{"id":"https://openalex.org/W2167204367","doi":"https://doi.org/10.1073/pnas.1004604107","title":"Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance","display_name":"Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance","publication_year":2010,"publication_date":"2010-05-24","ids":{"openalex":"https://openalex.org/W2167204367","doi":"https://doi.org/10.1073/pnas.1004604107","mag":"2167204367","pmid":"https://pubmed.ncbi.nlm.nih.gov/20498076"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1004604107","doi":"https://doi.org/10.1073/pnas.1004604107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1004604107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890783","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060238118","display_name":"Olga B. Garbuzenko","orcid":"https://orcid.org/0000-0003-3685-7703","observed_orcids":["https://orcid.org/0000-0003-3685-7703"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga B. Garbuzenko","raw_affiliation_strings":["Departments of aPharmaceutics,","Departments of a Pharmaceutics,","Rutgers, The State University of New Jersey, Piscataway, NJ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of aPharmaceutics,","institution_ids":[]},{"raw_affiliation_string":"Departments of a Pharmaceutics,","institution_ids":[]},{"raw_affiliation_string":"Rutgers, The State University of New Jersey, Piscataway, NJ,","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027237358","display_name":"Maha Saad","orcid":"https://orcid.org/0000-0001-8049-4837","observed_orcids":["https://orcid.org/0000-0001-8049-4837"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maha Saad","raw_affiliation_strings":["Departments of aPharmaceutics,","Departments of a Pharmaceutics,","Rutgers, The State University of New Jersey, Piscataway, NJ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of aPharmaceutics,","institution_ids":[]},{"raw_affiliation_string":"Departments of a Pharmaceutics,","institution_ids":[]},{"raw_affiliation_string":"Rutgers, The State University of New Jersey, Piscataway, NJ,","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064826962","display_name":"Vitaly P. Pozharov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vitaly P. Pozharov","raw_affiliation_strings":["Departments of aPharmaceutics,","Departments of a Pharmaceutics,","Rutgers, The State University of New Jersey, Piscataway, NJ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of aPharmaceutics,","institution_ids":[]},{"raw_affiliation_string":"Departments of a Pharmaceutics,","institution_ids":[]},{"raw_affiliation_string":"Rutgers, The State University of New Jersey, Piscataway, NJ,","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039403500","display_name":"Kenneth R. Reuhl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4210109165","display_name":"Environmental and Occupational Health Sciences Institute","ror":"https://ror.org/01vta4r13","country_code":"US","type":"education","lineage":["https://openalex.org/I4210109165"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth R. Reuhl","raw_affiliation_strings":["Cancer Institute of New Jersey, New Brunswick, NJ 08903","Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08855; and","Pharmacology and Toxicology, and","Pharmacology and Toxicology, and e Environmental Sciences, Rutgers, The State University of New Jersey, Piscataway, NJ 08854;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of New Jersey, New Brunswick, NJ 08903","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08855; and","institution_ids":["https://openalex.org/I4210109165"]},{"raw_affiliation_string":"Pharmacology and Toxicology, and","institution_ids":[]},{"raw_affiliation_string":"Pharmacology and Toxicology, and e Environmental Sciences, Rutgers, The State University of New Jersey, Piscataway, NJ 08854;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071394033","display_name":"Gediminas Mainelis","orcid":"https://orcid.org/0000-0002-5837-0413","observed_orcids":["https://orcid.org/0000-0002-5837-0413"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4210109165","display_name":"Environmental and Occupational Health Sciences Institute","ror":"https://ror.org/01vta4r13","country_code":"US","type":"education","lineage":["https://openalex.org/I4210109165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gediminas Mainelis","raw_affiliation_strings":["Environmental Sciences, Rutgers, The State University of New Jersey, Piscataway, NJ 08854;","Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08855; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Sciences, Rutgers, The State University of New Jersey, Piscataway, NJ 08854;","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08855; and","institution_ids":["https://openalex.org/I4210109165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084229113","display_name":"Tamara Minko","orcid":"https://orcid.org/0000-0002-1633-4705","observed_orcids":["https://orcid.org/0000-0002-1633-4705"]},"institutions":[{"id":"https://openalex.org/I4210109165","display_name":"Environmental and Occupational Health Sciences Institute","ror":"https://ror.org/01vta4r13","country_code":"US","type":"education","lineage":["https://openalex.org/I4210109165"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tamara Minko","raw_affiliation_strings":["Cancer Institute of New Jersey, New Brunswick, NJ 08903","Departments of aPharmaceutics,","Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08855; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute of New Jersey, New Brunswick, NJ 08903","institution_ids":["https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Departments of aPharmaceutics,","institution_ids":[]},{"raw_affiliation_string":"Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08855; and","institution_ids":["https://openalex.org/I4210109165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084229113"],"corresponding_institution_ids":["https://openalex.org/I4210109165","https://openalex.org/I4390039325"],"apc_list":null,"apc_paid":null,"fwci":9.5785,"has_fulltext":false,"cited_by_count":185,"citation_normalized_percentile":{"value":0.98461475,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"107","issue":"23","first_page":"10737","last_page":"10742"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8519999980926514},{"id":"https://openalex.org/keywords/pulmonary-drug-delivery","display_name":"pulmonary drug delivery","score":0.7540000081062317},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mrp1","display_name":"MRP1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.949999988079071},{"id":"https://openalex.org/keywords/nanoscale-drug-delivery-systems","display_name":"nanoscale drug delivery systems","score":0.7900000214576721},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7229302525520325},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6423286199569702},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6347772479057312},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5515130758285522},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5207455158233643},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.48768413066864014},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.47503000497817993},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4746951460838318},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4481394588947296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42045435309410095},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41452962160110474},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.4117979407310486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30924737453460693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2475569248199463},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.19460830092430115},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13555243611335754},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"Multidrug Resistance-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"Multidrug Resistance-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027425","descriptor_name":"ATP-Binding Cassette, Sub-Family C Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.1004604107","doi":"https://doi.org/10.1073/pnas.1004604107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1004604107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:20498076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20498076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2890783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890783","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2890783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890783","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8799999952316284}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1050258367","display_name":null,"funder_award_id":"CA100098","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2335379388","display_name":null,"funder_award_id":"R01CA111766","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5240131893","display_name":null,"funder_award_id":"CA111766","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6266095117","display_name":null,"funder_award_id":"R01- CA 100098","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6732002110","display_name":"Targeted Proapoptotic Anticancer Drug Delivery Systems","funder_award_id":"5r01ca100098-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000308976","display_name":null,"funder_award_id":"CA111766","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000908092","display_name":"Rutgers Center for Environmental Exposure and Disease (CEED)","funder_award_id":"5p30es005022-38","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G979940031","display_name":null,"funder_award_id":"P-30 ES-005022","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W4042391","https://openalex.org/W8201858","https://openalex.org/W165638465","https://openalex.org/W1528605240","https://openalex.org/W1970856195","https://openalex.org/W1977821855","https://openalex.org/W1987194369","https://openalex.org/W1988754095","https://openalex.org/W1996684647","https://openalex.org/W2005312471","https://openalex.org/W2005883236","https://openalex.org/W2015299325","https://openalex.org/W2019013760","https://openalex.org/W2019333319","https://openalex.org/W2024655431","https://openalex.org/W2054841768","https://openalex.org/W2058277702","https://openalex.org/W2078975507","https://openalex.org/W2081666018","https://openalex.org/W2098115672","https://openalex.org/W2098602548","https://openalex.org/W2103273069","https://openalex.org/W2112397292","https://openalex.org/W2126954923","https://openalex.org/W2127587523","https://openalex.org/W2138344667","https://openalex.org/W2139105036","https://openalex.org/W2144779713","https://openalex.org/W2148307534","https://openalex.org/W2150702593","https://openalex.org/W2152510700","https://openalex.org/W2318149311","https://openalex.org/W2405586907","https://openalex.org/W6808776614"],"related_works":["https://openalex.org/W2357590574","https://openalex.org/W2984941165","https://openalex.org/W2364091570","https://openalex.org/W2192248769","https://openalex.org/W2530972874","https://openalex.org/W2075277543","https://openalex.org/W3030144693","https://openalex.org/W2040295781","https://openalex.org/W2347640185","https://openalex.org/W2169311351"],"abstract_inverted_index":{"Development":[0],"of":[1,7,25,37,44,73,83,95,111,133,144,148],"cancer":[2,135],"cell":[3,61],"resistance,":[4,85],"low":[5,107],"accumulation":[6],"therapeutic":[8],"drug":[9],"in":[10,40],"the":[11,131],"lungs,":[12],"and":[13,46,76,88,106,146,150],"severe":[14],"adverse":[15,108],"treatment":[16,115,132],"side":[17,109],"effects":[18,110],"represent":[19],"main":[20],"obstacles":[21],"to":[22,67,77,130],"efficient":[23],"chemotherapy":[24],"lung":[26,97,134],"cancer.":[27],"To":[28,50],"overcome":[29],"these":[30],"difficulties,":[31],"we":[32],"propose":[33],"inhalation":[34,142],"local":[35,141],"delivery":[36,55,143],"anticancer":[38],"drugs":[39,145],"combination":[41],"with":[42],"suppressors":[43,147],"pump":[45,74,149],"nonpump":[47,84,151],"cellular":[48,152],"resistance.":[49,153],"test":[51],"this":[52],"approach,":[53],"nanoscale-based":[54],"systems":[56],"containing":[57],"doxorubicin":[58],"as":[59,70,80],"a":[60,71,81,138],"death":[62],"inducer,":[63],"antisense":[64],"oligonucleotides":[65],"targeted":[66],"MRP1":[68],"mRNA":[69,79],"suppressor":[72,82],"resistance":[75],"BCL2":[78],"were":[86],"developed":[87],"examined":[89],"on":[90],"an":[91],"orthotopic":[92],"murine":[93],"model":[94],"human":[96],"carcinoma.":[98],"The":[99,125],"experimental":[100],"results":[101],"show":[102],"high":[103],"antitumor":[104],"activity":[105],"proposed":[112],"complex":[113],"inhalatory":[114],"that":[116],"cannot":[117],"be":[118],"achieved":[119],"by":[120,136],"individual":[121],"components":[122],"applied":[123],"separately.":[124],"present":[126],"work":[127],"potentially":[128],"contributes":[129],"describing":[137],"unique":[139],"combinatorial":[140]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-20T09:52:01.089006","created_date":"2025-10-10T00:00:00"}