{"id":"https://openalex.org/W2167107922","doi":"https://doi.org/10.1128/iai.9.3.591-598.1974","title":"Influences of Dietary and Environmental Stress on Microbial Populations in the Murine Gastrointestinal Tract","display_name":"Influences of Dietary and Environmental Stress on Microbial Populations in the Murine Gastrointestinal Tract","publication_year":1974,"publication_date":"1974-03-01","ids":{"openalex":"https://openalex.org/W2167107922","doi":"https://doi.org/10.1128/iai.9.3.591-598.1974","mag":"2167107922","pmid":"https://pubmed.ncbi.nlm.nih.gov/4593471","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/414848"},"language":"en","primary_location":{"id":"doi:10.1128/iai.9.3.591-598.1974","doi":"https://doi.org/10.1128/iai.9.3.591-598.1974","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.9.3.591-598.1974","pdf_url":"https://iai.asm.org/content/iai/9/3/591.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iai.asm.org/content/iai/9/3/591.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079098463","display_name":"Gerald W. Tannock","orcid":"https://orcid.org/0000-0002-9197-733X","observed_orcids":["https://orcid.org/0000-0002-9197-733X"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald W. Tannock","raw_affiliation_strings":["Department of Microbiology, University of Illinois, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Illinois, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110798906","display_name":"Dwayne C. Savage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dwayne C. Savage","raw_affiliation_strings":["Department of Microbiology, University of Illinois, Urbana, Illinois 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Illinois, Urbana, Illinois 61801","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":null,"apc_paid":null,"fwci":1.6186,"has_fulltext":false,"cited_by_count":349,"citation_normalized_percentile":{"value":0.82149146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"9","issue":"3","first_page":"591","last_page":"598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nutrient-stress","display_name":"nutritional stress","score":0.8429999947547913},{"id":"https://openalex.org/keywords/environmental-stress","display_name":"environmental stress","score":0.968999981880188},{"id":"https://openalex.org/keywords/food-deprivation","display_name":"food deprivation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.9679999947547913},{"id":"https://openalex.org/keywords/coliform-bacteria","display_name":"coliform bacteria","score":0.7360000014305115},{"id":"https://openalex.org/keywords/lactobacilli","display_name":"lactobacilli","score":0.9779999852180481},{"id":"https://openalex.org/keywords/fusiform-bacteria","display_name":"fusiform bacteria","score":0.7459999918937683},{"id":"https://openalex.org/keywords/anaerobic-bacteria","display_name":"anaerobic bacteria","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cecal-bacteria","display_name":"cecal bacteria","score":0.43299999833106995},{"id":"https://openalex.org/keywords/intestinal-bacteria","display_name":"intestinal bacteria","score":0.3059999942779541},{"id":"https://openalex.org/keywords/mouse-strains","display_name":"mouse strains","score":0.5080000162124634},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2777507495","wikidata":"https://www.wikidata.org/wiki/Q185317","display_name":"Cecum","level":2,"score":0.9282137155532837},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8577470779418945},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6989904046058655},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6723655462265015},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.6697233319282532},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.6385949850082397},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.6377521753311157},{"id":"https://openalex.org/C2781317952","wikidata":"https://www.wikidata.org/wiki/Q4878190","display_name":"Caecum","level":2,"score":0.5275083184242249},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.4878954589366913},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4805369973182678},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.46145638823509216},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.45938733220100403},{"id":"https://openalex.org/C2776366702","wikidata":"https://www.wikidata.org/wiki/Q185765","display_name":"Jejunum","level":2,"score":0.4337605834007263},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.4154682457447052},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23165392875671387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17475023865699768},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.11477762460708618},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10428336262702942},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0660434365272522},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000332","descriptor_name":"Aerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000693","descriptor_name":"Anaerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002432","descriptor_name":"Cecum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005508","descriptor_name":"Food Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007583","descriptor_name":"Jejunum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013270","descriptor_name":"Stomach","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014868","descriptor_name":"Water Deprivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/iai.9.3.591-598.1974","doi":"https://doi.org/10.1128/iai.9.3.591-598.1974","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.9.3.591-598.1974","pdf_url":"https://iai.asm.org/content/iai/9/3/591.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:414848","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/414848","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:4593471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4593471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/iai.9.3.591-598.1974","doi":"https://doi.org/10.1128/iai.9.3.591-598.1974","is_oa":true,"landing_page_url":"https://doi.org/10.1128/iai.9.3.591-598.1974","pdf_url":"https://iai.asm.org/content/iai/9/3/591.full.pdf","source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2167107922.pdf"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1021571322","https://openalex.org/W1232181365","https://openalex.org/W1572428773","https://openalex.org/W1572601691","https://openalex.org/W1583475661","https://openalex.org/W1589701136","https://openalex.org/W1751648671","https://openalex.org/W1917933135","https://openalex.org/W1973316462","https://openalex.org/W1986924464","https://openalex.org/W2035179936","https://openalex.org/W2035263655","https://openalex.org/W2052957845","https://openalex.org/W2063563129","https://openalex.org/W2084581006","https://openalex.org/W2086887398","https://openalex.org/W2088155518","https://openalex.org/W2125484216","https://openalex.org/W2130644152","https://openalex.org/W2138258598","https://openalex.org/W2162373569","https://openalex.org/W2181258884","https://openalex.org/W2240978050","https://openalex.org/W2315509513","https://openalex.org/W2733125291"],"related_works":["https://openalex.org/W2138258598","https://openalex.org/W7097271975","https://openalex.org/W1982285526","https://openalex.org/W2137392437","https://openalex.org/W2143862999","https://openalex.org/W2112741355","https://openalex.org/W3047384141","https://openalex.org/W7119747436","https://openalex.org/W2112673542","https://openalex.org/W2091730948"],"abstract_inverted_index":{"Aerobic":[0],"and":[1,5,18,49,70,78,84,99,116,120,168,195,199,221,229],"anaerobic":[2,187],"cultural":[3],"techniques":[4],"histological":[6,184],"methods":[7],"were":[8,37,51,173,189],"used":[9],"in":[10,39,67,96,104,106,117,151,170,175,192,207,226],"a":[11,40],"study":[12],"of":[13,16,25,29,45,64,81,93,110,122,136,143,154,157,165,183,224],"the":[14,22,26,68,107,118,139,144,162,166,204,215,219,227],"effects":[15],"environmental":[17],"dietary":[19,200],"stress":[20,201],"on":[21],"indigenous":[23],"microbiota":[24,206],"gastrointestinal":[27,205],"tract":[28],"mice.":[30,208],"Mice":[31,73],"previously":[32,55,74,126],"inoculated":[33,56,75,113,127],"with":[34,57,76,114,128,161],"Salmonella":[35,65,77,115],"typhimurium":[36,59],"examined":[38],"similar":[41],"manner.":[42],"Three":[43],"strains":[44],"mice":[46,112,124,131,147,172,177],"(CD-1,":[47],"Ha/ICr,":[48],"C57BL)":[50],"used.":[52],"Control":[53,130],"animals":[54],"S.":[58],"had":[60,132],"low":[61],"population":[62,91,134,222],"levels":[63,92,135,223],"bacteria":[66,95,159],"small":[69,98],"large":[71,100,108],"bowel.":[72],"then":[79],"deprived":[80],"food,":[82],"water,":[83],"bedding":[85],"for":[86],"48":[87],"h":[88],"harbored":[89],"high":[90,133],"these":[94,152],"their":[97],"bowels.":[101],"Coliforms":[102],"increased":[103],"numbers":[105],"bowel":[109],"stressed":[111,123,176,194],"jejunum-ileum":[119],"cecum":[121,167],"not":[125],"Salmonella.":[129],"lactobacilli":[137],"inhabiting":[138],"keratinized":[140],"squamous":[141],"epithelium":[142,164],"stomach.":[145],"Stressed":[146],"showed":[148],"dramatic":[149],"reductions":[150],"populations":[153],"lactobacilli.":[155],"Populations":[156],"fusiform-shaped":[158],"associated":[160],"mucosal":[163],"colon":[169],"control":[171,196],"reduced":[174],"as":[178],"determined":[179],"by":[180],"microscope":[181],"examination":[182],"sections.":[185],"Total":[186],"counts":[188],"similar,":[190],"however,":[191],"both":[193],"animals.":[197],"Environmental":[198],"markedly":[202],"alter":[203],"Therefore,":[209],"such":[210],"stressful":[211],"conditions":[212],"profoundly":[213],"affect":[214],"factors":[216],"that":[217],"regulate":[218],"localization":[220],"microorganisms":[225],"stomach":[228],"intestines.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}