{"id":"https://openalex.org/W2167127342","doi":"https://doi.org/10.1083/jcb.97.1.145","title":"Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture.","display_name":"Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture.","publication_year":1983,"publication_date":"1983-07-01","ids":{"openalex":"https://openalex.org/W2167127342","doi":"https://doi.org/10.1083/jcb.97.1.145","mag":"2167127342","pmid":"https://pubmed.ncbi.nlm.nih.gov/6863388","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112489"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.97.1.145","doi":"https://doi.org/10.1083/jcb.97.1.145","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.97.1.145","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112489","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032995907","display_name":"Urs S. Rutishauser","orcid":"https://orcid.org/0000-0001-7869-600X","observed_orcids":["https://orcid.org/0000-0001-7869-600X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Rutishauser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016024281","display_name":"Martin Grumet","orcid":"https://orcid.org/0000-0002-0447-6634","observed_orcids":["https://orcid.org/0000-0002-0447-6634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Grumet","raw_affiliation_strings":["School of Arts and Sciences, Cell Biology & Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Arts and Sciences, Cell Biology & Neuroscience","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111917213","display_name":"Gerald M. Edelman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G M Edelman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.5127,"has_fulltext":false,"cited_by_count":189,"citation_normalized_percentile":{"value":0.98275862,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"97","issue":"1","first_page":"145","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd56","display_name":"CD56","score":0.996999979019165},{"id":"https://openalex.org/keywords/n-cam","display_name":"N-CAM","score":0.9350000023841858},{"id":"https://openalex.org/keywords/spinal-neurons","display_name":"spinal cord neurons","score":0.640999972820282},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.878000020980835},{"id":"https://openalex.org/keywords/myotubes","display_name":"myotubes","score":0.7860000133514404},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.5569999814033508},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.5849999785423279},{"id":"https://openalex.org/keywords/epitopes","display_name":"antigenic determinants","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C122871604","wikidata":"https://www.wikidata.org/wiki/Q2248886","display_name":"Neural cell adhesion molecule","level":4,"score":0.8028939962387085},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.7571940422058105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7266793251037598},{"id":"https://openalex.org/C65232495","wikidata":"https://www.wikidata.org/wiki/Q1813773","display_name":"Synaptogenesis","level":2,"score":0.6704957485198975},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.6647271513938904},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.607001543045044},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5640562772750854},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5243282914161682},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.46228575706481934},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.4432600736618042},{"id":"https://openalex.org/C2778993516","wikidata":"https://www.wikidata.org/wiki/Q7226934","display_name":"Polysialic acid","level":5,"score":0.4209677577018738},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4003804624080658},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28754132986068726},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2751249670982361},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18645834922790527},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1558171510696411},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14999282360076904},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.97.1.145","doi":"https://doi.org/10.1083/jcb.97.1.145","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.97.1.145","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2112489","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112489","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:6863388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6863388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.5794","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.5794","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/65/53/J_Cell_Biol_1983_Jul_1_97(1)_145-152.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2112489","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112489","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W167923556","https://openalex.org/W169501377","https://openalex.org/W1416261912","https://openalex.org/W1480181846","https://openalex.org/W1516340190","https://openalex.org/W1653543413","https://openalex.org/W1663863013","https://openalex.org/W1974333192","https://openalex.org/W1981147697","https://openalex.org/W1981284490","https://openalex.org/W1984775157","https://openalex.org/W1989191938","https://openalex.org/W1996401658","https://openalex.org/W2004752421","https://openalex.org/W2006298249","https://openalex.org/W2006939821","https://openalex.org/W2013727967","https://openalex.org/W2016050897","https://openalex.org/W2018289835","https://openalex.org/W2019518084","https://openalex.org/W2025079340","https://openalex.org/W2044832727","https://openalex.org/W2055325893","https://openalex.org/W2055627347","https://openalex.org/W2059397627","https://openalex.org/W2063278106","https://openalex.org/W2070141228","https://openalex.org/W2072364076","https://openalex.org/W2085979160","https://openalex.org/W2088859219","https://openalex.org/W2098274855","https://openalex.org/W2100837269","https://openalex.org/W2120994890","https://openalex.org/W2125213900","https://openalex.org/W2137738386","https://openalex.org/W2170203009","https://openalex.org/W2172124787","https://openalex.org/W7097864451"],"related_works":["https://openalex.org/W1996401658","https://openalex.org/W1979577515","https://openalex.org/W2045633617","https://openalex.org/W1965491546","https://openalex.org/W2104145284","https://openalex.org/W2113084612","https://openalex.org/W2058985714","https://openalex.org/W2141547794","https://openalex.org/W2076917151","https://openalex.org/W2058752488"],"abstract_inverted_index":{"Previous":[0],"studies":[1,60],"in":[2,24,55,97,150,172],"this":[3,78],"laboratory":[4],"have":[5],"described":[6],"a":[7,22],"cell":[8,13,50],"surface":[9],"glycoprotein,":[10],"called":[11],"neural":[12,28],"adhesion":[14,26,45,75,112,145],"molecule":[15,79],"or":[16],"N-CAM,":[17],"that":[18,62,73,106,143,162],"appears":[19],"to":[20,36,119,129],"be":[21,37,167],"ligand":[23],"the":[25,69,91,107,149],"between":[27,48,81,156],"membranes.":[29],"N-CAM":[30,70,144,165],"antigenic":[31,64],"determinants":[32,65],"were":[33],"also":[34],"shown":[35],"present":[38,59],"on":[39],"embryonic":[40],"muscle":[41,53,86,104],"and":[42,52,72,85,117,131,134,158,160],"an":[43,168],"N-CAM-dependent":[44],"was":[46],"demonstrated":[47],"retinal":[49],"membranes":[51,84],"cells":[54,118],"short-term":[56],"assays.":[57],"The":[58,121],"indicate":[61,142],"these":[63],"are":[66],"associated":[67],"with":[68,102],"polypeptide,":[71],"rapid":[74],"mediated":[76],"by":[77],"occurs":[80],"spinal":[82,100,114],"cord":[83,101,115],"cells.":[87],"Detailed":[88],"examination":[89],"of":[90,93,99,113,127,153],"effects":[92],"anti-(N-CAM)":[94],"Fab'":[95,108,122],"fragments":[96,109],"cultures":[98],"skeletal":[103],"showed":[105],"specifically":[110],"block":[111],"neurites":[116,128],"myotubes.":[120],"did":[123,135],"not":[124,136],"affect":[125],"binding":[126,163],"fibroblasts":[130],"collagen":[132],"substrate,":[133],"alter":[137],"myotube":[138],"morphology.":[139],"These":[140],"results":[141],"is":[146],"essential":[147],"for":[148],"vitro":[151],"establishment":[152],"physical":[154],"associations":[155],"nerve":[157],"muscle,":[159],"suggest":[161],"involving":[164],"may":[166],"important":[169],"early":[170],"step":[171],"synaptogenesis.":[173]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}