{"id":"https://openalex.org/W2166861430","doi":null,"title":"Unraveling the Wnt secretion pathway","display_name":"Unraveling the Wnt secretion pathway","publication_year":2011,"publication_date":"2011-06-29","ids":{"openalex":"https://openalex.org/W2166861430","mag":"2166861430"},"language":"en","primary_location":{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/205841","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/205841","pdf_url":"https://dspace.library.uu.nl/handle/1874/205841","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/205841","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046582662","display_name":"Martin Harterink","orcid":"https://orcid.org/0000-0002-8256-6651","observed_orcids":["https://orcid.org/0000-0002-8256-6651"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Martin Harterink","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8256-6651","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046582662"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-secretion","display_name":"Wnt secretion","score":0.8830000162124634},{"id":"https://openalex.org/keywords/wntless","display_name":"Wntless","score":0.9179999828338623},{"id":"https://openalex.org/keywords/retromer-complex","display_name":"retromer complex","score":0.9179999828338623},{"id":"https://openalex.org/keywords/secreted-frizzled-related-proteins","display_name":"secreted frizzled-related proteins","score":0.515999972820282},{"id":"https://openalex.org/keywords/sfrp1","display_name":"SFRP1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/wnt-inhibitors","display_name":"Wnt inhibitors","score":0.7089999914169312},{"id":"https://openalex.org/keywords/neuroblast-migration","display_name":"neuroblast migration","score":0.9700000286102295},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.888802170753479},{"id":"https://openalex.org/C145458877","wikidata":"https://www.wikidata.org/wiki/Q7317044","display_name":"Retromer","level":4,"score":0.8529806137084961},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7435853481292725},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.7249976396560669},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6133267879486084},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.6102012395858765},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6064947843551636},{"id":"https://openalex.org/C182819311","wikidata":"https://www.wikidata.org/wiki/Q18028670","display_name":"LRP5","level":4,"score":0.4787158966064453},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.44529443979263306},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3420882225036621},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14114102721214294},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.11988794803619385},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/205841","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/205841","pdf_url":"https://dspace.library.uu.nl/handle/1874/205841","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:knaw:oai:pure.knaw.nl:publications/4510925d-a5ee-40be-a72a-9e0dc05ca1d8","doi":null,"is_oa":false,"landing_page_url":"https://pure.knaw.nl/portal/en/publications/4510925d-a5ee-40be-a72a-9e0dc05ca1d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:oai:dspace.library.uu.nl:1874/205841","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/205841","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/205841","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/205841","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2166861430","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/bitstream/1874/205841/1/harterink.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/205841","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/205841","pdf_url":"https://dspace.library.uu.nl/handle/1874/205841","source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320868","display_name":"Boehringer Ingelheim Fonds","ror":"https://ror.org/00dkye506"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320325136","display_name":"Boehringer Ingelheim Stiftung","ror":"https://ror.org/03tx8dq56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2166861430.pdf","grobid_xml":"https://content.openalex.org/works/W2166861430.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W123573145","https://openalex.org/W1523269786","https://openalex.org/W1580875833","https://openalex.org/W1590222856","https://openalex.org/W1605394511","https://openalex.org/W1784854092","https://openalex.org/W1943532060","https://openalex.org/W1943866178","https://openalex.org/W1966787570","https://openalex.org/W1967073403","https://openalex.org/W1969559038","https://openalex.org/W1969910714","https://openalex.org/W1973202110","https://openalex.org/W1980269923","https://openalex.org/W1983253019","https://openalex.org/W1986006829","https://openalex.org/W1986223562","https://openalex.org/W1987074443","https://openalex.org/W1997999543","https://openalex.org/W1999056400","https://openalex.org/W1999408122","https://openalex.org/W1999683314","https://openalex.org/W2000523961","https://openalex.org/W2003362984","https://openalex.org/W2003731107","https://openalex.org/W2009379859","https://openalex.org/W2010361379","https://openalex.org/W2013131355","https://openalex.org/W2017955219","https://openalex.org/W2023658088","https://openalex.org/W2025453970","https://openalex.org/W2029307548","https://openalex.org/W2030557396","https://openalex.org/W2031653487","https://openalex.org/W2038492783","https://openalex.org/W2043481572","https://openalex.org/W2048683930","https://openalex.org/W2048858607","https://openalex.org/W2058449530","https://openalex.org/W2059037223","https://openalex.org/W2059656320","https://openalex.org/W2062772445","https://openalex.org/W2063129130","https://openalex.org/W2063289307","https://openalex.org/W2067937471","https://openalex.org/W2069186229","https://openalex.org/W2071887987","https://openalex.org/W2073039366","https://openalex.org/W2073914665","https://openalex.org/W2076480502","https://openalex.org/W2077475973","https://openalex.org/W2077487482","https://openalex.org/W2077588880","https://openalex.org/W2078802378","https://openalex.org/W2079714598","https://openalex.org/W2079819294","https://openalex.org/W2079911954","https://openalex.org/W2082379606","https://openalex.org/W2084440375","https://openalex.org/W2086141702","https://openalex.org/W2088911470","https://openalex.org/W2091884933","https://openalex.org/W2093262727","https://openalex.org/W2093767206","https://openalex.org/W2094546487","https://openalex.org/W2098924417","https://openalex.org/W2099515731","https://openalex.org/W2100253475","https://openalex.org/W2101889783","https://openalex.org/W2102735467","https://openalex.org/W2103090750","https://openalex.org/W2107648723","https://openalex.org/W2108173304","https://openalex.org/W2111952822","https://openalex.org/W2112562104","https://openalex.org/W2113263838","https://openalex.org/W2113695281","https://openalex.org/W2114219172","https://openalex.org/W2114677172","https://openalex.org/W2115990578","https://openalex.org/W2116020415","https://openalex.org/W2118660540","https://openalex.org/W2120419344","https://openalex.org/W2121775620","https://openalex.org/W2122163057","https://openalex.org/W2123513684","https://openalex.org/W2125586511","https://openalex.org/W2128683321","https://openalex.org/W2129835543","https://openalex.org/W2130112137","https://openalex.org/W2130643664","https://openalex.org/W2135835127","https://openalex.org/W2136449953","https://openalex.org/W2137351340","https://openalex.org/W2138435964","https://openalex.org/W2139866795","https://openalex.org/W2142480219","https://openalex.org/W2147864074","https://openalex.org/W2149404019","https://openalex.org/W2150561062","https://openalex.org/W2151690346","https://openalex.org/W2159171327","https://openalex.org/W2159803165","https://openalex.org/W2166748685","https://openalex.org/W2168698734","https://openalex.org/W2170429915","https://openalex.org/W2170551347","https://openalex.org/W2187425347","https://openalex.org/W7075576566"],"related_works":["https://openalex.org/W2073914665","https://openalex.org/W7098911049","https://openalex.org/W1996944279","https://openalex.org/W1969559038","https://openalex.org/W2012231277","https://openalex.org/W2078366752","https://openalex.org/W7095177809","https://openalex.org/W2003731107","https://openalex.org/W2025453970","https://openalex.org/W2020208696"],"abstract_inverted_index":{"The":[0,111],"Wnt":[1,24,61,75,82,109,139,186,204,258],"family":[2],"of":[3,60,108,121,153,156,206,242,255],"signaling":[4,20],"proteins":[5,25,62],"has":[6,54,97],"essential":[7],"functions":[8],"in":[9,71,145,178,188,219],"development":[10],"and":[11,40,42,129,164,257],"adult":[12],"tissue":[13],"homeostasis":[14],"throughout":[15],"the":[16,49,58,74,81,84,87,102,119,146,162,185,189,194,201,207,214,220,223,231,246,261],"animal":[17],"kingdom.":[18],"Although":[19],"cascades":[21],"triggered":[22],"by":[23],"have":[26,173],"been":[27],"extensively":[28],"studied,":[29],"much":[30],"remains":[31],"to":[32,86,92,98,101,116,150,182,235],"be":[33,99],"learned":[34],"about":[35],"how":[36,43],"Wnts":[37,215,238,256],"are":[38,135,216],"produced":[39],"secreted":[41,203],"their":[44],"activity":[45,120],"is":[46,73,225,233],"regulated.":[47],"Over":[48],"past":[50],"few":[51],"years":[52],"it":[53],"become":[55],"clear":[56],"that":[57,213,230,252],"secretion":[59],"requires":[63,118],"a":[64,105],"specialized":[65],"trafficking":[66],"pathway.":[67,170],"A":[68],"central":[69],"player":[70],"this":[72,125,250],"sorting":[76],"receptor":[77],"Wntless,":[78],"which":[79,134],"escorts":[80],"from":[83,114],"Golgi":[85,103,117,151],"plasma":[88],"membrane.":[89],"In":[90,124],"order":[91],"efficiently":[93],"secrete":[94],"Wnts,":[95],"Wntless":[96,112],"retrieved":[100],"for":[104,137,239],"novel":[106],"round":[107],"secretion.":[110,140],"transport":[113],"endosomes":[115],"retromer":[122,147,163,168],"complex.":[123],"thesis":[126],"we":[127,172,199],"identified":[128],"describe":[130],"several":[131,237,243],"new":[132],"component,":[133,158],"required":[136],"efficient":[138],"These":[141],"play":[142],"important":[143,234],"roles":[144],"dependent":[148],"endosome":[149],"traffic":[152],"Wntless.":[154],"One":[155],"these":[157],"snx-3,":[159],"associates":[160],"with":[161],"defines":[165],"an":[166,175],"alternative":[167],"retrieval":[169],"Finally":[171],"used":[174],"adapted":[176],"fluorescent":[177],"situ":[179],"labeling":[180],"protocol":[181],"carefully":[183],"examine":[184],"expression":[187],"nematode":[190],"C.":[191],"elegans":[192],"at":[193],"single":[195],"transcript":[196],"level.":[197],"Additionally,":[198],"included":[200],"only":[202],"inhibitor":[205,224,232,259],"SFRP":[208],"family,":[209],"sfrp-1.":[210],"We":[211,228],"found":[212,229],"mostly":[217],"expressed":[218],"posterior":[221],"whereas":[222],"anteriorly":[226],"expressed.":[227],"suppress":[236],"correct":[240],"migration":[241],"neuroblasts":[244],"along":[245],"anteroposterior":[247,262],"axis.":[248,263],"Altogether":[249],"suggests":[251],"opposing":[253],"activities":[254],"patter":[260]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}