{"id":"https://openalex.org/W2167350182","doi":"https://doi.org/10.3109/07853899609033127","title":"New Insights into the Genetics of Alzheimer's Disease","display_name":"New Insights into the Genetics of Alzheimer's Disease","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2167350182","doi":"https://doi.org/10.3109/07853899609033127","mag":"2167350182","pmid":"https://pubmed.ncbi.nlm.nih.gov/8811169"},"language":"en","primary_location":{"id":"doi:10.3109/07853899609033127","doi":"https://doi.org/10.3109/07853899609033127","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07853899609033127","pdf_url":null,"source":{"id":"https://openalex.org/S203391715","display_name":"Annals of Medicine","issn_l":"0785-3890","issn":["0785-3890","1365-2060"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John Hardy","raw_affiliation_strings":["Suncoast Alzheimer's Disease Laboratory, University of South Florida, Tampa 33613, USA","Suncoast Alzheimer's Disease Laboratory, University of South Florida, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Suncoast Alzheimer's Disease Laboratory, University of South Florida, Tampa 33613, USA","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Suncoast Alzheimer's Disease Laboratory, University of South Florida, Tampa, FL, USA","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020514779"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":null,"fwci":2.6274,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.90919007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"28","issue":"3","first_page":"255","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease-genetics","display_name":"Alzheimer's disease genetics","score":0.9089999794960022},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9620000123977661},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.7870000004768372},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/psen2","display_name":"presenilin 2","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.8679999709129333},{"id":"https://openalex.org/keywords/amyloid-hypothesis","display_name":"amyloid hypothesis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/early-onset-alzheimer-s-disease","display_name":"early-onset Alzheimer's disease","score":0.8050000071525574},{"id":"https://openalex.org/keywords/genetic-loci","display_name":"genetic loci","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.7953712344169617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6205968856811523},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6135004758834839},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5864723920822144},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5302521586418152},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.48584362864494324},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.44066694378852844},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.42496562004089355},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4110139012336731},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3648940324783325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2937377393245697},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23133432865142822}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/07853899609033127","doi":"https://doi.org/10.3109/07853899609033127","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07853899609033127","pdf_url":null,"source":{"id":"https://openalex.org/S203391715","display_name":"Annals of Medicine","issn_l":"0785-3890","issn":["0785-3890","1365-2060"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medicine","raw_type":"journal-article"},{"id":"pmid:8811169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8811169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of medicine","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1358981","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1358981/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ANNALS OF MEDICINE , 28 (3) pp. 255-258. (1996)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1539232350","https://openalex.org/W1965496447","https://openalex.org/W1972706019","https://openalex.org/W1979750648","https://openalex.org/W1980906872","https://openalex.org/W1985253611","https://openalex.org/W1987794474","https://openalex.org/W1990668385","https://openalex.org/W1991662012","https://openalex.org/W1993414253","https://openalex.org/W1996623888","https://openalex.org/W1999902101","https://openalex.org/W2003527151","https://openalex.org/W2006409771","https://openalex.org/W2011199056","https://openalex.org/W2011924331","https://openalex.org/W2019251951","https://openalex.org/W2021181758","https://openalex.org/W2029486567","https://openalex.org/W2033325438","https://openalex.org/W2034622004","https://openalex.org/W2036362108","https://openalex.org/W2040781771","https://openalex.org/W2045153164","https://openalex.org/W2046209489","https://openalex.org/W2046590674","https://openalex.org/W2053152816","https://openalex.org/W2070277156","https://openalex.org/W2072682191","https://openalex.org/W2083633251","https://openalex.org/W2087671869","https://openalex.org/W2090271811","https://openalex.org/W2128931247","https://openalex.org/W2139930052","https://openalex.org/W2144907624","https://openalex.org/W2145838320","https://openalex.org/W2621518294","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W45226499","https://openalex.org/W149643554","https://openalex.org/W2205982756","https://openalex.org/W2044317680","https://openalex.org/W2051803489","https://openalex.org/W2152298778","https://openalex.org/W34985557","https://openalex.org/W2409997419","https://openalex.org/W2059806453","https://openalex.org/W1565052679"],"abstract_inverted_index":{"In":[0,91],"early":[1,18],"1993,":[2],"the":[3,7,14,34,42,46,50,64,67,69,76,84,96,99,108,111],"genetic":[4,57],"data":[5],"implicating":[6,36],"amyloid":[8,112],"precursor":[9],"protein":[10],"as":[11,41],"one":[12],"of":[13,28,39,45,66],"loci":[15,58],"leading":[16,48],"to":[17,49,105],"onset":[19],"Alzheimer's":[20],"disease":[21],"were":[22],"reviewed":[23],"(Hardy":[24],"and":[25,83,103],"Duff,":[26],"Annals":[27],"Medicine,":[29],"25:":[30],"437-440),":[31],"together":[32],"with":[33],"evidence":[35,109],"abnormal":[37],"deposition":[38],"beta-amyloid":[40],"initiating":[43],"point":[44],"process":[47],"disease.":[51],"Since":[52],"that":[53],"time,":[54],"three":[55,101],"other":[56],"have":[59],"been":[60],"directly":[61],"implicated":[62],"in":[63],"aetiology":[65],"disease:":[68],"apolipoprotein":[70],"E":[71],"locus":[72],"on":[73,80,88],"chromosome":[74,81,89],"19,":[75],"presenilin":[77,85],"1":[78],"gene":[79,87],"14":[82],"2":[86],"1.":[90],"this":[92],"article,":[93],"I":[94],"review":[95],"progress":[97],"over":[98],"last":[100],"years":[102],"attempt":[104],"assess":[106],"whether":[107],"for":[110],"cascade":[113],"hypothesis":[114],"still":[115],"stands":[116],"scrutiny.":[117]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
