{"id":"https://openalex.org/W2166895667","doi":"https://doi.org/10.1101/gr.5.2.136","title":"Statistical methods for polyploid radiation hybrid mapping.","display_name":"Statistical methods for polyploid radiation hybrid mapping.","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W2166895667","doi":"https://doi.org/10.1101/gr.5.2.136","mag":"2166895667","pmid":"https://pubmed.ncbi.nlm.nih.gov/9132268"},"language":"en","primary_location":{"id":"doi:10.1101/gr.5.2.136","doi":"https://doi.org/10.1101/gr.5.2.136","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.5.2.136","pdf_url":"https://genome.cshlp.org/content/5/2/136.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://genome.cshlp.org/content/5/2/136.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070269135","display_name":"Kenneth L. Lange","orcid":"https://orcid.org/0000-0002-1313-5030","observed_orcids":["https://orcid.org/0000-0002-1313-5030"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Lange","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003810507","display_name":"Michael Boehnke","orcid":"https://orcid.org/0000-0002-6442-7754","observed_orcids":["https://orcid.org/0000-0002-6442-7754"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Boehnke","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103747073","display_name":"David R. Cox","orcid":"https://orcid.org/0000-0002-7270-2525","observed_orcids":["https://orcid.org/0000-0002-7270-2525"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Cox","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086558373","display_name":"Kathryn L. Lunetta","orcid":"https://orcid.org/0000-0002-9268-810X","observed_orcids":["https://orcid.org/0000-0002-9268-810X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K L Lunetta","raw_affiliation_strings":["Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":173,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"2","first_page":"136","last_page":"150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0617000013589859,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.056299999356269836,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-hybrid-mapping","display_name":"radiation hybrid mapping","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chromosome-mapping","display_name":"chromosome mapping","score":0.5149999856948853},{"id":"https://openalex.org/keywords/hidden-markov-models","display_name":"hidden Markov models","score":0.8560000061988831},{"id":"https://openalex.org/keywords/typing-errors","display_name":"typing errors","score":0.9229999780654907},{"id":"https://openalex.org/keywords/human-chromosome-4","display_name":"human chromosome 4","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8006563782691956},{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.6239268183708191},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5924215912818909},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5758882761001587},{"id":"https://openalex.org/C2779377595","wikidata":"https://www.wikidata.org/wiki/Q21045424","display_name":"Approximate Bayesian computation","level":3,"score":0.5491408109664917},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4992790222167969},{"id":"https://openalex.org/C2776626444","wikidata":"https://www.wikidata.org/wiki/Q213410","display_name":"Polyploid","level":4,"score":0.49308153986930847},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.4112965166568756},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4104202389717102},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.329105943441391},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18763995170593262},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17250755429267883},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1308726668357849},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002894","descriptor_name":"Chromosomes, Human, Pair 4","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008432","descriptor_name":"Mathematical Computing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1101/gr.5.2.136","doi":"https://doi.org/10.1101/gr.5.2.136","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.5.2.136","pdf_url":"https://genome.cshlp.org/content/5/2/136.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},{"id":"pmid:9132268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9132268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/gr.5.2.136","doi":"https://doi.org/10.1101/gr.5.2.136","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gr.5.2.136","pdf_url":"https://genome.cshlp.org/content/5/2/136.full.pdf","source":{"id":"https://openalex.org/S43092948","display_name":"Genome Research","issn_l":"1088-9051","issn":["1088-9051","1549-5469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1543282891","display_name":null,"funder_award_id":"CA-16 042","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3468304963","display_name":null,"funder_award_id":"HG-00376","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5614205444","display_name":null,"funder_award_id":"HG53275","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000898870","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016042","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2166895667.pdf","grobid_xml":"https://content.openalex.org/works/W2166895667.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W156148808","https://openalex.org/W194242946","https://openalex.org/W1480281978","https://openalex.org/W1492369005","https://openalex.org/W1519076012","https://openalex.org/W1550127064","https://openalex.org/W1575431606","https://openalex.org/W1603339577","https://openalex.org/W1708197474","https://openalex.org/W1911732579","https://openalex.org/W1966786763","https://openalex.org/W1970045504","https://openalex.org/W1970486714","https://openalex.org/W1972630358","https://openalex.org/W1987750200","https://openalex.org/W2005900670","https://openalex.org/W2017696952","https://openalex.org/W2038619833","https://openalex.org/W2047507542","https://openalex.org/W2049633694","https://openalex.org/W2060601854","https://openalex.org/W2067871613","https://openalex.org/W2074196849","https://openalex.org/W2094326229","https://openalex.org/W2096339657","https://openalex.org/W2114355145","https://openalex.org/W2122293056","https://openalex.org/W2125838338","https://openalex.org/W2167266655","https://openalex.org/W2211373325","https://openalex.org/W2751862591","https://openalex.org/W3004157836","https://openalex.org/W3158027121","https://openalex.org/W4253635922"],"related_works":["https://openalex.org/W2122293056","https://openalex.org/W1989880353","https://openalex.org/W1480281978","https://openalex.org/W2096339657","https://openalex.org/W1987750200","https://openalex.org/W235331263","https://openalex.org/W2735796019","https://openalex.org/W2046107237","https://openalex.org/W1841786131","https://openalex.org/W2053666726"],"abstract_inverted_index":{"Radiation":[0],"hybrid":[1],"mapping":[2],"is":[3,144,163],"a":[4,13,25,78,100],"somatic":[5],"cell":[6,76],"technique":[7],"for":[8,32],"ordering":[9],"genetic":[10],"loci":[11,178],"along":[12,87],"chromosome":[14,41,185],"and":[15,30,109,124,147],"estimating":[16],"physical":[17],"distances":[18],"between":[19],"adjacent":[20],"loci.":[21],"This":[22],"paper":[23],"presents":[24],"model":[26,67],"of":[27,39,42,77,107,153,183],"fragment":[28],"generation":[29],"retention":[31,102,112],"data":[33,48],"involving":[34],"two":[35],"or":[36,58,62],"more":[37],"copies":[38],"the":[40,74,97,105,151,180],"interest":[43],"per":[44],"clone.":[45],"Such":[46],"polyploid":[47],"can":[49,128,136],"be":[50,129,137],"generated":[51,72],"by":[52,59,139],"initially":[53],"irradiating":[54],"normal":[55],"diploid":[56,63],"cells":[57],"pooling":[60],"haploid":[61],"clones.":[64],"The":[65,169],"current":[66],"assumes":[68],"that":[69],"fragments":[70,92],"are":[71,93,174],"in":[73,96],"ancestral":[75],"clone":[79,98],"according":[80],"to":[81,131,165,176],"an":[82],"independent":[83],"Poisson":[84],"breakage":[85],"process":[86],"each":[88],"chromosome.":[89],"Once":[90],"generated,":[91],"independently":[94],"retained":[95],"with":[99],"common":[101],"probability.":[103],"On":[104],"basis":[106],"this":[108,160],"less":[110],"restrictive":[111],"models,":[113],"statistical":[114,170],"criteria":[115],"such":[116],"as":[117],"minimum":[118],"obligate":[119],"breaks,":[120],"maximum":[121,140],"likelihood":[122],"ratios,":[123],"Bayesian":[125],"posterior":[126],"probabilities":[127],"used":[130],"decide":[132],"locus":[133],"order.":[134],"Distances":[135],"estimated":[138],"likelihood.":[141],"Likelihood":[142],"computation":[143],"particularly":[145],"challenging,":[146],"computing":[148],"techniques":[149],"from":[150],"theory":[152],"hidden":[154],"Markov":[155],"chains":[156],"prove":[157],"crucial.":[158],"Within":[159],"context":[161],"it":[162],"possible":[164],"incorporate":[166],"typing":[167],"errors.":[168],"tools":[171],"discussed":[172],"here":[173],"applied":[175],"14":[177],"on":[179],"short":[181],"arm":[182],"human":[184],"4.":[186]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}