{"id":"https://openalex.org/W2167127947","doi":null,"title":"Functional analysis of genes in the developing zebrafish pronephros and vasculature","display_name":"Functional analysis of genes in the developing zebrafish pronephros and vasculature","publication_year":2009,"publication_date":"2009-08-21","ids":{"openalex":"https://openalex.org/W2167127947","mag":"2167127947"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26911864","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Functional_analysis_of_genes_in_the_developing_zebrafish_pronephros_and_vasculature/26911864","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/38036","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105460556","display_name":"Lwaki Ebarasi","orcid":"https://orcid.org/0000-0001-7767-196X","observed_orcids":["https://orcid.org/0000-0001-7767-196X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lwaki Ebarasi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5105460556"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glomerulogenesis","display_name":"glomerulogenesis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/glomerular-filtration-barrier","display_name":"glomerular filtration barrier","score":0.8880000114440918},{"id":"https://openalex.org/keywords/podocytes","display_name":"podocytes","score":0.722000002861023},{"id":"https://openalex.org/keywords/slit-diaphragm","display_name":"slit diaphragm","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nephrin","display_name":"nephrin","score":0.6809999942779541},{"id":"https://openalex.org/keywords/apicobasal-polarity","display_name":"apical-basal polarity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/angiomotin","display_name":"angiomotin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.49799999594688416},{"id":"https://openalex.org/keywords/mesangial-cells","display_name":"mesangial cells","score":0.7820000052452087},{"id":"https://openalex.org/keywords/glomerular-permeability","display_name":"glomerular permeability","score":0.8100000023841858},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C3018201436","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Slit diaphragm","level":5,"score":0.8318158388137817},{"id":"https://openalex.org/C31697123","wikidata":"https://www.wikidata.org/wiki/Q2656768","display_name":"Pronephros","level":4,"score":0.7701475620269775},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7592424750328064},{"id":"https://openalex.org/C2778305430","wikidata":"https://www.wikidata.org/wiki/Q26261754","display_name":"Glomerulus","level":3,"score":0.743287205696106},{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.7096418738365173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6763748526573181},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5778124928474426},{"id":"https://openalex.org/C3018920779","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Renal glomerulus","level":4,"score":0.5404447317123413},{"id":"https://openalex.org/C136571751","wikidata":"https://www.wikidata.org/wiki/Q424607","display_name":"Morpholino","level":4,"score":0.41604506969451904},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.27891576290130615},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.2650284469127655},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2482626736164093},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23987168073654175},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.20652297139167786},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1582118272781372}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26911864","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Functional_analysis_of_genes_in_the_developing_zebrafish_pronephros_and_vasculature/26911864","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/38036","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38036","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2167127947","doi":null,"is_oa":false,"landing_page_url":"http://openarchive.ki.se/xmlui/bitstream/10616/38036/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/38036","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38036","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":119,"referenced_works":["https://openalex.org/W130911030","https://openalex.org/W140105264","https://openalex.org/W170348712","https://openalex.org/W183565456","https://openalex.org/W334103251","https://openalex.org/W1495901582","https://openalex.org/W1499677744","https://openalex.org/W1521774859","https://openalex.org/W1528367246","https://openalex.org/W1531738684","https://openalex.org/W1560056935","https://openalex.org/W1566059459","https://openalex.org/W1574816972","https://openalex.org/W1604175377","https://openalex.org/W1679229092","https://openalex.org/W1715095109","https://openalex.org/W1821971849","https://openalex.org/W1933480341","https://openalex.org/W1946731981","https://openalex.org/W1962628502","https://openalex.org/W1965064672","https://openalex.org/W1966032423","https://openalex.org/W1967853257","https://openalex.org/W1978871485","https://openalex.org/W1980642761","https://openalex.org/W1980979311","https://openalex.org/W1982486040","https://openalex.org/W1983350492","https://openalex.org/W1985366772","https://openalex.org/W1994061670","https://openalex.org/W1994404140","https://openalex.org/W1994755074","https://openalex.org/W1995698561","https://openalex.org/W1998756807","https://openalex.org/W2004434166","https://openalex.org/W2008345098","https://openalex.org/W2009671571","https://openalex.org/W2010589579","https://openalex.org/W2012569825","https://openalex.org/W2013614705","https://openalex.org/W2014434196","https://openalex.org/W2021933189","https://openalex.org/W2022724803","https://openalex.org/W2026431524","https://openalex.org/W2027097760","https://openalex.org/W2027654614","https://openalex.org/W2029863361","https://openalex.org/W2037817314","https://openalex.org/W2038855861","https://openalex.org/W2039537505","https://openalex.org/W2040435657","https://openalex.org/W2040575932","https://openalex.org/W2043474702","https://openalex.org/W2044158279","https://openalex.org/W2046013104","https://openalex.org/W2046831598","https://openalex.org/W2048156844","https://openalex.org/W2048501294","https://openalex.org/W2052374677","https://openalex.org/W2054225562","https://openalex.org/W2057452785","https://openalex.org/W2057846426","https://openalex.org/W2058172582","https://openalex.org/W2061105559","https://openalex.org/W2063197874","https://openalex.org/W2065940152","https://openalex.org/W2070572720","https://openalex.org/W2072084253","https://openalex.org/W2073606372","https://openalex.org/W2075047490","https://openalex.org/W2075321187","https://openalex.org/W2078298967","https://openalex.org/W2080064943","https://openalex.org/W2082188115","https://openalex.org/W2082589861","https://openalex.org/W2084341903","https://openalex.org/W2085544165","https://openalex.org/W2086272423","https://openalex.org/W2087358436","https://openalex.org/W2091760375","https://openalex.org/W2092550529","https://openalex.org/W2096791952","https://openalex.org/W2097245106","https://openalex.org/W2097581597","https://openalex.org/W2097860814","https://openalex.org/W2104088479","https://openalex.org/W2105388550","https://openalex.org/W2110001721","https://openalex.org/W2113506655","https://openalex.org/W2119619243","https://openalex.org/W2119711419","https://openalex.org/W2124091323","https://openalex.org/W2126022125","https://openalex.org/W2126394082","https://openalex.org/W2127065370","https://openalex.org/W2128545033","https://openalex.org/W2128680169","https://openalex.org/W2128796050","https://openalex.org/W2129416468","https://openalex.org/W2132531056","https://openalex.org/W2133282797","https://openalex.org/W2137506447","https://openalex.org/W2138846202","https://openalex.org/W2141744996","https://openalex.org/W2142941757","https://openalex.org/W2146412972","https://openalex.org/W2148985319","https://openalex.org/W2156549070","https://openalex.org/W2158624339","https://openalex.org/W2164705615","https://openalex.org/W2167103757","https://openalex.org/W2168287443","https://openalex.org/W2168436318","https://openalex.org/W2169199162","https://openalex.org/W2171761187","https://openalex.org/W2172160601","https://openalex.org/W2276129660","https://openalex.org/W2303555161","https://openalex.org/W2415146999"],"related_works":["https://openalex.org/W2073606372","https://openalex.org/W2028089759","https://openalex.org/W4383710365","https://openalex.org/W2241269383","https://openalex.org/W3093638833","https://openalex.org/W1588480621","https://openalex.org/W7168129953","https://openalex.org/W2056927344","https://openalex.org/W3032935995","https://openalex.org/W2118827680"],"abstract_inverted_index":{"During":[0],"glomerulogenesis,":[1],"the":[2,22,25,42,47,50,67,76,81,90,100,106,112,116,130,149,170,190,197,222,264,312,355,359,367,376,391,425,435,441,445,448,453,455,465,471,479,492,507,520,544,550,584,592,662,667],"recruitment":[3],"and":[4,14,46,83,86,94,119,124,193,302,332,335,387,397,407,423,467,497,510,528],"assembly":[5],"of":[6,24,34,49,69,78,102,114,164,182,189,196,270,306,315,323,337,393,430,447,452,514,519,543,560,591,602,664],"visceral":[7],"epithelial":[8],"cells":[9,121,459,489,499,540],"(podocytes),":[10],"endothelial":[11,328,404,639],"capillary":[12],"cells,":[13],"smooth":[15],"muscle":[16],"pericytes":[17,463,665],"(mesangial":[18],"cells)":[19],"result":[20],"in":[21,105,141,200,221,229,258,287,327,354,362,390,403,419,506,517,537,583],"formation":[23,310,334,392,422],"glomerular":[26,43,64,85,151,165,183,219,231,248,256,436,472,521,545,593],"tuft.":[27,546],"The":[28,319],"mature":[29,131],"glomerulus":[30,132,173,466],"functions":[31],"by":[32,61],"passage":[33],"plasma":[35],"under":[36],"hemodynamic":[37],"pressure":[38],"across":[39],"a":[40,144,156,175,206,214,246,268,279,304,345,384,401,475,531,553,589],"filter,":[41],"filtration":[44,70,107,250,594],"barrier,":[45],"integrity":[48],"barrier":[51,71,108],"is":[52,66,133,216,284],"crucial":[53],"for":[54,218,254,417,427,530,534,555,661],"proper":[55],"function.":[56,232,291],"A":[57,577,579,658],"common":[58],"pathology":[59],"shared":[60],"virtually":[62],"all":[63],"diseases":[65],"loss":[68],"function":[72,122,220,382,416],"leading":[73],"to":[74,160,178,204,252,444],"proteinuria,":[75],"leakage":[77],"protein":[79,300],"into":[80],"urine,":[82],"further":[84],"tubular":[87],"damage.":[88],"Thus,":[89],"podocyte":[91,271],"slit":[92,281],"diaphragm":[93,282],"its":[95],"associated":[96,503],"proteins":[97,297,324],"have":[98,168,239],"been":[99,483],"focus":[101],"intense":[103],"research":[104],"field.":[109],"Even":[110],"so,":[111],"understanding":[113,307],"how":[115],"podocytes,":[117],"endothelia,":[118],"mesangial":[120,456,539],"together":[123],"communicate":[125],"with":[126,202,245,470,504],"each":[127],"other":[128],"within":[129,311,342,366,375,434,464,478,666],"at":[134],"an":[135,413],"early":[136,493],"stage.":[137],"With":[138],"this":[139,234,338,398],"question":[140],"mind,":[142],"GlomBase,":[143],"bioinformatics":[145],"database":[146],"that":[147,212,277,295,490],"describes":[148],"mammalian":[150,230],"transcriptome,":[152],"was":[153],"created":[154],"as":[155,174,267,552,588],"foundation":[157],"from":[158,400],"which":[159,372],"explore":[161],"new":[162],"aspects":[163,181],"biology.":[166,184],"We":[167,210,262,275,438,487],"applied":[169,440],"zebrafish":[171,223,260,363,442,480,551,585],"pronephric":[172],"model":[176],"system":[177,199,554],"study":[179,446],"novel":[180,235],"Our":[185],"approach":[186],"takes":[187],"advantage":[188],"rapid":[191],"development":[192],"genetic":[194,236,581],"accessibility":[195],"renal":[198],"combination":[201],"GlomBase":[203],"conduct":[205],"highthroughput":[207],"functional":[208],"analysis.":[209],"reasoned":[211],"if":[213],"gene":[215,241,266,361],"important":[217,228],"it":[224],"might":[225],"also":[226,501],"be":[227],"In":[233],"screen,":[237],"we":[238,357],"coupled":[240],"knockdown":[242,513],"using":[243,364],"morpholinos":[244,365],"physiological":[247],"dye":[249],"assay":[251],"test":[253],"selective":[255],"permeability":[257],"living":[259],"larvae.":[261],"identified":[263,412],"crb2b":[265,290,587],"regulator":[269,590],"foot":[272,308],"process":[273,309],"formation.":[274,409],"found":[276,488],"Nephrin,":[278],"major":[280],"component,":[283],"apically":[285],"mis-localized":[286],"podocytes":[288],"lacking":[289,380],"These":[292,410,547],"observations":[293],"suggest":[294],"Crb":[296],"may":[298],"regulate":[299],"trafficking":[301],"provide":[303],"way":[305,426],"larger":[313],"context":[314],"apical-basal":[316],"cell":[317,330,405,450,640],"differentiation.":[318],"Angiomotin":[320,351,637],"(Amot)":[321],"family":[322,339,352,432],"plays":[325],"roles":[326],"migration,":[329],"shape,":[331],"tube":[333],"members":[336,353,433],"are":[340,460],"present":[341],"GlomBase.":[343],"As":[344],"first":[346],"step":[347],"towards":[348],"functionally":[349],"characterizing":[350],"zebrafish,":[356],"inactivated":[358],"amot":[360,381,418],"Tg":[368],"(fli1:EGFP)y1":[369],"transgenic":[370],"line":[371],"expresses":[373],"GFP":[374],"developing":[377],"vasculature.":[378,437],"Zebrafish":[379],"showed":[383],"clear,":[385],"specific,":[386],"quantifiable":[388],"defect":[389,402],"intersegmental":[394],"vessels":[395],"(ISVs)":[396],"arose":[399],"migration":[406,641],"filopodia":[408],"studies":[411,429,548],"evolutionarily":[414],"conserved":[415,532],"blood":[420],"vessel":[421],"paved":[424],"future":[428],"Amot":[431],"then":[439],"pronephros":[443],"third":[449],"type":[451],"glomerulus,":[454],"cell.":[457],"Mesangial":[458],"specialized":[461],"vascular":[462],"associate":[468],"intimately":[469],"capillaries.":[473],"However,":[474],"pericyte":[476,494,557],"population":[477],"has":[481],"not":[482],"thus":[484],"far":[485],"described.":[486],"express":[491],"marker":[495],"pdgfrb":[496,515],"these":[498],"were":[500],"closely":[502],"vasculature":[505],"eye,":[508],"brain,":[509],"glomerulus.":[511],"Morpholino":[512],"resulted":[516],"dilation":[518],"capillaries":[522],"phenocopying":[523],"mouse":[524],"knock":[525],"out":[526],"data":[527],"arguing":[529],"role":[533],"Pdgfrb":[535],"signaling":[536],"recruiting":[538],"during":[541,642],"maturation":[542],"establish":[549],"studying":[556],"development.":[558],"List":[559],"scientific":[561],"papers":[562],"I.":[563],"Ebarasi":[564,610,651],"L,":[565,567,611,613,631,652],"He":[566],"Hultenby":[568],"K,":[569,575,607,654],"Takemoto":[570],"M,":[571,609],"Betsholtz":[572,655],"C,":[573,617,656],"Tryggvason":[574],"Majumdar":[576,614,657],"(2009).":[578,659],"reverse":[580],"screen":[582],"identifies":[586],"barrier.":[595],"Dev":[596],"Biol.":[597],"Apr":[598],"23:":[599],"Epub":[600],"ahead":[601],"print":[603],"https://pubmed.ncbi.nlm.nih.gov/19393641":[604],"II.":[605],"Aase":[606],"Ernkvist":[608],"Jakobsson":[612],"A,":[615,623,633],"Yi":[616],"Birot":[618],"O,":[619],"Ming":[620],"Y,":[621],"Kvanta":[622],"Edholm":[624],"D,":[625],"Aspenstr\u00f6m":[626],"P,":[627],"Kissil":[628],"J,":[629],"Claesson-Welsh":[630],"Shimono":[632],"Holmgren":[634],"L":[635],"(2007).":[636],"regulates":[638],"embryonic":[643],"angiogenesis.":[644],"Genes":[645],"Dev.":[646],"21(16):":[647],"2055-68":[648],"https://pubmed.ncbi.nlm.nih.gov/17699752":[649],"III.":[650],"Gaengel":[653],"Evidence":[660],"presence":[663],"zebrafish.":[668],"[Manuscript]":[669]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}
