{"id":"https://openalex.org/W2167016752","doi":"https://doi.org/10.1083/jcb.200402082","title":"Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization","display_name":"Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization","publication_year":2004,"publication_date":"2004-09-20","ids":{"openalex":"https://openalex.org/W2167016752","doi":"https://doi.org/10.1083/jcb.200402082","mag":"2167016752","pmid":"https://pubmed.ncbi.nlm.nih.gov/15381688","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172020"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.200402082","doi":"https://doi.org/10.1083/jcb.200402082","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200402082","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172020","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002773490","display_name":"Gideon W.A. Lansbergen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gideon Lansbergen","raw_affiliation_strings":["1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027044812","display_name":"Yulia A. Komarova","orcid":"https://orcid.org/0000-0002-3526-6082","observed_orcids":["https://orcid.org/0000-0002-3526-6082"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Yulia Komarova","raw_affiliation_strings":["3Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611","4Laboratory of Cell Motility, A.N. Belozersky Institute, Moscow State University, Moscow, 119992, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"4Laboratory of Cell Motility, A.N. Belozersky Institute, Moscow State University, Moscow, 119992, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058213120","display_name":"Mauro Modesti","orcid":"https://orcid.org/0000-0002-4964-331X","observed_orcids":["https://orcid.org/0000-0002-4964-331X"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mauro Modesti","raw_affiliation_strings":["1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013000014","display_name":"Claire Wyman","orcid":"https://orcid.org/0000-0003-2549-6893","observed_orcids":["https://orcid.org/0000-0003-2549-6893"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Claire Wyman","raw_affiliation_strings":["1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands","2Department of Radiation Oncology, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"2Department of Radiation Oncology, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058356091","display_name":"Casper C. Hoogenraad","orcid":"https://orcid.org/0000-0002-2666-0758","observed_orcids":["https://orcid.org/0000-0002-2666-0758"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Casper C. Hoogenraad","raw_affiliation_strings":["1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080531193","display_name":"Holly V. Goodson","orcid":"https://orcid.org/0000-0001-7942-8349","observed_orcids":["https://orcid.org/0000-0001-7942-8349"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly V. Goodson","raw_affiliation_strings":["5Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034374767","display_name":"R\u00e9gis Lemaitre","orcid":"https://orcid.org/0000-0002-4881-7541","observed_orcids":["https://orcid.org/0000-0002-4881-7541"]},"institutions":[{"id":"https://openalex.org/I4210159854","display_name":"Max Planck Institute of Molecular Cell Biology and Genetics","ror":"https://ror.org/05b8d3w18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210159854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Re\u0301gis P. Lemaitre","raw_affiliation_strings":["6Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany","institution_ids":["https://openalex.org/I4210159854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005829280","display_name":"David N. Drechsel","orcid":"https://orcid.org/0000-0002-6100-1328","observed_orcids":["https://orcid.org/0000-0002-6100-1328"]},"institutions":[{"id":"https://openalex.org/I4210159854","display_name":"Max Planck Institute of Molecular Cell Biology and Genetics","ror":"https://ror.org/05b8d3w18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210159854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David N. Drechsel","raw_affiliation_strings":["6Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany","institution_ids":["https://openalex.org/I4210159854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030899768","display_name":"Erik B. van Munster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156196","display_name":"Van Leeuwenhoek Centre for Advanced Microscopy","ror":"https://ror.org/013rctf62","country_code":"NL","type":"facility","lineage":["https://openalex.org/I2898336195","https://openalex.org/I4387156196","https://openalex.org/I887064364"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Erik van Munster","raw_affiliation_strings":["7Section of Molecular Cytology and Centre for Advanced Microscopy, Swammerdam Institute for Life Science, University of Amsterdam, 1098 SM Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Section of Molecular Cytology and Centre for Advanced Microscopy, Swammerdam Institute for Life Science, University of Amsterdam, 1098 SM Amsterdam, Netherlands","institution_ids":["https://openalex.org/I4387156196","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083451833","display_name":"Theodorus W. J. Gadella","orcid":"https://orcid.org/0000-0002-7639-219X","observed_orcids":["https://orcid.org/0000-0002-7639-219X"]},"institutions":[{"id":"https://openalex.org/I4387156196","display_name":"Van Leeuwenhoek Centre for Advanced Microscopy","ror":"https://ror.org/013rctf62","country_code":"NL","type":"facility","lineage":["https://openalex.org/I2898336195","https://openalex.org/I4387156196","https://openalex.org/I887064364"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Theodorus W.J. Gadella","raw_affiliation_strings":["7Section of Molecular Cytology and Centre for Advanced Microscopy, Swammerdam Institute for Life Science, University of Amsterdam, 1098 SM Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Section of Molecular Cytology and Centre for Advanced Microscopy, Swammerdam Institute for Life Science, University of Amsterdam, 1098 SM Amsterdam, Netherlands","institution_ids":["https://openalex.org/I4387156196","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056347519","display_name":"Frank G. Grosveld","orcid":"https://orcid.org/0000-0002-7051-4715","observed_orcids":["https://orcid.org/0000-0002-7051-4715"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frank Grosveld","raw_affiliation_strings":["1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068993400","display_name":"Niels Galjart","orcid":"https://orcid.org/0000-0003-1964-3607","observed_orcids":["https://orcid.org/0000-0003-1964-3607"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Niels Galjart","raw_affiliation_strings":["1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002316771","display_name":"Gary G. Borisy","orcid":"https://orcid.org/0000-0002-0266-8018","observed_orcids":["https://orcid.org/0000-0002-0266-8018"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary G. Borisy","raw_affiliation_strings":["3Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024109873","display_name":"Anna S. Akhmanova","orcid":"https://orcid.org/0000-0002-9048-8614","observed_orcids":["https://orcid.org/0000-0002-9048-8614"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Anna Akhmanova","raw_affiliation_strings":["1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1MGC Department of Cell Biology and Genetics, Erasmus Medical Center, 3000 DR Rotterdam, Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5024109873"],"corresponding_institution_ids":["https://openalex.org/I2801952686"],"apc_list":null,"apc_paid":null,"fwci":3.9403,"has_fulltext":true,"cited_by_count":178,"citation_normalized_percentile":{"value":0.94558319,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"166","issue":"7","first_page":"1003","last_page":"1014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clip-170","display_name":"CLIP-170","score":0.996999979019165},{"id":"https://openalex.org/keywords/dynactin","display_name":"dynactin","score":0.8299999833106995},{"id":"https://openalex.org/keywords/p150glued","display_name":"p150Glued","score":0.9259999990463257},{"id":"https://openalex.org/keywords/lis1","display_name":"LIS1","score":0.8980000019073486},{"id":"https://openalex.org/keywords/microtubule-plus-ends","display_name":"microtubule plus ends","score":0.7739999890327454},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.8109999895095825},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7710000276565552},{"id":"https://openalex.org/keywords/metal-binding-motif","display_name":"metal-binding motifs","score":0.8539999723434448},{"id":"https://openalex.org/keywords/intramolecular-interactions","display_name":"intramolecular interactions","score":0.8610000014305115},{"id":"https://openalex.org/keywords/dynein","display_name":"dynein","score":0.6859999895095825},{"id":"https://openalex.org/keywords/microtubule-binding-protein","display_name":"microtubule-binding protein","score":0.6209999918937683},{"id":"https://openalex.org/keywords/rnai-knockdown","display_name":"RNAi knockdown","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C134729014","wikidata":"https://www.wikidata.org/wiki/Q21105411","display_name":"Dynactin","level":4,"score":0.9808310270309448},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.7376846075057983},{"id":"https://openalex.org/C106987784","wikidata":"https://www.wikidata.org/wiki/Q410134","display_name":"Dynein","level":3,"score":0.6939716339111328},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.5717875957489014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.555476188659668},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.53282231092453},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5197070240974426},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4956873655319214},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.4611651301383972},{"id":"https://openalex.org/C61081601","wikidata":"https://www.wikidata.org/wiki/Q1102066","display_name":"Microtubule-associated protein","level":3,"score":0.45315879583358765},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4493187665939331},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4466637074947357},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2569124698638916},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.19126439094543457},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10275882482528687},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072159","descriptor_name":"Dynactin Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":15,"locations":[{"id":"doi:10.1083/jcb.200402082","doi":"https://doi.org/10.1083/jcb.200402082","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200402082","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1371538","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172020","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:15381688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15381688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2172020","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2172020/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmh:oai:pure.eur.nl:openaire/02102df1-4488-4a6b-95ab-e83c3f3e90b4","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/02102df1-4488-4a6b-95ab-e83c3f3e90b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lansbergen, G, Komarova, YA, Modesti, M, Wyman, C L, Hoogenraad, CC, Goodson, HV, Lemaitre, RP, Drechsel, DN, van Munster, E, Gadella jr., TWJ, Grosveld, F, Galjart, N, Borisy, GG & Akhmanova, A 2004, 'Conformational changes in CLIP-170 regulate its binding to microtubule dynactin localization', Journal of Cell Biology, vol. 166, no. 7, pp. 1003-1014. https://doi.org/10.1083/jcb.200402082","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.uva.nl:openaire_cris_publications/6cd58223-6c8c-49b5-a605-45bfaa8543d0","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/conformational-changes-in-clip170-regulate-its-binding-to-microtubules-and-dynactin-localization(6cd58223-6c8c-49b5-a605-45bfaa8543d0).html","pdf_url":"https://pure.uva.nl/ws/files/4071064/33977_1003.pdf","source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lansbergen, G, Komarova, Y, Modesti, M, Wyman, C, Hoogenraad, C C, Goodson, H V, Lemaitre, R P, Drechsel, D N, van Munster, E B, Gadella, T W J, Grosveld, F, Galjart, N, Borisy, G G & Akhmanova, A 2005, 'Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization.', Journal of Cell Biology, vol. 166, pp. 1003-1014. https://doi.org/10.1083/jcb.200402082","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.274.3598","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.274.3598","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b5/13/J_Cell_Biol_2004_Sep_27_166(7)_1003-1014.tar.gz","raw_type":"text"},{"id":"pmh:eur:oai:pure.eur.nl:publications/02102df1-4488-4a6b-95ab-e83c3f3e90b4","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/02102df1-4488-4a6b-95ab-e83c3f3e90b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cell Biology, 166(7), 1003 - 1014. Rockefeller University Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:66227","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/66227","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Cell Biology, 166(7), 1003 - 1014","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:8362","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/8362","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Cell Biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:edoc.mpg.de:229760","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/229760","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cell Biology, v.166, 1003-1014 (2004)","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_2570088","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0001-121F-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cell Biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repub.eur.nl:66227","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/66227","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Cell Biology vol. 166 no. 7, pp. 1003-1014","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repub.eur.nl:8362","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/8362","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Cell Biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/6cd58223-6c8c-49b5-a605-45bfaa8543d0","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/conformational-changes-in-clip170-regulate-its-binding-to-microtubules-and-dynactin-localization(6cd58223-6c8c-49b5-a605-45bfaa8543d0).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cell Biology, 166, 1003 - 1014. Rockefeller University Press","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1371538","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172020","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3264798404","display_name":null,"funder_award_id":"GM 25062","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3375591756","display_name":"MECHANISM AND CONTROL OF MICROTUBULE ASSEMBLY","funder_award_id":"R37GM025062","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G560830566","display_name":"MECHANISM AND CONTROL OF MICROTUBULE ASSEMBLY","funder_award_id":"R01GM025062","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167016752.pdf","grobid_xml":"https://content.openalex.org/works/W2167016752.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1481912803","https://openalex.org/W1561680043","https://openalex.org/W1600225469","https://openalex.org/W1963851313","https://openalex.org/W1965256428","https://openalex.org/W1972548252","https://openalex.org/W1984979116","https://openalex.org/W1997564419","https://openalex.org/W1997863565","https://openalex.org/W1999191945","https://openalex.org/W2005748892","https://openalex.org/W2021135236","https://openalex.org/W2038783205","https://openalex.org/W2041158925","https://openalex.org/W2042992389","https://openalex.org/W2045675250","https://openalex.org/W2049413879","https://openalex.org/W2057351369","https://openalex.org/W2058938762","https://openalex.org/W2061300314","https://openalex.org/W2070275392","https://openalex.org/W2074888950","https://openalex.org/W2091946706","https://openalex.org/W2093717429","https://openalex.org/W2118036121","https://openalex.org/W2121515452","https://openalex.org/W2125625974","https://openalex.org/W2127012355","https://openalex.org/W2128647989","https://openalex.org/W2129096696","https://openalex.org/W2133664013","https://openalex.org/W2141391862","https://openalex.org/W2141475257","https://openalex.org/W2149151220","https://openalex.org/W2154968967","https://openalex.org/W2156293240","https://openalex.org/W2157319245","https://openalex.org/W2163174294","https://openalex.org/W2164606836","https://openalex.org/W2166663417","https://openalex.org/W2171088911","https://openalex.org/W4231355269","https://openalex.org/W4243817179"],"related_works":["https://openalex.org/W7098823911","https://openalex.org/W2049413879","https://openalex.org/W1992775480","https://openalex.org/W2753232694","https://openalex.org/W2119545286","https://openalex.org/W1799360651","https://openalex.org/W2125625974","https://openalex.org/W2065921905","https://openalex.org/W2081660891","https://openalex.org/W414495372"],"abstract_inverted_index":{"Cytoplasmic":[0],"linker":[1],"protein":[2],"(CLIP)-170,":[3],"CLIP-115,":[4],"and":[5,65,117,133,163],"the":[6,18,43,54,72,75,88,95,103,131,142,145,164],"dynactin":[7,41,86],"subunit":[8],"p150(Glued)":[9,50,64],"are":[10,156],"structurally":[11],"related":[12],"proteins,":[13],"which":[14],"associate":[15],"specifically":[16],"with":[17,74,102,141],"ends":[19],"of":[20,29,40,49,57,98,136,144],"growing":[21],"microtubules":[22],"(MTs).":[23],"Here,":[24],"we":[25,123],"show":[26,93],"that":[27,80,94,151],"down-regulation":[28],"CLIP-170":[30,58,76,99,104,146,155],"by":[31],"RNA":[32],"interference":[33],"results":[34],"in":[35,154],"a":[36,67],"strongly":[37],"reduced":[38],"accumulation":[39],"at":[42],"MT":[44,89,165],"tips.":[45,90,166],"The":[46],"NH(2)":[47,132],"terminus":[48,56,106],"binds":[51],"directly":[52],"to":[53,84,147,160],"COOH":[55,77,105,134],"through":[59,107],"its":[60,108],"second":[61],"metal-binding":[62,110],"motif.":[63,111],"LIS1,":[66,162],"dynein-associating":[68],"protein,":[69],"compete":[70],"for":[71,126,158],"interaction":[73,129,139],"terminus,":[78],"suggesting":[79],"LIS1":[81],"can":[82],"act":[83],"release":[85],"from":[87],"We":[91,149],"also":[92],"NH(2)-terminal":[96],"part":[97],"itself":[100],"associates":[101],"first":[109],"By":[112],"using":[113],"scanning":[114],"force":[115],"microscopy":[116],"fluorescence":[118],"resonance":[119],"energy":[120],"transfer-based":[121],"experiments":[122],"provide":[124],"evidence":[125],"an":[127],"intramolecular":[128],"between":[130],"termini":[135],"CLIP-170.":[137],"This":[138],"interferes":[140],"binding":[143,159],"MTs.":[148],"propose":[150],"conformational":[152],"changes":[153],"important":[157],"dynactin,":[161]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}