{"id":"https://openalex.org/W2167036262","doi":"https://doi.org/10.1111/j.1476-4431.2009.00495.x","title":"Conventional and molecular diagnostic testing for the acute neurologic patient","display_name":"Conventional and molecular diagnostic testing for the acute neurologic patient","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W2167036262","doi":"https://doi.org/10.1111/j.1476-4431.2009.00495.x","mag":"2167036262","pmid":"https://pubmed.ncbi.nlm.nih.gov/20230434","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7169320"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-4431.2009.00495.x","doi":"https://doi.org/10.1111/j.1476-4431.2009.00495.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-4431.2009.00495.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-4431.2009.00495.x","source":{"id":"https://openalex.org/S190491254","display_name":"Journal of Veterinary Emergency and Critical Care","issn_l":"1476-4431","issn":["1476-4431","1479-3261"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Emergency and Critical Care","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-4431.2009.00495.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071737472","display_name":"Peter P. Nghiem","orcid":"https://orcid.org/0000-0002-8796-8123","observed_orcids":["https://orcid.org/0000-0002-8796-8123"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter P. Nghiem","raw_affiliation_strings":["Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30606, USA","From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30606, USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30606","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076186614","display_name":"Scott J. Schatzberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott J. Schatzberg","raw_affiliation_strings":["From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30606","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165733156"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.1804,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.17582418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"1","first_page":"46","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":0.31790000200271606,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":0.31790000200271606,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13201","display_name":"Infectious Encephalopathies and Encephalitis","score":0.3003000020980835,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.11209999769926071,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.6460000276565552},{"id":"https://openalex.org/keywords/real-time-pcr","display_name":"real-time PCR","score":0.8500000238418579},{"id":"https://openalex.org/keywords/canine-distemper-virus","display_name":"canine distemper virus","score":0.734000027179718},{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neospora-caninum","display_name":"Neospora caninum","score":0.9919999837875366},{"id":"https://openalex.org/keywords/rickettsial-diseases","display_name":"rickettsial infection","score":0.8240000009536743},{"id":"https://openalex.org/keywords/borrelia","display_name":"Borrelia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/bartonella","display_name":"Bartonella","score":0.9980000257492065},{"id":"https://openalex.org/keywords/central-nervous-system-fungal-infection","display_name":"central nervous system fungal infection","score":0.7850000262260437},{"id":"https://openalex.org/keywords/necrotizing-encephalitis","display_name":"necrotizing encephalitis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/granulomatous-meningoencephalitis","display_name":"granulomatous meningoencephalitis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/veterinary-neurology","display_name":"veterinary neurology","score":0.5550000071525574},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.47200000286102295},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9357626438140869},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.504845917224884},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.4724823832511902},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.19426026940345764}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002371","descriptor_name":"Cat Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002494","descriptor_name":"Central Nervous System Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002494","descriptor_name":"Central Nervous System Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002555","descriptor_name":"Cerebrospinal Fluid","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-4431.2009.00495.x","doi":"https://doi.org/10.1111/j.1476-4431.2009.00495.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-4431.2009.00495.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-4431.2009.00495.x","source":{"id":"https://openalex.org/S190491254","display_name":"Journal of Veterinary Emergency and Critical Care","issn_l":"1476-4431","issn":["1476-4431","1479-3261"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Emergency and Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7169320","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7169320","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Vet Emerg Crit Care (San Antonio)","raw_type":"Text"},{"id":"pmid:20230434","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20230434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-4431.2009.00495.x","doi":"https://doi.org/10.1111/j.1476-4431.2009.00495.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-4431.2009.00495.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-4431.2009.00495.x","source":{"id":"https://openalex.org/S190491254","display_name":"Journal of Veterinary Emergency and Critical Care","issn_l":"1476-4431","issn":["1476-4431","1479-3261"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Emergency and Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167036262.pdf","grobid_xml":"https://content.openalex.org/works/W2167036262.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W88175282","https://openalex.org/W106140140","https://openalex.org/W161373651","https://openalex.org/W1572495495","https://openalex.org/W1750026457","https://openalex.org/W1857797918","https://openalex.org/W1886146679","https://openalex.org/W1964363017","https://openalex.org/W1965624414","https://openalex.org/W1967414895","https://openalex.org/W1978106620","https://openalex.org/W1981231104","https://openalex.org/W1984178787","https://openalex.org/W1991144795","https://openalex.org/W1994788542","https://openalex.org/W1995630406","https://openalex.org/W1996972483","https://openalex.org/W1997859164","https://openalex.org/W1998125999","https://openalex.org/W2000528744","https://openalex.org/W2003605298","https://openalex.org/W2005623684","https://openalex.org/W2007323502","https://openalex.org/W2007962362","https://openalex.org/W2008636018","https://openalex.org/W2009802670","https://openalex.org/W2010247351","https://openalex.org/W2012051038","https://openalex.org/W2013636404","https://openalex.org/W2014150986","https://openalex.org/W2018498004","https://openalex.org/W2023259847","https://openalex.org/W2026010270","https://openalex.org/W2029111220","https://openalex.org/W2031727485","https://openalex.org/W2035608966","https://openalex.org/W2036289720","https://openalex.org/W2036832556","https://openalex.org/W2039194589","https://openalex.org/W2041964832","https://openalex.org/W2044013865","https://openalex.org/W2045872294","https://openalex.org/W2050218255","https://openalex.org/W2054964390","https://openalex.org/W2055193938","https://openalex.org/W2056932428","https://openalex.org/W2058904094","https://openalex.org/W2059372215","https://openalex.org/W2064233378","https://openalex.org/W2064732115","https://openalex.org/W2071049552","https://openalex.org/W2071768295","https://openalex.org/W2071902333","https://openalex.org/W2074882823","https://openalex.org/W2078300875","https://openalex.org/W2083279714","https://openalex.org/W2083467658","https://openalex.org/W2088552854","https://openalex.org/W2100761712","https://openalex.org/W2101271346","https://openalex.org/W2101776519","https://openalex.org/W2101802727","https://openalex.org/W2104548316","https://openalex.org/W2106747167","https://openalex.org/W2109297926","https://openalex.org/W2109985208","https://openalex.org/W2110809521","https://openalex.org/W2112020473","https://openalex.org/W2112736362","https://openalex.org/W2114404137","https://openalex.org/W2115401483","https://openalex.org/W2121842229","https://openalex.org/W2127239044","https://openalex.org/W2127985307","https://openalex.org/W2128057429","https://openalex.org/W2130495662","https://openalex.org/W2131145551","https://openalex.org/W2135985304","https://openalex.org/W2136484280","https://openalex.org/W2142301592","https://openalex.org/W2152539474","https://openalex.org/W2164095252","https://openalex.org/W2169975361","https://openalex.org/W2170303054","https://openalex.org/W2170939735","https://openalex.org/W2181612975","https://openalex.org/W2239195511","https://openalex.org/W2288964959","https://openalex.org/W2289081142","https://openalex.org/W2315684477","https://openalex.org/W2418079554","https://openalex.org/W2777920084","https://openalex.org/W3135667697","https://openalex.org/W3171580589","https://openalex.org/W4232141012","https://openalex.org/W4233881735","https://openalex.org/W4234015100","https://openalex.org/W4253548830","https://openalex.org/W4298296216"],"related_works":["https://openalex.org/W2269490214","https://openalex.org/W2083279714","https://openalex.org/W4389362460","https://openalex.org/W395504091","https://openalex.org/W2011311699","https://openalex.org/W2268792476","https://openalex.org/W2029111220","https://openalex.org/W7120852759","https://openalex.org/W4210821935","https://openalex.org/W4387940178"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1],"aim":[2],"of":[3,28,149,172,192,259,279],"this":[4],"review":[5],"is":[6,266],"to":[7,56,166,223],"describe":[8],"and":[9,13,20,118,134,136,139,168,185,210,216,233,236,261],"evaluate":[10],"both":[11],"conventional":[12,184,260],"molecular":[14,38,262],"diagnostic":[15,39,129,180,263],"testing":[16,40,130,181],"utilized":[17,143],"in":[18,46,153,189],"dogs":[19],"cats":[21],"with":[22,36],"acute":[23,243],"neurologic":[24,244],"diseases.":[25],"Various":[26],"types":[27],"polymerase":[29],"chain":[30],"reaction":[31],"(PCR)":[32],"are":[33,142,247,285],"explored":[34],"along":[35],"novel":[37,173],"that":[41,252,268,284],"ultimately":[42],"may":[43],"prove":[44],"useful":[45],"the":[47,115,146,190,242,269,272,277,280],"critical":[48],"care":[49],"setting.":[50],"DATA":[51,126,177],"SOURCES:":[52],"PUBMED":[53],"was":[54],"searched":[55],"obtain":[57],"relevant":[58],"references":[59],"material":[60],"using":[61,157],"keywords:":[62],"'canine":[63],"OR":[64,72,77,87,92,97,102,104,106,108],"feline":[65,73,78,88,93,98],"meningitis":[66,83],"AND":[67,74,79,89,94,99,110],"meningoencephalitis,''feline":[68],"infectious":[69,150,198,250],"peritonitis,''canine":[70],"distemper,''canine":[71],"toxoplasma,''canine":[75],"neospora,''canine":[76],"rickettsia,''granulomatous":[80],"meningoencephalitis,''steroid":[81],"responsive":[82],"arteritis,''necrotizing":[84],"encephalitis,''novel":[85],"neurodiagnostics,''canine":[86],"CNS":[90,95,100],"borrelia,''canine":[91],"bartonella,''canine":[96],"fungal,''nested":[101],"multiplex":[103],"degenerate":[105,137,159,217],"consensus":[107,135,158,215],"CODEHOP":[109],"PCR.'":[111],"Research":[112],"findings":[113],"from":[114],"authors'":[116],"laboratory":[117],"current":[119],"veterinary":[120],"textbooks":[121],"also":[122],"were":[123],"utilized.":[124],"HUMAN":[125],"SYNTHESIS:":[127,178],"Molecular":[128,179],"including":[131,200,226],"conventional,":[132],"real-time,":[133],"PCR":[138,156,187,218],"microarray":[140],"analysis":[141],"routinely":[144],"for":[145,228],"antemortem":[147],"diagnosis":[148,191],"meningoencephalitis":[151],"(ME)":[152],"humans.":[154],"Recently,":[155,212],"hybrid":[160],"primers":[161],"(CODEHOP)":[162],"has":[163],"been":[164,221],"used":[165],"identify":[167],"characterize":[169],"a":[170,257],"number":[171],"human":[174],"viruses.":[175],"VETERINARY":[176],"such":[182],"as":[183,274,276],"real-time":[186],"aid":[188],"several":[193,248],"important":[194,267],"central":[195],"nervous":[196],"system":[197],"agents":[199],"canine":[201,224],"distemper":[202],"virus,":[203],"Toxoplasma":[204],"gondii,":[205],"Neospora":[206],"caninum,":[207],"rickettsial":[208,229],"species,":[209],"others.":[211],"broadly":[213],"reactive":[214],"reactions":[219],"have":[220],"applied":[222],"ME":[225],"assays":[227],"organisms,":[230],"Borrelia":[231],"spp.":[232],"Bartonella":[234],"spp.,":[235],"various":[237,281],"viral":[238],"families.":[239],"CONCLUSIONS:":[240],"In":[241],"patient,":[245],"there":[246],"key":[249],"diseases":[251],"can":[253],"be":[254],"pursued":[255],"by":[256],"combination":[258],"testing.":[264],"It":[265],"clinician":[270],"understands":[271],"utility,":[273],"well":[275],"limitations,":[278],"neurodiagnostic":[282],"tests":[283],"available.":[286]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
