":[45],"patients.":[46],"A":[47],"prospective":[48],"double-blinded":[49],"design":[50],"used":[52],"to":[53],"assess":[54],"99":[64],"patients":[65,197],"(64":[66],"men,":[67],"35":[68],"women;":[69],"age":[70],"range,":[71],"22-87":[72],"years).":[73],"After":[74],"clinical":[76,200],"sample":[77,201],"retrieved,":[79],"a":[80,108,178,212,229,234],"specimen":[82],"an":[84,257],"extra":[85],"pass":[87],"divided":[89],"independently":[91],"analyzed":[92],"for":[93],"cytologic":[94,120,154,224,251,274],"characteristics":[95],"activity.":[98],"final":[100],"based":[103],"on":[104],"chart":[105],"at":[107],"minimum":[109],"1-year":[110],"follow-up.":[111],"Statistical":[112],"analyses":[113],"included":[114],"sensitivity,":[115,136,158],"specificity,":[116,137,159],"accuracy":[118,139,161],"examination":[121,155,225,252],"and/or":[122],"predicting":[126,145,163,261],"RESULTS:":[128],"Data":[129],"indicated":[133],"that":[134,203],"(n=99)":[143],"malignancy":[146,164],"were":[147,165,204],"55%,":[148],"79%,":[149],"60%,":[151],"respectively.":[152,170],"For":[153],"(n=86),":[156],"74%,":[166],"94%,":[167],"78%,":[169],"Combining":[171],"two":[173],"tests":[174],"(n=86)":[175],"classifying":[177],"positive":[179],"reading":[180],"with":[181,223],"either":[182],"test":[183],"as":[184,206],"malignant":[185],"improved":[186],"(83%)":[188],"(P":[189,216],"<.05)":[190,217],"without":[191],"altering":[192],"(76%).":[194],"In":[195,239,263],"20":[196],"who":[198],"had":[199],"reports":[202],"classified":[205],"indeterminate,":[207],"(n=20)":[210],"yielded":[211,228,256],"higher":[213],"(62%)":[215],"similar":[219],"(86%)":[221],"compared":[222],"(n=15),":[226],"which":[227],"11%":[232],"83%.":[237],"CONCLUSION:":[238],"abdomen":[245],"pelvis,":[247],"combination":[249],"increased":[258],"addition,":[264],"assessing":[265],"can":[268],"help":[269],"identify":[270],"cancer":[271],"even":[272],"when":[273],"results":[275],"are":[276],"indeterminate.":[277]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
