{"id":"https://openalex.org/W2167036604","doi":"https://doi.org/10.1586/17474086.2.1.57","title":"Leukotriene pathway in sickle cell disease: a potential target for directed therapy","display_name":"Leukotriene pathway in sickle cell disease: a potential target for directed therapy","publication_year":2009,"publication_date":"2009-02-01","ids":{"openalex":"https://openalex.org/W2167036604","doi":"https://doi.org/10.1586/17474086.2.1.57","mag":"2167036604","pmid":"https://pubmed.ncbi.nlm.nih.gov/21082995"},"language":"en","primary_location":{"id":"doi:10.1586/17474086.2.1.57","doi":"https://doi.org/10.1586/17474086.2.1.57","is_oa":false,"landing_page_url":"https://doi.org/10.1586/17474086.2.1.57","pdf_url":null,"source":{"id":"https://openalex.org/S73682863","display_name":"Expert Review of Hematology","issn_l":"1747-4086","issn":["1747-4086","1747-4094"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Hematology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066015128","display_name":"Jessica E. Knight\u2010Perry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Knight-Perry","raw_affiliation_strings":["Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047418153","display_name":"Michael Rutledge DeBaun","orcid":"https://orcid.org/0000-0002-0574-1604","observed_orcids":["https://orcid.org/0000-0002-0574-1604"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R DeBaun","raw_affiliation_strings":["Departments of Pediatrics, Biostatistics and Neurology, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, Biostatistics and Neurology, Washington University School of Medicine, St Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087955329","display_name":"Robert C. Strunk","orcid":"https://orcid.org/0000-0002-1583-6025","observed_orcids":["https://orcid.org/0000-0002-1583-6025"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C Strunk","raw_affiliation_strings":["Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024412886","display_name":"Joshua J. Field","orcid":"https://orcid.org/0000-0001-8148-055X","observed_orcids":["https://orcid.org/0000-0001-8148-055X","https://orcid.org/0009-0005-6640-1848"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua J Field","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, Box 8125, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA. jfield@dom.wustl.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, Box 8125, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA. jfield@dom.wustl.edu","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":0.0394,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.04545455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2","issue":"1","first_page":"57","last_page":"68"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":1.0},{"id":"https://openalex.org/keywords/leukotrienes","display_name":"leukotrienes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/leukotriene-pathway","display_name":"leukotriene pathway","score":0.9430000185966492},{"id":"https://openalex.org/keywords/vessel-occlusion","display_name":"vascular occlusion","score":0.9480000138282776},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/asthma-comorbidity","display_name":"asthma comorbidity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/acute-chest-syndrome","display_name":"acute chest syndrome","score":0.8389999866485596},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.8320000171661377},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9261125326156616},{"id":"https://openalex.org/C2780976302","wikidata":"https://www.wikidata.org/wiki/Q4677915","display_name":"Acute chest syndrome","level":4,"score":0.7597975730895996},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7411541938781738},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7171469330787659},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.633902370929718},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5938777327537537},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5823525786399841},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.5030779242515564},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5007941722869873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1757911741733551},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.1737799048423767}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1586/17474086.2.1.57","doi":"https://doi.org/10.1586/17474086.2.1.57","is_oa":false,"landing_page_url":"https://doi.org/10.1586/17474086.2.1.57","pdf_url":null,"source":{"id":"https://openalex.org/S73682863","display_name":"Expert Review of Hematology","issn_l":"1747-4086","issn":["1747-4086","1747-4094"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Hematology","raw_type":"journal-article"},{"id":"pmid:21082995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21082995","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of hematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8799999952316284,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3469946262","display_name":null,"funder_award_id":"K12 HL08710","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W7055056","https://openalex.org/W50870326","https://openalex.org/W53646502","https://openalex.org/W118094748","https://openalex.org/W132410613","https://openalex.org/W176130659","https://openalex.org/W1256655297","https://openalex.org/W1540490820","https://openalex.org/W1544939802","https://openalex.org/W1547764055","https://openalex.org/W1556663106","https://openalex.org/W1597151660","https://openalex.org/W1604761302","https://openalex.org/W1605675838","https://openalex.org/W1640193551","https://openalex.org/W1936798053","https://openalex.org/W1963981548","https://openalex.org/W1963989515","https://openalex.org/W1966962451","https://openalex.org/W1968391383","https://openalex.org/W1974266575","https://openalex.org/W1974783945","https://openalex.org/W1979032722","https://openalex.org/W1979169104","https://openalex.org/W1981361161","https://openalex.org/W1981916494","https://openalex.org/W1982989569","https://openalex.org/W1983335588","https://openalex.org/W1984789764","https://openalex.org/W1987738542","https://openalex.org/W1990033742","https://openalex.org/W1990132839","https://openalex.org/W1990139289","https://openalex.org/W1990241120","https://openalex.org/W1990926485","https://openalex.org/W1992525172","https://openalex.org/W1994668210","https://openalex.org/W1994900465","https://openalex.org/W1997561160","https://openalex.org/W1998903070","https://openalex.org/W2001798594","https://openalex.org/W2002477479","https://openalex.org/W2004561916","https://openalex.org/W2005348832","https://openalex.org/W2009253424","https://openalex.org/W2014473048","https://openalex.org/W2016702970","https://openalex.org/W2017485498","https://openalex.org/W2021152399","https://openalex.org/W2022723088","https://openalex.org/W2024176341","https://openalex.org/W2029354019","https://openalex.org/W2035680640","https://openalex.org/W2038661530","https://openalex.org/W2039153957","https://openalex.org/W2046679315","https://openalex.org/W2048079401","https://openalex.org/W2048820411","https://openalex.org/W2049611541","https://openalex.org/W2052525169","https://openalex.org/W2053939881","https://openalex.org/W2070040208","https://openalex.org/W2073817403","https://openalex.org/W2075895818","https://openalex.org/W2078992248","https://openalex.org/W2079333020","https://openalex.org/W2082268007","https://openalex.org/W2083151439","https://openalex.org/W2083399493","https://openalex.org/W2084183581","https://openalex.org/W2085961346","https://openalex.org/W2092572278","https://openalex.org/W2093499369","https://openalex.org/W2104264335","https://openalex.org/W2104505088","https://openalex.org/W2106942411","https://openalex.org/W2112468123","https://openalex.org/W2116594128","https://openalex.org/W2126396294","https://openalex.org/W2132346004","https://openalex.org/W2142752948","https://openalex.org/W2143740873","https://openalex.org/W2149047900","https://openalex.org/W2150570905","https://openalex.org/W2154766878","https://openalex.org/W2155408132","https://openalex.org/W2155803841","https://openalex.org/W2160493215","https://openalex.org/W2161297641","https://openalex.org/W2172149963","https://openalex.org/W2258655905","https://openalex.org/W2313541759","https://openalex.org/W2322074970","https://openalex.org/W2332642667","https://openalex.org/W2334263927","https://openalex.org/W2336959523","https://openalex.org/W2338826424","https://openalex.org/W2343804872","https://openalex.org/W2415102292","https://openalex.org/W2418505864","https://openalex.org/W2626246102","https://openalex.org/W3113247834","https://openalex.org/W3144617671","https://openalex.org/W4230004982","https://openalex.org/W4236219361","https://openalex.org/W4243258875","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4401854665","https://openalex.org/W2461483782","https://openalex.org/W4403078107","https://openalex.org/W2794850401","https://openalex.org/W1982955412","https://openalex.org/W2756026287","https://openalex.org/W1530740642","https://openalex.org/W868376623","https://openalex.org/W2027123051","https://openalex.org/W3090111942"],"abstract_inverted_index":{"Sickle":[0],"cell":[1],"disease":[2],"(SCD)":[3],"is":[4,19,59,118],"characterized":[5],"by":[6],"recurrent":[7],"episodes":[8,88],"of":[9,24,38,49,68,85,89,103,125,131],"vaso-occlusion,":[10,142],"resulting":[11],"in":[12,100],"tissue":[13],"ischemia":[14],"and":[15,26,33,74,105,141],"end-organ":[16],"damage.":[17],"Inflammation":[18,76],"critical":[20],"to":[21],"the":[22,36,45,66,82,101,123,129,137,147],"pathogenesis":[23,102],"vaso-occlusion":[25],"has":[27],"been":[28,107],"associated":[29,77,108],"with":[30,56,78,109,143],"SCD-related":[31,110],"morbidity":[32],"mortality.":[34],"Despite":[35],"impact":[37],"inflammation,":[39],"no":[40],"directed":[41],"anti-inflammatory":[42],"therapies":[43,127],"for":[44,122,128],"treatment":[46,130],"or":[47],"prevention":[48],"vaso-occlusive":[50],"events":[51],"currently":[52],"exist.":[53],"Among":[54],"individuals":[55],"SCD,":[57,86],"asthma":[58,79,104],"a":[60,97,119],"comorbid":[61],"inflammatory":[62,93,113],"condition":[63],"that":[64,95],"increases":[65],"risk":[67],"pain":[69],"episodes,":[70],"acute":[71],"chest":[72],"syndrome":[73],"death.":[75],"could":[80],"augment":[81],"proinflammatory":[83],"state":[84],"increasing":[87],"vaso-occlusion.":[90],"Leukotrienes":[91],"are":[92],"mediators":[94],"play":[96],"prominent":[98],"role":[99],"have":[106],"morbidity.":[111],"Targeting":[112],"mediators,":[114],"such":[115],"as":[116],"leukotrienes,":[117],"promising":[120],"approach":[121],"development":[124],"novel":[126],"SCD.":[132],"This":[133],"review":[134],"will":[135],"examine":[136],"relationship":[138],"between":[139],"inflammation":[140],"particular":[144],"focus":[145],"on":[146],"leukotriene":[148],"pathway.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
