{"id":"https://openalex.org/W2167018410","doi":"https://doi.org/10.1076/apab.110.1.129.900","title":"Mammalian Gonadotropin-Releasing Hormone (GnRH) Receptor Subtypes","display_name":"Mammalian Gonadotropin-Releasing Hormone (GnRH) Receptor Subtypes","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2167018410","doi":"https://doi.org/10.1076/apab.110.1.129.900","mag":"2167018410","pmid":"https://pubmed.ncbi.nlm.nih.gov/11935410"},"language":"en","primary_location":{"id":"doi:10.1076/apab.110.1.129.900","doi":"https://doi.org/10.1076/apab.110.1.129.900","is_oa":false,"landing_page_url":"https://doi.org/10.1076/apab.110.1.129.900","pdf_url":null,"source":{"id":"https://openalex.org/S19783875","display_name":"Archives of Physiology and Biochemistry","issn_l":"0778-3124","issn":["0778-3124","1381-3455","1744-4160"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103498956","display_name":"Jimmy D. Neill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J.D. Neill","raw_affiliation_strings":["Department of Physiology and Biophysics, School of Medicine, University of Alabama, Birmingham 35294-0005, USA. neill@uab.edu","Department of Physiology and Biophysics, School of Medicine, University of Alabama, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, School of Medicine, University of Alabama, Birmingham 35294-0005, USA. neill@uab.edu","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, School of Medicine, University of Alabama, Birmingham, AL, USA","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103498956"],"corresponding_institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":2.6795,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.88745295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"110","issue":"1-2","first_page":"129","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gnrh-i","display_name":"GnRH-I","score":0.8050000071525574},{"id":"https://openalex.org/keywords/gnrh-ii","display_name":"GnRH-II","score":0.9990000128746033},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/c-terminal-tail","display_name":"C-terminal tail","score":0.6549999713897705},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.972000002861023},{"id":"https://openalex.org/keywords/superagonists","display_name":"superagonists","score":0.7490000128746033},{"id":"https://openalex.org/keywords/gnrh-antagonist","display_name":"GnRH antagonist","score":0.8690000176429749},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.7950000166893005},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.8489999771118164},{"id":"https://openalex.org/keywords/receptor-pharmacology","display_name":"receptor pharmacology","score":0.5149999856948853},{"id":"https://openalex.org/keywords/tissue-expression","display_name":"tissue expression","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2779045069","wikidata":"https://www.wikidata.org/wiki/Q24725203","display_name":"Gonadotropin-releasing hormone receptor","level":5,"score":0.6882597208023071},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6816630363464355},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.6736851930618286},{"id":"https://openalex.org/C133603901","wikidata":"https://www.wikidata.org/wiki/Q14905267","display_name":"Thyrotropin-releasing hormone receptor","level":5,"score":0.6337084770202637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6242188215255737},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5910157561302185},{"id":"https://openalex.org/C2778837531","wikidata":"https://www.wikidata.org/wiki/Q7322394","display_name":"Riboprobe","level":5,"score":0.5815600156784058},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5796469449996948},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.4489160180091858},{"id":"https://openalex.org/C75184817","wikidata":"https://www.wikidata.org/wiki/Q5381540","display_name":"Enzyme-linked receptor","level":3,"score":0.4397779107093811},{"id":"https://openalex.org/C91977512","wikidata":"https://www.wikidata.org/wiki/Q5401840","display_name":"Estrogen-related receptor gamma","level":5,"score":0.428936630487442},{"id":"https://openalex.org/C17971392","wikidata":"https://www.wikidata.org/wiki/Q18027445","display_name":"5-HT5A receptor","level":3,"score":0.4201834201812744},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.3251672089099884},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.24021697044372559},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.220046728849411},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19519883394241333},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.1615937054157257},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.147197425365448},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11148703098297119},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09211805462837219},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.07193389534950256},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1076/apab.110.1.129.900","doi":"https://doi.org/10.1076/apab.110.1.129.900","is_oa":false,"landing_page_url":"https://doi.org/10.1076/apab.110.1.129.900","pdf_url":null,"source":{"id":"https://openalex.org/S19783875","display_name":"Archives of Physiology and Biochemistry","issn_l":"0778-3124","issn":["0778-3124","1381-3455","1744-4160"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:11935410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11935410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of physiology and biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1566317770","https://openalex.org/W1852077611","https://openalex.org/W1901684315","https://openalex.org/W1964074947","https://openalex.org/W1964512812","https://openalex.org/W1964717087","https://openalex.org/W1990804226","https://openalex.org/W1994117869","https://openalex.org/W1994775100","https://openalex.org/W2002788608","https://openalex.org/W2011664306","https://openalex.org/W2020055321","https://openalex.org/W2036423270","https://openalex.org/W2038133272","https://openalex.org/W2043773563","https://openalex.org/W2052768984","https://openalex.org/W2065625184","https://openalex.org/W2065831230","https://openalex.org/W2072629570","https://openalex.org/W2074956929","https://openalex.org/W2082898071","https://openalex.org/W2085348594","https://openalex.org/W2089670528","https://openalex.org/W2090728323","https://openalex.org/W2090977762","https://openalex.org/W2100279119","https://openalex.org/W2104140978","https://openalex.org/W2138170248","https://openalex.org/W2139981662","https://openalex.org/W2149937006","https://openalex.org/W2152988989","https://openalex.org/W2169001309","https://openalex.org/W4244259398"],"related_works":["https://openalex.org/W2002788608","https://openalex.org/W2127678755","https://openalex.org/W7096778714","https://openalex.org/W2153083446","https://openalex.org/W4415240282","https://openalex.org/W4376270671","https://openalex.org/W3203769375","https://openalex.org/W2069839260","https://openalex.org/W2974703647","https://openalex.org/W1972536915"],"abstract_inverted_index":{"Mammalian":[0],"gonadotropin-releasing":[1],"hormone":[2],"(GnRH":[3],"I)":[4],"is":[5],"a":[6,60,67,102,114,132,167,174],"hypothalamic":[7],"decapeptide":[8],"that":[9,65,228],"governs":[10],"gonadotropin":[11,273],"secretion":[12],"through":[13],"interaction":[14],"with":[15,70,78,254],"its":[16,129,194],"seven":[17],"transmembrane":[18],"(7TM),":[19],"G":[20],"protein-coupled":[21],"receptor":[22,83,95,106,124,162,186,200,213,226,265],"(GPCR)":[23],"expressed":[24,45],"by":[25,190,203,217],"anterior":[26],"pituitary":[27,99],"cells.":[28],"A":[29,52],"second":[30],"decapeptide,":[31],"GnRH":[32,73,81,93,110,133,144,151,160,184,198,204,211,218,224,229,236,242,245,256,263],"II,":[33],"originally":[34],"discovered":[35],"in":[36,46,125],"the":[37,47,55,79,109,123,179,191,197,208,223,255,262],"chicken":[38],"hypothalamus":[39,49],"was":[40,164,201,214],"recently":[41],"reported":[42],"to":[43],"be":[44],"mammalian":[48],"as":[50,131],"well.":[51],"search":[53],"of":[54,90,122,137,146,153,159,182,193,222,261,272],"recently-sequenced":[56],"human":[57,80,168,183],"genome":[58],"identified":[59],"7TM/GPCR":[61],"on":[62],"chromosome":[63],"1":[64],"exhibited":[66],"higher":[68],"identity":[69,130],"non-mammalian":[71],"vertebrate":[72],"II":[74,94,134,145,161,185,199,205,225,257,264],"receptors":[75],"(55%)":[76],"than":[77,235,241],"I":[82,111,152,212,230,237,246],"(39%).":[84],"Molecular":[85],"cloning":[86],"and":[87,119,149,173],"nucleotide":[88],"sequencing":[89],"this":[91],"putative":[92],"cDNA":[96],"from":[97],"monkey":[98],"gland":[100],"revealed":[101,141,227],"379":[103],"amino":[104],"acid":[105],"that,":[107],"unlike":[108],"receptor,":[112],"possessed":[113],"C-terminal":[115,195],"tail.":[116],"Heterologous":[117],"expression":[118,158,171],"functional":[120],"testing":[121],"COS-1":[126],"cells":[127],"confirmed":[128],"receptor:":[135],"measurement":[136],"3H-inositol":[138],"phosphate":[139],"accumulation":[140],"EC(50)s":[142],"for":[143,150],"0.86":[147],"nM":[148],"337":[154],"nM.":[155],"Ubiquitous":[156],"tissue":[157,169],"mRNA":[163],"observed":[165],"using":[166],"RNA":[170],"array":[172],"32P-labeled":[175],"antisense":[176],"riboprobe":[177],"representing":[178],"7TM":[180],"region":[181],"cDNA.":[187],"As":[188],"predicted":[189],"presence":[192],"tail,":[196],"desensitized":[202,216],"treatment":[206],"whereas":[207],"naturally":[209],"tail-less":[210],"not":[215],"I.":[219],"Pharmacological":[220],"analysis":[221],"'superagonists'":[231],"were":[232],"more":[233],"potent":[234,240],"but":[238,268],"less":[239],"II.":[243],"Numerous":[244],"antagonists":[247],"showed":[248],"neither":[249],"antagonistic":[250],"nor":[251],"agonistic":[252],"activity":[253],"receptor.":[258],"The":[259],"functions":[260],"are":[266],"unknown":[267],"may":[269],"include":[270],"regulation":[271],"secretion,":[274],"female":[275],"sexual":[276],"behavior,":[277],"or":[278],"tumor":[279],"cell":[280],"growth.":[281]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}