{"id":"https://openalex.org/W2167536088","doi":"https://doi.org/10.1146/annurev-biochem-061909-093311","title":"Sumoylation: A Regulatory Protein Modification in Health and Disease","display_name":"Sumoylation: A Regulatory Protein Modification in Health and Disease","publication_year":2013,"publication_date":"2013-06-02","ids":{"openalex":"https://openalex.org/W2167536088","doi":"https://doi.org/10.1146/annurev-biochem-061909-093311","mag":"2167536088","pmid":"https://pubmed.ncbi.nlm.nih.gov/23746258"},"language":"en","primary_location":{"id":"doi:10.1146/annurev-biochem-061909-093311","doi":"https://doi.org/10.1146/annurev-biochem-061909-093311","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-biochem-061909-093311","pdf_url":null,"source":{"id":"https://openalex.org/S53860259","display_name":"Annual Review of Biochemistry","issn_l":"0066-4154","issn":["0066-4154","1545-4509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043610778","display_name":"Annette Flotho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210151100","display_name":"DKFZ-ZMBH Alliance","ror":"https://ror.org/05x8b4491","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I4210151100"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annette Flotho","raw_affiliation_strings":["Zentrum f\u00fcr Molekulare Biologie der Universit\u00e4t Heidelberg, DKFZ-ZMBH, Heidelberg D-69120, Germany;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum f\u00fcr Molekulare Biologie der Universit\u00e4t Heidelberg, DKFZ-ZMBH, Heidelberg D-69120, Germany;,","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210151100"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015270905","display_name":"Frauke Melchior","orcid":"https://orcid.org/0000-0001-9546-8797","observed_orcids":["https://orcid.org/0000-0001-9546-8797"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210151100","display_name":"DKFZ-ZMBH Alliance","ror":"https://ror.org/05x8b4491","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I4210151100"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frauke Melchior","raw_affiliation_strings":["Zentrum f\u00fcr Molekulare Biologie der Universit\u00e4t Heidelberg, DKFZ-ZMBH, Heidelberg D-69120, Germany;,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zentrum f\u00fcr Molekulare Biologie der Universit\u00e4t Heidelberg, DKFZ-ZMBH, Heidelberg D-69120, Germany;,","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210151100"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.7812,"has_fulltext":false,"cited_by_count":1101,"citation_normalized_percentile":{"value":0.98946919,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"82","issue":"1","first_page":"357","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.9120000004768372},{"id":"https://openalex.org/keywords/reversible-protein-modification","display_name":"reversible protein modification","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.9409999847412109},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.875},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.996999979019165},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/protein-trafficking","display_name":"protein trafficking","score":0.7630000114440918},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sumoylation-inhibitors","display_name":"SUMOylation inhibitors","score":0.7459999918937683},{"id":"https://openalex.org/keywords/disease","display_name":"disease","score":0.875}],"concepts":[{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.9919151067733765},{"id":"https://openalex.org/C144519050","wikidata":"https://www.wikidata.org/wiki/Q7394994","display_name":"SUMO enzymes","level":5,"score":0.718613862991333},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5828863978385925},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.5554552674293518},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5460212230682373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45020005106925964},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.442507803440094},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3718748092651367},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.347972571849823},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3172851800918579},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24323195219039917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21379736065864563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1520436406135559},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025841","descriptor_name":"Small Ubiquitin-Related Modifier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058207","descriptor_name":"Sumoylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev-biochem-061909-093311","doi":"https://doi.org/10.1146/annurev-biochem-061909-093311","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev-biochem-061909-093311","pdf_url":null,"source":{"id":"https://openalex.org/S53860259","display_name":"Annual Review of Biochemistry","issn_l":"0066-4154","issn":["0066-4154","1545-4509"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Biochemistry","raw_type":"journal-article"},{"id":"pmid:23746258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23746258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":221,"referenced_works":["https://openalex.org/W95252060","https://openalex.org/W1490806999","https://openalex.org/W1520109974","https://openalex.org/W1541379084","https://openalex.org/W1600888450","https://openalex.org/W1666755687","https://openalex.org/W1758502057","https://openalex.org/W1864629140","https://openalex.org/W1959908262","https://openalex.org/W1964661304","https://openalex.org/W1964711168","https://openalex.org/W1965073686","https://openalex.org/W1965818711","https://openalex.org/W1967707683","https://openalex.org/W1968682449","https://openalex.org/W1969770800","https://openalex.org/W1970042886","https://openalex.org/W1971987130","https://openalex.org/W1972892391","https://openalex.org/W1973480232","https://openalex.org/W1973657734","https://openalex.org/W1975059674","https://openalex.org/W1975537268","https://openalex.org/W1975658312","https://openalex.org/W1978318806","https://openalex.org/W1978783141","https://openalex.org/W1978806306","https://openalex.org/W1979275431","https://openalex.org/W1981243923","https://openalex.org/W1981700185","https://openalex.org/W1983132795","https://openalex.org/W1983606049","https://openalex.org/W1984007953","https://openalex.org/W1984710705","https://openalex.org/W1985274333","https://openalex.org/W1985313012","https://openalex.org/W1986606670","https://openalex.org/W1986760774","https://openalex.org/W1987344383","https://openalex.org/W1987780245","https://openalex.org/W1988805210","https://openalex.org/W1988841577","https://openalex.org/W1988923344","https://openalex.org/W1989643386","https://openalex.org/W1989644272","https://openalex.org/W1991189921","https://openalex.org/W1991601985","https://openalex.org/W1991841644","https://openalex.org/W1992363628","https://openalex.org/W1993180829","https://openalex.org/W1993287528","https://openalex.org/W1994218254","https://openalex.org/W1994473965","https://openalex.org/W1995456120","https://openalex.org/W1996611653","https://openalex.org/W1997935740","https://openalex.org/W1998123095","https://openalex.org/W2000129411","https://openalex.org/W2000313986","https://openalex.org/W2000726054","https://openalex.org/W2001029086","https://openalex.org/W2001341780","https://openalex.org/W2002879843","https://openalex.org/W2003199010","https://openalex.org/W2003724178","https://openalex.org/W2004722555","https://openalex.org/W2006976630","https://openalex.org/W2007072101","https://openalex.org/W2007336920","https://openalex.org/W2009128158","https://openalex.org/W2009780554","https://openalex.org/W2012398131","https://openalex.org/W2013108773","https://openalex.org/W2013337055","https://openalex.org/W2014231458","https://openalex.org/W2015122435","https://openalex.org/W2015848423","https://openalex.org/W2018686658","https://openalex.org/W2021044341","https://openalex.org/W2021618108","https://openalex.org/W2021776926","https://openalex.org/W2021992655","https://openalex.org/W2022190569","https://openalex.org/W2022533652","https://openalex.org/W2024249948","https://openalex.org/W2024973490","https://openalex.org/W2026421562","https://openalex.org/W2026803031","https://openalex.org/W2027410891","https://openalex.org/W2028224002","https://openalex.org/W2028400370","https://openalex.org/W2029189334","https://openalex.org/W2032172345","https://openalex.org/W2032612990","https://openalex.org/W2032644941","https://openalex.org/W2034728759","https://openalex.org/W2035143588","https://openalex.org/W2035665453","https://openalex.org/W2035827341","https://openalex.org/W2039162046","https://openalex.org/W2039741753","https://openalex.org/W2040825545","https://openalex.org/W2043369995","https://openalex.org/W2043574957","https://openalex.org/W2043927273","https://openalex.org/W2044229112","https://openalex.org/W2044287615","https://openalex.org/W2044644461","https://openalex.org/W2046628354","https://openalex.org/W2047134964","https://openalex.org/W2048915427","https://openalex.org/W2048917471","https://openalex.org/W2050895547","https://openalex.org/W2053972916","https://openalex.org/W2054782539","https://openalex.org/W2054879089","https://openalex.org/W2056801882","https://openalex.org/W2058489202","https://openalex.org/W2058788882","https://openalex.org/W2060139840","https://openalex.org/W2061093635","https://openalex.org/W2061503855","https://openalex.org/W2061874168","https://openalex.org/W2063905858","https://openalex.org/W2064686852","https://openalex.org/W2064723340","https://openalex.org/W2067463001","https://openalex.org/W2069078243","https://openalex.org/W2070182263","https://openalex.org/W2070767128","https://openalex.org/W2071189887","https://openalex.org/W2071545806","https://openalex.org/W2072890656","https://openalex.org/W2073133734","https://openalex.org/W2073590048","https://openalex.org/W2079708844","https://openalex.org/W2079864309","https://openalex.org/W2081184451","https://openalex.org/W2082970207","https://openalex.org/W2083312621","https://openalex.org/W2084117490","https://openalex.org/W2085225882","https://openalex.org/W2085610925","https://openalex.org/W2085752596","https://openalex.org/W2086438431","https://openalex.org/W2087678982","https://openalex.org/W2088357489","https://openalex.org/W2089884508","https://openalex.org/W2090411918","https://openalex.org/W2091069088","https://openalex.org/W2091073356","https://openalex.org/W2094274021","https://openalex.org/W2096093342","https://openalex.org/W2100200896","https://openalex.org/W2100419900","https://openalex.org/W2103210708","https://openalex.org/W2103552916","https://openalex.org/W2103601342","https://openalex.org/W2104079111","https://openalex.org/W2104203125","https://openalex.org/W2105289395","https://openalex.org/W2107947480","https://openalex.org/W2109256153","https://openalex.org/W2109560748","https://openalex.org/W2110548948","https://openalex.org/W2110768070","https://openalex.org/W2111833081","https://openalex.org/W2112158920","https://openalex.org/W2112441454","https://openalex.org/W2113354406","https://openalex.org/W2113504375","https://openalex.org/W2115214832","https://openalex.org/W2116988305","https://openalex.org/W2118810511","https://openalex.org/W2119301405","https://openalex.org/W2120818622","https://openalex.org/W2125074509","https://openalex.org/W2125945836","https://openalex.org/W2129581798","https://openalex.org/W2132293498","https://openalex.org/W2132765410","https://openalex.org/W2133740529","https://openalex.org/W2135965804","https://openalex.org/W2136204556","https://openalex.org/W2136956610","https://openalex.org/W2138057005","https://openalex.org/W2139180375","https://openalex.org/W2140484442","https://openalex.org/W2140740835","https://openalex.org/W2141829793","https://openalex.org/W2144691234","https://openalex.org/W2144724051","https://openalex.org/W2145069182","https://openalex.org/W2146585914","https://openalex.org/W2147542927","https://openalex.org/W2147917253","https://openalex.org/W2148789090","https://openalex.org/W2148794709","https://openalex.org/W2150857291","https://openalex.org/W2151137171","https://openalex.org/W2152573239","https://openalex.org/W2152763796","https://openalex.org/W2153894357","https://openalex.org/W2153938645","https://openalex.org/W2154805387","https://openalex.org/W2154837790","https://openalex.org/W2154983385","https://openalex.org/W2155808639","https://openalex.org/W2156374607","https://openalex.org/W2160938666","https://openalex.org/W2163056216","https://openalex.org/W2166680118","https://openalex.org/W2166987747","https://openalex.org/W2168239981","https://openalex.org/W2168736281","https://openalex.org/W2168830189","https://openalex.org/W2169095840","https://openalex.org/W2170508619","https://openalex.org/W2170520669","https://openalex.org/W2172298521","https://openalex.org/W2478279870"],"related_works":["https://openalex.org/W2390048294","https://openalex.org/W1866623334","https://openalex.org/W3014809609","https://openalex.org/W2051961867","https://openalex.org/W4214578575","https://openalex.org/W2036044162","https://openalex.org/W2762079811","https://openalex.org/W2033605213","https://openalex.org/W2370621141","https://openalex.org/W2898671206"],"abstract_inverted_index":{"Posttranslational":[0],"modification":[1],"with":[2,63],"small":[3],"ubiquitin-related":[4],"modifier":[5],"(SUMO)":[6],"proteins":[7,24],"is":[8,50,65],"now":[9],"established":[10],"as":[11,29],"one":[12],"of":[13,23,82],"the":[14,80],"key":[15],"regulatory":[16],"protein":[17,37],"modifications":[18],"in":[19,26,79],"eukaryotic":[20],"cells.":[21],"Hundreds":[22],"involved":[25],"processes":[27],"such":[28],"chromatin":[30],"organization,":[31],"transcription,":[32],"DNA":[33],"repair,":[34],"macromolecular":[35],"assembly,":[36],"homeostasis,":[38],"trafficking,":[39],"and":[40,60,75],"signal":[41],"transduction":[42],"are":[43,56],"subject":[44],"to":[45,58],"reversible":[46],"sumoylation.":[47,83],"Hence,":[48],"it":[49],"not":[51],"surprising":[52],"that":[53,61],"disease":[54],"links":[55],"beginning":[57],"emerge":[59],"interference":[62],"sumoylation":[64],"being":[66],"considered":[67],"for":[68],"intervention.":[69],"Here,":[70],"we":[71],"summarize":[72],"basic":[73],"mechanisms":[74],"highlight":[76],"recent":[77],"developments":[78],"physiology":[81]},"counts_by_year":[{"year":2026,"cited_by_count":51},{"year":2025,"cited_by_count":68},{"year":2024,"cited_by_count":80},{"year":2023,"cited_by_count":73},{"year":2022,"cited_by_count":89},{"year":2021,"cited_by_count":109},{"year":2020,"cited_by_count":107},{"year":2019,"cited_by_count":111},{"year":2018,"cited_by_count":87},{"year":2017,"cited_by_count":102},{"year":2016,"cited_by_count":74},{"year":2015,"cited_by_count":73},{"year":2014,"cited_by_count":66},{"year":2013,"cited_by_count":8}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}