{"id":"https://openalex.org/W2166935005","doi":"https://doi.org/10.1093/jnci/95.1.19","title":"Placebo Effects in Oncology","display_name":"Placebo Effects in Oncology","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2166935005","doi":"https://doi.org/10.1093/jnci/95.1.19","mag":"2166935005","pmid":"https://pubmed.ncbi.nlm.nih.gov/12509397"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/95.1.19","doi":"https://doi.org/10.1093/jnci/95.1.19","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/95.1.19","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070587841","display_name":"Gis\u00e8le Chvetzoff","orcid":"https://orcid.org/0000-0002-2957-1531","observed_orcids":["https://orcid.org/0000-0002-2957-1531"]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"G. Chvetzoff","raw_affiliation_strings":["Department of Medical Oncology, Centre L\u00e9on B\u00e9rard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Centre L\u00e9on B\u00e9rard, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063846121","display_name":"Ian F. Tannock","orcid":"https://orcid.org/0000-0002-2636-7041","observed_orcids":["https://orcid.org/0000-0002-2636-7041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. F. Tannock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070587841"],"corresponding_institution_ids":["https://openalex.org/I4210105738"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":0.861,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.59917355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"95","issue":"1","first_page":"19","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12035","display_name":"Pain Management and Placebo Effect","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12035","display_name":"Pain Management and Placebo Effect","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placebo-effect","display_name":"placebo effect","score":0.824999988079071},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.8420000076293945},{"id":"https://openalex.org/keywords/symptom-management","display_name":"symptom management","score":0.7369999885559082},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tumor-response","display_name":"tumor response","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.8019999861717224},{"id":"https://openalex.org/keywords/appetite","display_name":"appetite","score":0.9449999928474426},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.8870000243186951},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.9779999852180481},{"id":"https://openalex.org/keywords/best-supportive-care","display_name":"best supportive care","score":0.9869999885559082},{"id":"https://openalex.org/keywords/analgesic-use","display_name":"analgesic use","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8805505633354187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8423243165016174},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.7050668001174927},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.7038356065750122},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5472367405891418},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5148569941520691},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4375549852848053},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.42412570118904114},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1719989776611328},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1206829845905304},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07942688465118408},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001066","descriptor_name":"Appetite","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015990","descriptor_name":"Placebo Effect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017567","descriptor_name":"Karnofsky Performance Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/jnci/95.1.19","doi":"https://doi.org/10.1093/jnci/95.1.19","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/95.1.19","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:12509397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12509397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.516.8132","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.516.8132","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnci.oxfordjournals.org/content/95/1/19.full.pdf","raw_type":"text"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/1003131","doi":null,"is_oa":false,"landing_page_url":"http://worldcatlibraries.org/registry/gateway?version=1.0&url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&atitle=Placebo+effects+in+oncology&title=Journal+of+the+National+Cancer+Institute+&volume=95&issue=1&spage=19-29&date=2003-01&au=Chvetzoff,+Gisele;+Tannock,+Ian+F.","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eweb:256413","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W24992650","https://openalex.org/W83138054","https://openalex.org/W1154914111","https://openalex.org/W1781229955","https://openalex.org/W1783763910","https://openalex.org/W1835001492","https://openalex.org/W1870686894","https://openalex.org/W1873198075","https://openalex.org/W1922104747","https://openalex.org/W1935714962","https://openalex.org/W1953212353","https://openalex.org/W1963635251","https://openalex.org/W1964312509","https://openalex.org/W1967950617","https://openalex.org/W1970325604","https://openalex.org/W1979285610","https://openalex.org/W1983235754","https://openalex.org/W1990248574","https://openalex.org/W1992408996","https://openalex.org/W1997810478","https://openalex.org/W2003562529","https://openalex.org/W2006545734","https://openalex.org/W2013024718","https://openalex.org/W2013582820","https://openalex.org/W2014702689","https://openalex.org/W2015526987","https://openalex.org/W2017062373","https://openalex.org/W2017514236","https://openalex.org/W2019972027","https://openalex.org/W2020255415","https://openalex.org/W2023671892","https://openalex.org/W2026848003","https://openalex.org/W2034557970","https://openalex.org/W2036792232","https://openalex.org/W2036990943","https://openalex.org/W2037628350","https://openalex.org/W2039542922","https://openalex.org/W2039875234","https://openalex.org/W2040376363","https://openalex.org/W2043956678","https://openalex.org/W2047234060","https://openalex.org/W2050184715","https://openalex.org/W2069489114","https://openalex.org/W2072673199","https://openalex.org/W2079706772","https://openalex.org/W2083939213","https://openalex.org/W2085664147","https://openalex.org/W2090562093","https://openalex.org/W2091580529","https://openalex.org/W2092885501","https://openalex.org/W2096122707","https://openalex.org/W2098076970","https://openalex.org/W2108198721","https://openalex.org/W2108890677","https://openalex.org/W2117858690","https://openalex.org/W2118499426","https://openalex.org/W2130522735","https://openalex.org/W2140777712","https://openalex.org/W2146129917","https://openalex.org/W2148500695","https://openalex.org/W2160796458","https://openalex.org/W2161347796","https://openalex.org/W2167571044","https://openalex.org/W2187548005","https://openalex.org/W2228157008","https://openalex.org/W2241551134","https://openalex.org/W2246231529","https://openalex.org/W2287833444","https://openalex.org/W2288888750","https://openalex.org/W2322957625","https://openalex.org/W2329376561","https://openalex.org/W2331364533","https://openalex.org/W2403355975","https://openalex.org/W2406439470","https://openalex.org/W2408053455","https://openalex.org/W2410933080","https://openalex.org/W4231647528","https://openalex.org/W4243863958","https://openalex.org/W7116885012"],"related_works":["https://openalex.org/W2186570769","https://openalex.org/W2149962369","https://openalex.org/W2024582238","https://openalex.org/W7212280266","https://openalex.org/W97930207","https://openalex.org/W7095936237","https://openalex.org/W1968097510","https://openalex.org/W4256441380","https://openalex.org/W2410933080","https://openalex.org/W2331364533"],"abstract_inverted_index":{"BACKGROUND:":[0],"Previous":[1],"studies":[2,37],"have":[3,9,32],"suggested":[4],"that":[5,82,130,195,297],"placebo":[6,114,138,200,365],"treatment":[7],"can":[8],"positive":[10,348],"effects":[11],"on":[12],"a":[13,113,119,199,270],"variety":[14],"of":[15,50,59,65,84,92,105,144,150,158,166,173,205,215,221,228,236,260,278,286,329,338,357],"disorders":[16],"and":[17,26,67,90,153,226,307,343,355],"disease-related":[18],"symptoms.":[19],"However,":[20],"the":[21,28,36,42,51,57,137],"methodology":[22],"used":[23],"to":[24,55,98,198,296,361,364],"collect":[25],"interpret":[27],"data":[29],"may":[30],"not":[31,39,45,96,242],"been":[33],"ideal,":[34],"because":[35],"were":[38,44,146,191,317],"double-blinded":[40],"or":[41,63,118,181,210],"endpoints":[43],"properly":[46],"validated.":[47],"The":[48,284],"purpose":[49],"present":[52],"study":[53],"was":[54,112,241,255,273,293],"determine":[56],"probability":[58,285],"improvement":[60,231,288,304],"in":[61,70,76,109,136,141,148,154,156,163,171,182,201,232,244,257,275,289,298,305,353],"symptoms":[62,339,354],"quality":[64,91,172,356],"life":[66,93,174,237,358],"tumor":[68,99,310,349],"response":[69,197,248,311],"cancer":[71],"patients":[72,135,206,216,222,229,240,262,280,290,299,314],"treated":[73],"with":[74,326,335,347],"placebos":[75,85,331],"randomized":[77,106,321],"controlled":[78,107],"trials.":[79,160],"We":[80,102],"hypothesized":[81],"administration":[83],"would":[86,95],"improve":[87],"symptom":[88,287],"control":[89,337],"but":[94,345],"lead":[97],"response.":[100,350],"METHODS:":[101],"reviewed":[103],"reports":[104],"trials":[108,129,152,194,264,282],"which":[110],"there":[111],"arm":[115,124],"(37":[116],"trials)":[117,190,316],"best":[120],"supportive":[121],"care":[122],"(BSC)":[123],"(10":[125],"trials).":[126],"RESULTS:":[127],"In":[128,193,320],"assessed":[131,176,186,196,249,268],"average":[132,142,164],"responses":[133],"for":[134,238],"arm,":[139],"improvements":[140,162,352],"levels":[143,165],"pain":[145,209,306,342],"reported":[147,243],"two":[149],"six":[151],"appetite,":[155],"one":[157,309],"seven":[159],"No":[161],"weight":[167,224],"gain":[168],"(six":[169],"trials),":[170,180],"(as":[175,185],"by":[177,187,250,269],"patients;":[178],"10":[179,258],"performance":[183,233],"status":[184],"physicians;":[188],"nine":[189],"reported.":[192,318],"individual":[202,239],"patients,":[203],"0%-21%":[204],"showed":[207,217,223,230],"reduced":[208],"decreased":[211],"analgesic":[212],"intake,":[213],"8%-27%":[214],"appetite":[218,344],"improvement,":[219],"7%-17%":[220],"gain,":[225],"6%-14%":[227],"status.":[234],"Quality":[235],"any":[245],"trial.":[246],"Tumor":[247],"World":[251],"Health":[252],"Organization":[253],"criteria":[254],"observed":[256,274],"(2.7%)":[259],"375":[261],"(seven":[263],"total).":[265,283],"Response":[266],"as":[267,341],"serum":[271],"marker":[272],"1":[276],"(1.7%)":[277],"60":[279],"(two":[281],"receiving":[291,300],"BSC":[292],"generally":[294],"similar":[295],"placebo,":[301],"although":[302],"no":[303],"only":[308],"among":[312],"191":[313],"(five":[315],"CONCLUSION:":[319],"double-blinded,":[322],"placebo-controlled":[323],"trials,":[324],"presumably":[325],"minimum":[327],"sources":[328],"bias,":[330],"are":[332,359],"sometimes":[333],"associated":[334],"improved":[336],"such":[340],"rarely":[346],"Substantial":[351],"unlikely":[360],"be":[362],"due":[363],"effects.":[366]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}