{"id":"https://openalex.org/W2167057191","doi":null,"title":"Mecanismos moleculares de la disfunci\u00f3n endotelial: de la s\u00edntesis a la acci\u00f3n del \u00f3xido n\u00edtrico","display_name":"Mecanismos moleculares de la disfunci\u00f3n endotelial: de la s\u00edntesis a la acci\u00f3n del \u00f3xido n\u00edtrico","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W2167057191","mag":"2167057191"},"language":"es","primary_location":{"id":"pmh:oai:bibmed.ucla.edu.ve:T070000064127/2","doi":null,"is_oa":false,"landing_page_url":"http://bibmed.ucla.edu.ve/cgi-win/be_alex.exe?Acceso=T070000064127/2&Nombrebd=bmucla","pdf_url":null,"source":{"id":"https://openalex.org/S7407064131","display_name":"UCLA - Biblioteca de Ciencias de la Salud","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I19325673","host_organization_name":"Universidad Centroccidental Lisandro Alvarado","host_organization_lineage":["https://openalex.org/I19325673"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036985418","display_name":"Acosta Alejandro Guillermo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1648549","display_name":"Universidad del Zulia","ror":"https://ror.org/04vy5s568","country_code":"VE","type":"education","lineage":["https://openalex.org/I1648549"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Acosta Alejandro Guillermo","raw_affiliation_strings":["La Universidad del Zulia Centro de Investigaciones Endocrino-Metab\u00f3licas Dr. F\u00e9lix G\u00f3mez, Maracaibo, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"La Universidad del Zulia Centro de Investigaciones Endocrino-Metab\u00f3licas Dr. F\u00e9lix G\u00f3mez, Maracaibo, Venezuela","institution_ids":["https://openalex.org/I1648549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062241558","display_name":"Johnny A\u00f1ez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johnny \u00c1\u00f1ez Vermolen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006554124","display_name":"Carla Andara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carla Andara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058933826","display_name":"Valmore Berm\u00fadez","orcid":"https://orcid.org/0000-0003-1880-8887","observed_orcids":["https://orcid.org/0000-0003-1880-8887"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valmore Berm\u00fadez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1880-8887","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103580533","display_name":"Fernando Berm\u00fadez Arias","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Berm\u00fadez Arias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"25","issue":"2","first_page":"54","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9919999837875366},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9409999847412109},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.9390000104904175},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6290000081062317},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9330000281333923},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.921999990940094},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9139999747276306},{"id":"https://openalex.org/keywords/molecular-mechanisms","display_name":"molecular mechanisms","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6160018444061279},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5779790282249451},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5713074803352356},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5330347418785095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5011639595031738},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20749467611312866}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:bibmed.ucla.edu.ve:T070000064127/2","doi":null,"is_oa":false,"landing_page_url":"http://bibmed.ucla.edu.ve/cgi-win/be_alex.exe?Acceso=T070000064127/2&Nombrebd=bmucla","pdf_url":null,"source":{"id":"https://openalex.org/S7407064131","display_name":"UCLA - Biblioteca de Ciencias de la Salud","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I19325673","host_organization_name":"Universidad Centroccidental Lisandro Alvarado","host_organization_lineage":["https://openalex.org/I19325673"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:redalyc.org:55925203","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=55925203","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archivos Venezolanos de Farmacolog\u00eda y Terap\u00e9utica (Rep\u00fablica Bolivariana de Venezuela) Num.2 Vol.25","raw_type":"art\u00edculo cient\u00edfico"},{"id":"mag:2167057191","doi":null,"is_oa":false,"landing_page_url":"https://biblat.unam.mx/ca/revista/archivos-venezolanos-de-farmacologia-y-terapeutica/articulo/mecanismos-moleculares-de-la-disfuncion-endotelial-de-la-sintesis-a-la-accion-del-oxido-nitrico","pdf_url":null,"source":{"id":"https://openalex.org/S4306502950","display_name":"Archivos Venezolanos de Farmacolog\u00eda y Terap\u00e9utica","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Archivos Venezolanos de Farmacolog\u00eda y Terap\u00e9utica","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W119779276","https://openalex.org/W985930308","https://openalex.org/W1886375502","https://openalex.org/W1963495254","https://openalex.org/W1963834943","https://openalex.org/W1970728146","https://openalex.org/W1970904231","https://openalex.org/W1975974235","https://openalex.org/W1981647923","https://openalex.org/W1982584549","https://openalex.org/W1994506978","https://openalex.org/W2004398529","https://openalex.org/W2016018685","https://openalex.org/W2026425756","https://openalex.org/W2034083518","https://openalex.org/W2035199836","https://openalex.org/W2035508242","https://openalex.org/W2037854429","https://openalex.org/W2038697600","https://openalex.org/W2044941841","https://openalex.org/W2048635427","https://openalex.org/W2051048068","https://openalex.org/W2055870525","https://openalex.org/W2065796822","https://openalex.org/W2066231048","https://openalex.org/W2069083293","https://openalex.org/W2076680300","https://openalex.org/W2078331312","https://openalex.org/W2098154479","https://openalex.org/W2103790130","https://openalex.org/W2120785970","https://openalex.org/W2127466966","https://openalex.org/W2130401548","https://openalex.org/W2132464590","https://openalex.org/W2134785329","https://openalex.org/W2144188723","https://openalex.org/W2144521922","https://openalex.org/W2149398546","https://openalex.org/W2151035518","https://openalex.org/W2153110646","https://openalex.org/W2154346498","https://openalex.org/W2162779892","https://openalex.org/W2163763036","https://openalex.org/W2171284332","https://openalex.org/W2211096163","https://openalex.org/W2221330666"],"related_works":["https://openalex.org/W1826896992","https://openalex.org/W2169170418","https://openalex.org/W571215747","https://openalex.org/W1963932676","https://openalex.org/W2131100702","https://openalex.org/W203463631","https://openalex.org/W2141537184","https://openalex.org/W92570626","https://openalex.org/W936115879","https://openalex.org/W2794954943"],"abstract_inverted_index":{"\"La":[0],"relevancia":[1],"cl\u00ednica":[2],"y":[3,11,50,61,76,113],"cient\u00edfica":[4],"de":[5,8,12,21,38,56,72,82,92,98,101,109,118],"las":[6,39],"alteraciones":[7,43,88],"la":[9,13,22,36,64,66,74,77,96,99,107],"s\u00edn-tesis":[10],"biodisponibilidad":[14],"del":[15],"\u00f3xido":[16],"n\u00edtrico":[17],"en":[18,27,35,47,51,53,115],"el":[19,54,68,70,116],"curso":[20],"disfunci\u00f3n":[23],"endotelial":[24],"se":[25,44,89],"fundamenta":[26],"que":[28],"esta":[29],"variaci\u00f3n":[30],"es":[31],"un":[32],"factor":[33],"com\u00fan":[34],"patog\u00e9nesis":[37],"enfermedades":[40],"cardiovasculares.":[41],"Dichas":[42],"han":[45],"demostrado":[46],"modelos":[48],"animales":[49],"humanos,":[52],"\u00e1mbito":[55],"condiciones":[57],"patol\u00f3gicas":[58],"tan":[59],"peligrosas":[60],"diversas":[62],"como":[63],"hipertensi\u00f3n,":[65],"hipercolesterolemia,":[67],"envejecimiento,":[69],"consumo":[71],"cigarri-llo,":[73],"diabetes":[75],"insuficiencia":[78],"card\u00edaca.":[79],"El":[80],"conocimiento":[81],"los":[83],"procesos":[84],"relacionados":[85],"con":[86],"estas":[87,119],"hace":[90],"entonces":[91],"vital":[93],"importancia":[94],"para":[95,106],"comprensi\u00f3n":[97],"fisiopatolog\u00eda":[100],"dichas":[102],"enfermedades,":[103],"as\u00ed":[104],"como,":[105],"generaci\u00f3n":[108],"estrategias":[110],"terap\u00e9uticas":[111],"innovadoras":[112],"eficaces":[114],"tratamiento":[117],"patolog\u00eda\"":[120]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
