{"id":"https://openalex.org/W2167095229","doi":null,"title":"Chronic blockade of class I PI3-kinase attenuates Ang II-induced cardiac hypertrophy and autophagic alteration.","display_name":"Chronic blockade of class I PI3-kinase attenuates Ang II-induced cardiac hypertrophy and autophagic alteration.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2167095229","mag":"2167095229","pmid":"https://pubmed.ncbi.nlm.nih.gov/25807429"},"language":"en","primary_location":{"id":"pmid:25807429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25807429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"W Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"W Yan","raw_affiliation_strings":["Department of Cardiovascular Surgery, Second Hospital of Jilin University, Jilin University, Changchun, Jilin, China. Chengwen.Sun@ndsu.edu","Department of Cardiovascular Surgery, Second Hospital of Jilin University, Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Second Hospital of Jilin University, Jilin University, Changchun, Jilin, China. Chengwen.Sun@ndsu.edu","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]},{"raw_affiliation_string":"Department of Cardiovascular Surgery, Second Hospital of Jilin University, Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055907331","display_name":"Guo Lr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L R Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057607407","display_name":"Q. Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Q Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100899848","display_name":"Sun Wz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W-Z Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020289230","display_name":"O'Rourke St","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S T O'Rourke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085287847","display_name":"Liu Kx","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K-X Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"C-W Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C-W Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1327,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79248612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"19","issue":"5","first_page":"772","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.11710000038146973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9639999866485596},{"id":"https://openalex.org/keywords/akt-mtor-signaling-pathway","display_name":"Akt/mTOR signaling","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.7549999952316284},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.5320000052452087},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7257530689239502},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.6887080669403076},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.665166974067688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6391347050666809},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6265296936035156},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5721471309661865},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5362977385520935},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5165240168571472},{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.5079429745674133},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4990668296813965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49127310514450073},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47155141830444336},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3144657015800476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2835959196090698},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2251569628715515},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.13260918855667114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04694652557373047}],"mesh":[{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25807429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25807429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2167095229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25807429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1891771451","display_name":"Apelin: A Novel Neural Regulator of Cardiovascular Functions","funder_award_id":"R21NS055008","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1972401614","https://openalex.org/W1983692570","https://openalex.org/W1995455049","https://openalex.org/W2021458745","https://openalex.org/W2034901688","https://openalex.org/W2036272929","https://openalex.org/W2036903182","https://openalex.org/W2047373489","https://openalex.org/W2065152591","https://openalex.org/W2067837318","https://openalex.org/W2079029315","https://openalex.org/W2086041680","https://openalex.org/W2086974200","https://openalex.org/W2092943609","https://openalex.org/W2100971797","https://openalex.org/W2105981183","https://openalex.org/W2112016861","https://openalex.org/W2123933189","https://openalex.org/W2134040438","https://openalex.org/W2135596918","https://openalex.org/W2138100642","https://openalex.org/W2142393775","https://openalex.org/W2143397461","https://openalex.org/W2143677012","https://openalex.org/W2147371753","https://openalex.org/W2158952806","https://openalex.org/W2164624052","https://openalex.org/W2172157436","https://openalex.org/W2189460424","https://openalex.org/W2732484141"],"related_works":["https://openalex.org/W3173250713","https://openalex.org/W2922087427","https://openalex.org/W3132587118","https://openalex.org/W3017070479","https://openalex.org/W2996766998","https://openalex.org/W2061444919","https://openalex.org/W2520280394","https://openalex.org/W3029086772","https://openalex.org/W3205374812","https://openalex.org/W2730013887"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Chronic":[1,116],"Ang":[2,38,59,80,111,119,164,176,192,205,220,249],"II":[3,39,60,81,120,141,206],"stimulation":[4],"is":[5,246],"linked":[6],"to":[7],"cardiac":[8,14,41,123,151,178,214,257,266],"remodeling":[9],"characterized":[10],"by":[11],"fibrosis":[12,127],"and":[13,44,100,125,142,153,169,180,196,211,213,225,259],"hypertrophy.":[15],"However,":[16],"the":[17,30,34,78,129,185,243],"underlying":[18,33,188],"cellular":[19,186],"mechanisms":[20,32,187],"involved":[21,247],"are":[22],"not":[23],"yet":[24],"fully":[25],"known.":[26],"Here,":[27],"we":[28],"studied":[29,62],"molecular":[31],"chronic":[35],"effect":[36],"of":[37,51,58,67,72,107,118,150,156,160,167,171,191,209,216,223,242,252,255],"on":[40,88],"hypertrophy,":[42,94,258],"fibrosis,":[43,95,260],"autophagy.":[45,231],"MATERIALS":[46],"AND":[47],"METHODS:":[48],"The":[49],"role":[50],"class":[52,237],"I":[53,238],"PI3-kinase":[54,73],"in":[55,77,104,128,139,144,200,248],"these":[56,203],"actions":[57,190],"was":[61,82],"using":[63,90],"lentiviral":[64],"vector-mediated":[65],"expression":[66],"a":[68,136,227,262],"dominant":[69],"negative":[70],"form":[71],"subunit":[74],"p85\u03b1":[75],"(Lv-DNp85)":[76],"heart.":[79,130],"infused":[83],"subcutaneously":[84],"for":[85,265],"4":[86],"weeks":[87],"rats":[89,108],"osmotic":[91],"pumps.":[92],"Cardiac":[93,158],"reactive":[96],"oxygen":[97],"species":[98],"(ROS),":[99],"autophagy":[101,152,168],"were":[102,133,198],"examined":[103],"four":[105],"groups":[106],"(Ang":[109],"II+Lv-DNp85,":[110],"II+Lv-GFP,":[112],"Saline+Lv-DNp85,":[113],"Saline+Lv-GFP).":[114],"RESULTS:":[115],"infusion":[117],"induced":[121],"severe":[122],"hypertrophy":[124,179],"perivascular":[126,181],"These":[131,233],"effects":[132],"associated":[134],"with":[135],"significant":[137],"reduction":[138],"LC3":[140],"elevation":[143,170,254],"ROS":[145],"levels,":[146],"suggesting":[147,261],"marked":[148],"impairment":[149,166,251],"increased":[154,207],"generation":[155],"ROS.":[157],"transduction":[159,215],"Lv-DNp85":[161,217],"significantly":[162,218],"attenuated":[163],"II-induced":[165,177,221,250],"ROS,":[172,256],"as":[173,175],"well":[174],"fibrosis.":[182],"To":[183],"study":[184],"those":[189],"II,":[193],"phosphorylated":[194],"Akt":[195,210,224],"mTOR":[197],"measured":[199],"hearts":[201],"from":[202],"rats.":[204],"phosphorylation":[208,222],"mTOR;":[212],"abolished":[219],"mTOR,":[226],"signaling":[228],"pathway":[229],"inhibiting":[230],"CONCLUSIONS:":[232],"results":[234],"demonstrate":[235],"that":[236],"PI3-kinase,":[239],"via":[240],"activation":[241],"Akt-mTOR":[244],"pathway,":[245],"autophagy,":[253],"novel":[263],"target":[264],"protection.":[267]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}