{"id":"https://openalex.org/W2167621077","doi":"https://doi.org/10.1055/s-2006-944546","title":"Twelve-week Monotherapy with the DPP-4 Inhibitor Vildagliptin Improves Glycemic Control in Subjects with Type 2 Diabetes","display_name":"Twelve-week Monotherapy with the DPP-4 Inhibitor Vildagliptin Improves Glycemic Control in Subjects with Type 2 Diabetes","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W2167621077","doi":"https://doi.org/10.1055/s-2006-944546","mag":"2167621077","pmid":"https://pubmed.ncbi.nlm.nih.gov/16823726"},"language":"en","primary_location":{"id":"doi:10.1055/s-2006-944546","doi":"https://doi.org/10.1055/s-2006-944546","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-944546","pdf_url":null,"source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059098934","display_name":"Richard E. Pratley","orcid":"https://orcid.org/0000-0002-2912-1389","observed_orcids":["https://orcid.org/0000-0002-2912-1389"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I2801980284","display_name":"University of Vermont Medical Center","ror":"https://ror.org/04cewr321","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801980284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Pratley","raw_affiliation_strings":["University of Vermont College of Medicine, Burlington, VT 05401, USA. richard.pratley@uvm.edu","University of Vermont College of Medicine, Burlington, VT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont College of Medicine, Burlington, VT 05401, USA. richard.pratley@uvm.edu","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I2801980284"]},{"raw_affiliation_string":"University of Vermont College of Medicine, Burlington, VT, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068356955","display_name":"S. Jauffret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S. Jauffret-Kamel","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053335837","display_name":"Elizabeth J. Galbreath","orcid":"https://orcid.org/0000-0003-0162-8329","observed_orcids":["https://orcid.org/0000-0003-0162-8329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Galbreath","raw_affiliation_strings":["Novartis Pharmaceuticals, East Hanover, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, East Hanover, NJ, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048870129","display_name":"David Holmes","orcid":"https://orcid.org/0009-0003-5549-0019","observed_orcids":["https://orcid.org/0009-0003-5549-0019"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D. Holmes","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":24.0012,"has_fulltext":false,"cited_by_count":191,"citation_normalized_percentile":{"value":0.99680452,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"6","first_page":"423","last_page":"428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vildagliptin","display_name":"vildagliptin","score":1.0},{"id":"https://openalex.org/keywords/dpp-4-inhibitors","display_name":"DPP-4 inhibitors","score":0.9520000219345093},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9449999928474426},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.703000009059906},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.8379999995231628},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.8600000143051147},{"id":"https://openalex.org/keywords/insulin-response","display_name":"insulin response","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.5580000281333923},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2776453732","wikidata":"https://www.wikidata.org/wiki/Q421042","display_name":"Vildagliptin","level":4,"score":0.9852675199508667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7867002487182617},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7682528495788574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7647994756698608},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.7567998170852661},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6516320109367371},{"id":"https://openalex.org/C2778763485","wikidata":"https://www.wikidata.org/wiki/Q419770","display_name":"Dipeptidyl peptidase-4 inhibitor","level":4,"score":0.6452362537384033},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6332077980041504},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6282254457473755},{"id":"https://openalex.org/C2778881409","wikidata":"https://www.wikidata.org/wiki/Q1420402","display_name":"Incretin","level":4,"score":0.5577128529548645},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.5448611974716187},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5164106488227844},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5086525678634644},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.49903225898742676},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.39948147535324097},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077597","descriptor_name":"Vildagliptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000218","descriptor_name":"Adamantane","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000218","descriptor_name":"Adamantane","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011759","descriptor_name":"Pyrrolidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018819","descriptor_name":"Dipeptidyl Peptidase 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058892","descriptor_name":"Adenosine Deaminase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2006-944546","doi":"https://doi.org/10.1055/s-2006-944546","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2006-944546","pdf_url":null,"source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},{"id":"pmid:16823726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16823726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1991565451","https://openalex.org/W1993287695","https://openalex.org/W2036167841","https://openalex.org/W2036230400","https://openalex.org/W2043121816","https://openalex.org/W2067766854","https://openalex.org/W2081869806","https://openalex.org/W2084139518","https://openalex.org/W2093303670","https://openalex.org/W2104763836","https://openalex.org/W2133795831","https://openalex.org/W2138593383","https://openalex.org/W2143014102","https://openalex.org/W2146232529","https://openalex.org/W2147883561","https://openalex.org/W2160234571","https://openalex.org/W2168552871"],"related_works":["https://openalex.org/W3189636675","https://openalex.org/W2049323977","https://openalex.org/W1998192422","https://openalex.org/W2497789978","https://openalex.org/W2077303050","https://openalex.org/W2131626154","https://openalex.org/W2135193404","https://openalex.org/W2071648045","https://openalex.org/W7099824808","https://openalex.org/W2068345319"],"abstract_inverted_index":{"UNLABELLED:":[0],"Inhibition":[1],"of":[2,8,31,167],"dipeptidyl":[3,37],"peptidase-4":[4,38],"enhances":[5],"the":[6,27,32,87],"activity":[7],"incretin":[9],"hormones,":[10],"improving":[11],"glycemic":[12,191],"control":[13,192],"in":[14,49,69,73,129,172,193,202],"subjects":[15,52,97,173,195],"with":[16,53,98,184,196,209],"type":[17,54,197],"2":[18,55,198],"diabetes.":[19,56,199],"This":[20],"twelve-week":[21],"randomized,":[22],"double-masked,":[23],"placebo-controlled":[24],"study":[25],"assessed":[26],"efficacy":[28],"and":[29,34,64,93,107,118,136,146,178,189],"tolerability":[30],"specific":[33],"potent":[35],"oral":[36],"inhibitor,":[39],"vildagliptin":[40,179,185],"(25":[41],"mg,":[42],"bid,":[43],"n=70)":[44],"VS.":[45],"placebo":[46,175],"(bid,":[47],"n=28)":[48],"previously":[50],"diet-treated":[51,194],"Standardized":[57],"meal":[58],"tests":[59],"were":[60,111,140,205],"performed":[61],"at":[62,133],"baseline":[63,76,99,211],"endpoint.":[65],"The":[66,126,165],"between-group":[67,127],"difference":[68],"adjusted":[70],"mean":[71,108,137],"change":[72],"HbA1c":[74,100,212],"from":[75],"to":[77],"endpoint":[78],"was":[79,170],"-":[80,102],"0.6":[81],"+/-":[82,115,120,143,149],"0.2":[83],"%":[84,95],"(p=0.0012)":[85],"for":[86,96],"whole":[88],"cohort":[89],"(baseline":[90],"8.0":[91,101],"%)":[92,177],"-1.2":[94],"9.5":[103],"%.":[104],"Fasting":[105],"glucose":[106,110,135],"prandial":[109,138],"reduced":[112],"by":[113],"1.1":[114],"0.4":[116],"(p=0.0043)":[117],"1.9":[119],"0.5":[121],"mmol/l":[122],"(p":[123],"<0.0001),":[124],"respectively.":[125,153],"differences":[128],"corrected":[130],"insulin":[131],"response":[132],"peak":[134],"C-peptide":[139],"+":[141,147],"0.06":[142],"0.02":[144],"(p=0.0258)":[145],"0.10":[148],"0.03":[150],"nmol/l":[151],"(p=0.0031),":[152],"Vildagliptin":[154],"had":[155],"no":[156],"effect":[157],"on":[158],"fasting":[159],"lipid":[160],"levels":[161,213],"or":[162],"body":[163],"weight.":[164],"incidence":[166],"adverse":[168],"events":[169],"similar":[171],"receiving":[174],"(71.4":[176],"(55.7":[180],"%).":[181],"CONCLUSION:":[182],"monotherapy":[183],"is":[186],"well":[187],"tolerated":[188],"improves":[190],"Concomitant":[200],"improvements":[201],"beta-cell":[203],"function":[204],"also":[206],"observed.":[207],"Subjects":[208],"higher":[210],"showed":[214],"greater":[215],"response.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}