{"id":"https://openalex.org/W2167565713","doi":"https://doi.org/10.1194/jlr.m800131-jlr200","title":"Identification of putative active site residues of ACAT enzymes","display_name":"Identification of putative active site residues of ACAT enzymes","publication_year":2008,"publication_date":"2008-05-14","ids":{"openalex":"https://openalex.org/W2167565713","doi":"https://doi.org/10.1194/jlr.m800131-jlr200","mag":"2167565713","pmid":"https://pubmed.ncbi.nlm.nih.gov/18480028","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2444009"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.m800131-jlr200","doi":"https://doi.org/10.1194/jlr.m800131-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m800131-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520346964/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jlr.org/article/S0022227520346964/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111202493","display_name":"Akash Das","orcid":"https://orcid.org/0009-0004-6974-1875","observed_orcids":["https://orcid.org/0009-0004-6974-1875"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akash Das","raw_affiliation_strings":["Department of Biochemistry, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040, USA","Department of Biochemistry, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040, USA","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Biochemistry, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Matthew A. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Davis","raw_affiliation_strings":["Section on Lipid Sciences , Wake Forest University School of Medicine , Winston Salem , NC 27157-1040","Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Lipid Sciences , Wake Forest University School of Medicine , Winston Salem , NC 27157-1040","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108472089","display_name":"Lawrence L. Rudel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lawrence L. Rudel","raw_affiliation_strings":["Department of Biochemistry , and Department of Pathology ,","Section on Lipid Sciences , Wake Forest University School of Medicine , Winston Salem , NC 27157-1040","Department of Biochemistry, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040","Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry , and Department of Pathology ,","institution_ids":[]},{"raw_affiliation_string":"Section on Lipid Sciences , Wake Forest University School of Medicine , Winston Salem , NC 27157-1040","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Biochemistry, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157-1040","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108472089"],"corresponding_institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.3625,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.88800266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"49","issue":"8","first_page":"1770","last_page":"1781"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.06109999865293503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyl-coa-cholesterol-acyltransferase","display_name":"acyl-CoA:cholesterol acyltransferase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/active-site-residues","display_name":"active site residues","score":0.925000011920929},{"id":"https://openalex.org/keywords/catalytic-triad","display_name":"catalytic triad","score":0.9259999990463257},{"id":"https://openalex.org/keywords/acat1","display_name":"ACAT1","score":0.7400000095367432},{"id":"https://openalex.org/keywords/acat2","display_name":"ACAT2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tyrosine-residues","display_name":"tyrosine residues","score":0.6209999918937683},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/enzyme-stability","display_name":"enzyme stability","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.7767509818077087},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.716579794883728},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.604394793510437},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5156177878379822},{"id":"https://openalex.org/C2780622759","wikidata":"https://www.wikidata.org/wiki/Q76818446","display_name":"Thioesterase","level":4,"score":0.4715452492237091},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4464702010154724},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44195476174354553},{"id":"https://openalex.org/C145770059","wikidata":"https://www.wikidata.org/wiki/Q751908","display_name":"Catalytic triad","level":4,"score":0.4289941191673279},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3994990885257721},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.13692429661750793}],"mesh":[{"descriptor_ui":"D000097587","descriptor_name":"Sterol O-Acyltransferase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002785","descriptor_name":"Sterol O-Acyltransferase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1194/jlr.m800131-jlr200","doi":"https://doi.org/10.1194/jlr.m800131-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m800131-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520346964/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2444009","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2444009","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Lipid Res","raw_type":"Text"},{"id":"pmid:18480028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18480028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:18eafed97b684cf5b1599971286fa30d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/18eafed97b684cf5b1599971286fa30d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 49, Iss 8, Pp 1770-1781 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.m800131-jlr200","doi":"https://doi.org/10.1194/jlr.m800131-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.m800131-jlr200","pdf_url":"http://www.jlr.org/article/S0022227520346964/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8993664908","display_name":"Lipoprotein Metabolism in Atherosclerosis","funder_award_id":"P01HL049373","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167565713.pdf","grobid_xml":"https://content.openalex.org/works/W2167565713.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1508733793","https://openalex.org/W1557947614","https://openalex.org/W1832765217","https://openalex.org/W1964959608","https://openalex.org/W1967018843","https://openalex.org/W1968330653","https://openalex.org/W1977828235","https://openalex.org/W1979830788","https://openalex.org/W1995278899","https://openalex.org/W2001718927","https://openalex.org/W2008634509","https://openalex.org/W2012176370","https://openalex.org/W2017520720","https://openalex.org/W2022923134","https://openalex.org/W2030412283","https://openalex.org/W2048954674","https://openalex.org/W2055240842","https://openalex.org/W2061961744","https://openalex.org/W2063960234","https://openalex.org/W2075980355","https://openalex.org/W2078932350","https://openalex.org/W2081606553","https://openalex.org/W2085649019","https://openalex.org/W2088892171","https://openalex.org/W2094437760","https://openalex.org/W2100505770","https://openalex.org/W2104584308","https://openalex.org/W2104976642","https://openalex.org/W2123854534","https://openalex.org/W2133097088","https://openalex.org/W2152311269","https://openalex.org/W2161975833","https://openalex.org/W2167670101","https://openalex.org/W2169792817","https://openalex.org/W2216055948","https://openalex.org/W2402903841","https://openalex.org/W2411629130"],"related_works":["https://openalex.org/W2269905478","https://openalex.org/W2282273209","https://openalex.org/W2008634509","https://openalex.org/W2336529048","https://openalex.org/W2094437760","https://openalex.org/W1993198500","https://openalex.org/W1561931819","https://openalex.org/W1976259744","https://openalex.org/W2043012847","https://openalex.org/W2900022995"],"abstract_inverted_index":{"In":[0,101],"this":[1],"report,":[2],"we":[3,57,117],"sought":[4],"to":[5,38,47,120,135],"determine":[6],"the":[7,22,26,32,63,70,114,158,162,180,193,204],"putative":[8,33],"active":[9,34,71],"site":[10,35,72],"residues":[11,147],"of":[12,21,25,42,66,73,81,111,125,161],"ACAT":[13,27,50,74,152,170,198,206],"enzymes.":[14],"For":[15],"experimental":[16],"purposes,":[17],"a":[18,78],"particular":[19],"region":[20],"C-terminal":[23],"end":[24],"protein":[28],"was":[29,104,133,140,167,174,186],"selected":[30],"as":[31],"domain":[36,65],"due":[37],"its":[39],"high":[40],"degree":[41],"sequence":[43],"conservation":[44],"from":[45],"yeast":[46],"humans.":[48],"Because":[49],"enzymes":[51,75],"have":[52],"an":[53],"intrinsic":[54],"thioesterase":[55,64],"activity,":[56,178],"hypothesized":[58],"that":[59,90,127,145,157,192],"by":[60],"analogy":[61],"with":[62],"fatty":[67],"acid":[68,85,195],"synthase,":[69],"may":[76,148,200],"comprise":[77],"catalytic":[79,129],"triad":[80],"ser-his-asp":[82],"(S-H-D)":[83],"amino":[84,194],"residues.":[86],"Mutagenesis":[87],"studies":[88,143],"revealed":[89],"in":[91,183],"ACAT1,":[92],"S456,":[93],"H460,":[94],"and":[95],"D400":[96],"were":[97,118],"essential":[98],"for":[99,106,151,169,176,197,203],"activity.":[100,108,130,153,171],"ACAT2,":[102,184],"H438":[103],"required":[105],"enzymatic":[107],"However,":[109],"mutation":[110],"D378":[112],"destabilized":[113],"enzyme.":[115],"Surprisingly,":[116],"unable":[119],"identify":[121],"any":[122],"S":[123],"mutations":[124],"ACAT2":[126,132],"abolished":[128],"Moreover,":[131],"insensitive":[134],"serine-modifying":[136],"reagents,":[137],"whereas":[138,179],"ACAT1":[139,177],"not.":[141,187],"Further":[142],"indicated":[144],"tyrosine":[146,159],"be":[149,201],"important":[150,168],"Mutational":[154],"analysis":[155],"showed":[156],"residue":[160,182],"highly":[163],"conserved":[164],"FYXDWWN":[165],"motif":[166],"Furthermore,":[172],"Y518":[173],"necessary":[175],"analogous":[181],"Y496,":[185],"The":[188],"available":[189],"data":[190],"suggest":[191],"requirement":[196],"activity":[199],"different":[202],"two":[205],"isozymes.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}