{"id":"https://openalex.org/W2167619153","doi":null,"title":"Antitumor x anti-CD3 bifunctional antibodies redirect T-cells activated in vivo with staphylococcal enterotoxin B to neutralize pulmonary metastases.","display_name":"Antitumor x anti-CD3 bifunctional antibodies redirect T-cells activated in vivo with staphylococcal enterotoxin B to neutralize pulmonary metastases.","publication_year":1994,"publication_date":"1994-05-15","ids":{"openalex":"https://openalex.org/W2167619153","mag":"2167619153","pmid":"https://pubmed.ncbi.nlm.nih.gov/8168104"},"language":"en","primary_location":{"id":"pmid:8168104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8168104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109130752","display_name":"Christophe Penna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Penna","raw_affiliation_strings":["Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102153528","display_name":"Phillip A. Dean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P A Dean","raw_affiliation_strings":["Mayo Clinic Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102773546","display_name":"Heidi D Nelson","orcid":"https://orcid.org/0000-0003-2308-8167","observed_orcids":["https://orcid.org/0000-0003-2308-8167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Nelson","raw_affiliation_strings":["Colon and Rectal Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colon and Rectal Surgery","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9735,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.74804688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"54","issue":"10","first_page":"2738","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.07370000332593918,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bifunctional-antibody","display_name":"bifunctional antibody","score":0.9419999718666077},{"id":"https://openalex.org/keywords/staphylococcal-enterotoxin-b","display_name":"staphylococcal enterotoxin B","score":0.9539999961853027},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/anti-cd3-antibody","display_name":"anti-CD3 antibody","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.37599998712539673},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/il-2-receptor","display_name":"interleukin-2 receptor","score":0.9129999876022339},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.734000027179718},{"id":"https://openalex.org/keywords/mhc-restriction","display_name":"MHC restriction","score":0.46700000762939453},{"id":"https://openalex.org/keywords/syngeneic-mouse-model","display_name":"syngeneic mouse model","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6394034624099731},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.45578545331954956},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4538480341434479},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.44724148511886597},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.44666677713394165},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.44095537066459656},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4223264157772064},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4056653380393982},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39182060956954956},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3917596936225891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3709661662578583},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2212841510772705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07044166326522827},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8168104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8168104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2167619153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8168104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1587255960","https://openalex.org/W1625902346","https://openalex.org/W1882520884","https://openalex.org/W1970166758","https://openalex.org/W1981853681","https://openalex.org/W2020737978","https://openalex.org/W2028697515","https://openalex.org/W2042941572","https://openalex.org/W2065272367","https://openalex.org/W2070597847","https://openalex.org/W2117925216","https://openalex.org/W2142490832","https://openalex.org/W2164102491","https://openalex.org/W2322553446"],"related_works":["https://openalex.org/W2056163448","https://openalex.org/W2010771374","https://openalex.org/W2033730482","https://openalex.org/W2001750152","https://openalex.org/W1503143053","https://openalex.org/W2084721360","https://openalex.org/W2391087068","https://openalex.org/W1617294693","https://openalex.org/W1505210763","https://openalex.org/W1498976410"],"abstract_inverted_index":{"T-cell":[0],"antitumor":[1,53,63,181,246],"activities":[2],"are":[3],"limited":[4],"by":[5,114,224],"the":[6,76,131,173,179,184],"requirement":[7],"of":[8,25,44,110,133,183,231],"two":[9],"specific":[10],"major":[11,34],"histocompatibility":[12,35],"complex":[13,36],"restricted":[14,37],"steps,":[15],"T-helper":[16],"cell":[17],"activation":[18,43,109],"and":[19,50,81,119,147,226],"cytotoxic":[20],"T-lymphocyte":[21],"targeting.":[22],"The":[23],"aim":[24],"this":[26,234],"study":[27],"was":[28],"to":[29,150,158],"investigate":[30],"whether":[31],"bypassing":[32],"these":[33],"steps":[38],"using":[39],"nonspecific":[40],"in":[41,168,199,222],"vivo":[42,223],"T-cells":[45,111,218],"with":[46,52,70,87,143,160,172,178,188,207,228],"staphylococcal":[47],"enterotoxin-B":[48],"(SE-B)":[49],"retargeting":[51],"x":[54,92,204],"anti-CD3":[55,90],"bifunctional":[56],"antibody":[57],"(BFA)":[58],"could":[59],"provide":[60],"an":[61],"effective":[62],"response.":[64,247],"C3H/HeN":[65],"mice":[66],"were":[67,82,98,170],"injected":[68],"i.v.":[69],"CL-62":[71],"melanoma":[72,78],"cells,":[73],"which":[74],"express":[75],"human":[77],"antigen":[79],"p97,":[80],"treated":[83],"10":[84,127],"min":[85],"later":[86],"SE-B":[88,104,123,144,161,189,225,240],"and/or":[89],"(500A2)":[91],"anti-p97":[93],"(96.5)":[94],"BFA.":[95,185,232],"Pulmonary":[96],"metastases":[97,135,156,169],"counted":[99],"14":[100],"days":[101],"following":[102],"injections.":[103],"alone":[105,162],"induced":[106],"a":[107,244],"dose-dependent":[108],"as":[112],"measured":[113],"increased":[115],"interleukin-2":[116],"receptor":[117],"expression":[118],"enhanced":[120],"proliferative":[121],"responses.":[122],"doses":[124,230],"greater":[125],"than":[126,196],"micrograms":[128],"significantly":[129,153],"reduced":[130],"number":[132],"pulmonary":[134,155,237],"versus":[136],"control":[137],"(P":[138,163],"<":[139,164,212],"0.01).":[140],"Combined":[141,186],"treatment":[142,159],"(50":[145],"micrograms)":[146,152],"BFA":[148,175,191,208,242],"(5":[149],"50":[151],"decreased":[154],"compared":[157],"0.05).":[165,213],"Similar":[166],"reductions":[167],"observed":[171],"F(ab')2":[174],"but":[176],"not":[177],"unconjugated":[180],"component":[182],"treatments":[187],"plus":[190,241],"accomplished":[192],"better":[193],"tumor":[194],"neutralization":[195],"adoptively":[197],"transferred":[198],"vitro":[200],"activated":[201,221],"splenocytes":[202],"(4":[203],"10(7))":[205],"retargeted":[206,227],"(5-100":[209],"micrograms;":[210],"P":[211],"These":[214],"studies":[215],"demonstrate":[216],"that":[217],"can":[219],"be":[220],"small":[229],"In":[233],"immunocompetent":[235],"syngeneic":[236],"metastasis":[238],"model,":[239],"provided":[243],"dramatic":[245]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
