{"id":"https://openalex.org/W2167307330","doi":null,"title":"Role of loss of heterozygosity on chromosomes 8 and 9 in the development and progression of cancer bladder.","display_name":"Role of loss of heterozygosity on chromosomes 8 and 9 in the development and progression of cancer bladder.","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W2167307330","mag":"2167307330","pmid":"https://pubmed.ncbi.nlm.nih.gov/17102820"},"language":"en","primary_location":{"id":"pmid:17102820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17102820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Egyptian National Cancer Institute","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010837421","display_name":"Abdel Hady A. Abdel Wahab","orcid":"https://orcid.org/0000-0002-5110-2600","observed_orcids":["https://orcid.org/0000-0002-5110-2600"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abdel Hady A Abdel Wahab","raw_affiliation_strings":["The Department of Biochemistry & Molecular Biology Unit, NCI, Cairo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Biochemistry & Molecular Biology Unit, NCI, Cairo University","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076719034","display_name":"Abo-Zeid Hi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamdy I Abo-Zeid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073128662","display_name":"El-Husseini Mi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Motawa I El-Husseini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mohsein Ismail","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohsein Ismail","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058310790","display_name":"El-Khor Am","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akmal M El-Khor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"17","issue":"4","first_page":"260","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.906000018119812},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":0.828000009059906},{"id":"https://openalex.org/keywords/chromosome-8","display_name":"chromosome 8","score":0.9459999799728394},{"id":"https://openalex.org/keywords/chromosome-9","display_name":"chromosome 9","score":1.0},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9380000233650208},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.9169999957084656},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9020000100135803},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6119999885559082},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.6190000176429749},{"id":"https://openalex.org/keywords/egypt","display_name":"Egypt","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.9330991506576538},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.7050073146820068},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.5817834734916687},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5386917591094971},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5034965872764587},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.47562435269355774},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.460843563079834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45108067989349365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4006960093975067},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3286895453929901},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2610657215118408},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24437764286994934},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.172480046749115},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.13311690092086792},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002898","descriptor_name":"Chromosomes, Human, Pair 8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012553","descriptor_name":"Schistosomiasis haematobia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17102820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17102820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Egyptian National Cancer Institute","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.493.3993","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.493.3993","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.nci.cu.edu.eg/journal/dec2005/can_5.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W373694398","https://openalex.org/W1495871951","https://openalex.org/W1556964337","https://openalex.org/W1578360608","https://openalex.org/W1586205496","https://openalex.org/W1930547966","https://openalex.org/W1938606373","https://openalex.org/W1975637274","https://openalex.org/W1980265288","https://openalex.org/W1980391116","https://openalex.org/W1980591242","https://openalex.org/W1983348452","https://openalex.org/W1983528692","https://openalex.org/W1983892050","https://openalex.org/W1986373643","https://openalex.org/W1995308076","https://openalex.org/W1997073961","https://openalex.org/W2011743880","https://openalex.org/W2013082284","https://openalex.org/W2039609330","https://openalex.org/W2044616474","https://openalex.org/W2048564117","https://openalex.org/W2056319006","https://openalex.org/W2058922488","https://openalex.org/W2063573121","https://openalex.org/W2070767841","https://openalex.org/W2082551213","https://openalex.org/W2095129853","https://openalex.org/W2098528310","https://openalex.org/W2115180191","https://openalex.org/W2117680513","https://openalex.org/W2123335542","https://openalex.org/W2127001212","https://openalex.org/W2135687675","https://openalex.org/W2138684882","https://openalex.org/W2139212919","https://openalex.org/W2142438542","https://openalex.org/W2144634347","https://openalex.org/W2152416636","https://openalex.org/W2162147642","https://openalex.org/W2259431586","https://openalex.org/W2266358381","https://openalex.org/W2280945471","https://openalex.org/W2289092351","https://openalex.org/W2315914439","https://openalex.org/W2318318177","https://openalex.org/W2326370166","https://openalex.org/W2331638751","https://openalex.org/W2333334059","https://openalex.org/W2395608744","https://openalex.org/W2407060063","https://openalex.org/W2460306028","https://openalex.org/W2466317016"],"related_works":["https://openalex.org/W2001937439","https://openalex.org/W2048564117","https://openalex.org/W1596875459","https://openalex.org/W2365612475","https://openalex.org/W4251946978","https://openalex.org/W2259431586","https://openalex.org/W2318318177","https://openalex.org/W2091024913","https://openalex.org/W2402601875","https://openalex.org/W2380311244"],"abstract_inverted_index":{"BACKGROUND:":[0],"Loss":[1],"of":[2,17,37,43,59,65,74,84,90,92,107,139,151,191,203,218,249,265,295,325,358,383,399,436,448,459,461],"heterozygosity":[3],"(LOH)":[4],"in":[5,34,53,79,205,210,267,330,334,355,381,396,419,457],"tumor":[6,20,131,251,345,376,401,438],"samples":[7,138],"is":[8,47,69,394,429],"believed":[9],"to":[10,56,70,102,243,431,483],"be":[11,244,432,481],"a":[12,18,35,370,433,488],"marker":[13],"for":[14,181,222,228,231,235,277,285],"the":[15,44,49,57,66,72,80,104,108,130,134,195,250,296,323,400,412,442,462],"absence":[16],"functional":[19],"suppressor":[21,346,377,439],"gene.":[22],"Non-random":[23],"chromosome":[24,206,239,268,467],"deletion":[25],"and":[26,77,114,133,146,164,171,177,233,252,272,288,327,351,364,452,469],"LOH":[27,91,105,173,204,219,253,266,299,328,460],"at":[28,174,188,211,238,254,300,362,366,372,407,415],"specific":[29],"chromosomal":[30],"regions":[31,190],"are":[32,353,417],"identified":[33],"number":[36],"common":[38],"human":[39],"cancers":[40],"including":[41],"carcinoma":[42,422],"bladder,":[45],"which":[46],"considered":[48,430],"most":[50],"predominant":[51],"cancer":[52,87,143,456,479,485],"Egypt":[54],"due":[55],"prevalence":[58],"schistosomiasis.":[60],"PURPOSE:":[61],"The":[62,200,215,262],"main":[63],"objective":[64],"present":[67,443],"study":[68,387,444],"clarify":[71],"role":[73],"chromosomes":[75,175,193,349],"8":[76,93,176,182,207,240,350,468],"9":[78,178,269,352],"establishment":[81],"and/or":[82],"progression":[83],"schistosomiasis-related":[85],"bladder":[86,117,142,359,384,455,478,484],"through":[88],"detection":[89],"microsatellite":[94,185,464],"markers":[95,110,186,332,465],"on":[96,348,466],"both":[97,192,397],"chromosomes.":[98],"It":[99],"also":[100,388],"aims":[101],"compare":[103],"pattern":[106],"tested":[109,463],"between":[111,322,450],"schistosomiasis-":[112],"associated":[113,245,257],"non":[115,147,453],"schistosomiasis-associated":[116,454],"cancer.":[118,385],"MATERIAL":[119],"AND":[120],"METHODS:":[121],"To":[122],"achieve":[123],"this":[124,335],"purpose,":[125],"DNA":[126],"was":[127,179,208,220,256,270,276,320],"extracted":[128],"from":[129,476],"specimens":[132],"corresponding":[135],"peripheral":[136],"blood":[137],"42":[140],"primary":[141],"patients":[144],"(schistosomal":[145],"schistosomal).":[148],"Twenty":[149],"nine":[150,292],"these":[152],"were":[153,161,166,241,302,312],"diagnosed":[154,303],"as":[155,304,409,411],"squamous":[156,305,420],"cell":[157,306,314,421],"type":[158,307,315],"(SCC),":[159,308],"11":[160],"transitional":[162,313,425],"(TCC),":[163],"2":[165],"adenocarcinoma":[167],"(with":[168],"different":[169,189],"stages":[170],"grades).":[172],"evaluated":[180],"highly":[183],"polymorphic":[184],"distributed":[187],"using":[194],"dinucleotide":[196],"repeat-PCR":[197],"technique.":[198],"RESULTS:":[199],"overall":[201,263],"percentage":[202,264],"74%":[209],"least":[212],"one":[213,344,361],"marker.":[214],"highest":[216,274],"incidence":[217,275],"recorded":[221,321],"D8S84":[223],"(41%)":[224],"followed":[225,280],"by":[226,281,487],"37%":[227],"D8S87,":[229],"29%":[230],"D8S85,":[232],"25%":[234],"D8S88.":[236],"Deletions":[237],"shown":[242],"with":[246,258,298],"high":[247,356],"grade":[248],"D8S85":[255],"metastatic":[259],"lymph":[260],"nodes.":[261],"54%":[271],"its":[273],"D9S126":[278],"(36%),":[279],"26%,":[282],"21%,":[283],"19%":[284],"D9S166,":[286],"D9S128":[287],"D9S180,":[289],"respectively.":[290],"Fifty":[291],"percent":[293],"(59%)":[294],"cases":[297],"9q":[301],"whereas":[309],"9%":[310],"only":[311],"(TCC).":[316],"No":[317],"significant":[318],"association":[319],"presence":[324],"schistosomiasis":[326,489],"detected":[329],"all":[331],"used":[333],"study.":[336],"CONCLUSION:":[337],"Our":[338,386],"data":[339,474],"indicate":[340],"that":[341,379,390,473],"more":[342],"than":[343,424],"gene":[347,378,414],"involved":[354,380,395,418],"grades":[357],"carcinogenesis,":[360],"8p12":[363],"another":[365],"8q21.1":[367],"regions.":[368],"Also,":[369],"region":[371,393,435],"8q23-quarter":[373],"may":[374],"harbor":[375],"metastasis":[382],"revealed":[389],"9p21":[391],"(p16INK4)":[392],"types":[398],"(SCC":[402],"&":[403],"TCC).":[404],"PTCH":[405],"located":[406],"9q22.3,":[408],"well":[410],"TSC":[413],"9q34":[416],"rather":[423],"carcinoma.":[426],"Region":[427],"9q12-13":[428],"critical":[434],"urothelial":[437],"genes.":[440],"Finally,":[441],"shows":[445],"no":[446],"line":[447],"demarcation":[449],"schistosomiasis-associate":[451],"terms":[458],"9.":[470],"This":[471],"suggests":[472],"obtained":[475],"schistosoma-associated":[477],"can":[480],"extrapolated":[482],"induced":[486],"independent":[490],"mechanism.":[491]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
